Anyong Xie

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Role of mammalian Mre11 in classical and alternative nonhomologous end joining
    Anyong Xie
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Struct Mol Biol 16:814-8. 2009
  2. pmc Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair
    Anyong Xie
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Cell 28:1045-57. 2007
  3. pmc BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids
    Gurushankar Chandramouly
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Nat Commun 4:2404. 2013
  4. pmc Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells
    Emilie Rass
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 288:7086-95. 2013
  5. pmc Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C
    Ganesh Nagaraju
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Cell Biol 26:8075-86. 2006
  6. pmc H2AX post-translational modifications in the ionizing radiation response and homologous recombination
    Anyong Xie
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Cell Cycle 9:3602-10. 2010
  7. pmc Double strand break repair functions of histone H2AX
    Ralph Scully
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, United States Electronic address
    Mutat Res 750:5-14. 2013
  8. ncbi BRCA1 and BRCA2 in breast cancer predisposition and recombination control
    Ralph Scully
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Mammary Gland Biol Neoplasia 9:237-46. 2004
  9. pmc Control of sister chromatid recombination by histone H2AX
    Anyong Xie
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    Mol Cell 16:1017-25. 2004
  10. pmc Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks
    Andrea J Hartlerode
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA
    PLoS ONE 7:e49211. 2012

Collaborators

Detail Information

Publications15

  1. pmc Role of mammalian Mre11 in classical and alternative nonhomologous end joining
    Anyong Xie
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Struct Mol Biol 16:814-8. 2009
    ..The NHEJ function of Mre11 is independent of H2A.X. We propose a model in which both enzymatic and scaffolding functions of Mre11 cooperate to support mammalian NHEJ...
  2. pmc Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair
    Anyong Xie
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Cell 28:1045-57. 2007
    ..These results suggest a specialized adaptation of the "histone code" in which distinct histone tail-protein interactions promote engagement of distinct DSBR pathways...
  3. pmc BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids
    Gurushankar Chandramouly
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Nat Commun 4:2404. 2013
    ..This suggests that BRCA1/CtIP-mediated processing of the second end of the break controls the annealing step that normally terminates SDSA, thereby suppressing the error-prone LTGC outcome. ..
  4. pmc Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells
    Emilie Rass
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 288:7086-95. 2013
    ....
  5. pmc Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C
    Ganesh Nagaraju
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Cell Biol 26:8075-86. 2006
    ..2 kb in length. These results indicate that Rad51C plays a pivotal role in determining the "choice" between short- and long-tract gene conversion and in suppressing gene amplifications associated with sister chromatid recombination...
  6. pmc H2AX post-translational modifications in the ionizing radiation response and homologous recombination
    Anyong Xie
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Cell Cycle 9:3602-10. 2010
    ..The results suggest that the HR and IR-resistance functions of H2AX are controlled in large part by specific MDC1-interacting residues of H2AX, but that additional H2AX residues modulate these core functions of H2AX...
  7. pmc Double strand break repair functions of histone H2AX
    Ralph Scully
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, United States Electronic address
    Mutat Res 750:5-14. 2013
    ..Here, we review progress in research aimed at understanding how γH2AX contributes to double strand break repair in mammalian cells. ..
  8. ncbi BRCA1 and BRCA2 in breast cancer predisposition and recombination control
    Ralph Scully
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Mammary Gland Biol Neoplasia 9:237-46. 2004
    ..Our aim here is to highlight new advances in the study of BRCA1 and BRCA2 , and to place these advances in the context of existing knowledge...
  9. pmc Control of sister chromatid recombination by histone H2AX
    Anyong Xie
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    Mol Cell 16:1017-25. 2004
    ..H2AX phosphorylation may help set up a favorable disposition between sister chromatids...
  10. pmc Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks
    Andrea J Hartlerode
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA
    PLoS ONE 7:e49211. 2012
    ..We found that WHSC1 homozygous mutant MEFs reveal an alteration in balance of H4K20 methylation patterns; however, 53BP1 DSB responses in these cells appear normal...
  11. pmc Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts
    Christine L Nguyen
    Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA, USA
    Mol Cell Biol 32:3963-77. 2012
    ..Together, these observations implicate Nek4 as a novel regulator of replicative senescence and the response to double-stranded DNA damage...
  12. pmc In my end is my beginning: control of end resection and DSBR pathway 'choice' by cyclin-dependent kinases
    Ralph Scully
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    Oncogene 24:2871-6. 2005
    ..Recent evidence in yeast of a role for cyclin-dependent kinases in DNA end resection suggests a possible solution to the long-standing puzzle of how DSBR pathway 'choice' is regulated through the cell cycle...
  13. pmc RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci
    Yiduo Hu
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 25:685-700. 2011
    ..Since chromosomal instability emerges when BRCA1 HR function is either unbridled or absent, active tuning of BRCA1 activity, executed in nuclear foci, is important to genome integrity maintenance...
  14. pmc Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX
    Anyong Xie
    Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Cell 27:178-9. 2007
    ..2007) characterized a gamma-herpesvirus protein, which phosphorylates histone H2AX during infection, suggesting that the virus actively initiates and benefits from the host DNA damage response...
  15. ncbi Molecular functions of BRCA1 in the DNA damage response
    Ralph Scully
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Biol Ther 3:521-7. 2004
    ..In particular, BRCA1 functions in concert with Rad51, BRCA2 and other genes to control double strand break repair (DSBR) and homologous recombination. Here, we reassess the role of BRCA1 and its associated proteins in this process...