Kenichiro Yamashita

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells
    James McDaid
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 19:458-60. 2005
  2. ncbi request reprint Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts
    Kenichiro Yamashita
    Department of Surgery, Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA 02215, USA
    FASEB J 18:765-7. 2004
  3. ncbi request reprint Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs
    Kenichiro Yamashita
    Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 20:776-8. 2006
  4. ncbi request reprint Donor treatment with carbon monoxide can yield islet allograft survival and tolerance
    Hongjun Wang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, RN 361, Boston, MA 02215, USA
    Diabetes 54:1400-6. 2005
  5. ncbi request reprint Heme oxygenase-1-generated biliverdin ameliorates experimental murine colitis
    Pascal O Berberat
    Immunobiology Research Center, Department of Surgery, Beth Israel Deconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Inflamm Bowel Dis 11:350-9. 2005
  6. ncbi request reprint Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation
    Robert Ollinger
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Circulation 112:1030-9. 2005
  7. ncbi request reprint Biliverdin therapy protects rat livers from ischemia and reperfusion injury
    Constantino Fondevila
    Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7054, USA
    Hepatology 40:1333-41. 2004
  8. ncbi request reprint Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury
    Yorihiro Akamatsu
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 18:771-2. 2004
  9. ncbi request reprint Therapeutic applications of bilirubin and biliverdin in transplantation
    Robert Ollinger
    Department of Surgery, Medical University Innsbruck, Innsbruck, Austria
    Antioxid Redox Signal 9:2175-85. 2007
  10. ncbi request reprint Dimeric but not monomeric soluble CD40 prolongs allograft survival and generates regulatory T cells that inhibit CTL function
    Taro Masunaga
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Transplantation 80:1614-22. 2005

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells
    James McDaid
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 19:458-60. 2005
    ....
  2. ncbi request reprint Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts
    Kenichiro Yamashita
    Department of Surgery, Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA 02215, USA
    FASEB J 18:765-7. 2004
    ..These findings support the potential use of biliverdin, a natural product, in transplantation and other T cell mediated immune disorders...
  3. ncbi request reprint Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs
    Kenichiro Yamashita
    Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 20:776-8. 2006
    ....
  4. ncbi request reprint Donor treatment with carbon monoxide can yield islet allograft survival and tolerance
    Hongjun Wang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, RN 361, Boston, MA 02215, USA
    Diabetes 54:1400-6. 2005
    ..Our present findings show that induction of HO-1 in, or administration of CO to, only the donor, islets, or the recipient or combinations of such treatments improve allogeneic islet survival...
  5. ncbi request reprint Heme oxygenase-1-generated biliverdin ameliorates experimental murine colitis
    Pascal O Berberat
    Immunobiology Research Center, Department of Surgery, Beth Israel Deconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Inflamm Bowel Dis 11:350-9. 2005
    ..We tested whether HO-1 has protective effects in the development of colitis and determined that specific enzymatic products of HO-1 are responsible for these effects...
  6. ncbi request reprint Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation
    Robert Ollinger
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Circulation 112:1030-9. 2005
    ....
  7. ncbi request reprint Biliverdin therapy protects rat livers from ischemia and reperfusion injury
    Constantino Fondevila
    Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7054, USA
    Hepatology 40:1333-41. 2004
    ..Our results provide the rationale for a novel therapeutic approach using BV to maximize the function and thus the availability of donor organs...
  8. ncbi request reprint Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury
    Yorihiro Akamatsu
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 18:771-2. 2004
    ..The observation that exposure of the donor and the graft to CO is sufficient to afford this protective effect should have important clinical implications in terms of preventing IRI associated with heart transplantation in humans...
  9. ncbi request reprint Therapeutic applications of bilirubin and biliverdin in transplantation
    Robert Ollinger
    Department of Surgery, Medical University Innsbruck, Innsbruck, Austria
    Antioxid Redox Signal 9:2175-85. 2007
    ..This review attempts to summarize these protective roles as well as the molecular mechanisms by which biliverdin/bilirubin benefit IRI and solid-organ transplantation, including chronic rejection, and islet transplantation...
  10. ncbi request reprint Dimeric but not monomeric soluble CD40 prolongs allograft survival and generates regulatory T cells that inhibit CTL function
    Taro Masunaga
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Transplantation 80:1614-22. 2005
    ..To address this we have compared the ability of dimeric and monomeric soluble CD40 to prolong allograft survival in vivo and generate regulatory T cells in vitro...
  11. ncbi request reprint Heme oxygenase-1: unleashing the protective properties of heme
    Leo E Otterbein
    Division of Pulmonary and Critical Care Medicine, Montifiore University Hospital, University of Pittsburgh School of Medicine, 3459 5th Avenue, Pittsburgh, PA 15213, USA
    Trends Immunol 24:449-55. 2003
    ..This Review is the third in a series on the regulation of the immune system by metabolic pathways...
  12. ncbi request reprint Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice
    Gabriele Sass
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Hepatology 38:909-18. 2003
    ..In conclusion, HO-1 is a potent protective factor for cytokine- and CD95-mediated apoptotic liver damage. Induction of HO-1 might be of a therapeutic modality for inflammatory liver diseases...
  13. ncbi request reprint Long-term acceptance of rat cardiac allografts on the basis of adenovirus mediated CD40Ig plus CTLA4Ig gene therapies
    Kenichiro Yamashita
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Transplantation 76:1089-96. 2003
    ..In this study, we asked whether these gene-therapy-based costimulation blockade would induce tolerance in cardiac transplantation...
  14. ncbi request reprint Control of allograft rejection by applying a novel nuclear factor-kappaB inhibitor, dehydroxymethylepoxyquinomicin
    Shinya Ueki
    First Department of Surgery, Hokkaido University, Sapporo, Japan
    Transplantation 82:1720-7. 2006
    ..We examined the immunosuppressive effect of a newly developed NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) in allotransplantation...
  15. ncbi request reprint Cooperative effect of biliverdin and carbon monoxide on survival of mice in immune-mediated liver injury
    Gabriele Sass
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    Hepatology 40:1128-35. 2004
    ..g., tumor necrosis factor (TNF) and interferon gamma (IFN-gamma). In conclusion, HO-1-induced prolongation of survival, but not the protection from liver damage, seems to be dependent on down-regulation of cytokine synthesis...
  16. ncbi request reprint Bilirubin and biliverdin treatment of atherosclerotic diseases
    Robert Ollinger
    Department of Surgery, Innsbruck Medical University, Innsbruck, Austria
    Cell Cycle 6:39-43. 2007
    ....
  17. ncbi request reprint Induction of donor-specific tolerance by adenovirus-mediated CD40Ig gene therapy in rat liver transplantation
    Masaru Nomura
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Transplantation 73:1403-10. 2002
    ..Seeking for simple and effective approach to interfere this signaling, we applied adenovirus-mediated gene therapy by encoding CD40Ig gene (AdCD40Ig)...
  18. ncbi request reprint Gene therapy-mediated CD40L and CD28 co-stimulatory signaling blockade plus transient anti-xenograft antibody suppression induces long-term acceptance of cardiac xenografts
    Nan Hua
    First Department of Surgery, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Transplantation 78:1463-70. 2004
    ..In this study, the authors examined whether co-stimulation blockade with a brief course treatment of FK779, a novel leflunomide derivative, would be an ideal strategy for controlling xenograft rejection...
  19. ncbi request reprint A new immunosuppressant, FTY720, in canine kidney transplantation: effect of single-drug, induction and combination treatments
    Tomomi Suzuki
    The First Department of Surgery, Hokkaido University School of Medicine, N 15, W 7, Kita ku, 060 8638 Sapporo, Japan
    Transpl Int 17:574-84. 2004
    ..FTY720 holds promise as a candidate in a new category of drugs that can be combined with conventional agents for induction and maintenance immunosuppression in clinical organ transplantation...
  20. ncbi request reprint Stromal cell-derived factor-1 and CXCR4 interaction is critical for development of transplant arteriosclerosis
    Hideyasu Sakihama
    Division of Molecular Immunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Circulation 110:2924-30. 2004
    ..Recent studies suggest that the smooth muscle cells (SMCs) constituting the neointima are derived from recipient hematopoietic stem cells (HSCs). However, the underlying mechanisms of the process are not yet fully elucidated...
  21. doi request reprint The novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin, prevents local and remote organ injury following intestinal ischemia/reperfusion in rats
    Tomomi Suzuki
    Department of Surgery, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    J Surg Res 149:69-75. 2008
    ..Here, we examined the anti-inflammatory efficacy of a newly developed nuclear factor-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), in the intestinal I/R injury model of rats...