Research Topics
| Ona WuSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imagingO Wu
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
Stroke 32:933-42. 2001..We designed and analyzed statistical algorithms to evaluate the risk of infarction for each voxel of tissue using acute human functional MRI...
Predicting clinical outcome in comatose cardiac arrest patients using early noncontrast computed tomographyOna Wu
Athinoula A Martinos Center for Biomedical Imaging, 149 13th Street, CNY 2301, Charlestown, MA 02129, USA
Stroke 42:985-92. 2011..We hypothesize that quantitative noncontrast computed tomography (NCCT) combined with neurological assessments, are predictive of outcome...- Comatose patients with cardiac arrest: predicting clinical outcome with diffusion-weighted MR imagingOna Wu
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129, USA
Radiology 252:173-81. 2009..To examine whether the severity and spatial distribution of reductions in apparent diffusion coefficient (ADC) are associated with clinical outcomes in patients who become comatose after cardiac arrest... - Multiparametric magnetic resonance imaging of brain disordersOna Wu
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Top Magn Reson Imaging 21:129-38. 2010..We describe here various implementations for combining multiparametric imaging and their merits in the evaluation of brain diseases... - Effects of tracer arrival time on flow estimates in MR perfusion-weighted imagingOna Wu
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology Harvard Medical School, Boston, 02129, USA
Magn Reson Med 50:856-64. 2003..These conditions may occur in practice due to the application of a user-selected AIF that is not the "true AIF" and therefore caution must be taken in interpreting CBF and MTT estimates... - Imaging stroke patients with unclear onset timesOna Wu
Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH, 149 Thirteenth Street Suite 2301, Charlestown, MA 02129, USA
Neuroimaging Clin N Am 21:327-44, xi. 2011..This article reviews and compares some of these imaging-based approaches to thrombolysis eligibility, which can potentially expand the use of thrombolytic therapy to a broader population of acute stroke patients... - Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrixOna Wu
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Boston, Massachusetts 02129, USA
Magn Reson Med 50:164-74. 2003..Shift maps can continue to provide a sensitive reflection of disturbed hemodynamics... 
Severity of leukoaraiosis and susceptibility to infarct growth in acute strokeHakan Ay
A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Stroke 39:1409-13. 2008..We hypothesized that the volume of LA correlated with the proportion of initially ischemic but eventually infarcted tissue in acute human stroke...- Acute stroke imaging research roadmapMax Wintermark
Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
AJNR Am J Neuroradiol 29:e23-30. 2008..The present article summarizes these recommendations and examines practical steps to achieve them... - Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic strokeOna Wu
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Cereb Blood Flow Metab 32:1800-9. 2012..In addition, CBV responses to NBO challenge may have potential as an imaging marker to distinguish ischemic core from salvageable tissues... - Existence of the diffusion-perfusion mismatch within 24 hours after onset of acute stroke: dependence on proximal arterial occlusionWilliam A Copen
Department of Radiology, Massachusetts General Hospital, GRB 273A, 55 Fruit St, Boston, MA 02114, USA
Radiology 250:878-86. 2009.... - Interexaminer difference in infarct volume measurements on MRI: a source of variance in stroke researchHakan Ay
Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown MA 02129, USA
Stroke 39:1171-6. 2008..We sought to quantify the variance imposed by measurement error in DWI and PWI lesion volume measurements in ischemic stroke... - Transient ischemic attack with infarction: a unique syndrome?Hakan Ay
Department of A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Radiology, Boston, MA 02129, USA
Ann Neurol 57:679-86. 2005..3% in those with ischemic stroke. TIA with infarction appears to have unique features separate from TIA without infarction and ischemic stroke. We propose identifying TSI as a separate clinical syndrome with distinct prognostic features... - Early time points perfusion imaging: relative time of arrival, maximum derivatives and fractional derivativesKenneth K Kwong
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 57:979-90. 2011..5 to 2, estimated rCBF results were found to demonstrate a gray-white matter ratio of approximately 3, a number consistent with flow ratio reported in the literature... - Perfusion magnetic resonance imaging of acute ischemic strokePamela W Schaefer
Neuroradiology Division, Stroke Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Semin Roentgenol 37:230-6. 2002 - Age-dependent susceptibility to infarct growth in womenFigen Gokcay
AA Martinos Center for Biomedical Imaging and Stroke Service, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Stroke 42:947-51. 2011..We sought to identify whether the proportion of initially ischemic to eventually infarcted tissue was different between men and women with ischemic stroke... - Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic strokeNorio Fujiwara
Neuroprotection Research Laboratory, Departments of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
BMC Neurosci 10:79. 2009..NBO was maintained for 3 hours. Infarct volume, brain swelling and hemorrhagic transformation were quantified at 24 hours. Outcome assessments were blinded to therapy... - Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging studyRick M Dijkhuizen
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosci 23:510-7. 2003.... - Reliability of cerebral blood volume maps as a substitute for diffusion-weighted imaging in acute ischemic strokeAmy R Deipolyi
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Magn Reson Imaging 36:1083-7. 2012..Some propose using perfusion imaging, specifically CBV maps, in place of DWI. We examined whether CBV maps can reliably subsitute for DWI, and assessed the effect of scan duration on calculated CBV... - Lower hemoglobin correlates with larger stroke volumes in acute ischemic strokeW Taylor Kimberly
Department of Neurology, Massachusetts General Hospital, Boston, Mass, USA
Cerebrovasc Dis Extra 1:44-53. 2011..Hemoglobin tetramers are the major oxygen-carrying molecules within the blood. We hypothesized that a lower hemoglobin level and its reduced oxygen-carrying capacity would associate with larger infarction in acute ischemic stroke patients... - Evaluating effects of normobaric oxygen therapy in acute stroke with MRI-based predictive modelsOna Wu
Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston MA 02114, USA
Med Gas Res 2:5. 2012..abstract:.. - MR perfusion imaging in acute ischemic strokeWilliam A Copen
Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, GRB 273A, 55 Fruit Street, Boston, MA 02114, USA
Neuroimaging Clin N Am 21:259-83, x. 2011..This review discusses the basic pathophysiology of acute stroke, the utility of different kinds of perfusion images, and research on the continually evolving role of MR perfusion imaging in acute stroke care... - Technical aspects of perfusion-weighted imagingOna Wu
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimaging Clin N Am 15:623-37, xi. 2005..Understanding the technical aspects of PWI may improve comprehension of the capabilities and limitations of this technique... - Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injuryThierry A G M Huisman
MGH-NMR Center, Division of Neuroradiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
AJNR Am J Neuroradiol 25:370-6. 2004..CONCLUSION: DTI reveals changes in the white matter that are correlated with both acute GCS and Rankin scores at discharge. DTI may be a valuable biomarker for the severity of tissue injury and a predictor for outcome... - Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathyKei Yamada
Massachusetts General Hospital NMR Center, Harvard Medical School, Boston, USA
Stroke 33:87-94. 2002..Steno-occlusive disease in the parent vessels is another factor that may affect the results of the PWI. The purpose of this study was to elucidate the effect of the calculation methods and underlying vasculopathy on PWI... - Acute stroke imaging research roadmapMax Wintermark
University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
Stroke 39:1621-8. 2008..The present article summarizes these recommendations and examines practical steps to achieve them... - Early time points perfusion imagingKenneth K Kwong
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 54:1070-82. 2011..A recipe to run ET was presented, with attention paid to the noise problem around the time of arrival (TOA) of the contrast agent... - Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disordersBrian L Edlow
Department of Neurology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
J Neuropathol Exp Neurol 71:531-46. 2012.... - Diffusion magnetic resonance imaging of acute ischemic strokePamela W Schaefer
Neuroradiology Division, Stroke Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Semin Roentgenol 37:219-29. 2002 - Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke modelRick M Dijkhuizen
Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass, USA
Stroke 33:2100-4. 2002..Our aim was to characterize acute effects of rtPA administration on the integrity of microvascular barriers... - Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI studyNikos Makris
Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
Neurobiol Aging 28:1556-67. 2007..To our knowledge this is the first investigation reporting such alterations in the aging monkey... - Advanced neuroimaging in traumatic brain injuryBrian L Edlow
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
Semin Neurol 32:374-400. 2012..Finally, given the vast amounts of advanced imaging data that will soon be available to clinicians, we discuss strategies for optimizing data integration, visualization, and interpretation... - Inferring origin of vascular supply from tracer arrival timing patterns using bolus tracking MRISøren Christensen
Center for Functionally Integrative Neuroscience, Arhus University Hospital, Arhus, Denmark
J Magn Reson Imaging 27:1371-81. 2008..Collateral blood supply is believed to be of paramount importance in acute stroke, yet clinical evaluation is challenging as the gold standard digital subtraction angiography is often not feasible in the acute scenario... - Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke modelsOna Wu
Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
J Cereb Blood Flow Metab 27:196-204. 2007..Our study shows that predictive algorithms are promising metrics for diagnosis, prognosis and therapeutic evaluation after acute stroke that can translate readily from preclinical to clinical settings... - Manganese-enhanced MRI of brain plasticity in relation to functional recovery after experimental strokeJet P van der Zijden
Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
J Cereb Blood Flow Metab 28:832-40. 2008..Our data suggest that the plateau stage of functional recovery is associated with restoration of ipsilateral sensorimotor pathways and enhanced interhemispheric connectivity... - Applying instance-based techniques to prediction of final outcome in acute strokeChristian Gottrup
DIMAC A S, Højbjerg, Denmark
Artif Intell Med 33:223-36. 2005..This requires an accurate prediction of the extent of infarction if untreated. In this study, we investigate the applicability of highly flexible instance-based (IB) methods for such predictions... - Changes in neuronal connectivity after stroke in rats as studied by serial manganese-enhanced MRIJet P van der Zijden
Image Sciences Institute, University Medical Center Utrecht, Bolognalaan 50, 3584 CJ, Utrecht, The Netherlands
Neuroimage 34:1650-7. 2007..This study demonstrates that MEMRI enables in vivo assessment of spatiotemporal alterations in neuronal connectivity after stroke, which may lead to improved insights in mechanisms underlying functional loss and recovery after stroke... - Ischemic injury detected by diffusion imaging 11 minutes after strokeNiels Hjort
Department of Neuroradiology, Center for Functionally Integrative Neuroscience, Arhus University Hospital, Arhus, Denmark
Ann Neurol 58:462-5. 2005..The data show early, abrupt diffusion changes in hypoperfused tissue, adding to our understanding of the progression of microstructural abnormalities in the hyperacute phase of stroke... - Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRIOna Wu
Center for Functionally Integrative Neuroscience, Department of Neuroradiology, Arhus University Hospital, Arhus C, Denmark
Brain 129:2384-93. 2006..MRI-based algorithms may therefore provide a more sensitive means for monitoring therapeutic effects on a voxel-wise basis... - MRI detection of early blood-brain barrier disruption: parenchymal enhancement predicts focal hemorrhagic transformation after thrombolysisNiels Hjort
Stroke 39:1025-8. 2008..CONCLUSIONS: PE detected 2 hours after thrombolytic therapy predicts HT with high specificity. Contrast-enhanced MRI may provide a tool for studying HT and targeting future therapies to reduce risk of hemorrhagic complications... - Evolution of water diffusion and anisotropy in hyperacute stroke: significant correlation between fractional anisotropy and T2Yelda Ozsunar
Department of Radiology, School of Medicine, Adnan Menderes University, Aydin, Turkey
AJNR Am J Neuroradiol 25:699-705. 2004..CONCLUSION: Change in FA is inversely correlated with T2 signal intensity and, to a lesser extent, the time of onset, but it is not well correlated with ADC values in the acute stage... - Model of the human vasculature for studying the influence of contrast injection speed on cerebral perfusion MRIMatthias J P van Osch
Department of Radiology, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Magn Reson Med 50:614-22. 2003..Additionally, it was determined that decreasing the temporal resolution of the acquisition results in an underestimation of the CBF values, and an increase of the standard deviation (SD) of CBF measurements... - In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the ratPieter van Eijsden
Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Brain Res 1030:11-8. 2004..These pathological phenomena are the first to contribute to the pathophysiology of spontaneous recurrent seizures in a later stage in this animal model...
Research Grants
- Quantitative MRI-based metrics for multi-center stroke treatment assessmentOna Wu; Fiscal Year: 2009..This quantitative assessment of patient's infarction risk can be used for the objective evaluation of efficacy of novel therapies, thereby speeding the development of much-needed new stroke therapies. ..
- Quantitative MRI-based metrics for multi-center stroke treatment assessmentOna Wu; Fiscal Year: 2010..This quantitative assessment of patient's infarction risk can be used for the objective evaluation of efficacy of novel therapies, thereby speeding the development of much-needed new stroke therapies. ..