R Y Zee

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Islet amyloid polypeptide gene variation (IAPP) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chim Acta 412:785-7. 2011
  2. ncbi C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 197:931-6. 2008
  3. ncbi Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism
    Robert Y L Zee
    Laboratory of Genetic and Molecular Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medial School, 900 CommonwealthAvenue East, Boston, MA 02215, USA
    Atherosclerosis 197:694-9. 2008
  4. ncbi Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy women
    Robert Y L Zee
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 53:845-51. 2007
  5. ncbi Genetic risk determinants in stroke: a global task
    Robert Y L Zee
    Laboratory of Genetic and Molecular Epidemiology, The Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Neurol India 54:348-9. 2006
  6. ncbi Polymorphisms of the phosphodiesterase 4D, cAMP-specific (PDE4D) gene and risk of ischemic stroke: a prospective, nested case-control evaluation
    Robert Y L Zee
    Laboratory of Genetic and Molecular Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, Massachusetts 02215, USA
    Stroke 37:2012-7. 2006
  7. ncbi Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach
    Robert Y L Zee
    Laboratory of Genetic and Molecular Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, Massachusetts 02215, USA
    Stroke 37:2007-11. 2006
  8. ncbi Polymorphisms in the advanced glycosylation end product-specific receptor gene and risk of incident myocardial infarction or ischemic stroke
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, The Donald W Reynolds Center for Cardiovascular Research, The Leducq Center for Molecular and Genetic Epidemiology, Boston, Mass, USA
    Stroke 37:1686-90. 2006
  9. ncbi Polymorphism in the beta2-adrenergic receptor and lipoprotein lipase genes as risk determinants for idiopathic venous thromboembolism: a multilocus, population-based, prospective genetic analysis
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 113:2193-200. 2006
  10. ncbi Multi-locus candidate gene polymorphisms and risk of myocardial infarction: a population-based, prospective genetic analysis
    R Y L Zee
    Center for Cardiovascular Disease Prevention, Harvard Medical School, Boston, MA 02215, USA
    J Thromb Haemost 4:341-8. 2006

Detail Information

Publications81

  1. pmc Islet amyloid polypeptide gene variation (IAPP) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chim Acta 412:785-7. 2011
    ..Islet amyloid polypeptide (IAPP) gene variation has recently been implicated in type 2 diabetes mellitus (T2D). However, to date, no prospective epidemiological data are available...
  2. ncbi C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 197:931-6. 2008
    ..C-reactive protein (CRP) gene variation, in particular an rs2794521 variant was recently associated with type 2 diabetes mellitus (T2DM) in Pima Indians...
  3. ncbi Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism
    Robert Y L Zee
    Laboratory of Genetic and Molecular Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medial School, 900 CommonwealthAvenue East, Boston, MA 02215, USA
    Atherosclerosis 197:694-9. 2008
    ..The present investigation provides evidence for an association of the P2RY12 haplotype H2 with lower risk of DVT/PE; however these findings require replication in other well-designed studies...
  4. ncbi Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy women
    Robert Y L Zee
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 53:845-51. 2007
    ..To address this apparent paradox, we explored whether interaction between genetic and dietary factors related to homocysteine metabolism contributes to CVD risk...
  5. ncbi Genetic risk determinants in stroke: a global task
    Robert Y L Zee
    Laboratory of Genetic and Molecular Epidemiology, The Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Neurol India 54:348-9. 2006
  6. ncbi Polymorphisms of the phosphodiesterase 4D, cAMP-specific (PDE4D) gene and risk of ischemic stroke: a prospective, nested case-control evaluation
    Robert Y L Zee
    Laboratory of Genetic and Molecular Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, Massachusetts 02215, USA
    Stroke 37:2012-7. 2006
    ..Case-control studies in other populations have yielded mixed evidence for association. A recent analysis in a prospective, non-Icelandic study found an association with stroke after stratification by hypertension...
  7. ncbi Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach
    Robert Y L Zee
    Laboratory of Genetic and Molecular Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, Massachusetts 02215, USA
    Stroke 37:2007-11. 2006
    ..Recent findings have implicated specific gene polymorphisms of arachidonate 5-lipoxygenase-activating protein (ALOX5AP), and 2 at-risk haplotypes (HapA, HapB) in myocardial infarction and stroke. To date, no prospective data are available...
  8. ncbi Polymorphisms in the advanced glycosylation end product-specific receptor gene and risk of incident myocardial infarction or ischemic stroke
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, The Donald W Reynolds Center for Cardiovascular Research, The Leducq Center for Molecular and Genetic Epidemiology, Boston, Mass, USA
    Stroke 37:1686-90. 2006
    ..However, to date, no genetic-epidemiological data are available on risk of atherothrombotic events among nondiabetic populations...
  9. ncbi Polymorphism in the beta2-adrenergic receptor and lipoprotein lipase genes as risk determinants for idiopathic venous thromboembolism: a multilocus, population-based, prospective genetic analysis
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 113:2193-200. 2006
    ..Candidate genes in inflammation, thrombosis, coagulation, and lipid metabolism pathways have been implicated in venous thromboembolism (VTE)...
  10. ncbi Multi-locus candidate gene polymorphisms and risk of myocardial infarction: a population-based, prospective genetic analysis
    R Y L Zee
    Center for Cardiovascular Disease Prevention, Harvard Medical School, Boston, MA 02215, USA
    J Thromb Haemost 4:341-8. 2006
    ..Polymorphisms in candidate genes related to lipid metabolism, thrombosis, hemostasis, cell-matrix adhesion, and inflammation have been suggested clinically useful in risk assessment of cardiovascular disease...
  11. ncbi Intercellular adhesion molecule 1 (ICAM1) Lys56Met and Gly241Arg gene variants, plasma-soluble ICAM1 concentrations, and risk of incident cardiovascular events in 23,014 initially healthy white women
    Robert Y L Zee
    Donald W Reynolds Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Stroke 38:3152-7. 2007
    ..However, to date, no large prospective, genetic-epidemiological data set is available that would allow evaluation of the degree of association of these gene variants with risk of CVD...
  12. pmc Genetic variants within the interleukin-1 gene cluster, and risk of incident myocardial infarction, and ischemic stroke: a nested case-control approach
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, The Donald W Reynolds Center for Cardiovascular Research, The Leducq Center for Molecular and Genetic Epidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 022215, USA
    Atherosclerosis 201:124-9. 2008
    ..However, to date, no prospective, genetic-epidemiological data are available...
  13. pmc Mitochondrial uncoupling protein gene cluster variation (UCP2-UCP3) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study
    Robert Y L Zee
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Atherosclerosis 214:107-9. 2011
    ..Uncoupling protein 2, mitochondrial, (UCP2) gene variation has recently been implicated in type 2 diabetes mellitus (T2DM). To date, no prospective epidemiological data are available...
  14. pmc Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chim Acta 412:199-202. 2011
    ..Candidate genes associated with telomere length maintenance, an important molecular marker for biological aging, represent potential risk predictors for cardiovascular disease (CVD). To date, no prospective data are available...
  15. pmc Relative leukocyte telomere length and risk of incident ischemic stroke in men: a prospective, nested case-control approach
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Rejuvenation Res 13:411-4. 2010
    ..More importantly, our present findings require replication/confirmation in future large, prospective studies...
  16. pmc An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study
    Robert Y L Zee
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Genet 2:57-62. 2009
    ..Although pathways associated with hemostasis and thrombosis are well documented to have an impact on venous thromboembolism (VTE), whether the inflammatory cascade also influences VTE risk is uncertain...
  17. pmc Mean telomere length and risk of incident colorectal carcinoma: a prospective, nested case-control approach
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 18:2280-2. 2009
    ....
  18. pmc Mean telomere length and risk of incident venous thromboembolism: a prospective, nested case-control approach
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chim Acta 406:148-50. 2009
    ..Recent studies have shown telomere-length shortening as a risk predictor for cardiovascular disease. However, to date, no prospective data are available on its potential involvement in venous thromboembolism (VTE)...
  19. pmc Genetic variants of 11 telomere-pathway gene loci and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Atherosclerosis 218:144-6. 2011
    ..Whether this observation was modulated by genetic variation within the telomere-pathway genes remains elusive. To date, no prospective epidemiological data on the relationship of telomere-pathway gene variation with T2D are available...
  20. pmc Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chim Acta 402:189-92. 2009
    ....
  21. pmc Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, United States
    Clin Chim Acta 403:139-41. 2009
    ..Recent data have implicated telomere length shortening as a potential risk predictor for cardiovascular disease. However, to date, prospective epidemiological data are scarce...
  22. ncbi Complement factor H Y402H gene polymorphism, C-reactive protein, and risk of incident myocardial infarction, ischaemic stroke, and venous thromboembolism: a nested case-control study
    Robert Y L Zee
    Laboratory of Genetic Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 187:332-5. 2006
    ..An exonic polymorphism (Y402H) in the complement factor H (CFH) gene, which locates within the binding sites for heparin and C-reactive protein, has recently been described and hypothesized to play an important role in atherothrombosis...
  23. ncbi Tryptophanyl-tRNA synthetase gene polymorphisms and risk of incident myocardial infarction
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, The LeDucq Center for Cardiovascular Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Atherosclerosis 181:137-41. 2005
    ..In conclusion, we found no evidence for an association between the common polymorphisms or haplotypes of the tryptophanyl-tRNA synthetase gene tested and risk of myocardial infarction...
  24. ncbi TP53 haplotype-based analysis and incidence of post-angioplasty restenosis
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Hum Genet 114:386-90. 2004
    ..Furthermore, our study demonstrates that a haplotype-based approach can be more informative than a single-marker or marker-by-marker analysis...
  25. ncbi Prospective evaluation of the alcohol dehydrogenase gamma1/gamma2 gene polymorphism and risk of stroke
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Stroke 35:e39-42. 2004
    ..Genetic polymorphism of the alcohol dehydrogenase type 3 gene (ADH1C) has recently been associated with reduced risk of myocardial infarction. However, data on risk of stroke are not available...
  26. ncbi A prospective evaluation of the heat shock protein 70 gene polymorphisms and the risk of stroke
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Thromb Haemost 87:622-5. 2002
    ..In this large, prospective study, genetic polymorphisms in the HSP70 genes were not associated with risks of future stroke. Screening for these polymorphisms is unlikely to be a useful tool for risk assessment...
  27. ncbi IL-1 cluster genes and occurrence of post-percutaneous transluminal coronary angioplasty restenosis: a prospective, angiography-based evaluation
    Robert Y L Zee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
    Atherosclerosis 171:259-64. 2003
    ..Our data indicate that the common variants in the IL-1 cluster genes are not associated with incidence of restenosis after PTCA...
  28. ncbi Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis
    Robert Y L Zee
    Division of Preventive Medicine, The Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
    Atherosclerosis 162:217-9. 2002
    ..These data suggest that genetic and environmental determinants each importantly contribute to the vascular risk associated with inflammation...
  29. ncbi A prospective evaluation of the CD14 and CD18 gene polymorphisms and risk of stroke
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Stroke 33:892-5. 2002
    ....
  30. ncbi A prospective evaluation of the angiotensin-converting enzyme D/I polymorphism and left ventricular remodeling in the 'Healing and Early Afterload Reducing Therapy' study
    R Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Clin Genet 61:21-5. 2002
    ....
  31. ncbi Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Divisions of Preventive Medicine and Cardiovascular Diseases, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02115, USA
    Atherosclerosis 175:91-4. 2004
    ..If confirmed in other cohorts, these data support the emerging hypothesis that eotaxin participates in atherosclerosis...
  32. ncbi C-reactive protein gene polymorphisms and the risk of venous thromboembolism: a haplotype-based analysis
    R Y L Zee
    Center for Cardiovascular Disease Prevention, Harvard Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Thromb Haemost 2:1240-3. 2004
    ..66, P = 0.72) yielded similar null findings. In conclusion, we found no evidence for an association between the CRP polymorphisms/haplotypes tested and the risk of venous thromboembolism...
  33. ncbi Toll-like receptor 4 Asp299Gly gene polymorphism and risk of atherothrombosis
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, and the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Stroke 36:154-7. 2005
    ..Recent findings of an association between a functional toll-like receptor 4 (TLR4) D299G gene variant and reduced risk of atherothrombotic disorders have generated great interest...
  34. ncbi Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Hum Mol Genet 13:389-96. 2004
    ..These population-based data demonstrate the ability of prospective, epidemiological studies to test candidate gene associations for athero-thrombotic disease...
  35. pmc Haplotype analysis of the beta2 adrenergic receptor gene and risk of myocardial infarction in humans
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, LeDucq Center for Molecular and Genetic Epidemiology, Harvard Medical School, Boston, Massachusetts 02215, USA
    Genetics 169:1583-7. 2005
    ..In conclusion, variation in haplotype frequencies for the beta2 adrenergic receptor gene was found to be associated with risk of myocardial infarction...
  36. ncbi A prospective evaluation of the interleukin-1 receptor antagonist intron 2 gene polymorphism and the risk of myocardial infarction
    R Y Zee
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Thromb Haemost 86:1141-3. 2001
    ..These data also highlight the importance of hypothesis testing studies in genetic epidemiology, particularly for hypotheses generated from small samples or post hoc subgroup analyses...
  37. ncbi C-reactive protein gene polymorphisms and the incidence of post-angioplasty restenosis
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 176:393-6. 2004
    ..In conclusion, we found no evidence for an association between the polymorphisms/haplotypes thereof tested and restenosis after angioplasty...
  38. ncbi A prospective evaluation of the CD14 C(-260)T gene polymorphism and the risk of myocardial infarction
    R Y Zee
    Center of Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Atherosclerosis 154:699-702. 2001
    ..Thus, in contrast to prior studies, these data indicate that screening for CD14 C(-260)T genotypes is unlikely to be a useful tool for risk assessment...
  39. ncbi Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke
    R Y Zee
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 99:340-3. 1999
    ..We investigated the association between ACE genotype and the incidence of stroke in a large, prospective, matched case-control sample from the Physicians' Health Study...
  40. pmc Estrogen receptor 1 gene polymorphisms and decreased risk of obesity in women
    Alessandra C Goulart
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 58:759-64. 2009
    ..One or more copies of the C allele were associated with decreased risk of obesity in white postmenopausal women...
  41. ncbi Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, Mass 02215, USA
    Arterioscler Thromb Vasc Biol 23:859-63. 2003
    ..Because diabetes and atherothrombosis share common antecedents, we sought evidence that this polymorphism might also be associated with reduced risk of myocardial infarction...
  42. pmc Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study
    David Conen
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Hypertens 27:476-83. 2009
    ..The aim of the present study was to assess the association of 77 previously characterized gene variants in 52 candidate genes from various biological pathways with blood pressure (BP) progression and incident hypertension...
  43. pmc Polymorphisms and haplotypes of the estrogen receptor-beta gene (ESR2) and cardiovascular disease in men and women
    Kathryn M Rexrode
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 53:1749-56. 2007
    ..Cohort studies suggest an association between variation in the estrogen receptor-alpha gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-beta gene (ESR2)...
  44. ncbi Ace D/I polymorphism and incidence of post-PTCA restenosis: a prospective, angiography-based evaluation
    R Y Zee
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hypertension 37:851-5. 2001
    ..On the basis of the power of this study, we conclude that in a general population, the ACE D/I polymorphism is not a useful marker to assess risk of post-PTCA restenosis...
  45. ncbi Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE protein
    D I Chasman
    Division of Preventive Medicine and Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA 02215, USA
    Genes Immun 7:211-9. 2006
    ..Quantitative analysis suggested that the effect on CRP is more likely a consequence of intrinsic functional differences among the E2, E3, and E4 apoE proteins than different levels of apoE protein or LDL-C in the plasma...
  46. pmc Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control study
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Clin Chem Lab Med 48:259-62. 2010
    ..To date, no prospective epidemiological data are available, particularly in women, on mean leukocyte telomere length as a risk predictor...
  47. pmc Associations of the estrogen receptors 1 and 2 gene polymorphisms with the metabolic syndrome in women
    Alessandra C Goulart
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Metab Syndr Relat Disord 7:111-7. 2009
    ..Genetic variation of the estrogen receptor alpha (ESR1) and beta (ESR2) has been associated with components of the metabolic syndrome...
  48. ncbi Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study
    D Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Intern Med 263:376-85. 2008
    ..The aim of this study was to assess the relationship between a set of well-characterized genetic variants of the renin-angiotensin system and the endothelial nitric oxide synthase (NOS3) gene and the incidence of type 2 diabetes...
  49. pmc Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 82:1185-92. 2008
    ....
  50. pmc Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, The Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Cardiovasc Genet 2:26-33. 2009
    ..One method to evaluate this issue is to examine whether polymorphisms in the CETP gene that impact on HDL-C levels also impact on the future development of myocardial infarction...
  51. pmc Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease
    Markus Schürks
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    Neurology 71:505-13. 2008
    ..Interrelationships among the MTHFR 677C>T polymorphism (rs1801133), migraine, and cardiovascular disease (CVD) are plausible but remain controversial...
  52. ncbi Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study
    Hillary H Hegener
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chem 52:2021-7. 2006
    ..No prospective data are available, however, on the risk of atherothrombotic disorders in persons with ADIPOQ variations who do not have diabetes...
  53. pmc Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    J Hypertens 26:1780-6. 2008
    ..The aim of the present study was to assess the relationship of six previously characterized gene variants in the renin-angiotensin system and the NOS3 gene with blood pressure progression and incident hypertension...
  54. pmc Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: data from
    Michelle A Albert
    Center for Cardiovascular Disease Prevention, Donald W Reynolds Center for Cardiovascular Disease Research, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
    Am Heart J 157:777-83.e1. 2009
    ..We examined the relationship between specific polymorphisms in the FGB, homocysteine, and ICAM-1 genes and their respective inflammatory biomarker concentrations at baseline in women from different race/ethnic groups...
  55. pmc Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Cancer Causes Control 21:897-908. 2010
    ....
  56. pmc A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration
    Debra A Schaumberg
    Division of Preventive Medicine, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, and Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02215, USA
    Invest Ophthalmol Vis Sci 47:2336-40. 2006
    ..Although plasma CRP levels have been related to AMD and plasma CRP levels are partly determined by genetic variation, there is no information on whether genetic variants in CRP are associated with AMD...
  57. pmc Association between polymorphisms in the beta2-adrenergic receptor gene with myocardial infarction and ischaemic stroke in women
    Markus Schürks
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
    Thromb Haemost 101:351-8. 2009
    ....
  58. doi Gene variation of the transient receptor potential cation channel, subfamily M, member 2 (TRPM2) and type 2 diabetes mellitus: A case-control study
    Jose R Romero
    Divisions of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Clin Chim Acta 411:1437-40. 2010
    ..We hypothesized that gene variation of TRPM2 may play a role in the pathophysiology of type 2 diabetes mellitus (T2DM)...
  59. pmc A candidate gene association study of 77 polymorphisms in migraine
    Markus Schürks
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 CommonwealthAvenue East, 3rd Floor, Boston, MA 02215 1204, SUA
    J Pain 10:759-66. 2009
    ..Our data suggest an association of polymorphisms implicated in inflammatory pathways and migraine in women. TNF, CCR2, TGFB1, NOS3, and IL9 warrant further investigation...
  60. pmc Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Genet 1:21-30. 2008
    ....
  61. pmc Gene variation of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7), and risk of incident ischemic stroke: prospective, nested, case-control study
    Jose R Romero
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    Stroke 40:2965-8. 2009
    ..We hypothesized that TRPM7 gene variation might play a role in the risk of ischemic stroke...
  62. ncbi Tree and spline based association analysis of gene-gene interaction models for ischemic stroke
    Nancy R Cook
    Center for Cardiovascular Disease Prevention and the Leducq Center for Molecular and Genetic Epidemiology, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Stat Med 23:1439-53. 2004
    ..Although further external validation of these models is necessary, these methods may be valuable in exploring and identifying potential gene-gene as well as gene-environment interactions in association studies...
  63. doi Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study
    Robert Y L Zee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Transl Res 155:166-9. 2010
    ..If corroborated in other studies, our findings suggest the potential importance of telomere biology in T2DM...
  64. ncbi Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Circulation 116:1497-503. 2007
    ..Supplementation with vitamin E may antagonize vitamin K in healthy adults, but it is unclear whether intake of vitamin E decreases the risk of venous thromboembolism (VTE)...
  65. pmc Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy
    Daniel I Chasman
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, United States
    Atherosclerosis 203:371-6. 2009
    ..We investigated whether this allele was associated with elevated Lp(a) and cardiovascular risk in the Women's Health Study, a randomized trial of low-dose aspirin, and whether aspirin reduced cardiovascular risk in minor allele carriers...
  66. ncbi Interaction between inflammation-related gene polymorphisms and cigarette smoking on the risk of myocardial infarction in the Physician's Health Study
    Sarah A Rosner
    Department of Epidemiology, Harvard School of Public Health Kresge 911, 677 Huntington Avenue, Boston, MA 02115, USA
    Hum Genet 118:287-94. 2005
    ..However, these results should be interpreted with caution due to the potential for false positive results that can arise from analyses with multiple comparisons...
  67. pmc Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000118. 2008
    ..2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes...
  68. ncbi Non-random chromosomal distribution of SSLPs: systematic assessment using a novel genetic linkage map between two closely related rat strains
    B Gigante
    Department of Internal Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA
    Cytogenet Cell Genet 95:64-72. 2001
    ..Notably, the majority of regions thus identified was also seen when we examined an unrelated set of strains from the literature, indicating, on a more generic level, the presence of mutagenically more and less stable genomic regions...
  69. ncbi Natriuretic peptide precursor a gene polymorphisms and risk of blood pressure progression and incident hypertension
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Hypertension 50:1114-9. 2007
    ..031), respectively. If corroborated by other large-scale, prospective studies, our findings indicate that the natriuretic peptide precursor A gene plays a significant role in blood pressure regulation and development of hypertension...
  70. ncbi Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy american women
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA, USA
    Clin Chem 54:249-55. 2008
    ..Thus, with continued follow-up of the WHS, the WGHS provides a unique scientific resource-a full-cohort, prospective, genome-wide association study among initially healthy American women...
  71. doi Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study
    Jose R Romero
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Transl Res 156:235-41. 2010
    ..If corroboration occurs in future large prospective investigations, then the present investigation further suggests that TRPM6 and TRPM7 gene variation may not be useful predictors for T2DM risk assessment...
  72. pmc Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study
    Jacqueline S Danik
    Center for Cardiovascular Disease Prevention, Donald W Reynolds Center for Cardiovascular Research, and Translational Medicine Division, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Circ Cardiovasc Genet 2:134-41. 2009
    ..Despite evidence of crucial biological function and moderate heritability, comprehensive analysis of the influence of genetic variation on fibrinogen is not available...
  73. pmc Association between polymorphisms in the beta2-adrenoceptor gene and migraine in women
    Markus Schürks
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Headache 49:235-44. 2009
    ..To investigate the role of three common polymorphisms in the beta2-adrenoceptor gene in migraine...
  74. ncbi Lack of association between genetic variation in 9 innate immunity genes and baseline CRP levels
    Piotr Kozlowski
    Division of Hematology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Hum Genet 70:574-86. 2006
    ....
  75. pmc Polymorphisms in the renin-angiotensin system and migraine in women
    Markus Schürks
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Headache 49:292-9. 2009
    ..Recent findings suggest an association between the renin-angiotensin system and migraine. However, genetic studies are scarce and controversial...
  76. doi Genetic variants of tumor necrosis factor superfamily, member 4 (TNFSF4), and risk of incident atherothrombosis and venous thromboembolism
    Anders Malarstig
    Atherosclerosis Research Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Clin Chem 54:833-40. 2008
    ..Recent data have implicated tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4) gene variation in myocardial infarction in women; however, no prospective data are available on either incident arterial or venous disorders...
  77. doi Genetic variation of the androgen receptor and risk of myocardial infarction and ischemic stroke in women
    Kathryn M Rexrode
    Stroke 39:1590-2. 2008
    ..Some studies suggest an association between AR gene variation and risk of cardiovascular disease (CVD) in men; however, the relationship has not been examined in women...
  78. doi A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study
    Dov Shiffman
    Celera, Alameda, California 94502, USA
    J Am Coll Cardiol 51:444-8. 2008
    ..We asked if carriers of the 719Arg allele of kinesin family member 6 (KIF6) have increased risk of coronary heart disease (CHD) in a cohort of initially healthy Caucasian American women...
  79. ncbi Relation of polymorphism within the C-reactive protein gene and plasma CRP levels
    H Jacqueline Suk
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02215, USA
    Atherosclerosis 178:139-45. 2005
    ..Whether genetic markers can add to information yielded by high sensitivity CRP (hsCRP) in assessing cardiovascular risk needs further evaluation...
  80. ncbi Ethnic differences in the linkage disequilibrium and distribution of single-nucleotide polymorphisms in 35 candidate genes for cardiovascular diseases
    Maggie C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
    Genomics 83:559-65. 2004
    ....
  81. ncbi Two common gene variants on chromosome 9 and risk of atherothrombosis
    Robert Y L Zee
    Stroke 38:e111. 2007