Junying Yuan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity
    Juying Li
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 181:321-33. 2008
  2. pmc A genome-wide RNAi screen reveals multiple regulators of caspase activation
    Caroline H Yi
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 179:619-26. 2007
  3. pmc A novel role for RIP1 kinase in mediating TNFα production
    D E Christofferson
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Death Dis 3:e320. 2012
  4. pmc The channel of death
    A Degterev
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Cell Biol 155:695-8. 2001
  5. doi request reprint Control of life-or-death decisions by RIP1 kinase
    Dana E Christofferson
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 email
    Annu Rev Physiol 76:129-50. 2014
  6. pmc Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
    T Nakagawa
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 150:887-94. 2000
  7. ncbi request reprint Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 23:1-12. 2006
  8. ncbi request reprint Inducing autophagy harmlessly
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Autophagy 4:249-50. 2008
  9. ncbi request reprint Diversity in the mechanisms of neuronal cell death
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Neuron 40:401-13. 2003
  10. pmc Alternative cell death mechanisms in development and beyond
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 24:2592-602. 2010

Collaborators

Detail Information

Publications76

  1. pmc Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity
    Juying Li
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 181:321-33. 2008
    ..Our study provides a new mechanism controlling the localization and activation of proinflammatory caspases...
  2. pmc A genome-wide RNAi screen reveals multiple regulators of caspase activation
    Caroline H Yi
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 179:619-26. 2007
    ..Our data suggest a previously unappreciated fundamental connection between various cellular processes and caspase-dependent cell death...
  3. pmc A novel role for RIP1 kinase in mediating TNFα production
    D E Christofferson
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Death Dis 3:e320. 2012
    ..These findings implicate cIAP1/2 and Traf2 as negative regulators of this RIP1 kinase-dependent TNFα production pathway and suggest a novel role for RIP1 kinase in mediating TNFα production under certain conditions...
  4. pmc The channel of death
    A Degterev
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Cell Biol 155:695-8. 2001
    ....
  5. doi request reprint Control of life-or-death decisions by RIP1 kinase
    Dana E Christofferson
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 email
    Annu Rev Physiol 76:129-50. 2014
    ..This review focuses on the functional roles of RIP1 in regulating multiple cellular mechanisms, the dynamic regulation of RIP1, and the physiological and pathological roles of RIP1 kinase in human health and disease. ..
  6. pmc Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
    T Nakagawa
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 150:887-94. 2000
    ..These data suggest a novel apoptotic pathway involving calcium-mediated calpain activation and cross-talks between calpain and caspase families...
  7. ncbi request reprint Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 23:1-12. 2006
    ..Such evidence suggests that evolution has led to an extensive integration of mammalian apoptosis machinery with multiple cellular physiological processes...
  8. ncbi request reprint Inducing autophagy harmlessly
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Autophagy 4:249-50. 2008
    ..An important role of autophagy in the clearance of misfolded proteins in neurons has been demonstrated. The challenge now is to see if we can develop small molecules that can induce autophagy without causing cellular damage...
  9. ncbi request reprint Diversity in the mechanisms of neuronal cell death
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Neuron 40:401-13. 2003
    ..This review evaluates the evidence supporting the existence of alternative mechanisms of neuronal cell death and proposes the possible existence of an evolutionarily conserved pathway of necrosis...
  10. pmc Alternative cell death mechanisms in development and beyond
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 24:2592-602. 2010
    ..The physiological relevance of alternative cell death mechanisms as primary and backup mechanisms is discussed...
  11. pmc Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Apoptosis 14:469-77. 2009
    ....
  12. ncbi request reprint Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization
    Juying Li
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Nat Cell Biol 9:276-86. 2007
    ..These data demonstrate a novel cell autonomous caspase-mediated mechanism that regulates actin dynamics and mammalian cell migration distinct from the receptor mediated Rho-Rac-Cdc42 pathway...
  13. ncbi request reprint Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis
    Shin Jung Kang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:5455-60. 2003
    ..Our study urges caution when considering the inhibition of caspases as a direct therapeutic method for the treatment of chronic neurodegenerative diseases...
  14. pmc Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1
    Jidong Zhu
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:6584-9. 2008
    ..Our study provides a direct link between the growth factor signaling pathways regulated by PI3 kinase/Akt and MAP kinases with Myc-mediated transcription...
  15. pmc Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays
    Yong Zhang
    Center for Bioinformatics, Harvard Center for Neurodegeneration and Repair, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 35:1502-15. 2007
    ..All these properties make the proposed algorithm attractive for high-throughput screening of neuron-based assays...
  16. pmc Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains
    Benchun Miao
    Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 107:20126-31. 2010
    ..Overall, our studies demonstrate the feasibility of developing specific small molecule antagonists of PIP3 signaling...
  17. ncbi request reprint Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms
    Or Gozani
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Adv Enzyme Regul 45:171-85. 2005
    ..Finally, our work supports a model that endogenous PtdInsPs regulate sub-nuclear localization and function of endogenous nuclear PtdInsP-binding proteins...
  18. pmc Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
    Junichi Hitomi
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 135:1311-23. 2008
    ..Our study defines a cellular signaling network that regulates necroptosis and the molecular bifurcation that controls apoptosis and necroptosis...
  19. pmc ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells
    Kevin F Bryant
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Virology 379:197-204. 2008
    ..Taken together, our data indicate that salubrinal has both ICP34.5-dependent and -independent activities in HSV-1 infected cells...
  20. pmc A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions
    Marta M Lipinski
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 18:1041-52. 2010
    ....
  21. pmc Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice
    Zerong You
    Neuroscience Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 28:1564-73. 2008
    ..The data suggest that necroptosis plays a significant role in the pathogenesis of cell death and functional outcome after TBI and that necrostatin-1 may have therapeutic potential for patients with TBI...
  22. pmc Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity
    Bénédicte F Py
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 38:1063-72. 2013
    ..By producing cochlin, FDCs thus contribute to the innate immune response in defense against bacteria...
  23. pmc A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses
    Bénédicte F Py
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Autophagy 5:393-6. 2009
    ....
  24. ncbi request reprint Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders
    Ivelisse Sanchez
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 421:373-9. 2003
    ..We conclude that oligomerization is a crucial determinant in the biochemical properties of expanded polyglutamine that are central to their chronic cytotoxicity...
  25. ncbi request reprint Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    Alexei Degterev
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Chem Biol 1:112-9. 2005
    ..Our study identifies a previously undescribed basic cell-death pathway with potentially broad relevance to human pathologies...
  26. pmc Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma
    Alexander H Stegh
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 21:98-111. 2007
    ..Thus, Bcl2L12 contributes to the classical tumor biological features of GBM such as intense apoptosis resistance and florid necrosis, and may provide a target for enhanced therapeutic responsiveness of this lethal cancer...
  27. ncbi request reprint c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1
    Lei Xu
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 28:914-22. 2007
    ..Our results demonstrate that c-IAP1 exerts its oncogenic functions by promoting the degradation of an important negative regulator in the Myc pathway...
  28. ncbi request reprint Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G
    Nathan J Moerke
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell 128:257-67. 2007
    ..The identification of this compound provides a new tool for studying translational control and establishes a possible new strategy for cancer therapy...
  29. pmc Chaperone-mediated autophagy degrades mutant p53
    Helin Vakifahmetoglu-Norberg
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 27:1718-30. 2013
    ....
  30. ncbi request reprint Caspase-11 is not necessary for chemotherapy-induced intestinal mucositis
    Shin Jung Kang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    DNA Cell Biol 23:490-5. 2004
    ..These findings suggest that while caspase-11 activation occurs in response to melphalan, it does not have a primary role in the pathogenesis of intestinal mucositis...
  31. pmc Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
    Marta M Lipinski
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14164-9. 2010
    ..Finally, we provide a list of candidate drug targets that can be used to safely modulate levels of autophagy without causing cell death...
  32. pmc Negative regulation of Vps34 by Cdk mediated phosphorylation
    Tsuyoshi Furuya
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 38:500-11. 2010
    ..We propose that phosphorylation of Thr159 in Vps34 is a key regulatory mechanism that controls the class III PtdIns3 kinase activity in cell-cycle progression, development, and human diseases including neurodegeneration and cancers...
  33. ncbi request reprint Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1
    Yasuhito Terui
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    J Biol Chem 279:28257-65. 2004
    ....
  34. ncbi request reprint A cellular response to an internal energy crisis
    Marta M Lipinski
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 123:3-5. 2005
    ..2005) describe a new mechanism that directly links nutrient availability to apoptosis in Xenopus oocytes and show that age-dependent changes in the nutritional state of a cell might lead to caspase activation and apoptotic cell death...
  35. ncbi request reprint Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo
    Yasushi Takai
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 144:69-74. 2003
    ....
  36. pmc Role of protein misfolding in DFNA9 hearing loss
    Jianhua Yao
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:14909-19. 2010
    ..Our study suggests a possible molecular mechanism underlying DFNA9 hearing loss and provides an in vitro model that may be used to explore protein-misfolding diseases in general...
  37. pmc Parcs is a dual regulator of cell proliferation and apaf-1 function
    Roberto Sanchez-Olea
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 283:24400-5. 2008
    ..We conclude that Parcs may define a molecular checkpoint in the control of cell proliferation for normal cells that is lost in tumor cells...
  38. ncbi request reprint Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
    Mamoru Shibata
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:14474-85. 2006
    ..100, 15077-15082), we propose that the age-dependent decrease of beclin 1 expression may lead to a reduction of autophagic activity during aging, which in turn promotes the accumulation of mutant Htt and the progression of the disease...
  39. ncbi request reprint Expansion and evolution of cell death programmes
    Alexei Degterev
    Tufts University, School of Medicine, Department of Biochemistry, 136 Harrison Ave, Boston, Massachusetts 02111, USA
    Nat Rev Mol Cell Biol 9:378-90. 2008
    ..Here we examine how and why these different cell death programmes have evolved, with an eye towards new cytoprotective therapeutic opportunities...
  40. ncbi request reprint Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans
    Jianhua Qiu
    Neuroscience Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 22:3504-11. 2002
    ..These data suggest that Fas-associated DISCs assemble in neurons overexpressing Fas ligand as well as within mouse and human contused brain after TBI. Therefore, Fas may function as a death receptor after brain injury...
  41. ncbi request reprint The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor
    Or Gozani
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 114:99-111. 2003
    ..Together, our data identify the PHD finger as a phosphoinositide binding module and a nuclear PtdInsP receptor, and suggest that PHD-phosphoinositide interactions directly regulate nuclear responses to DNA damage...
  42. ncbi request reprint A decade of caspases
    Alexei Degterev
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Oncogene 22:8543-67. 2003
    ....
  43. pmc The Jekyll and Hyde functions of caspases
    Caroline H Yi
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 16:21-34. 2009
    ..Exciting recent developments have focused on uncovering nonapoptotic roles of caspases ranging from immune regulation to spermatogenesis, in highly specialized cellular frameworks...
  44. doi request reprint Identification of RIP1 kinase as a specific cellular target of necrostatins
    Alexei Degterev
    Tufts University, School of Medicine, Department of Biochemistry, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Nat Chem Biol 4:313-21. 2008
    ..Overall, our data establish necrostatins as the first-in-class inhibitors of RIP1 kinase, the key upstream kinase involved in the activation of necroptosis...
  45. pmc Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival
    Caroline H Yi
    Department of Cell Biology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Cell 146:607-20. 2011
    ..We propose that acetyl-CoA serves as a signaling molecule that couples apoptotic sensitivity to metabolism by regulating protein N-alpha-acetylation...
  46. ncbi request reprint A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
    Michael Boyce
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 307:935-9. 2005
    ..More broadly, salubrinal demonstrates the feasibility of selective pharmacological targeting of cellular dephosphorylation events...
  47. doi request reprint Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
    Bénédicte F Py
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 49:331-8. 2013
    ..Our results elucidate a regulatory mechanism involving BRCC3-dependent NLRP3 regulation and highlight NLRP3 ubiquitination as a potential therapeutic target for inflammatory diseases...
  48. pmc Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening
    Dimitry Ofengeim
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 287:8714-23. 2012
    ..Overall, our work establishes the feasibility of identifying small molecule inhibitors of Aβ-induced neurite loss using the NeuriteIQ pipeline and provides novel insights into the mechanisms of neuroprotection by NSAIDs...
  49. pmc Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation
    Dean A Le
    Stroke and Neurovascular Regulation Laboratory, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 99:15188-93. 2002
    ....
  50. pmc Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
    Gilad Twig
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
    EMBO J 27:433-46. 2008
    ..Together, these findings suggest that fission followed by selective fusion segregates dysfunctional mitochondria and permits their removal by autophagy...
  51. pmc Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis
    Xiao Bo Qiu
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 23:800-10. 2004
    ..Thus, BRUCE normally inhibits apoptosis, and Nrdp1 can be important in the initiation of apoptosis by catalyzing ubiquitination and degradation of BRUCE...
  52. ncbi request reprint A PHD finger motif in the C terminus of RAG2 modulates recombination activity
    Sheryl K Elkin
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 280:28701-10. 2005
    ..We propose a model in which the equilibrium between these states modulates recombination activity. Together, these data identify the PHD finger as a novel and functionally important domain of RAG2...
  53. ncbi request reprint Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner
    Lina I Yoo
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 66:1929-39. 2006
    ..Our results reveal alternative downstream signaling pathways activated by Pten deficiency that lead to tissue-specific susceptibilities to tumorigenesis...
  54. doi request reprint Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death
    Dimitry Ofengeim
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Mol Cell Biol 14:727-36. 2013
    ..Targeting RIP1 might be a novel therapeutic strategy for the treatment of both acute and chronic human diseases. ..
  55. ncbi request reprint Mechanisms of cell death in polyglutamine expansion diseases
    Marta M Lipinski
    Harvard Medical School, Department of Cell Biology, 240 Longwood Ave, Boston MA 02115, USA
    Curr Opin Pharmacol 4:85-90. 2004
    ....
  56. ncbi request reprint A novel tracing algorithm for high throughput imaging Screening of neuron-based assays
    Yong Zhang
    Center for Bioinformatics, Harvard Center for Neurodegeneration and Repair, Harvard Medical School, Boston, MA 02215, United States
    J Neurosci Methods 160:149-62. 2007
    ..Detailed results on experimental validation of the proposed method and on its comparative performance with other proposed schemes are included...
  57. ncbi request reprint Caspase-11 controls interleukin-1β release through degradation of TRPC1
    Bénédicte F Py
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA International Center for Infectiology Research, Inserm U1111, CNRS UMR5308, Ecole Normale Superieure de Lyon, Claude Bernard Lyon 1 University, 69007 Lyon, France
    Cell Rep 6:1122-8. 2014
    ..Altogether, our data suggest that caspase-11 modulates the cationic channel composition of the cell and thus regulates the unconventional secretion pathway in a manner independent of caspase-1. ..
  58. ncbi request reprint Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection
    Bénédicte F Py
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Autophagy 3:117-25. 2007
    ....
  59. ncbi request reprint To kill or to arrest: that is the new question for Apaf-1
    Roberto Sanchez-Olea
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 28:520-1. 2007
    ..2007) report that Apaf-1 is essential for the DNA damage-induced intra-S phase checkpoint response. This new role for Apaf-1 is unrelated to its proapoptotic function but is evolutionarily conserved in Ced-4...
  60. pmc Necroptosis as an alternative form of programmed cell death
    Dana E Christofferson
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, United States
    Curr Opin Cell Biol 22:263-8. 2010
    ..Necroptosis and necrostatins provide an exciting new opportunity for developing new treatments for multiple human diseases involving necrosis and inflammation...
  61. ncbi request reprint LKB1--a master tumour suppressor of the small intestine and beyond
    Lina I Yoo
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Cancer 2:529-35. 2002
  62. doi request reprint A degradative detour for mutant TP53
    Helin Vakifahmetoglu-Norberg
    Department of Cell Biology, Harvard Medical School, Boston, MA USA
    Autophagy 9:2158-60. 2013
    ..We propose CMA as a new degradative mechanism for mutant TP53 and the possibility of activating CMA as a new treatment for cancers with mutant TP53. ..
  63. ncbi request reprint Alpha-synuclein oligomerization: a role for lipids?
    Kevin Welch
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Trends Neurosci 26:517-9. 2003
    ..alpha-Synuclein oligomers might be a first step in the formation of alpha-synuclein aggregates present in a number of neurodegenerative diseases, although their cytotoxicity remains to be directly demonstrated...
  64. ncbi request reprint A first insight into the molecular mechanisms of apoptosis
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Cell 116:S53-6, 1 p following S59. 2004
  65. pmc Junying Yuan: changing avenues without losing focus. Interview by Nicole LeBrasseur
    Junying Yuan
    J Cell Biol 179:174-5. 2007
    An interest in neurodegenerative diseases drove Junying Yuan to study cell death as a graduate student at Harvard University...
  66. ncbi request reprint Caspase cascades in human immunodeficiency virus-associated neurodegeneration
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 22:4015-24. 2002
    ..These findings suggest that pharmacologic interventions aimed at the caspase enzyme pathways may be beneficial for the prevention or treatment of HAD...
  67. pmc Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
    Wei Xing Zong
    Department of Cancer Biology, Abramson Cancer Center, 421 Curie Blvd, BRB II III, 445, Philadelphia, PA 19104 6160, USA
    J Cell Biol 162:59-69. 2003
    ..These findings demonstrate that in addition to their functions at mitochondria, Bax and Bak also localize to the ER and function to initiate a parallel pathway of caspase activation and apoptosis...
  68. ncbi request reprint Structure-activity relationship study of novel necroptosis inhibitors
    Xin Teng
    Laboratory for Drug Discovery in Neurodegeneration, Harvard Center for Neurodegeneration and Repair, Brigham and Women s Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Bioorg Med Chem Lett 15:5039-44. 2005
    ..A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration...
  69. ncbi request reprint Releasing the nerve cell killers
    Kevin Welch
    Nat Med 8:564-5. 2002
  70. pmc Small molecule regulators of autophagy identified by an image-based high-throughput screen
    Lihong Zhang
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
    Proc Natl Acad Sci U S A 104:19023-8. 2007
    ..Our studies suggest the possibility that some of these drugs may be useful for the treatment of Huntington's and other human diseases associated with the accumulation of misfolded proteins...
  71. doi request reprint Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells
    Yeo Kyoung Oh
    Department of Molecular Biology, Sejong University, Seoul, Korea
    J Neurochem 104:993-1005. 2008
    ..These results suggest that the misfolding of ALS-related mutant SOD1 induces ER stress possibly prior to the formation of visible aggregates, which may contribute to the motor neuron degeneration in ALS pathogenesis...
  72. ncbi request reprint Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels
    Toshifumi Matsui
    Alzheimer Research Unit, Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neuropathol Exp Neurol 65:508-15. 2006
    ..Thus, a principal caspase pathway from caspase-8 to caspase-3 and/or 7 may contribute to neuron loss in AD brain...
  73. ncbi request reprint LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma
    Shintaro Takeda
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Anticancer Res 27:761-8. 2007
    ..These results suggest that LKB1 is critical for TRAIL-induced apoptosis induction, cooperating with DAP3 in osteosarcoma cells. It is predicted that LKB1 and DAP3 could be critical target molecules for the treatment of osteosarcomas...
  74. ncbi request reprint Structure-activity relationship study of tricyclic necroptosis inhibitors
    Prakash G Jagtap
    Laboratory for Drug Discovery in Neurodegeneration, Harvard Center for Neurodegeneration and Repair, Brigham and Women s Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA
    J Med Chem 50:1886-95. 2007
    ..Amides at the 2-position of the tricyclic ring were best. The Nec-3 series provides new tools for elucidating caspase-independent cell death pathways and potentially lead compounds for therapeutic development...

Research Grants28

  1. Dissecting the Molecular Pathway of Aponecrosis
    Junying Yuan; Fiscal Year: 2005
    ..This work is a close collaboration between John Porco, an organic chemist at Boston University, and Junying Yuan, a cell biologist at Harvard Medical School...
  2. Molecular mechanism of a cellular necrotic cell death pathway
    Junying Yuan; Fiscal Year: 2010
    ..Understanding the mechanism by which cells regulate necroptotic cell death may provide unique opportunities for developing novel therapies of major human diseases with little or no known treatment. ..
  3. P33ING1 IN CELLULAR SENESCENCE AND ORGANISIMAL AGING
    Junying Yuan; Fiscal Year: 2003
    ..These works will illustrate the role of p33ING1 in mediating cellular senescence in culture and organismal aging in vivo. ..
  4. Dissecting the Molecular Pathway of Aponecrosis
    Junying Yuan; Fiscal Year: 2004
    ..This work is a close collaboration between John Porco, an organic chemist at Boston University, and Junying Yuan, a cell biologist at Harvard Medical School...
  5. THE ROLE OF PEUTZ JEGHER GENE IN APOPTOSIS
    Junying Yuan; Fiscal Year: 2004
    ..We will also search for evidence of apoptosis inhibition in the polyps regions of the intestinal samples from Peutz-Jegher patients. ..
  6. THE ROLE OF PEUTZ JEGHER GENE IN APOPTOSIS
    Junying Yuan; Fiscal Year: 2005
    ..We will also search for evidence of apoptosis inhibition in the polyps regions of the intestinal samples from Peutz-Jegher patients. ..
  7. Development of Anti-necrosis Drug for Acute Brain Injury
    Junying Yuan; Fiscal Year: 2007
    ..This project will culminate with the filing of an IND application with the FDA in order to enter a Phase I human clinical trial. ..
  8. Mechanism and Regulation of Caspase-11
    Junying Yuan; Fiscal Year: 2007
    ..abstract_text> ..
  9. A High Throughput Screen for Inhibitors of a Novel Necrotic Cell Death Pathway
    Junying Yuan; Fiscal Year: 2007
    ..Necroptosis has been shown to be a promising target for the treatment of stroke as it represents a type of delayed cell death in stroke and offers an extended time window for therapy. ..
  10. Mechanism and Regulation of Caspase-11
    Junying Yuan; Fiscal Year: 2007
    ..This work will also provide novel insights into the non-apoptotic function of caspases which are directly relevant for development of caspase inhibitors as drugs for treatment of human diseases. ..
  11. Molecular mechanism of a cellular necrotic cell death pathway
    Junying Yuan; Fiscal Year: 2009
    ..Understanding the mechanism by which cells regulate necroptotic cell death may provide unique opportunities for developing novel therapies of major human diseases with little or no known treatment. ..
  12. THE ROLE OF PEUTZ JEGHER GENE IN APOPTOSIS
    Junying Yuan; Fiscal Year: 2003
    ..We will also search for evidence of apoptosis inhibition in the polyps regions of the intestinal samples from Peutz-Jegher patients. ..
  13. Dissecting the Molecular Pathway of Aponecrosis
    Junying Yuan; Fiscal Year: 2003
    ..This work is a close collaboration between John Porco, an organic chemist at Boston University, and Junying Yuan, a cell biologist at Harvard Medical School...
  14. P33ING1 IN CELLULAR SENESCENCE AND ORGANISIMAL AGING
    Junying Yuan; Fiscal Year: 1999
    ..These works will illustrate the role of p33ING1 in mediating cellular senescence in culture and organismal aging in vivo. ..
  15. MECHANISM & FUNCTIONS OF ICH-3 IN APOPTOSIS/INFLAMMATION
    Junying Yuan; Fiscal Year: 1999
    ..These works will have direct implication in control of apoptosis in normal and inflammatory conditions. ..
  16. MECHANISM & FUNCTIONS OF ICH-3 IN APOPTOSIS/INFLAMMATION
    Junying Yuan; Fiscal Year: 2000
    ..These works will have direct implication in control of apoptosis in normal and inflammatory conditions. ..
  17. P33ING1 IN CELLULAR SENESCENCE AND ORGANISIMAL AGING
    Junying Yuan; Fiscal Year: 2000
    ..These works will illustrate the role of p33ING1 in mediating cellular senescence in culture and organismal aging in vivo. ..
  18. THE ROLE OF PEUTZ JEGHER GENE IN APOPTOSIS
    Junying Yuan; Fiscal Year: 2001
    ..We will also search for evidence of apoptosis inhibition in the polyps regions of the intestinal samples from Peutz-Jegher patients. ..
  19. MECHANISM & FUNCTIONS OF ICH-3 IN APOPTOSIS/INFLAMMATION
    Junying Yuan; Fiscal Year: 2001
    ..These works will have direct implication in control of apoptosis in normal and inflammatory conditions. ..
  20. P33ING1 IN CELLULAR SENESCENCE AND ORGANISIMAL AGING
    Junying Yuan; Fiscal Year: 2001
    ..These works will illustrate the role of p33ING1 in mediating cellular senescence in culture and organismal aging in vivo. ..
  21. Dissecting the Molecular Pathway of Aponecrosis
    Junying Yuan; Fiscal Year: 2002
    ..This work is a close collaboration between John Porco, an organic chemist at Boston University, and Junying Yuan, a cell biologist at Harvard Medical School...
  22. THE ROLE OF PEUTZ JEGHER GENE IN APOPTOSIS
    Junying Yuan; Fiscal Year: 2002
    ..We will also search for evidence of apoptosis inhibition in the polyps regions of the intestinal samples from Peutz-Jegher patients. ..
  23. P33ING1 IN CELLULAR SENESCENCE AND ORGANISIMAL AGING
    Junying Yuan; Fiscal Year: 2002
    ..These works will illustrate the role of p33ING1 in mediating cellular senescence in culture and organismal aging in vivo. ..