Deborah Yurgelun-Todd

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Emotional and cognitive changes during adolescence
    Deborah Yurgelun-Todd
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Curr Opin Neurobiol 17:251-7. 2007
  2. ncbi fMRI during affect discrimination in bipolar affective disorder
    D A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Bipolar Disord 2:237-48. 2000
  3. doi Increased amygdala fMRI activation after secretin administration
    Deborah A Yurgelun-Todd
    Neuroimaging Laboratory, McLean Hospital Harvard Medical School, Belmont, MA 02478 9106, USA
    Exp Clin Psychopharmacol 16:191-8. 2008
  4. ncbi Mood disorders
    Deborah A Yurgelun-Todd
    Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA
    Neuroimaging Clin N Am 17:511-21, ix. 2007
  5. ncbi White matter abnormalities observed in bipolar disorder: a diffusion tensor imaging study
    Deborah A Yurgelun-Todd
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 9:504-12. 2007
  6. ncbi Fear-related activity in the prefrontal cortex increases with age during adolescence: a preliminary fMRI study
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neurosci Lett 406:194-9. 2006
  7. ncbi Functional magnetic resonance imaging studies in bipolar disorder
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging and Neuropsychology Laboratory, McLean Hospital, Belmont, MA 02478 9106, USA
    CNS Spectr 11:287-97. 2006
  8. ncbi Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of D-cycloserine
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 138:23-31. 2005
  9. ncbi Sex differences in cerebral tissue volume and cognitive performance during adolescence
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Psychol Rep 91:743-57. 2002
  10. ncbi Cognitive correlates of medial temporal lobe development across adolescence: a magnetic resonance imaging study
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Percept Mot Skills 96:3-17. 2003

Research Grants

  1. RESIDUAL COGNITIVE EFFECTS OF CANNABIS--AN FMRI STUDY
    Deborah Yurgelun Todd; Fiscal Year: 2002
  2. IMAGING THE CEREBELLUM IN PSYCHOTIC DISORDERS
    RUSSELL LOEBER; Fiscal Year: 2003
  3. Brain Changes with Cannabis and Methamphetamine
    Deborah Yurgelun Todd; Fiscal Year: 2007
  4. MRS/fMRI Investigations of Adolescent Cannabis Use
    Deborah Yurgelun Todd; Fiscal Year: 2007

Detail Information

Publications26

  1. ncbi Emotional and cognitive changes during adolescence
    Deborah Yurgelun-Todd
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Curr Opin Neurobiol 17:251-7. 2007
    ..These neurobiological changes are believed to contribute, in part, to the range in cognitive and affective behavior seen during adolescence...
  2. ncbi fMRI during affect discrimination in bipolar affective disorder
    D A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Bipolar Disord 2:237-48. 2000
    ..This study reports findings based on fMRI data acquired during fearful and happy affect recognition paradigms in patients with bipolar affective disorder and in healthy adult subjects...
  3. doi Increased amygdala fMRI activation after secretin administration
    Deborah A Yurgelun-Todd
    Neuroimaging Laboratory, McLean Hospital Harvard Medical School, Belmont, MA 02478 9106, USA
    Exp Clin Psychopharmacol 16:191-8. 2008
    ..The presence of increased activation of the amygdala during the viewing of fearful faces is consistent with findings from animal studies and suggests a mechanism by which secretin may modulate social behavior...
  4. ncbi Mood disorders
    Deborah A Yurgelun-Todd
    Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA
    Neuroimaging Clin N Am 17:511-21, ix. 2007
    ..The interpretation of neuroimaging studies in mood disorders is limited by potential confounding factors including medication effects, duration of illness, comorbidity, and gender...
  5. ncbi White matter abnormalities observed in bipolar disorder: a diffusion tensor imaging study
    Deborah A Yurgelun-Todd
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 9:504-12. 2007
    ..The objective of the present study was to examine white matter tract integrity, using diffusion tensor imaging (DTI), in bipolar patients and healthy comparison subjects...
  6. ncbi Fear-related activity in the prefrontal cortex increases with age during adolescence: a preliminary fMRI study
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neurosci Lett 406:194-9. 2006
    ..The hypothesis of age related decreases in amygdala activity was not supported, but may have been due to low signal-to-noise and inadequate power in the present sample to resolve subtle changes in this small structure...
  7. ncbi Functional magnetic resonance imaging studies in bipolar disorder
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging and Neuropsychology Laboratory, McLean Hospital, Belmont, MA 02478 9106, USA
    CNS Spectr 11:287-97. 2006
    ..New analytical techniques of fMRI data are needed in order to resolve some of these issues and identify how changes in neural networks relate to cognitive and emotional processing in bipolar disorder...
  8. ncbi Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of D-cycloserine
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 138:23-31. 2005
    ..These results suggest that the addition of D-cycloserine to conventional neuroleptics may improve negative symptoms through enhanced temporal lobe function...
  9. ncbi Sex differences in cerebral tissue volume and cognitive performance during adolescence
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Psychol Rep 91:743-57. 2002
    ..Findings suggest sex-specific developmental differences in the relations between cerebral structure and function...
  10. ncbi Cognitive correlates of medial temporal lobe development across adolescence: a magnetic resonance imaging study
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Percept Mot Skills 96:3-17. 2003
    ....
  11. ncbi Differences and similarities in insular and temporal pole MRI gray matter volume abnormalities in first-episode schizophrenia and affective psychosis
    Kiyoto Kasai
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Arch Gen Psychiatry 60:1069-77. 2003
    ..Results of previous volumetric magnetic resonance imaging investigations indicate that gray matter volume reductions in neocortical regions may be specific to schizophrenia...
  12. pmc Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia
    Kiyoto Kasai
    Clinical Neuroscience Division, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Am J Psychiatry 160:156-64. 2003
    ....
  13. pmc Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study
    Noriomi Kuroki
    Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA
    Am J Psychiatry 163:2103-10. 2006
    ..However, the middle and inferior temporal gyri have received little investigation, especially in first-episode schizophrenia...
  14. pmc Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study
    Kiyoto Kasai
    Laboratory of Neuroscience, Clinical Neuroscience Division, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, and Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
    Schizophr Res 71:65-76. 2004
    ..However, the association between abnormal CSP and limbic systems may be more specific to schizophrenia...
  15. ncbi Early-onset cannabis use and cognitive deficits: what is the nature of the association?
    Harrison G Pope
    Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 69:303-10. 2003
    ..Individuals who initiate cannabis use at an early age, when the brain is still developing, might be more vulnerable to lasting neuropsychological deficits than individuals who begin use later in life...
  16. pmc Test-retest reliability of fMRI during nonverbal semantic decisions in moderate-severe nonfluent aphasia patients
    Jacquie Kurland
    Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine and the Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA
    Behav Neurol 15:87-97. 2004
    ..This study provides fMRI reliability in chronic nonfluent aphasia, and adds to evidence supporting differences in individual cortical reorganization in aphasia recovery...
  17. pmc Why so impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokers
    Staci A Gruber
    Cognitive and Clinical Neuroimaging Core, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 19:231-42. 2011
    ..Early MJ use may result in reduced FA and increased diffusivity, which may be associated with increased impulsivity, and ultimately contribute to the initiation of MJ use or the inability to discontinue use...
  18. pmc Neuropsychological performance predicts clinical recovery in bipolar patients
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    J Affect Disord 105:253-60. 2008
    ..Although a number of investigations have reported cognitive deficits in patients with bipolar disorder, relatively few have focused on the relationship between these impairments and clinical outcome...
  19. ncbi Residual neuropsychological effects of illicit 3,4-methylenedioxymethamphetamine (MDMA) in individuals with minimal exposure to other drugs
    John H Halpern
    Alcohol and Drug Abuse Research Center, Harvard Medical School, Biological Psychiatry Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478 9106, USA
    Drug Alcohol Depend 75:135-47. 2004
    ..Most MDMA users, however, use other illicit drugs as well, so it is difficult to be certain that these deficits are due to MDMA, as opposed to other drug use or additional confounding factors...
  20. ncbi Overt propositional speech in chronic nonfluent aphasia studied with the dynamic susceptibility contrast fMRI method
    Margaret A Naeser
    Harold Goodglass Aphasia Research Center and Department of Neurology, Boston University School of Medicine and VA Boston Healthcare System, Boston, MA 02130, USA
    Neuroimage 22:29-41. 2004
    ....
  21. ncbi Psychological and cognitive effects of long-term peyote use among Native Americans
    John H Halpern
    Biological Psychiatry Laboratory, Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Biol Psychiatry 58:624-31. 2005
    ..However, the long-term residual psychological and cognitive effects of hallucinogens remain poorly understood...
  22. pmc Differential activation patterns of occipital and prefrontal cortices during motion processing: evidence from normal and schizophrenic brains
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Cogn Affect Behav Neurosci 8:293-303. 2008
    ..Furthermore, this result provides evidence that in the context of broadly distributed cortical dysfunction, the usual functional specificity of the cortex becomes modified, even across the domains of sensory and cognitive processing...
  23. ncbi Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal women
    Hadine Joffe
    Women s Center for Behavioral Endocrinology, McLean Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 13:411-22. 2006
    ....
  24. ncbi Fusiform gyrus volume reduction in first-episode schizophrenia: a magnetic resonance imaging study
    Chang Uk Lee
    Department of Psychiatry 116A, VA Boston Healthcare System, Brockton Division, Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
    Arch Gen Psychiatry 59:775-81. 2002
    ..of postmortem studies have suggested that fusiform gyrus volume is reduced in schizophrenia, but there have been no in vivo structural studies of the fusiform gyrus in schizophrenia using magnetic resonance imaging...
  25. ncbi Stroop performance in normal control subjects: an fMRI study
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478 9106, USA
    Neuroimage 16:349-60. 2002
    ..This study extends previous findings by demonstrating that in healthy adults, a subdivision of the cingulate cortex is specifically associated with the cognitive demands present in the interference condition...
  26. ncbi Cognitive measures in long-term cannabis users
    Harrison G Pope
    Biological Psychiatry Laboratory, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Clin Pharmacol 42:41S-47S. 2002
    ....

Research Grants7

  1. RESIDUAL COGNITIVE EFFECTS OF CANNABIS--AN FMRI STUDY
    Deborah Yurgelun Todd; Fiscal Year: 2002
    ..abstract_text> ..
  2. IMAGING THE CEREBELLUM IN PSYCHOTIC DISORDERS
    RUSSELL LOEBER; Fiscal Year: 2003
    ..The details of these measurements will provide information about the specific dysregulation of the functional components of the cerebellum. ..
  3. Brain Changes with Cannabis and Methamphetamine
    Deborah Yurgelun Todd; Fiscal Year: 2007
    ..An R01 application will then be prepared based on the data acquired during the R21 period. ..
  4. MRS/fMRI Investigations of Adolescent Cannabis Use
    Deborah Yurgelun Todd; Fiscal Year: 2007
    ....