Qin Yang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases
    Qin Yang
    Department of Microbiology and Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405 0068, USA Electronic address
    J Mol Biol 426:43-50. 2014
  2. pmc Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping
    Qin Yang
    Department of Microbiology and Molecular Genetics, University of Vermont, Stafford Hall, Burlington, VT 05405, USA
    Structure 19:368-77. 2011
  3. pmc The structure of human cleavage factor I(m) hints at functions beyond UGUA-specific RNA binding: a role in alternative polyadenylation and a potential link to 5' capping and splicing
    Qin Yang
    Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT, USA
    RNA Biol 8:748-53. 2011
  4. pmc Purification, crystallization and preliminary X-ray diffraction of a disulfide cross-linked complex between bovine poly(A) polymerase and a chemically modified 15-mer oligo(A) RNA
    Qin Yang
    Department of Microbiology and Molecular Genetics, Stafford Hall, University of Vermont, Burlington, Vermont 05405, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:241-4. 2011
  5. pmc Structural biology of poly(A) site definition
    Qin Yang
    Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, USA
    Wiley Interdiscip Rev RNA 2:732-47. 2011
  6. pmc Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing
    Qin Yang
    Department of Microbiology and Molecular Genetics, Stafford Hall, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 107:10062-7. 2010

Detail Information

Publications6

  1. pmc Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases
    Qin Yang
    Department of Microbiology and Molecular Genetics, University of Vermont, Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405 0068, USA Electronic address
    J Mol Biol 426:43-50. 2014
    ..The structure revealed that PAPγ closely resembles its PAPα ortholog. An analysis of residue conservation reveals a conserved catalytic binding pocket, whereas residues at the surface of the polymerase are more divergent. ..
  2. pmc Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping
    Qin Yang
    Department of Microbiology and Molecular Genetics, University of Vermont, Stafford Hall, Burlington, VT 05405, USA
    Structure 19:368-77. 2011
    ..The intrinsic ability of CFI(m) to direct RNA looping may provide a mechanism for its function in the regulation of alternative poly(A) site selection...
  3. pmc The structure of human cleavage factor I(m) hints at functions beyond UGUA-specific RNA binding: a role in alternative polyadenylation and a potential link to 5' capping and splicing
    Qin Yang
    Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, VT, USA
    RNA Biol 8:748-53. 2011
    ....
  4. pmc Purification, crystallization and preliminary X-ray diffraction of a disulfide cross-linked complex between bovine poly(A) polymerase and a chemically modified 15-mer oligo(A) RNA
    Qin Yang
    Department of Microbiology and Molecular Genetics, Stafford Hall, University of Vermont, Burlington, Vermont 05405, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:241-4. 2011
    ..The crystals, which belonged to space group P2 and harbored two protein-RNA complexes per asymmetric unit, diffracted X-rays to 2.25 Å resolution...
  5. pmc Structural biology of poly(A) site definition
    Qin Yang
    Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, USA
    Wiley Interdiscip Rev RNA 2:732-47. 2011
    ..WIREs RNA 2011 2 732-747 DOI: 10.1002/wrna.88 For further resources related to this article, please visit the WIREs website...
  6. pmc Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing
    Qin Yang
    Department of Microbiology and Molecular Genetics, Stafford Hall, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 107:10062-7. 2010
    ..Furthermore, the mutually exclusive binding of RNA and the signaling molecule Ap(4)A (diadenosine tetraphosphate) by CFI(m)25 suggests a potential role for small molecules in the regulation of mRNA 3' processing...