Marc Andre Wurbel

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Complex regulation of CCR9 at multiple discrete stages of T cell development
    Marc Andre Wurbel
    Joint Program in Transfusion Medicine, Children s Hospital, Boston, MA 02115, USA
    Eur J Immunol 36:73-81. 2006
  2. pmc CCL25/CCR9 interactions regulate large intestinal inflammation in a murine model of acute colitis
    Marc Andre Wurbel
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e16442. 2011
  3. pmc Impaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propria
    Marc Andre Wurbel
    Department of Dermatology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Immunol 178:7598-606. 2007
  4. pmc A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations
    Espen S Baekkevold
    Children s Hospital, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:1045-51. 2005
  5. pmc iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity
    Everett H Meyer
    Division of Immunology, Karp Laboratories, Children s Hospital, Boston, MA 02115, USA
    J Immunol 179:4661-71. 2007
  6. pmc Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses
    Eva Jasmin Freyschmidt
    Division of Immunology, Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:1295-302. 2010
  7. pmc Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice
    Deanna D Nguyen
    Gastrointestinal Unit and Center for Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 143:719-29.e1-2. 2012
  8. pmc Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin
    Michiko K Oyoshi
    Division of Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 121:2210-20. 2011
  9. pmc Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice
    Teresa Bianchi
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 182:4665-74. 2009
  10. ncbi request reprint CCL25/CCR9 Interactions Are Not Essential for Colitis Development but Are Required for Innate Immune Cell Protection from Chronic Experimental Murine Colitis
    Marc Andre Wurbel
    Divisions of Gastroenterology Nutrition and Immunology, Boston Children s Hospital Department of Pediatrics, Harvard Medical School and Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Inflamm Bowel Dis 20:1165-76. 2014

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Complex regulation of CCR9 at multiple discrete stages of T cell development
    Marc Andre Wurbel
    Joint Program in Transfusion Medicine, Children s Hospital, Boston, MA 02115, USA
    Eur J Immunol 36:73-81. 2006
    ..This suggests that naive CD8 T cells might have access to lymphoid microenvironments from which naive CD4 T cells are excluded...
  2. pmc CCL25/CCR9 interactions regulate large intestinal inflammation in a murine model of acute colitis
    Marc Andre Wurbel
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e16442. 2011
    ..We investigated here whether CCL25/CCR9 interactions also play a role in the regulation of inflammatory responses in the large intestine...
  3. pmc Impaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propria
    Marc Andre Wurbel
    Department of Dermatology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Immunol 178:7598-606. 2007
    ..Thus, although CCL25 is not necessary for generating memory-phenotype CD8 T cells with "gut-homing" properties, this chemokine is indispensable for their trafficking to the small intestine...
  4. pmc A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations
    Espen S Baekkevold
    Children s Hospital, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:1045-51. 2005
    ..We conclude that CCR4 expression provides a competitive advantage to cutaneous Th cells, either by participating in their development from naive Th cells, or by preferentially maintaining them within the memory population over time...
  5. pmc iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity
    Everett H Meyer
    Division of Immunology, Karp Laboratories, Children s Hospital, Boston, MA 02115, USA
    J Immunol 179:4661-71. 2007
    ..These results establish for the first time that the pulmonary localization of iNKT cells critical for the induction of AHR requires CCR4 expression by iNKT cells...
  6. pmc Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses
    Eva Jasmin Freyschmidt
    Division of Immunology, Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:1295-302. 2010
    ..p.) induced immune responses comparable to controls. Our findings implicate allergic skin inflammation resulting from local Treg deficiency in the pathogenesis of EV...
  7. pmc Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice
    Deanna D Nguyen
    Gastrointestinal Unit and Center for Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 143:719-29.e1-2. 2012
    ..We investigated the interactions between innate and adaptive immune cells in mucosal regulation during development of T cell-mediated colitis in mice with WASP-deficient cells of the innate immune system...
  8. pmc Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin
    Michiko K Oyoshi
    Division of Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 121:2210-20. 2011
    ..These results indicate that cutaneous exposure to food antigens can reprogram gut-homing effector T cells in LNs to express skin-homing receptors, eliciting skin lesions upon food allergen contact in orally sensitized AD patients...
  9. pmc Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice
    Teresa Bianchi
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 182:4665-74. 2009
    ..Taken together, controlled skin homing of T cells is critical for the maintenance of peripheral immune tolerance to epidermal self-Ags...
  10. ncbi request reprint CCL25/CCR9 Interactions Are Not Essential for Colitis Development but Are Required for Innate Immune Cell Protection from Chronic Experimental Murine Colitis
    Marc Andre Wurbel
    Divisions of Gastroenterology Nutrition and Immunology, Boston Children s Hospital Department of Pediatrics, Harvard Medical School and Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Inflamm Bowel Dis 20:1165-76. 2014
    ..In this study, we explored whether these interactions also regulate chronic colitis development in 2 independent murine models of experimental colitis...
  11. pmc Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis
    Madeliene E Gainers
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:8509-18. 2007
    ....
  12. pmc Cutting Edge: Chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4 T cells under physiological conditions
    James J Campbell
    Department of Dermatology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Immunol 178:3358-62. 2007
    ..We conclude that under physiological conditions, CCR4 is a nonredundant, necessary component of skin-specific lymphocyte trafficking...