Mary Zanarini

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD): a continuous measure of DSM-IV borderline psychopathology
    Mary C Zanarini
    Department of Psychiatry, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Pers Disord 17:233-42. 2003
  2. ncbi request reprint Predictors of 2-year outcome for patients with borderline personality disorder
    John G Gunderson
    McLean Hospital, 155 Mill St, Belmont, MA 02478, USA
    Am J Psychiatry 163:822-6. 2006
  3. ncbi request reprint The essential nature of borderline psychopathology
    Mary C Zanarini
    Laboratory of Adult Development, McLean Hospital, Belmont, Massachusetts 024778, USA
    J Pers Disord 21:518-35. 2007
  4. pmc Sexual orientation and relationship choice in borderline personality disorder over ten years of prospective follow-up
    D Bradford Reich
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Pers Disord 22:564-72. 2008
  5. pmc Cognitive experiences reported by patients with borderline personality disorder and axis II comparison subjects: a 16-year prospective follow-up study
    Mary C Zanarini
    McLean Hospital, Belmont, MA, USA
    Am J Psychiatry 170:671-9. 2013
  6. pmc Defense mechanisms reported by patients with borderline personality disorder and axis II comparison subjects over 16 years of prospective follow-up: description and prediction of recovery
    Mary C Zanarini
    McLean Hospital, Belmond, Mass, USA
    Am J Psychiatry 170:111-20. 2013
  7. doi request reprint Open-label treatment with olanzapine for patients with borderline personality disorder
    Mary C Zanarini
    McLean Hospital, Harvard Medical School, Harvard University, Boston, MA 02478, USA
    J Clin Psychopharmacol 32:398-402. 2012
  8. doi request reprint A preliminary, randomized trial of psychoeducation for women with borderline personality disorder
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Pers Disord 22:284-90. 2008
  9. pmc The 10-year course of physically self-destructive acts reported by borderline patients and axis II comparison subjects
    M C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    Acta Psychiatr Scand 117:177-84. 2008
  10. ncbi request reprint The subsyndromal phenomenology of borderline personality disorder: a 10-year follow-up study
    Mary C Zanarini
    Laboratory for the Study of Adult Development and the Psychiatric Epidemiology Research Program, McLean Hospital, 115 Mill St, Belmont 02478, and the Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 164:929-35. 2007

Research Grants

  1. MCLEAN STUDY OF ADULT DEVELOPMENT
    Mary Zanarini; Fiscal Year: 2009
  2. MCLEAN STUDY OF ADULT DEVELOPMENT
    Mary Zanarini; Fiscal Year: 2004
  3. MCLEAN STUDY OF ADULT DEVELOPMENT
    Mary C Zanarini; Fiscal Year: 2010

Detail Information

Publications94

  1. ncbi request reprint Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD): a continuous measure of DSM-IV borderline psychopathology
    Mary C Zanarini
    Department of Psychiatry, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Pers Disord 17:233-42. 2003
    ..Taken together, the results of this study suggest that the ZAN-BPD is a promising clinician-administered scale for the assessment of change in borderline psychopathology over time...
  2. ncbi request reprint Predictors of 2-year outcome for patients with borderline personality disorder
    John G Gunderson
    McLean Hospital, 155 Mill St, Belmont, MA 02478, USA
    Am J Psychiatry 163:822-6. 2006
    ..The primary purpose of this report was to investigate whether characteristics of subjects with borderline personality disorder observed at baseline can predict variations in outcome at the 2-year follow-up...
  3. ncbi request reprint The essential nature of borderline psychopathology
    Mary C Zanarini
    Laboratory of Adult Development, McLean Hospital, Belmont, Massachusetts 024778, USA
    J Pers Disord 21:518-35. 2007
    ..The treatment and nosological implications of this model are discussed...
  4. pmc Sexual orientation and relationship choice in borderline personality disorder over ten years of prospective follow-up
    D Bradford Reich
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Pers Disord 22:564-72. 2008
    ..Results of this study suggest that same-gender attraction and/or intimate relationship choice may be an important interpersonal issue for approximately one-third of both men and women with BPD...
  5. pmc Cognitive experiences reported by patients with borderline personality disorder and axis II comparison subjects: a 16-year prospective follow-up study
    Mary C Zanarini
    McLean Hospital, Belmont, MA, USA
    Am J Psychiatry 170:671-9. 2013
    ..They also compared the rates of these disturbed cognitions with those reported by axis II comparison subjects...
  6. pmc Defense mechanisms reported by patients with borderline personality disorder and axis II comparison subjects over 16 years of prospective follow-up: description and prediction of recovery
    Mary C Zanarini
    McLean Hospital, Belmond, Mass, USA
    Am J Psychiatry 170:111-20. 2013
    ..They also assessed the relationship between time-varying defenses and recovery from borderline personality disorder...
  7. doi request reprint Open-label treatment with olanzapine for patients with borderline personality disorder
    Mary C Zanarini
    McLean Hospital, Harvard Medical School, Harvard University, Boston, MA 02478, USA
    J Clin Psychopharmacol 32:398-402. 2012
    ..However, no medication is currently approved for treatment of BPD, and physicians should carefully weigh potential benefits and risks of antipsychotic treatment in this population...
  8. doi request reprint A preliminary, randomized trial of psychoeducation for women with borderline personality disorder
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Pers Disord 22:284-90. 2008
    ..They also suggest that such instruction may prove to be a useful and cost-efficient form of pre-treatment...
  9. pmc The 10-year course of physically self-destructive acts reported by borderline patients and axis II comparison subjects
    M C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    Acta Psychiatr Scand 117:177-84. 2008
    ..e. self-mutilation and suicide attempts) reported by borderline patients and axis II comparison subjects over 10 years of prospective follow-up...
  10. ncbi request reprint The subsyndromal phenomenology of borderline personality disorder: a 10-year follow-up study
    Mary C Zanarini
    Laboratory for the Study of Adult Development and the Psychiatric Epidemiology Research Program, McLean Hospital, 115 Mill St, Belmont 02478, and the Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 164:929-35. 2007
    ..The purpose of this study was to characterize the course of 24 symptoms of borderline personality disorder in terms of time to remission...
  11. ncbi request reprint Prediction of the 10-year course of borderline personality disorder
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Psychiatry 163:827-32. 2006
    ..The purpose of this study was to determine the most clinically relevant baseline predictors of time to remission for patients with borderline personality disorder...
  12. ncbi request reprint Reported childhood onset of self-mutilation among borderline patients
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Pers Disord 20:9-15. 2006
    ..The results of this study suggest that a sizable minority of borderline patients first engage in self-harm as children and that the course of their self-mutilation may be particularly malignant...
  13. ncbi request reprint The McLean Study of Adult Development (MSAD): overview and implications of the first six years of prospective follow-up
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, and the Department of Psychiatry, Harvard Medical School, USA
    J Pers Disord 19:505-23. 2005
    ..Taken together, these results suggest that the prognosis for BPD is better than previously recognized...
  14. pmc Time to attainment of recovery from borderline personality disorder and stability of recovery: A 10-year prospective follow-up study
    Mary C Zanarini
    McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 167:663-7. 2010
    ..The purposes of this study were to determine time to attainment of recovery from borderline personality disorder and to assess the stability of recovery...
  15. ncbi request reprint Psychosocial functioning of borderline patients and axis II comparison subjects followed prospectively for six years
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Pers Disord 19:19-29. 2005
    ..27% at 6 year follow-up). Taken together, the results of this study suggest that psychosocial improvement is both common among borderline patients and strongly related to their symptomatic status...
  16. ncbi request reprint Axis II comorbidity of borderline personality disorder: description of 6-year course and prediction to time-to-remission
    M C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA, USA
    Acta Psychiatr Scand 110:416-20. 2004
    ..The purpose of this study was to compare the axis II comorbidity of 202 patients whose borderline personality disorder (BPD) remitted over 6 years of prospective follow-up to that of 88 whose BPD never remitted...
  17. ncbi request reprint Borderline psychopathology in the first-degree relatives of borderline and axis II comparison probands
    Mary C Zanarini
    The Laboratory for the Study for Adult Development, McLean Hospital, and the Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    J Pers Disord 18:439-47. 2004
    ..Taken together, the results of this study suggest that the subsyndromal phenomenology of BPD may be more common than the borderline diagnosis itself...
  18. ncbi request reprint Axis I comorbidity in patients with borderline personality disorder: 6-year follow-up and prediction of time to remission
    Mary C Zanarini
    McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Psychiatry 161:2108-14. 2004
    ..The purpose of this study was to assess the prevalence of axis I disorders among patients with borderline personality disorder over 6 years of prospective follow-up...
  19. pmc Reasons for change in borderline personality disorder (and other axis II disorders)
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatr Clin North Am 31:505-15, viii. 2008
    ..Most patients who have borderline personality disorder improve over time; however, the reasons for this change are unclear. Therapy as usual and the reparations that adult life offers can facilitate these changes...
  20. pmc The course of dissociation for patients with borderline personality disorder and axis II comparison subjects: a 10-year follow-up study
    M C Zanarini
    Laboratory for Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    Acta Psychiatr Scand 118:291-6. 2008
    ..The purpose of this study was to assess the severity of dissociation reported by borderline patients and axis II comparison subjects over 10 years of prospective follow-up...
  21. doi request reprint Prevalence of DSM-IV borderline personality disorder in two community samples: 6,330 English 11-year-olds and 34,653 American adults
    Mary C Zanarini
    McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
    J Pers Disord 25:607-19. 2011
    ..Taken together, the results of this study suggest that late-latency children are about half as likely as adults to meet DSM-IV criteria for BPD. They also suggest that gender does not play a defining role in symptom expression...
  22. pmc The 10-year course of PTSD in borderline patients and axis II comparison subjects
    M C Zanarini
    McLean Hospital, Belmont, MA 02478, USA
    Acta Psychiatr Scand 124:349-56. 2011
    ..The second is to determine time-to-remission, recurrence, and new onset of PTSD, and the third is to assess the relationship between sexual adversity and the likelihood of remission and recurrence of PTSD...
  23. doi request reprint A dose comparison of olanzapine for the treatment of borderline personality disorder: a 12-week randomized, double-blind, placebo-controlled study
    Mary C Zanarini
    McLean Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 72:1353-62. 2011
    ..To examine the efficacy and safety of olanzapine at low and moderate doses for the treatment of borderline personality disorder...
  24. pmc Predictors of self-mutilation in patients with borderline personality disorder: A 10-year follow-up study
    Mary C Zanarini
    McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States
    J Psychiatr Res 45:823-8. 2011
    ..The purpose of this study was to determine the most clinically relevant baseline and time-varying predictors of self-mutilation over 10 years of prospective follow-up among patients with BPD...
  25. pmc The course of substance use disorders in patients with borderline personality disorder and Axis II comparison subjects: a 10-year follow-up study
    Mary C Zanarini
    McLean Hospital, Belmont, MA 02478, USA
    Addiction 106:342-8. 2011
    ..The purpose of this study is to detail the course of substance use disorders (SUDs) over 10 years of prospective follow-up among patients with borderline personality disorder (BPD) and Axis II comparison subjects...
  26. ncbi request reprint Methodological considerations treatment trials for persons personality disorder
    Mary C Zanarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Ann Clin Psychiatry 22:75-83. 2010
    ..The rapid growth of treatment research had led to the recognition that investigators face unique methodological issues with these challenging patients...
  27. pmc The 10-year course of psychosocial functioning among patients with borderline personality disorder and axis II comparison subjects
    M C Zanarini
    McLean Hospital, Belmont, MA 02478, USA
    Acta Psychiatr Scand 122:103-9. 2010
    ..The purpose of this study was to determine the 10-year course of the psychosocial functioning of patients with borderline personality disorder (BPD)...
  28. pmc Psychotherapy of borderline personality disorder
    M C Zanarini
    Harvard Medical School, Boston, MA, USA
    Acta Psychiatr Scand 120:373-7. 2009
    ..The other two are considered to be cognitive-behavioral in nature: dialectical behavioral therapy and schema-focused therapy...
  29. pmc Family history study of the familial coaggregation of borderline personality disorder with axis I and nonborderline dramatic cluster axis II disorders
    Mary C Zanarini
    Laboratory for the Study for Adult Development and the Psychiatric Epidemiology Research Program, McLean Hospital, and the Department of Psychiatry, Harvard Medical School, USA
    J Pers Disord 23:357-69. 2009
    ..Taken together, the results of this study suggest that common familial factors, particularly in the areas of affective disturbance and impulsivity, contribute to borderline personality disorder...
  30. pmc The 10-year course of social security disability income reported by patients with borderline personality disorder and axis II comparison subjects
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, and the Department of Psychiatry, Harvard Medical School, USA
    J Pers Disord 23:346-56. 2009
    ..The results of this study suggest that receiving SSDI benefits is both more common and more fluid over time for patients with BPD than previously known...
  31. pmc Defense mechanisms associated with borderline personality disorder
    Mary C Zanarini
    McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
    J Pers Disord 23:113-21. 2009
    ..They also suggest that the defensive triad of acting out, emotional hypochondriasis, and undoing may serve as a useful clinical marker for the borderline diagnosis, particularly in settings where the base rate of the disorder is high...
  32. pmc The course of eating disorders in patients with borderline personality disorder: a 10-year follow-up study
    Mary C Zanarini
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Int J Eat Disord 43:226-32. 2010
    ..The purpose of this study was to describe the longitudinal course of eating disorders in patients with borderline personality disorder...
  33. ncbi request reprint A preliminary, randomized trial of fluoxetine, olanzapine, and the olanzapine-fluoxetine combination in women with borderline personality disorder
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 65:903-7. 2004
    ....
  34. ncbi request reprint Update on pharmacotherapy of borderline personality disorder
    Mary C Zanarini
    Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Curr Psychiatry Rep 6:66-70. 2004
    ..It also suggests that the common practice of polypharmacy, which has no empiric support, may be unnecessary for most patients with borderline personality disorder...
  35. ncbi request reprint omega-3 Fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 160:167-9. 2003
    ..The purpose of this study was to compare the efficacy of ethyl-eicosapentaenoic acid (E-EPA) and placebo in the treatment of female subjects with borderline personality disorder...
  36. ncbi request reprint Inter-rater and test-retest reliability of the Revised Diagnostic Interview for Borderlines
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    J Pers Disord 16:270-6. 2002
    ..They also suggest that excellent reliability, once achieved, can be maintained over time for both the syndromal and subsyndromal phenomenology of BPD...
  37. ncbi request reprint The longitudinal course of borderline psychopathology: 6-year prospective follow-up of the phenomenology of borderline personality disorder
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, MA, USA
    Am J Psychiatry 160:274-83. 2003
    ..The syndromal and subsyndromal phenomenology of borderline personality disorder was tracked over 6 years of prospective follow-up...
  38. ncbi request reprint Olanzapine treatment of female borderline personality disorder patients: a double-blind, placebo-controlled pilot study
    M C Zanarini
    McLean Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 62:849-54. 2001
    ..The intent of this study was to compare the efficacy and safety of olanzapine versus placebo in the treatment of women meeting criteria for borderline personality disorder (BPD)...
  39. ncbi request reprint The Collaborative Longitudinal Personality Disorders Study: reliability of axis I and II diagnoses
    M C Zanarini
    Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    J Pers Disord 14:291-9. 2000
    ..They also suggest that the reliability of axis II disorders is roughly equivalent to that reliability found for most axis I disorders...
  40. ncbi request reprint A screening measure for BPD: the McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD)
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Pers Disord 17:568-73. 2003
    ..93 at a cutoff of 7 for the 63 subjects who were 25 years old or younger. The results of this study suggest that the MSI-BPD may be a useful screening instrument for the presence of DSM-IV borderline personality disorder...
  41. ncbi request reprint Childhood experiences associated with the development of borderline personality disorder
    M C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, Massachusetts, USA
    Psychiatr Clin North Am 23:89-101. 2000
    ..For now, the author suggests that one can admire patients with BPD for the integrity with which they have dealt with their pain. After all, not many people remain so loyal to and so respectful of such disheartening childhood experiences...
  42. ncbi request reprint Axis I comorbidity of borderline personality disorder
    M C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 155:1733-9. 1998
    ....
  43. ncbi request reprint Mental health service utilization by borderline personality disorder patients and Axis II comparison subjects followed prospectively for 6 years
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 65:28-36. 2004
    ..The purpose of this study was to describe the psychiatric treatment received by a well-defined sample of patients with borderline personality disorder and Axis II comparison subjects over 6 years of prospective follow-up...
  44. ncbi request reprint Biparental failure in the childhood experiences of borderline patients
    M C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Pers Disord 14:264-73. 2000
    ..They also suggest that biparental failure may significantly increase a preborderline girl's risk of being sexually abused by someone other than her parents...
  45. pmc Relationship between cumulative BMI and symptomatic, psychosocial, and medical outcomes in patients with borderline personality disorder
    Frances R Frankenburg
    Laboratory for the Study of Adult Development, McLean Hospital
    J Pers Disord 25:421-31. 2011
    ..Increases in cumulative BMI may be a marker for adverse symptomatic, functional, and medical outcomes in patients with BPD...
  46. ncbi request reprint Severity of reported childhood sexual abuse and its relationship to severity of borderline psychopathology and psychosocial impairment among borderline inpatients
    Mary C Zanarini
    The Laboratory for the Study for Adult Development, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
    J Nerv Ment Dis 190:381-7. 2002
    ....
  47. ncbi request reprint Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder
    John G Gunderson
    McLean Hospital, Department of Psychiatry, Belmont, MA
    Am J Psychiatry 163:1173-8. 2006
    ....
  48. ncbi request reprint Traumatic exposure and posttraumatic stress disorder in borderline, schizotypal, avoidant, and obsessive-compulsive personality disorders: findings from the collaborative longitudinal personality disorders study
    Shirley Yen
    Department of Psychiatry, Brown University Medical School, 700 Butler Drive, Providence, RI 02906, USA
    J Nerv Ment Dis 190:510-8. 2002
    ..In addition, they support an association between severity of PD and severity of traumatic exposure, as indicated by earlier trauma onset, trauma of an assaultive and personal nature, and more types of traumatic events...
  49. ncbi request reprint Major depressive disorder and borderline personality disorder revisited: longitudinal interactions
    John G Gunderson
    Harvard Medical School and McLean Hospital, Boston, Mass 02478, USA
    J Clin Psychiatry 65:1049-56. 2004
    ..This report investigates the longitudinal association of changes in major depressive disorder (MDD) and borderline personality disorder...
  50. pmc A longitudinal study of the 10-year course of interpersonal features in borderline personality disorder
    Lois W Choi-Kain
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Pers Disord 24:365-76. 2010
    ..The behavioral interpersonal features of BPD remit rapidly, while core affectively-oriented features related to intolerance of aloneness and conflicts over dependency are more persistent...
  51. ncbi request reprint Sexual relationship difficulties among borderline patients and axis II comparison subjects
    Mary C Zanarini
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    J Nerv Ment Dis 191:479-82. 2003
  52. doi request reprint A preliminary study of lamotrigine in the treatment of affective instability in borderline personality disorder
    Donald Bradford Reich
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    Int Clin Psychopharmacol 24:270-5. 2009
    ..001). Results from the study suggest that lamotrigine is an effective treatment for affective instability and for the general impulsivity characteristic of BPD...
  53. ncbi request reprint Ethnicity and four personality disorders
    Denise A Chavira
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Compr Psychiatry 44:483-91. 2003
    ..The factors contributing to these differences warrant further investigation...
  54. ncbi request reprint Do eating disorders co-occur with personality disorders? Comparison groups matter
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Int J Eat Disord 33:155-64. 2003
    ..The eating disorders met criteria outlined in the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)...
  55. ncbi request reprint Obesity and obesity-related illnesses in borderline patients
    Frances R Frankenburg
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Pers Disord 20:71-80. 2006
    ..These results suggest that obesity is common among heavily treated borderline patients and is associated with a number of chronic medical disorders...
  56. doi request reprint Olanzapine for the treatment of borderline personality disorder: variable dose 12-week randomised double-blind placebo-controlled study
    S Charles Schulz
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55454, USA
    Br J Psychiatry 193:485-92. 2008
    ..Despite the prevalence and clinical significance of borderline personality disorder, its treatment remains understudied...
  57. pmc Sedative-hypnotic use in patients with borderline personality disorder and axis II comparison subjects
    David T Plante
    Division of Sleep Medicine, Harvard Medicial School, Boston, MA, USA
    J Pers Disord 23:563-71. 2009
    ..81, 95% CI: 1.33-5.95). These results indicate that sedative-hypnotic use is greater among BPD than OPD subjects. They also confirm clinical observations that subjective sleep disturbance is a significant problem in BPD...
  58. ncbi request reprint Adult experiences of abuse reported by borderline patients and Axis II comparison subjects over six years of prospective follow-up
    Mary C Zanarini
    Laboratory for the Study for Adult Development, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    J Nerv Ment Dis 193:412-6. 2005
    ..They also suggest that adult experiences of abuse are strongly associated with a failure to remit from borderline personality disorder...
  59. ncbi request reprint The association between borderline personality disorder and chronic medical illnesses, poor health-related lifestyle choices, and costly forms of health care utilization
    Frances R Frankenburg
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, and the Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
    J Clin Psychiatry 65:1660-5. 2004
    ..The purpose of this study was to compare the physical health, lifestyle choices affecting physical health, and health care utilization of patients with remitted and nonremitted borderline personality disorder...
  60. ncbi request reprint Divalproex sodium treatment of women with borderline personality disorder and bipolar II disorder: a double-blind placebo-controlled pilot study
    Frances R Frankenburg
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 63:442-6. 2002
    ..The intent of this study was to compare the efficacy and safety of divalproex sodium and placebo in the treatment of women with borderline personality disorder and comorbid bipolar II disorder...
  61. pmc New onsets of substance use disorders in borderline personality disorder over 7 years of follow-ups: findings from the Collaborative Longitudinal Personality Disorders Study
    Marc Walter
    Harvard Medical School, McLean Hospital, Belmont, MA, USA
    Addiction 104:97-103. 2009
    ..The purpose of this study was to examine whether patients with borderline personality disorder (BPD) have a higher rate of new onsets of substance use disorders (SUD) than do patients with other personality disorders (OPD)...
  62. pmc Two-year prospective naturalistic study of remission from major depressive disorder as a function of personality disorder comorbidity
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Consult Clin Psychol 73:78-85. 2005
    ..These PDs emerged as robust predictors of slowed remission from MDD even when controlling for other negative prognostic predictors...
  63. ncbi request reprint Family studies of borderline personality disorder: a review
    Candace N White
    McLean Hospital, Belmont, Mass 02478, USA
    Harv Rev Psychiatry 11:8-19. 2003
    ..Because of significant methodological problems, most notably indirect assessments and inadequate sample size, major questions persist about the familial aggregation of this disorder that require more definitive methods...
  64. doi request reprint The relationship between self-reported attachment styles, interpersonal dysfunction, and borderline personality disorder
    Lois W Choi-Kain
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Nerv Ment Dis 197:816-21. 2009
    ..A combination of preoccupied and fearful self-reported attachment styles is more specific to BPD than either style alone or attachment insecurity in general...
  65. pmc Prospective assessment of treatment use by patients with personality disorders
    Donna S Bender
    Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, New York 10032, USA
    Psychiatr Serv 57:254-7. 2006
    ....
  66. pmc Two-year stability and change of schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Consult Clin Psychol 72:767-75. 2004
    ..Dimensionally, these findings suggest that PDs may be characterized by maladaptive trait constellations that are stable in their structure (individual differences) but can change in severity or expression over time...
  67. pmc Childhood antecedents of avoidant personality disorder: a retrospective study
    David C Rettew
    Harvard Medical School and McLean Hospital, USA
    J Am Acad Child Adolesc Psychiatry 42:1122-30. 2003
    ..To explore potential risk factors and early manifestations of avoidant personality disorder (AVPD) by examining retrospective reports of social functioning and adverse childhood experiences...
  68. ncbi request reprint "Late-onset" borderline personality disorder: a life unraveling
    Matthew E Bernstein
    McLean Hospital, Belmont, Mass 02478, USA
    Harv Rev Psychiatry 10:292-301. 2002
  69. ncbi request reprint Longitudinal diagnostic efficiency of DSM-IV criteria for borderline personality disorder: a 2-year prospective study
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Can J Psychiatry 52:357-62. 2007
    ..To examine the longitudinal diagnostic efficiency of the DSM-IV criteria for borderline personality disorder (BPD)...
  70. ncbi request reprint Substance or style? An investigation of the NEO-PI-R validity scales
    Leslie C Morey
    Department of Psychology, Texas A and M University, College Station 77843 4235, USA
    J Pers Assess 79:583-99. 2002
    ....
  71. pmc Two-year prevalence and stability of individual DSM-IV criteria for schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders: toward a hybrid model of axis II disorders
    Thomas H McGlashan
    Collaborative Longitudinal Personality Disorder Study, Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    Am J Psychiatry 162:883-9. 2005
    ..This study tracked the individual criteria of four DSM-IV personality disorders-borderline, schizotypal, avoidant, and obsessive-compulsive personality disorders-and how they change over 2 years...
  72. pmc Stability of functional impairment in patients with schizotypal, borderline, avoidant, or obsessive-compulsive personality disorder over two years
    Andrew E Skodol
    New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Psychol Med 35:443-51. 2005
    ....
  73. ncbi request reprint Confirmatory factor analysis of DSM-IV criteria for borderline personality disorder: findings from the collaborative longitudinal personality disorders study
    Charles A Sanislow
    Collaborative Longitudinal Personality Disorders Study
    Am J Psychiatry 159:284-90. 2002
    ..This study tested the factor structure of the DSM-IV criteria for borderline personality disorder by using confirmatory methods for the analysis of covariance structures in a large group from a multisite study...
  74. ncbi request reprint Functional impairment in patients with schizotypal, borderline, avoidant, or obsessive-compulsive personality disorder
    Andrew E Skodol
    Collaborative Longitudinal Personality Disorders Study
    Am J Psychiatry 159:276-83. 2002
    ..The purpose of this study was to compare psychosocial functioning in patients with schizotypal, borderline, avoidant, or obsessive-compulsive personality disorder and patients with major depressive disorder and no personality disorder...
  75. pmc Recent life events preceding suicide attempts in a personality disorder sample: findings from the collaborative longitudinal personality disorders study
    Shirley Yen
    Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, RI 02906, USA
    J Consult Clin Psychol 73:99-105. 2005
    ..Therefore, certain types of negative life events are unique risk factors for imminent suicide attempts among individuals with PDs...
  76. pmc Associations in the course of personality disorders and Axis I disorders over time
    M Tracie Shea
    Department of Psychiatry and Human Behavior, Brown University Medical School, Duncan Building, 700 Butler Drive, Providence, RI 20906, USA
    J Abnorm Psychol 113:499-508. 2004
    ..Two of the four personality disorders under examination (STPD and OCPD) showed little or no association with Axis I disorders...
  77. ncbi request reprint Clinical features and impairment in women with Borderline Personality Disorder (BPD) with Posttraumatic Stress Disorder (PTSD), BPD without PTSD, and other personality disorders with PTSD
    Caron Zlotnick
    Brown University School of Medicine, Department of Psychiatry and Human Behavior, Butler Hospital, Providence, RI 02906, USA
    J Nerv Ment Dis 191:706-13. 2003
    ..Consistent with other research, the findings suggest that PTSD does not appear to alter the central features of BPD. The clinical implications of our findings are considered...
  78. ncbi request reprint Temporal coherence of criteria for four personality disorders
    Leslie C Morey
    Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    J Pers Disord 18:394-8. 2004
    ..72 across 4 disorders), and reasonably specific to that syndrome relative to the other disorders. The results support the validity of these criterion sets as representing coherent syndromes...
  79. ncbi request reprint Testing an APA practice guideline: symptom-targeted medication utilization for patients with borderline personality disorder
    John M Oldham
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    J Psychiatr Pract 10:156-61. 2004
    ....
  80. ncbi request reprint Borderline personality disorder criteria associated with prospectively observed suicidal behavior
    Shirley Yen
    Department of Psychiatry and Human Behavior, Brown University, 700 Butler Drive, Duncan Building, Providence, RI 02906, USA
    Am J Psychiatry 161:1296-8. 2004
    ..The authors prospectively examined associations between each DSM-IV borderline personality disorder criterion and suicidal behaviors...
  81. ncbi request reprint Childhood maltreatment associated with adult personality disorders: findings from the Collaborative Longitudinal Personality Disorders Study
    Cynthia L Battle
    Collaborative Longitudinal PDs Study CLPS, Brown University Medical School, USA
    J Pers Disord 18:193-211. 2004
    ..However, even when controlling for the effect of borderline PD, other PD diagnoses were associated with specific types of maltreatment...
  82. ncbi request reprint Dimensional representations of DSM-IV personality disorders: relationships to functional impairment
    Andrew E Skodol
    New York State Psychiatric Institute, Box 129, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 162:1919-25. 2005
    ..This study compared three-dimensional representations of DSM-IV personality disorders and standard categories with respect to their associations with psychosocial functioning...
  83. pmc The Collaborative Longitudinal Personality Disorders Study (CLPS): overview and implications
    Andrew E Skodol
    New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, NY 10032, USA
    J Pers Disord 19:487-504. 2005
    ..Taken together, our results lead us to hypothesize that PDs may be reconceptualized as hybrids of stable personality traits and intermittently expressed symptomatic behaviors...
  84. doi request reprint A comparison of interview and self-report methods for the assessment of borderline personality disorder criteria
    Christopher J Hopwood
    Department of Psychology, Texas A and M University, USA
    Psychol Assess 20:81-5. 2008
    ....
  85. ncbi request reprint Gender differences in borderline personality disorder: findings from the Collaborative Longitudinal Personality Disorders Study
    Dawn M Johnson
    Summa Health System, St Thomas Hospital, Akron, OH 44310, USA
    Compr Psychiatry 44:284-92. 2003
    ..For example, no difference was found in rates of major depressive disorder, a condition that is more prevalent in females. Thus, BPD pathology may be a prevailing characterization that can attenuate usual gender-based distinctions...
  86. ncbi request reprint Short-term diagnostic stability of schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders
    M Tracie Shea
    Department of Psychiatry and Human Behavior, Brown University Medical School, Duncan Building, 700 Butler Drive, Providence, RI 20906, USA
    Am J Psychiatry 159:2036-41. 2002
    ..This study prospectively examined the stability of four personality disorders (schizotypal, borderline, avoidant, and obsessive-compulsive) over a 1-year follow-up period...
  87. ncbi request reprint Ethnicity and mental health treatment utilization by patients with personality disorders
    Donna S Bender
    Institute for Mental Health Research, USA
    J Consult Clin Psychol 75:992-9. 2007
    ..Future studies need to assess specific barriers to adequate and appropriate treatments for minority individuals with PDs...
  88. ncbi request reprint Personality traits predict current and future functioning comparably for individuals with major depressive and personality disorders
    Christopher J Hopwood
    Department of Psychology, Texas A and M University, College Station, Texas, USA
    J Nerv Ment Dis 195:266-9. 2007
    ..The data suggest that personality traits are significant and equally relevant predictors of functioning for both groups. The utility of assessing personality traits for individuals with both Axis I and II disorders is thus supported...
  89. ncbi request reprint Personality disorders and medical comorbidity
    Frances R Frankenburg
    Boston University School of Medicine, Edith Nourse Rogers Memorial VAMC, Bedford, MA 01730, USA
    Curr Opin Psychiatry 19:428-31. 2006
    ..Personality disorders are not usually thought of as being associated with medical comorbidity. Research shows that medical comorbidity in personality disorders is clinically important...
  90. ncbi request reprint Differential impairment as an indicator of sex bias in DSM-IV criteria for four personality disorders
    Christina D Boggs
    Department of Psychology, Texas A and M University, USA
    Psychol Assess 17:492-6. 2005
    ..The results suggest that most of the diagnostic criteria examined do not seem to display sex bias. However, those criteria that displayed evidence of bias came largely from the borderline diagnosis...
  91. pmc Effects of personality disorders on functioning and well-being in major depressive disorder
    Andrew E Skodol
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Psychiatr Pract 11:363-8. 2005
    ..Patients with depressive disorders have limitations in physical and emotional functioning comparable to patients with chronic medical conditions. Personality disorders (PDs) are also known to be associated with functional impairment...
  92. ncbi request reprint Confirmatory factor analysis of DSM-IV borderline, schizotypal, avoidant and obsessive-compulsive personality disorders: findings from the Collaborative Longitudinal Personality Disorders Study
    Charles A Sanislow
    Yale University School of Medicine, New Haven, CT 06520 8098, USA
    Acta Psychiatr Scand 105:28-36. 2002
    ..To test the diagnostic constructs implied by DSM-IV Axis-II personality disorders by examining relationships between different combinations of DSM-IV criteria...
  93. pmc Axis I and axis II disorders as predictors of prospective suicide attempts: findings from the collaborative longitudinal personality disorders study
    Shirley Yen
    Department of Psychiatry and Human Behavior, Brown Medical School, Brown University, Providence, Rhode Island 02906, USA
    J Abnorm Psychol 112:375-81. 2003
    ..Therefore, among individuals diagnosed with PDs. exacerbation of Axis I conditions, particularly MDD and substance use, heightens risk for a suicide attempt...
  94. ncbi request reprint The representation of borderline, avoidant, obsessive-compulsive, and schizotypal personality disorders by the five-factor model
    Leslie C Morey
    Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    J Pers Disord 16:215-34. 2002
    ..Differences between personality disorders may reflect diverse interactions among the dimensions, rather than differences on single dimensions...

Research Grants12

  1. MCLEAN STUDY OF ADULT DEVELOPMENT
    Mary Zanarini; Fiscal Year: 2009
    ..This proposed continuation will result in useful knowledge about the course of borderline psychopathology, with direct implications for patients, their families, and the clinicians treating them. ..
  2. MCLEAN STUDY OF ADULT DEVELOPMENT
    Mary Zanarini; Fiscal Year: 2004
    ..In addition, knowledgeable informants will be interviewed concerning each patient's psychosocial functioning, and medical, work, and school records will be collected and reviewed. ..
  3. MCLEAN STUDY OF ADULT DEVELOPMENT
    Mary C Zanarini; Fiscal Year: 2010
    ..This study will provide patients, their families, and those treating them with crucial information they need to plan for the future. ..