Tracy L Young-Pearse

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
    Tracy L Young-Pearse
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Neural Dev 3:15. 2008
  2. pmc Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development
    Tracy L Young-Pearse
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 30:10431-40. 2010
  3. ncbi request reprint A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference
    Tracy L Young-Pearse
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 27:14459-69. 2007
  4. pmc Pancortins interact with amyloid precursor protein and modulate cortical cell migration
    Heather C Rice
    Center for Neurologic Diseases, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Development 139:3986-96. 2012
  5. pmc Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein
    Heather C Rice
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, United States
    Biochemistry 52:3264-77. 2013
  6. pmc The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
    Christina R Muratore
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 23:3523-36. 2014

Research Grants

Collaborators

Detail Information

Publications6

  1. pmc Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
    Tracy L Young-Pearse
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Neural Dev 3:15. 2008
    ....
  2. pmc Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development
    Tracy L Young-Pearse
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 30:10431-40. 2010
    ....
  3. ncbi request reprint A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference
    Tracy L Young-Pearse
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 27:14459-69. 2007
    ..We conclude that full-length APP functions as an important factor for proper migration of neuronal precursors into the cortical plate during the development of the mammalian brain...
  4. pmc Pancortins interact with amyloid precursor protein and modulate cortical cell migration
    Heather C Rice
    Center for Neurologic Diseases, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Development 139:3986-96. 2012
    ..Taken together, these results suggest a biochemical and functional interaction between APP and pancortins, and reveal a previously unidentified role for pancortins in mammalian cortical development...
  5. pmc Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein
    Heather C Rice
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, United States
    Biochemistry 52:3264-77. 2013
    ..These findings led us to conduct further detailed analyses of the interactions of Reelin and Lingo-1 with APP. ..
  6. pmc The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
    Christina R Muratore
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 23:3523-36. 2014
    ..These studies use human neurons to reveal previously unrecognized effects of the most common fAD APP mutation and provide a model system for testing therapeutic strategies in the cell types most relevant to disease processes. ..

Research Grants2

  1. Functions of APP Family Members in Neuronal Development
    TRACY PEARSE; Fiscal Year: 2007
    ..Through these aims the function and mechanism of action of APP family members in developing neurons will be addressed. ..