Research Topics
Genomes and Genes
| Lei XuSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse modelsLei Xu
Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer Res 66:3971-7. 2006..Our study shows that PlGF overexpression decreases VEGF homodimer formation and inhibits tumor progression...- Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse modelLei Xu
Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer Res 65:5711-9. 2005.... - Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinomaLei Xu
Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, 100 Blossom Street, COX 7, Boston, MA 02114, USA
Mol Cancer Res 5:873-80. 2007.... - Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinasesFrank Winkler
E.L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
Cancer Cell 6:553-63. 2004..During the normalization window, but not before or after it, VEGFR2 blockade increases pericyte coverage of brain tumor vessels via upregulation of Ang1 and degrades their pathologically thick basement membrane via MMP activation... 
TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stromaJieqiong Liu
Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 109:16618-23. 2012....- Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancerLei Xu
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer Res 69:7905-10. 2009..These data show that VEGF blockade up-regulates inflammatory pathways and NRP1, which should be evaluated as potential targets for improving anti-VEGF therapy... - The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesisIgor Garkavtsev
Edwin L Steele Laboratory for Tumour Biology, Department of Radiation Oncology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 428:328-32. 2004..These results indicate that ING4 has an important role in brain tumour pathogenesis... 
Perivascular nitric oxide gradients normalize tumor vasculatureSatoshi Kashiwagi
Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA
Nat Med 14:255-7. 2008..Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature...- NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vesselsSatoshi Kashiwagi
Edwin L. Steele Laboratory, Department of Radiation Oncology, and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Clin Invest 115:1816-27. 2005..These data indicate that endothelial cell-derived NO induces mural cell recruitment as well as subsequent morphogenesis and stabilization of angiogenic vessels... - Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cellsLei Xu
Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Clin Cancer Res 10:701-7. 2004.... - Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenograftsMaximilian Bockhorn
Department of Radiation Oncology, Edwin L. Steele Laboratory, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA
Clin Cancer Res 9:4221-6. 2003..Anti-VEGF strategy appears promising for pancreatic cancer treatment... - Normalization of the vasculature for treatment of cancer and other diseasesShom Goel
Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Physiol Rev 91:1071-121. 2011..Here, we review the pathophysiology of tumor angiogenesis, the molecular underpinnings and functional consequences of vascular normalization, and the implications for treatment of cancer and nonmalignant diseases... - PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancerJieqiong Liu
Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
Clin Cancer Res 17:3638-48. 2011..Unlike platelet-derived growth factor-B (PDGF-B), the role of PDGF-D in tumor progression or treatment is largely unknown. To this end, we determined the role of PDGF-D in breast cancer progression, metastasis, and response to chemotherapy... - Tumour biology: herceptin acts as an anti-angiogenic cocktailYotaro Izumi
Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Nature 416:279-80. 2002..As a single agent that acts against multiple targets, herceptin, or drugs like it, may offer a simple alternative to combination anti-angiogenic treatments... - Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomideElizabeth R Gerstner
Stephen E and Catherine Pappas Center for Neuro Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA
J Neurooncol 103:325-32. 2011..Vatalanib was well tolerated and this study demonstrates the safety of oral small molecule inhibitors in newly diagnosed GBM patients. Blood biomarkers may be useful as pharmacodynamic markers of response to anti-angiogenic therapies... - CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?Dan G Duda
Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Clin Cancer Res 17:2074-80. 2011..g., AMD3100, NOX-A12, or CCX2066) as sensitizers to currently available therapies by targeting the CXCL12/CXCR4 and CXCL12/CXCR7 pathways... - alphaPlGF: a new kid on the antiangiogenesis blockRakesh K Jain
Steele Lab of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Cell 131:443-5. 2007..In this issue, Fischer et al. (2007) offer compelling evidence that a monoclonal antibody against placental growth factor (PlGF), a member of the VEGF family, has such potential in mice... - Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesisDai Fukumura
Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Circ Res 93:e88-97. 2003..The full text of this article is available online at http://www.circresaha.org... - Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesisJeroen Hagendoorn
Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA
Cancer Res 66:3360-4. 2006..In addition, the lymphatic vessels in hyperplastic/dysplastic lesions were partly compressed and nonfunctional. These novel insights may aid early detection and treatment strategies for cancer... - TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma modelsShan Liao
Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Cancer Res 17:1415-24. 2011..Whereas, the role of TGF-β in tumor progression has been well studied, the role of TGF-β in lymphatic vessel function is far from understood. Here, we sought to dissect the role of TGF-β blockade in the formation of ascites... - Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGFLei Xu
Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 277:11368-74. 2002..These results show that acidic pH activates Ras and the ERK1/2 MAPK pathway to enhance VEGF transcription via AP-1, leading to increased VEGF production... - GPR56 regulates pial basement membrane integrity and cortical laminationShihong Li
Division of Newborn Medicine, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 28:5817-26. 2008..Furthermore, a putative ligand of GPR56 is localized in the marginal zone or overlying extracellular matrix. These observations provide compelling evidence that GPR56 functions in regulating pial BM integrity during cortical development... - Epigenetic markers in rectal cancerLei Xu
Steele Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA
Clin Cancer Res 16:2699-701. 2010..Importantly, these changes may also function as a predictive marker to allow appropriate exclusion of (neo)adjuvant therapies in patients at low risk for disease recurrence, sparing them from potential treatment-related morbidities... - c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1Lei Xu
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 28:914-22. 2007..Our results demonstrate that c-IAP1 exerts its oncogenic functions by promoting the degradation of an important negative regulator in the Myc pathway... - Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarrayLei Xu
Department of Gastroenterology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Hepatobiliary Pancreat Dis Int 5:138-42. 2006..In this study we constructed tissue microarray containing specimens from pancreatic cancer, adjacent non-cancer tissue and normal tissue to survey the expression of p53, p16 and cyclooxygenase-2 (COX-2)... - Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastasesLei Xu
Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA, USA
Mol Cancer Res 6:760-9. 2008..Many genes encoding secreted and membrane proteins are included in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis... - GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasisLei Xu
Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 103:9023-8. 2006..We discuss the mechanisms whereby GPR56-TG2 interactions may suppress tumor growth and metastasis... - The temporal-spatial expression of VEGF, angiopoietins-1 and 2, and Tie-2 during tumor angiogenesis and their functional correlation with tumor neovascular architectureVictor Tse
Department of Neurosurgery, Stanford Medical School, Stanford, CA, USA
Neurol Res 25:729-38. 2003..The lack of concomitant expression of Ang-1 may underscore the unopposed endovascular induction by Ang-2 and VEGF resulting in the chaotic appearance and fragility of tumor vessels... - Specific keynote: molecular determinants of angiogenesis in ovarian cancerIsaiah J Fidler
University of Texas M. D. Anderson Cancer Center, USA
Gynecol Oncol 88:S29-36; discussion S37-42. 2003 - Construction of equalized short hairpin RNA library from human brain cDNALei Xu
Department of Biochemistry, Basic Medical School, Tongji University, No 1239, Siping Road, Shanghai 200092, China
J Biotechnol 128:477-85. 2007..After transfecting HEK 293T cells and detecting gene expression, three out of eight clones were demonstrated to significantly inhibit their target genes... - Expression of metastasis-related genes in human epithelial ovarian tumorsCarlos A Herrera
Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Int J Oncol 20:5-13. 2002..0005). Multivariate analysis of overall survival showed that the MMP:E-cadherin ratio was a significant independent prognostic factor, even after adjustment for known prognostic factors, such as histology, stage, and age... - Induction of angiogenesis in a mouse model using engineered transcription factorsEdward J Rebar
Sangamo BioSciences, Richmond, California, USA
Nat Med 8:1427-32. 2002..These data establish, for the first time, that specifically designed transcription factors can regulate an endogenous gene in vivo and evoke a potentially therapeutic biophysiologic effect... - Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processesSheng Zhang
Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06535, USA
Cell 108:45-56. 2002..We propose that Atrophin proteins function as versatile transcriptional corepressors and discuss a model that deregulation of transcription may contribute to the pathogenesis of neurodegeneration... - Molecular cloning and characterization of rat karyopherin alpha 1 gene: structure and expressionBingwei Wang
Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Gene 331:149-57. 2004..Our results suggest involvement of KPNA1 in the striatal responses to denervation following 6-hydroxydopamine (6-OHDA)-induced lesion... - [Shengjing Granule for varicocele in rats]Yu Feng Wu
Department of Urology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China
Zhonghua Nan Ke Xue 14:658-61. 2008..To study the influence and therapeutic effect of the Chinese herbal drug Shengjing Granule on varicocele in rats... - [Altered expression of PTEN gene and LOH of its epigenetic microsatellite in gastric carcinoma]Jin-Yi Li
Armed Police General Hospital, Beijing 100039, China
Zhonghua Zhong Liu Za Zhi 26:389-92. 2004..It suggests that altered PTEN gene contributes to tumorigenesis and progression of gastric carcinomas... - Merging microarray data from separate breast cancer studies provides a robust prognostic testLei Xu
The Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Bioinformatics 9:125. 2008..Integrating microarray data from multiple studies in order to increase sample size is therefore a promising approach to the development of more robust prognostic tests... - Cystatin C prevents degeneration of rat nigral dopaminergic neurons: in vitro and in vivo studiesLei Xu
Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghi Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P.R. China
Neurobiol Dis 18:152-65. 2005..The findings raise the possibility that cysteine proteinase inhibitors may be new candidates for neuroprotective treatment of Parkinson's disease. Cystatin C may be useful therapeutically in limiting neuropathy in Parkinson's disease... - Loss of heterozygosity and microsatellite instabilities of fragile histidine triad gene in gastric carcinomaYu Ping Xiao
Cancer Insititute, No 1 Hospital of China Medical University, Shenyang, Liaoning Province
World J Gastroenterol 12:3766-9. 2006.... - Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinomaBrian D Lawenda
Division of Radiation Oncology, Naval Medical Center, San Diego, CA 92134, USA
J Soc Integr Oncol 5:11-7. 2007..As supplementation with VE radioprotected normal tissue, additional studies on this putative benefit are recommended... - GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironmentLei Xu
Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Cell Cycle 6:160-5. 2007..The highly metastatic cells may escape from this inhibition by down-regulation of GPR56. Much future work will be needed to test this hypothesis and further our understanding of metastasis in general... - Astrocytic pathology in the immune-mediated motor neuron injuryYansu Guo
Department of Neurology, The Second Hospital of Hebei Medical University, China
Amyotroph Lateral Scler 8:230-4. 2007..The precise nature and origin of these inclusions deserve to be elucidated... - COX-2 expression in gastric cancer and its relationship with angiogenesis using tissue microarrayXiao Yun Mao
Department of Oncology, Sheng Jing Hospital, China Medical University, Shenyang 110022, Liaoning Province, China
World J Gastroenterol 13:3466-71. 2007.... - Large-scale integration of cancer microarray data identifies a robust common cancer signatureLei Xu
The Institute for Computational Medicine and Center for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Bioinformatics 8:275. 2007..DNA microarrays provide a means for measuring gene expression signatures which can then be used as components of genomic-based diagnostic tests to determine the presence of cancer... - Relationship between abnormality of FHIT gene and EBV infection in gastric cancerYu Ping Xiao
Cancer Institute, The First Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
World J Gastroenterol 11:3212-6. 2005..To examine the aberrant expression of fragile histidine triad (FHIT) gene and protein in gastric cancer, and to evaluate the role of FHIT gene and the relationship between FHIT gene and EBV infection in gastric carcinogenesis... - Effect of glutamate on inflammatory responses of intestine and brain after focal cerebral ischemiaLei Xu
Department of Anesthesiology, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
World J Gastroenterol 11:733-6. 2005..To study the modulation of glutamate on post-ischemic intestinal and cerebral inflammatory responses in a ischemic and excitotoxic rat model... - Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cellsGaofeng Jiang
Faculty of Preventive Medicine, Medical College, Wuhan University of Science and Technology, Huangjiahu Campus, Wuhan 430065, Hubei Province, People s Republic of China
Toxicology 244:49-55. 2008..9, 1.2, and 1.5 micromol/L concentrations. Our study indicated that long-term low-dose cadmium exposure could disrupt DNA methylation, which may be one of the possible underlying carcinogenic mechanisms of cadmium... - The vascular endothelial growth factor expression and vascular regeneration in infarcted myocardium by skeletal muscle satellite cellsJia hong Xia
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Chin Med J (Engl) 119:117-21. 2006..We hypothesized that VEGF expression and vascular regeneration increased in infarcted myocardium by skeletal muscle satellite cells, which can promote vascular producing and improve survival environment in infarcted myocardium... - [Immunostimulatory effect of human peripheral blood dendritic cells transfected by adeno-associated virus containing Her2/neu gene]Lei Xu
Department of Oncolagy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Di Yi Jun Yi Da Xue Xue Bao 25:1181-4. 2005..7+/-7.2)%. CONCLUSION: The immunostimulatory effect of human peripheral blood DCs can be enhanced by Her2/neu gene transfection mediated by adeno-associated virus...