Research Topics
Genomes and Genes | Gerburg M WulfSummaryAffiliation: Harvard University Country: USA Publications
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Publications
The amplifier effect: how Pin1 empowers mutant p53Hai Hu
Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
Breast Cancer Res 13:315. 2011....- Phosphorylation-specific prolyl isomerization: is there an underlying theme?Gerburg Wulf
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 1030, Boston, MA 02115, USA
Nat Cell Biol 7:435-41. 2005..Here, we provide an overview of the plethora of regulatory events that involve this unique enzyme, with a particular focus on oncogenic signalling and neurodegeneration... - Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant miceLaura N Burga
Division of Hematology Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston MA 02215, USA
Breast Cancer Res 13:R30. 2011..Here we examine the role of EGFR in mammary epithelial cells (MECs) in the emergence of BRCA1-related tumors and as a potential target for the prevention of TNBC... - PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cellsAkihide Ryo
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Mol Cell Biol 22:5281-95. 2002..Thus, Pin1 is an E2F target gene that is essential for the Neu/Ras-induced transformation of mammary epithelial cells through activation of cyclin D1... - Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stabilityPrudence B Lam
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, NRB 1030c, Boston, MA 02215, USA
Mol Cancer 7:91. 2008..The goal of this study was to examine the expression of prolyl isomerase Pin1 in human Her2+ breast cancer, and to study if Pin1 affects the expression of Her2/Neu itself... - The prolyl isomerase Pin1 in breast development and cancerGerburg Wulf
Cancer Biology Program, Division of Hematology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Breast Cancer Res 5:76-82. 2003..In addition, Pin1 knockout in mice prevents massive proliferation of breast epithelial cells during pregnancy. Pin1 plays a pivotal role in breast development and may be a promising new anticancer target... - Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesisGerburg Wulf
Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
EMBO J 23:3397-407. 2004..Thus, Pin1 is essential for tumorigenesis and is an attractive anticancer target. Our ex vivo assay can be used to study early events of breast cancer development in genetically predisposed mice... - Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesisFutoshi Suizu
Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Mol Cell Biol 26:1463-79. 2006..These results demonstrate for the first time that the phosphorylation-specific isomerase Pin1 regulates centrosome duplication and its deregulation can induce centrosome amplification, chromosome instability, and oncogenesis... - Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damageGerburg M Wulf
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 277:47976-9. 2002..Moreover, Pin1 null cells displayed significant defects in cell cycle checkpoints induced by DNA damage. These results demonstrate a new role of Pin1 in regulating p53 function during DNA damage... - The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta productionLucia Pastorino
Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Nature 440:528-34. 2006..These findings provide new insight into the pathogenesis and treatment of Alzheimer's disease... - Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancerAkihide Ryo
Cancer Biology Program, Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Cell Sci 116:773-83. 2003..Pin1 is also a critical regulator of the tumor suppressor p53 during DNA damage response. Given its role in cell growth control and oncogenesis, Pin1 could represent a new anti-cancer target... - Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelAAkihide Ryo
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, HIM 1047, Boston, MA 02215, USA
Mol Cell 12:1413-26. 2003..These findings uncover two important mechanisms of regulating NF-kappaB signaling and offer new insight into the pathogenesis and treatment of some human diseases such as cancers... - Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriersLaura N Burga
Department of Surgery, Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 69:1273-8. 2009..These altered growth and differentiation properties may render BRCA1-mutant PMECs vulnerable to transformation and predispose to the development of ER-negative, EGFR-positive breast cancers... - The prolyl isomerase Pin1 is a regulator of p53 in genotoxic responseHongwu Zheng
Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Nature 419:849-53. 2002..Together, these data suggest a mechanism for p53 regulation in cellular response to genotoxic stress... - Targeting carcinogenesis: a role for the prolyl isomerase Pin1?Kun Ping Lu
Department of Medicine, Cancer Biology Program, Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Carcinog 45:397-402. 2006..These results suggest that Pin1-mediated postphosphorylation regulation may provide a unique opportunity for disrupting oncogenic pathways, and thereby represent an appealing target for novel anticancer therapies... - Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interactionShao Yong Chen
Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Mol Cell Biol 26:929-39. 2006.... - Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenanceTae Ho Lee
Cancer Biology Program and Biology of Aging Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, CLS 0408, Boston, MA 02215, USA
Nat Cell Biol 11:97-105. 2009..Thus, Pin1 is an essential regulator of TRF1 stability, telomere maintenance and ageing...
Research Grants
- Role of the Prolylisomerase Pin1 in OncogenesisGerburg Wulf; Fiscal Year: 2006..This project is designed to train the principal investigator for a career as an independent physician scientist. ..