Lei Xu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models
    Lei Xu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 66:3971-7. 2006
  2. ncbi request reprint Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma
    Lei Xu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, 100 Blossom Street, COX 7, Boston, MA 02114, USA
    Mol Cancer Res 5:873-80. 2007
  3. ncbi request reprint Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model
    Lei Xu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 65:5711-9. 2005
  4. ncbi request reprint Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    Frank Winkler
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Cell 6:553-63. 2004
  5. pmc TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma
    Jieqiong Liu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:16618-23. 2012
  6. pmc Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer
    Lei Xu
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 69:7905-10. 2009
  7. ncbi request reprint The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis
    Igor Garkavtsev
    Edwin L Steele Laboratory for Tumour Biology, Department of Radiation Oncology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 428:328-32. 2004
  8. doi request reprint Perivascular nitric oxide gradients normalize tumor vasculature
    Satoshi Kashiwagi
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Med 14:255-7. 2008
  9. ncbi request reprint Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells
    Lei Xu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Cancer Res 10:701-7. 2004
  10. pmc NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels
    Satoshi Kashiwagi
    Edwin L Steele Laboratory, Department of Radiation Oncology, and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Invest 115:1816-27. 2005

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models
    Lei Xu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 66:3971-7. 2006
    ..Our study shows that PlGF overexpression decreases VEGF homodimer formation and inhibits tumor progression...
  2. ncbi request reprint Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma
    Lei Xu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, 100 Blossom Street, COX 7, Boston, MA 02114, USA
    Mol Cancer Res 5:873-80. 2007
    ....
  3. ncbi request reprint Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model
    Lei Xu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 65:5711-9. 2005
    ....
  4. ncbi request reprint Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    Frank Winkler
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Cell 6:553-63. 2004
    ..During the normalization window, but not before or after it, VEGFR2 blockade increases pericyte coverage of brain tumor vessels via upregulation of Ang1 and degrades their pathologically thick basement membrane via MMP activation...
  5. pmc TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma
    Jieqiong Liu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:16618-23. 2012
    ....
  6. pmc Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer
    Lei Xu
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 69:7905-10. 2009
    ..These data show that VEGF blockade up-regulates inflammatory pathways and NRP1, which should be evaluated as potential targets for improving anti-VEGF therapy...
  7. ncbi request reprint The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis
    Igor Garkavtsev
    Edwin L Steele Laboratory for Tumour Biology, Department of Radiation Oncology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 428:328-32. 2004
    ..These results indicate that ING4 has an important role in brain tumour pathogenesis...
  8. doi request reprint Perivascular nitric oxide gradients normalize tumor vasculature
    Satoshi Kashiwagi
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Med 14:255-7. 2008
    ..Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature...
  9. ncbi request reprint Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells
    Lei Xu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Cancer Res 10:701-7. 2004
    ..Here we show the upstream components of these signal transduction pathways that lead to IL-8 expression under hypoxia...
  10. pmc NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels
    Satoshi Kashiwagi
    Edwin L Steele Laboratory, Department of Radiation Oncology, and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Invest 115:1816-27. 2005
    ..These data indicate that endothelial cell-derived NO induces mural cell recruitment as well as subsequent morphogenesis and stabilization of angiogenic vessels...
  11. ncbi request reprint Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts
    Maximilian Bockhorn
    Department of Radiation Oncology, Edwin L Steele Laboratory, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA
    Clin Cancer Res 9:4221-6. 2003
    ....
  12. pmc Normalization of the vasculature for treatment of cancer and other diseases
    Shom Goel
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Physiol Rev 91:1071-121. 2011
    ..Here, we review the pathophysiology of tumor angiogenesis, the molecular underpinnings and functional consequences of vascular normalization, and the implications for treatment of cancer and nonmalignant diseases...
  13. ncbi request reprint Tumour biology: herceptin acts as an anti-angiogenic cocktail
    Yotaro Izumi
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Nature 416:279-80. 2002
    ..As a single agent that acts against multiple targets, herceptin, or drugs like it, may offer a simple alternative to combination anti-angiogenic treatments...
  14. pmc PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer
    Jieqiong Liu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 17:3638-48. 2011
    ..Unlike platelet-derived growth factor-B (PDGF-B), the role of PDGF-D in tumor progression or treatment is largely unknown. To this end, we determined the role of PDGF-D in breast cancer progression, metastasis, and response to chemotherapy...
  15. pmc Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide
    Elizabeth R Gerstner
    Stephen E and Catherine Pappas Center for Neuro Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA
    J Neurooncol 103:325-32. 2011
    ..Vatalanib was well tolerated and this study demonstrates the safety of oral small molecule inhibitors in newly diagnosed GBM patients. Blood biomarkers may be useful as pharmacodynamic markers of response to anti-angiogenic therapies...
  16. pmc Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma
    Matija Snuderl
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 152:1065-76. 2013
    ..This critical tumor-stroma interaction-mediated by Shh, PlGF, and Nrp1 across medulloblastoma subtypes-supports the development of therapies targeting PlGF/Nrp1 pathway...
  17. pmc CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
    Dan G Duda
    Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Cancer Res 17:2074-80. 2011
    ..g., AMD3100, NOX-A12, or CCX2066) as sensitizers to currently available therapies by targeting the CXCL12/CXCR4 and CXCL12/CXCR7 pathways...
  18. ncbi request reprint alphaPlGF: a new kid on the antiangiogenesis block
    Rakesh K Jain
    Steele Lab of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cell 131:443-5. 2007
    ..In this issue, Fischer et al. (2007) offer compelling evidence that a monoclonal antibody against placental growth factor (PlGF), a member of the VEGF family, has such potential in mice...
  19. ncbi request reprint Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis
    Jeroen Hagendoorn
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Res 66:3360-4. 2006
    ..In addition, the lymphatic vessels in hyperplastic/dysplastic lesions were partly compressed and nonfunctional. These novel insights may aid early detection and treatment strategies for cancer...
  20. pmc Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis
    Dai Fukumura
    Edwin L Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circ Res 93:e88-97. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  21. ncbi request reprint Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF
    Lei Xu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 277:11368-74. 2002
    ..These results show that acidic pH activates Ras and the ERK1/2 MAPK pathway to enhance VEGF transcription via AP-1, leading to increased VEGF production...
  22. pmc GPR56 regulates pial basement membrane integrity and cortical lamination
    Shihong Li
    Division of Newborn Medicine, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5817-26. 2008
    ..Furthermore, a putative ligand of GPR56 is localized in the marginal zone or overlying extracellular matrix. These observations provide compelling evidence that GPR56 functions in regulating pial BM integrity during cortical development...
  23. pmc TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models
    Shan Liao
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Cancer Res 17:1415-24. 2011
    ..Whereas, the role of TGF-β in tumor progression has been well studied, the role of TGF-β in lymphatic vessel function is far from understood. Here, we sought to dissect the role of TGF-β blockade in the formation of ascites...
  24. ncbi request reprint c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1
    Lei Xu
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 28:914-22. 2007
    ..Our results demonstrate that c-IAP1 exerts its oncogenic functions by promoting the degradation of an important negative regulator in the Myc pathway...
  25. doi request reprint Epigenetic markers in rectal cancer
    Lei Xu
    Steele Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 16:2699-701. 2010
    ..Importantly, these changes may also function as a predictive marker to allow appropriate exclusion of (neo)adjuvant therapies in patients at low risk for disease recurrence, sparing them from potential treatment-related morbidities...
  26. ncbi request reprint Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray
    Lei Xu
    Department of Gastroenterology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 5:138-42. 2006
    ..In this study we constructed tissue microarray containing specimens from pancreatic cancer, adjacent non-cancer tissue and normal tissue to survey the expression of p53, p16 and cyclooxygenase-2 (COX-2)...
  27. ncbi request reprint The temporal-spatial expression of VEGF, angiopoietins-1 and 2, and Tie-2 during tumor angiogenesis and their functional correlation with tumor neovascular architecture
    Victor Tse
    Department of Neurosurgery, Stanford Medical School, Stanford, CA, USA
    Neurol Res 25:729-38. 2003
    ..The lack of concomitant expression of Ang-1 may underscore the unopposed endovascular induction by Ang-2 and VEGF resulting in the chaotic appearance and fragility of tumor vessels...
  28. ncbi request reprint Specific keynote: molecular determinants of angiogenesis in ovarian cancer
    Isaiah J Fidler
    University of Texas M D Anderson Cancer Center, USA
    Gynecol Oncol 88:S29-36; discussion S37-42. 2003
  29. pmc Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases
    Lei Xu
    Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA, USA
    Mol Cancer Res 6:760-9. 2008
    ..Many genes encoding secreted and membrane proteins are included in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis...
  30. ncbi request reprint Construction of equalized short hairpin RNA library from human brain cDNA
    Lei Xu
    Department of Biochemistry, Basic Medical School, Tongji University, No 1239, Siping Road, Shanghai 200092, China
    J Biotechnol 128:477-85. 2007
    ..After transfecting HEK 293T cells and detecting gene expression, three out of eight clones were demonstrated to significantly inhibit their target genes...
  31. pmc GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis
    Lei Xu
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:9023-8. 2006
    ..We discuss the mechanisms whereby GPR56-TG2 interactions may suppress tumor growth and metastasis...
  32. ncbi request reprint Expression of metastasis-related genes in human epithelial ovarian tumors
    Carlos A Herrera
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 20:5-13. 2002
    ..0005). Multivariate analysis of overall survival showed that the MMP:E-cadherin ratio was a significant independent prognostic factor, even after adjustment for known prognostic factors, such as histology, stage, and age...
  33. ncbi request reprint [Altered expression of PTEN gene and LOH of its epigenetic microsatellite in gastric carcinoma]
    Jin Yi Li
    Armed Police General Hospital, Beijing 100039, China
    Zhonghua Zhong Liu Za Zhi 26:389-92. 2004
    ..To investigate the expression of PTEN and loss of heterozygosity (LOH) of its epigenetic microsatellite in gastric carcinoma and explore their roles in progression of gastric carcinoma...
  34. ncbi request reprint [Shengjing Granule for varicocele in rats]
    Yu Feng Wu
    Department of Urology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China
    Zhonghua Nan Ke Xue 14:658-61. 2008
    ..To study the influence and therapeutic effect of the Chinese herbal drug Shengjing Granule on varicocele in rats...
  35. ncbi request reprint Molecular cloning and characterization of rat karyopherin alpha 1 gene: structure and expression
    Bingwei Wang
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Gene 331:149-57. 2004
    ..Our results suggest involvement of KPNA1 in the striatal responses to denervation following 6-hydroxydopamine (6-OHDA)-induced lesion...
  36. ncbi request reprint Loss of heterozygosity and microsatellite instabilities of fragile histidine triad gene in gastric carcinoma
    Yu Ping Xiao
    Cancer Insititute, No 1 Hospital of China Medical University, Shenyang, Liaoning Province
    World J Gastroenterol 12:3766-9. 2006
    ....
  37. ncbi request reprint Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes
    Sheng Zhang
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06535, USA
    Cell 108:45-56. 2002
    ..We propose that Atrophin proteins function as versatile transcriptional corepressors and discuss a model that deregulation of transcription may contribute to the pathogenesis of neurodegeneration...
  38. ncbi request reprint Induction of angiogenesis in a mouse model using engineered transcription factors
    Edward J Rebar
    Sangamo BioSciences, Richmond, California, USA
    Nat Med 8:1427-32. 2002
    ..These data establish, for the first time, that specifically designed transcription factors can regulate an endogenous gene in vivo and evoke a potentially therapeutic biophysiologic effect...
  39. ncbi request reprint Cystatin C prevents degeneration of rat nigral dopaminergic neurons: in vitro and in vivo studies
    Lei Xu
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghi Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P R China
    Neurobiol Dis 18:152-65. 2005
    ..The findings raise the possibility that cysteine proteinase inhibitors may be new candidates for neuroprotective treatment of Parkinson's disease. Cystatin C may be useful therapeutically in limiting neuropathy in Parkinson's disease...
  40. ncbi request reprint The vascular endothelial growth factor expression and vascular regeneration in infarcted myocardium by skeletal muscle satellite cells
    Jia hong Xia
    Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Chin Med J (Engl) 119:117-21. 2006
    ..We hypothesized that VEGF expression and vascular regeneration increased in infarcted myocardium by skeletal muscle satellite cells, which can promote vascular producing and improve survival environment in infarcted myocardium...
  41. ncbi request reprint Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma
    Brian D Lawenda
    Division of Radiation Oncology, Naval Medical Center, San Diego, CA 92134, USA
    J Soc Integr Oncol 5:11-7. 2007
    ..As supplementation with VE radioprotected normal tissue, additional studies on this putative benefit are recommended...
  42. ncbi request reprint GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment
    Lei Xu
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cell Cycle 6:160-5. 2007
    ..The highly metastatic cells may escape from this inhibition by down-regulation of GPR56. Much future work will be needed to test this hypothesis and further our understanding of metastasis in general...
  43. ncbi request reprint Astrocytic pathology in the immune-mediated motor neuron injury
    Yansu Guo
    Department of Neurology, The Second Hospital of Hebei Medical University, China
    Amyotroph Lateral Scler 8:230-4. 2007
    ..The precise nature and origin of these inclusions deserve to be elucidated...
  44. ncbi request reprint COX-2 expression in gastric cancer and its relationship with angiogenesis using tissue microarray
    Xiao Yun Mao
    Department of Oncology, Sheng Jing Hospital, China Medical University, Shenyang 110022, Liaoning Province, China
    World J Gastroenterol 13:3466-71. 2007
    ....
  45. pmc Large-scale integration of cancer microarray data identifies a robust common cancer signature
    Lei Xu
    The Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Bioinformatics 8:275. 2007
    ..DNA microarrays provide a means for measuring gene expression signatures which can then be used as components of genomic-based diagnostic tests to determine the presence of cancer...
  46. ncbi request reprint [Immunostimulatory effect of human peripheral blood dendritic cells transfected by adeno-associated virus containing Her2/neu gene]
    Lei Xu
    Department of Oncolagy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 25:1181-4. 2005
    ..To observe the immunostimulatory effect of human peripheral blood dendritic cells (DCs) transfected by Her2/neu gene delivered by adeno-associated virus...
  47. ncbi request reprint Relationship between abnormality of FHIT gene and EBV infection in gastric cancer
    Yu Ping Xiao
    Cancer Institute, The First Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
    World J Gastroenterol 11:3212-6. 2005
    ..To examine the aberrant expression of fragile histidine triad (FHIT) gene and protein in gastric cancer, and to evaluate the role of FHIT gene and the relationship between FHIT gene and EBV infection in gastric carcinogenesis...
  48. ncbi request reprint Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cells
    Gaofeng Jiang
    Faculty of Preventive Medicine, Medical College, Wuhan University of Science and Technology, Huangjiahu Campus, Wuhan 430065, Hubei Province, People s Republic of China
    Toxicology 244:49-55. 2008
    ..9, 1.2, and 1.5 micromol/L concentrations. Our study indicated that long-term low-dose cadmium exposure could disrupt DNA methylation, which may be one of the possible underlying carcinogenic mechanisms of cadmium...
  49. ncbi request reprint Effect of glutamate on inflammatory responses of intestine and brain after focal cerebral ischemia
    Lei Xu
    Department of Anesthesiology, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 11:733-6. 2005
    ..To study the modulation of glutamate on post-ischemic intestinal and cerebral inflammatory responses in a ischemic and excitotoxic rat model...
  50. pmc Merging microarray data from separate breast cancer studies provides a robust prognostic test
    Lei Xu
    The Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Bioinformatics 9:125. 2008
    ..Integrating microarray data from multiple studies in order to increase sample size is therefore a promising approach to the development of more robust prognostic tests...