Bruce Yankner

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The aging brain
    Bruce A Yankner
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Pathol 3:41-66. 2008
  2. pmc Evolution of the aging brain transcriptome and synaptic regulation
    Patrick M Loerch
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e3329. 2008
  3. pmc The aging stress response
    Marcia C Haigis
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 40:333-44. 2010
  4. pmc Negative regulation of Vps34 by Cdk mediated phosphorylation
    Tsuyoshi Furuya
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 38:500-11. 2010
  5. ncbi request reprint Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
    Mamoru Shibata
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:14474-85. 2006
  6. pmc Neural mechanisms of ageing and cognitive decline
    Nicholas A Bishop
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 464:529-35. 2010
  7. pmc SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
    Philipp Oberdoerffer
    Department of Pathology and Glenn Labs for Aging Research, Harvard Medical School, Boston, MA 02115, USA
    Cell 135:907-18. 2008
  8. ncbi request reprint Gene regulation and DNA damage in the ageing human brain
    Tao Lu
    Department of Neurology and Division of Neuroscience, The Children s Hospital and Harvard Medical School, Enders 260, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 429:883-91. 2004
  9. ncbi request reprint The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
    Jin Xu
    Department of Neurology, Caritas St Elizabeth s Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Hum Mol Genet 14:1231-41. 2005
  10. pmc Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
    Marta M Lipinski
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14164-9. 2010

Research Grants

Collaborators

Detail Information

Publications10

  1. ncbi request reprint The aging brain
    Bruce A Yankner
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Pathol 3:41-66. 2008
    ..This review discusses potential approaches to unifying the systems biology of the aging brain with the pathogenesis of neurodegeneration...
  2. pmc Evolution of the aging brain transcriptome and synaptic regulation
    Patrick M Loerch
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e3329. 2008
    ..Thus, repression of neuronal gene expression is a prominent and recently evolved feature of brain aging in humans and rhesus macaques that may alter neural networks and contribute to age-related cognitive changes...
  3. pmc The aging stress response
    Marcia C Haigis
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 40:333-44. 2010
    ..The systems biology of stress response signaling thus provides a new approach to the understanding and potential treatment of age-related diseases...
  4. pmc Negative regulation of Vps34 by Cdk mediated phosphorylation
    Tsuyoshi Furuya
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 38:500-11. 2010
    ..We propose that phosphorylation of Thr159 in Vps34 is a key regulatory mechanism that controls the class III PtdIns3 kinase activity in cell-cycle progression, development, and human diseases including neurodegeneration and cancers...
  5. ncbi request reprint Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
    Mamoru Shibata
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:14474-85. 2006
    ..100, 15077-15082), we propose that the age-dependent decrease of beclin 1 expression may lead to a reduction of autophagic activity during aging, which in turn promotes the accumulation of mutant Htt and the progression of the disease...
  6. pmc Neural mechanisms of ageing and cognitive decline
    Nicholas A Bishop
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 464:529-35. 2010
    ..Recent advances in the biology of ageing in model organisms, together with molecular and systems-level studies of the brain, are beginning to shed light on these mechanisms and their potential roles in cognitive decline...
  7. pmc SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
    Philipp Oberdoerffer
    Department of Pathology and Glenn Labs for Aging Research, Harvard Medical School, Boston, MA 02115, USA
    Cell 135:907-18. 2008
    ..Thus, DNA damage-induced redistribution of SIRT1 and other chromatin-modifying proteins may be a conserved mechanism of aging in eukaryotes...
  8. ncbi request reprint Gene regulation and DNA damage in the ageing human brain
    Tao Lu
    Department of Neurology and Division of Neuroscience, The Children s Hospital and Harvard Medical School, Enders 260, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 429:883-91. 2004
    ..Thus, DNA damage may reduce the expression of selectively vulnerable genes involved in learning, memory and neuronal survival, initiating a programme of brain ageing that starts early in adult life...
  9. ncbi request reprint The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
    Jin Xu
    Department of Neurology, Caritas St Elizabeth s Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Hum Mol Genet 14:1231-41. 2005
    ..Mutations that impair the transcriptional co-activator function of DJ-1 render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of PD...
  10. pmc Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
    Marta M Lipinski
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14164-9. 2010
    ..Finally, we provide a list of candidate drug targets that can be used to safely modulate levels of autophagy without causing cell death...

Research Grants34

  1. Gene Regulation and DNA Damage in the Aging Brain
    Bruce Yankner; Fiscal Year: 2009
    ..These studies may provide new insights into brain aging, with potentially significant therapeutic implications. ..
  2. REGULATION OF AMYLOID BETA PROTEIN BY APOE & CHOLESTEROL
    Bruce Yankner; Fiscal Year: 2004
    ..These studies may help to elucidate the roles of apoE and dietary cholesterol in the pathogenesis of AD, with potentially important implications for early genotyping and therapeutic intervention. ..
  3. TRAINING IN THE MOLECULAR BIOLOGY OF NEURODEGENERATION
    Bruce Yankner; Fiscal Year: 2007
    ....
  4. Studies on the Mechanism of Beta Amyloid Neurotoxicity
    Bruce Yankner; Fiscal Year: 2007
    ..These studies may provide insights into a novel degenerative mechanism involving altered signal transduction, with potentially significant therapeutic implications for Alzheimer's disease. ..
  5. Genomic Analysis of Human Aging and Cognitive Decline
    Bruce Yankner; Fiscal Year: 2007
    ..These studies may provide insight into the pathogenesis of age-related cognitive decline, with potentially important diagnostic and therapeutic implications. ..
  6. MECHANISM OF BETA AMYLOID NEUROTOXICITY
    Bruce Yankner; Fiscal Year: 1993
    ..The studies outlined in this proposal will characterize a potential model system for the pathogenesis of AD and may lead to the rational design of new therapeutic interventions for AD...
  7. Gene Regulation and DNA Damage in the Aging Brain
    Bruce Yankner; Fiscal Year: 2007
    ..These studies may provide new insights into brain aging, with potentially significant therapeutic implications. ..
  8. Genomic Analysis of Human Aging and Cognitive Decline
    Bruce Yankner; Fiscal Year: 2009
    ..These studies may provide insight into the pathogenesis of age-related cognitive decline, with potentially important diagnostic and therapeutic implications. ..
  9. MECHANISM OF BETA AMYLOID NEUROTOXICITY
    Bruce Yankner; Fiscal Year: 2001
    ..The studies outlined in this proposal will characterize a potential model system for the pathogenesis of AD and may lead to the rational design of new therapeutic interventions for AD. ..
  10. REGULATION OF THE APP/NOTCH GAMMA SECRETASE
    Bruce Yankner; Fiscal Year: 2003
    ..These issues are central to understanding the pathogenesis of Alzheimer's disease and may provide new directions for therapeutic intervention. ..