Junying Yuan


Affiliation: Harvard University
Country: USA


  1. Su Z, Dziedzic S, Hu D, Barrett V, Broekema N, Li W, et al. ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner. Cell Death Differ. 2018;: pubmed publisher
  2. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, et al. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. 2018;174:1477-1491.e19 pubmed publisher
    ..Thus, aging facilitates RIPK1 activation by reducing TAK1 expression, which cooperates with genetic risk factors to promote the onset of ALS/FTD. ..
  3. Xia H, Najafov A, Geng J, Galan Acosta L, Han X, Guo Y, et al. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. J Cell Biol. 2015;210:705-16 pubmed publisher
    ..Our study delineates a novel pharmacological strategy to promote the degradation of HK2 in cancer cells. ..
  4. Yuan J. Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke. Apoptosis. 2009;14:469-77 pubmed publisher
  5. Yuan J, Kroemer G. Alternative cell death mechanisms in development and beyond. Genes Dev. 2010;24:2592-602 pubmed publisher
    ..The physiological relevance of alternative cell death mechanisms as primary and backup mechanisms is discussed. ..
  6. Ofengeim D, Giagtzoglou N, Huh D, Zou C, Yuan J. Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time. Trends Mol Med. 2017;23:563-576 pubmed publisher
    ..We advocate the application of scRNA-seq in the discovery of targets and biomarkers as a new approach in developing novel therapeutics for the treatment of neurodegenerative diseases. ..
  7. Christofferson D, Li Y, Yuan J. Control of life-or-death decisions by RIP1 kinase. Annu Rev Physiol. 2014;76:129-50 pubmed publisher
    ..This review focuses on the functional roles of RIP1 in regulating multiple cellular mechanisms, the dynamic regulation of RIP1, and the physiological and pathological roles of RIP1 kinase in human health and disease. ..
  8. Xiao J, Zhang T, Xu D, Wang H, Cai Y, Jin T, et al. FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. Genes Dev. 2015;29:184-96 pubmed publisher
  9. Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, et al. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science. 2016;353:603-8 pubmed publisher
    ..Furthermore, inhibiting RIPK1 kinase may provide an axonal protective strategy for the treatment of ALS and other human degenerative diseases characterized by axonal degeneration. ..

More Information


  1. Yuan J, Najafov A, Py B. Roles of Caspases in Necrotic Cell Death. Cell. 2016;167:1693-1704 pubmed publisher
    ..These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, adult homeostasis, and host defense response. ..
  2. Li Y, Yuan J. Systematic Metrics Depicting Cell Death Kinetics. Cell Chem Biol. 2017;24:785-786 pubmed publisher
    ..STACK provides a useful quantitative tool to determine how cell death kinetics may be modulated pharmacologically in cell culture systems. ..
  3. Geng J, Ito Y, Shi L, Amin P, Chu J, Ouchida A, et al. Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nat Commun. 2017;8:359 pubmed publisher
    ..Here the authors show that TNF?-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this decision. ..
  4. Ofengeim D, Mazzitelli S, Ito Y, Dewitt J, Mifflin L, Zou C, et al. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proc Natl Acad Sci U S A. 2017;114:E8788-E8797 pubmed publisher
    ..Our results support that RIPK1 is an important therapeutic target for the treatment of AD. ..
  5. Wang H, Meng H, Li X, Zhu K, Dong K, Mookhtiar A, et al. PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. Proc Natl Acad Sci U S A. 2017;114:11944-11949 pubmed publisher
    ..Finally, we show that Peli1-/- mice are sensitized to TNF?-induced apoptosis. Thus, PELI1 is a key modulator of RIPK1 that differentially controls the activation of necroptosis and apoptosis. ..
  6. Li Y, Qian L, Yuan J. Small molecule probes for cellular death machines. Curr Opin Chem Biol. 2017;39:74-82 pubmed publisher
    ..We suggest that the development and applications of small molecule probes for non-apoptotic cell death mechanisms provide an outstanding example showcasing the power of chemical biology in exploring novel biological mechanisms. ..