Genomes and Genes
Affiliation: Harvard University
- Yuan J, Najafov A, Py B. Roles of Caspases in Necrotic Cell Death. Cell. 2016;167:1693-1704 pubmed publisher..These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, adult homeostasis, and host defense response. ..
- Li Y, Yuan J. Systematic Metrics Depicting Cell Death Kinetics. Cell Chem Biol. 2017;24:785-786 pubmed publisher..STACK provides a useful quantitative tool to determine how cell death kinetics may be modulated pharmacologically in cell culture systems. ..
- Geng J, Ito Y, Shi L, Amin P, Chu J, Ouchida A, et al. Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nat Commun. 2017;8:359 pubmed publisher..Here the authors show that TNF?-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this decision. ..
- Ofengeim D, Mazzitelli S, Ito Y, Dewitt J, Mifflin L, Zou C, et al. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proc Natl Acad Sci U S A. 2017;114:E8788-E8797 pubmed publisher..Our results support that RIPK1 is an important therapeutic target for the treatment of AD. ..
- Wang H, Meng H, Li X, Zhu K, Dong K, Mookhtiar A, et al. PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. Proc Natl Acad Sci U S A. 2017;114:11944-11949 pubmed publisher..Finally, we show that Peli1-/- mice are sensitized to TNF?-induced apoptosis. Thus, PELI1 is a key modulator of RIPK1 that differentially controls the activation of necroptosis and apoptosis. ..
- Li Y, Qian L, Yuan J. Small molecule probes for cellular death machines. Curr Opin Chem Biol. 2017;39:74-82 pubmed publisher..We suggest that the development and applications of small molecule probes for non-apoptotic cell death mechanisms provide an outstanding example showcasing the power of chemical biology in exploring novel biological mechanisms. ..