Research Topics
| Deborah Yurgelun-ToddSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Emotional and cognitive changes during adolescenceDeborah Yurgelun-Todd
Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Curr Opin Neurobiol 17:251-7. 2007..These neurobiological changes are believed to contribute, in part, to the range in cognitive and affective behavior seen during adolescence...- fMRI during affect discrimination in bipolar affective disorderD A Yurgelun-Todd
Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Bipolar Disord 2:237-48. 2000..This study reports findings based on fMRI data acquired during fearful and happy affect recognition paradigms in patients with bipolar affective disorder and in healthy adult subjects... 
Increased amygdala fMRI activation after secretin administrationDeborah A Yurgelun-Todd
Neuroimaging Laboratory, McLean Hospital Harvard Medical School, Belmont, MA 02478 9106, USA
Exp Clin Psychopharmacol 16:191-8. 2008..The presence of increased activation of the amygdala during the viewing of fearful faces is consistent with findings from animal studies and suggests a mechanism by which secretin may modulate social behavior...- Mood disordersDeborah A Yurgelun-Todd
Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA
Neuroimaging Clin N Am 17:511-21, ix. 2007..The interpretation of neuroimaging studies in mood disorders is limited by potential confounding factors including medication effects, duration of illness, comorbidity, and gender... - White matter abnormalities observed in bipolar disorder: a diffusion tensor imaging studyDeborah A Yurgelun-Todd
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Bipolar Disord 9:504-12. 2007..The objective of the present study was to examine white matter tract integrity, using diffusion tensor imaging (DTI), in bipolar patients and healthy comparison subjects... - Fear-related activity in the prefrontal cortex increases with age during adolescence: a preliminary fMRI studyDeborah A Yurgelun-Todd
Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Neurosci Lett 406:194-9. 2006..The hypothesis of age related decreases in amygdala activity was not supported, but may have been due to low signal-to-noise and inadequate power in the present sample to resolve subtle changes in this small structure... - Functional magnetic resonance imaging studies in bipolar disorderDeborah A Yurgelun-Todd
Cognitive Neuroimaging and Neuropsychology Laboratory, McLean Hospital, Belmont, MA 02478 9106, USA
CNS Spectr 11:287-97. 2006..New analytical techniques of fMRI data are needed in order to resolve some of these issues and identify how changes in neural networks relate to cognitive and emotional processing in bipolar disorder... - Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of D-cycloserineDeborah A Yurgelun-Todd
Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Psychiatry Res 138:23-31. 2005..These results suggest that the addition of D-cycloserine to conventional neuroleptics may improve negative symptoms through enhanced temporal lobe function... - Sex differences in cerebral tissue volume and cognitive performance during adolescenceDeborah A Yurgelun-Todd
Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Psychol Rep 91:743-57. 2002..Findings suggest sex-specific developmental differences in the relations between cerebral structure and function... - Cognitive correlates of medial temporal lobe development across adolescence: a magnetic resonance imaging studyDeborah A Yurgelun-Todd
Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Percept Mot Skills 96:3-17. 2003.... - Differences and similarities in insular and temporal pole MRI gray matter volume abnormalities in first-episode schizophrenia and affective psychosisKiyoto Kasai
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System/Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
Arch Gen Psychiatry 60:1069-77. 2003.... 
Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophreniaKiyoto Kasai
Clinical Neuroscience Division, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
Am J Psychiatry 160:156-64. 2003..CONCLUSIONS: These findings demonstrate a progressive volume reduction of the left posterior superior temporal gyrus gray matter in patients with first-episode schizophrenia but not in patients with first-episode affective psychosis...- Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI studyNoriomi Kuroki
Department of Psychiatry, Harvard Medical School, Boston, MA 02301, USA
Am J Psychiatry 163:2103-10. 2006.... - Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI studyKiyoto Kasai
Laboratory of Neuroscience, Clinical Neuroscience Division, Department of Psychiatry, Boston VA Healthcare System, Brockton Division, and Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
Schizophr Res 71:65-76. 2004..However, the association between abnormal CSP and limbic systems may be more specific to schizophrenia... - Early-onset cannabis use and cognitive deficits: what is the nature of the association?Harrison G Pope
Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Drug Alcohol Depend 69:303-10. 2003..Individuals who initiate cannabis use at an early age, when the brain is still developing, might be more vulnerable to lasting neuropsychological deficits than individuals who begin use later in life... - Test-retest reliability of fMRI during nonverbal semantic decisions in moderate-severe nonfluent aphasia patientsJacquie Kurland
Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine and the Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA
Behav Neurol 15:87-97. 2004..This study provides fMRI reliability in chronic nonfluent aphasia, and adds to evidence supporting differences in individual cortical reorganization in aphasia recovery... - Why so impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokersStaci A Gruber
Cognitive and Clinical Neuroimaging Core, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Exp Clin Psychopharmacol 19:231-42. 2011..Early MJ use may result in reduced FA and increased diffusivity, which may be associated with increased impulsivity, and ultimately contribute to the initiation of MJ use or the inability to discontinue use... - Neuropsychological performance predicts clinical recovery in bipolar patientsStaci A Gruber
Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
J Affect Disord 105:253-60. 2008..Although a number of investigations have reported cognitive deficits in patients with bipolar disorder, relatively few have focused on the relationship between these impairments and clinical outcome... - Residual neuropsychological effects of illicit 3,4-methylenedioxymethamphetamine (MDMA) in individuals with minimal exposure to other drugsJohn H Halpern
Alcohol and Drug Abuse Research Center, Harvard Medical School, Biological Psychiatry Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478 9106, USA
Drug Alcohol Depend 75:135-47. 2004..Most MDMA users, however, use other illicit drugs as well, so it is difficult to be certain that these deficits are due to MDMA, as opposed to other drug use or additional confounding factors... - Overt propositional speech in chronic nonfluent aphasia studied with the dynamic susceptibility contrast fMRI methodMargaret A Naeser
Harold Goodglass Aphasia Research Center and Department of Neurology, Boston University School of Medicine and VA Boston Healthcare System, Boston, MA 02130, USA
Neuroimage 22:29-41. 2004.... - Differential activation patterns of occipital and prefrontal cortices during motion processing: evidence from normal and schizophrenic brainsYue Chen
McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts 02478, USA
Cogn Affect Behav Neurosci 8:293-303. 2008..Furthermore, this result provides evidence that in the context of broadly distributed cortical dysfunction, the usual functional specificity of the cortex becomes modified, even across the domains of sensory and cognitive processing... - Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal womenHadine Joffe
Women s Center for Behavioral Endocrinology, McLean Hospital, Harvard Medical School, Boston, MA, USA
Menopause 13:411-22. 2006.... - Fusiform gyrus volume reduction in first-episode schizophrenia: a magnetic resonance imaging studyChang Uk Lee
Department of Psychiatry (116A, VA Boston Healthcare System, Brockton Division, Harvard Medical School, 940 Belmont St, Brockton, MA 02301, USA
Arch Gen Psychiatry 59:775-81. 2002..CONCLUSION: Schizophrenia is associated with a bilateral reduction in fusiform gyrus gray matter volume that is evident at the time of first hospitalization and is different from the presentation of affective psychosis... - Stroop performance in normal control subjects: an fMRI studyStaci A Gruber
Cognitive Neuroimaging Laboratory, Brain Imaging Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478-9106, USA
Neuroimage 16:349-60. 2002..This study extends previous findings by demonstrating that in healthy adults, a subdivision of the cingulate cortex is specifically associated with the cognitive demands present in the interference condition... - Psychological and cognitive effects of long-term peyote use among Native AmericansJohn H Halpern
Biological Psychiatry Laboratory, Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Biol Psychiatry 58:624-31. 2005..However, the long-term residual psychological and cognitive effects of hallucinogens remain poorly understood... - Cognitive measures in long-term cannabis usersG Pope Harrison
Biological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Belmont, Massachusetts 02478, USA
J Clin Pharmacol 42:41S-47S. 2002....
Research Grants
- RESIDUAL COGNITIVE EFFECTS OF CANNABIS--AN FMRI STUDYDeborah Yurgelun Todd; Fiscal Year: 2002..abstract_text> ..
- IMAGING THE CEREBELLUM IN PSYCHOTIC DISORDERSRUSSELL LOEBER; Fiscal Year: 2003..The details of these measurements will provide information about the specific dysregulation of the functional components of the cerebellum. ..
- Brain Changes with Cannabis and MethamphetamineDeborah Yurgelun Todd; Fiscal Year: 2007..An R01 application will then be prepared based on the data acquired during the R21 period. ..
- MRS/fMRI Investigations of Adolescent Cannabis UseDeborah Yurgelun Todd; Fiscal Year: 2007....