Ona Wu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging
    O Wu
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Stroke 32:933-42. 2001
  2. pmc Comatose patients with cardiac arrest: predicting clinical outcome with diffusion-weighted MR imaging
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129, USA
    Radiology 252:173-81. 2009
  3. pmc Predicting clinical outcome in comatose cardiac arrest patients using early noncontrast computed tomography
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, 149 13th Street, CNY 2301, Charlestown, MA 02129, USA
    Stroke 42:985-92. 2011
  4. ncbi request reprint Effects of tracer arrival time on flow estimates in MR perfusion-weighted imaging
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology Harvard Medical School, Boston, 02129, USA
    Magn Reson Med 50:856-64. 2003
  5. pmc Multiparametric magnetic resonance imaging of brain disorders
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Top Magn Reson Imaging 21:129-38. 2010
  6. ncbi request reprint Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Boston, Massachusetts 02129, USA
    Magn Reson Med 50:164-74. 2003
  7. pmc Imaging stroke patients with unclear onset times
    Ona Wu
    Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH, 149 Thirteenth Street Suite 2301, Charlestown, MA 02129, USA
    Neuroimaging Clin N Am 21:327-44, xi. 2011
  8. doi request reprint Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke
    Hakan Ay
    A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 39:1409-13. 2008
  9. pmc Acute stroke imaging research roadmap
    Max Wintermark
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    AJNR Am J Neuroradiol 29:e23-30. 2008
  10. pmc Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 32:1800-9. 2012

Detail Information

Publications45

  1. ncbi request reprint Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging
    O Wu
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Stroke 32:933-42. 2001
    ..We designed and analyzed statistical algorithms to evaluate the risk of infarction for each voxel of tissue using acute human functional MRI...
  2. pmc Comatose patients with cardiac arrest: predicting clinical outcome with diffusion-weighted MR imaging
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129, USA
    Radiology 252:173-81. 2009
    ..To examine whether the severity and spatial distribution of reductions in apparent diffusion coefficient (ADC) are associated with clinical outcomes in patients who become comatose after cardiac arrest...
  3. pmc Predicting clinical outcome in comatose cardiac arrest patients using early noncontrast computed tomography
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, 149 13th Street, CNY 2301, Charlestown, MA 02129, USA
    Stroke 42:985-92. 2011
    ..We hypothesize that quantitative noncontrast computed tomography (NCCT) combined with neurological assessments, are predictive of outcome...
  4. ncbi request reprint Effects of tracer arrival time on flow estimates in MR perfusion-weighted imaging
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology Harvard Medical School, Boston, 02129, USA
    Magn Reson Med 50:856-64. 2003
    ..These conditions may occur in practice due to the application of a user-selected AIF that is not the "true AIF" and therefore caution must be taken in interpreting CBF and MTT estimates...
  5. pmc Multiparametric magnetic resonance imaging of brain disorders
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Top Magn Reson Imaging 21:129-38. 2010
    ..We describe here various implementations for combining multiparametric imaging and their merits in the evaluation of brain diseases...
  6. ncbi request reprint Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Boston, Massachusetts 02129, USA
    Magn Reson Med 50:164-74. 2003
    ..Shift maps can continue to provide a sensitive reflection of disturbed hemodynamics...
  7. pmc Imaging stroke patients with unclear onset times
    Ona Wu
    Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH, 149 Thirteenth Street Suite 2301, Charlestown, MA 02129, USA
    Neuroimaging Clin N Am 21:327-44, xi. 2011
    ..This article reviews and compares some of these imaging-based approaches to thrombolysis eligibility, which can potentially expand the use of thrombolytic therapy to a broader population of acute stroke patients...
  8. doi request reprint Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke
    Hakan Ay
    A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 39:1409-13. 2008
    ..We hypothesized that the volume of LA correlated with the proportion of initially ischemic but eventually infarcted tissue in acute human stroke...
  9. pmc Acute stroke imaging research roadmap
    Max Wintermark
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    AJNR Am J Neuroradiol 29:e23-30. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...
  10. pmc Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 32:1800-9. 2012
    ..In addition, CBV responses to NBO challenge may have potential as an imaging marker to distinguish ischemic core from salvageable tissues...
  11. pmc Disconnection of the ascending arousal system in traumatic coma
    Brian L Edlow
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    J Neuropathol Exp Neurol 72:505-23. 2013
    ..We propose that traumatic coma may be a subcortical disconnection syndrome related to the disconnection of specific brainstem arousal nuclei from the thalamus and basal forebrain...
  12. doi request reprint Existence of the diffusion-perfusion mismatch within 24 hours after onset of acute stroke: dependence on proximal arterial occlusion
    William A Copen
    Department of Radiology, Massachusetts General Hospital, GRB 273A, 55 Fruit St, Boston, MA 02114, USA
    Radiology 250:878-86. 2009
    ....
  13. ncbi request reprint Transient ischemic attack with infarction: a unique syndrome?
    Hakan Ay
    Department of A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Radiology, Boston, MA 02129, USA
    Ann Neurol 57:679-86. 2005
    ..3% in those with ischemic stroke. TIA with infarction appears to have unique features separate from TIA without infarction and ischemic stroke. We propose identifying TSI as a separate clinical syndrome with distinct prognostic features...
  14. pmc Early time points perfusion imaging: relative time of arrival, maximum derivatives and fractional derivatives
    Kenneth K Kwong
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 57:979-90. 2011
    ..5 to 2, estimated rCBF results were found to demonstrate a gray-white matter ratio of approximately 3, a number consistent with flow ratio reported in the literature...
  15. doi request reprint Interexaminer difference in infarct volume measurements on MRI: a source of variance in stroke research
    Hakan Ay
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown MA 02129, USA
    Stroke 39:1171-6. 2008
    ..We sought to quantify the variance imposed by measurement error in DWI and PWI lesion volume measurements in ischemic stroke...
  16. ncbi request reprint Perfusion magnetic resonance imaging of acute ischemic stroke
    Pamela W Schaefer
    Neuroradiology Division, Stroke Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Semin Roentgenol 37:230-6. 2002
  17. pmc Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke
    Norio Fujiwara
    Neuroprotection Research Laboratory, Departments of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    BMC Neurosci 10:79. 2009
    ..NBO was maintained for 3 hours. Infarct volume, brain swelling and hemorrhagic transformation were quantified at 24 hours. Outcome assessments were blinded to therapy...
  18. pmc Age-dependent susceptibility to infarct growth in women
    Figen Gokcay
    AA Martinos Center for Biomedical Imaging and Stroke Service, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 42:947-51. 2011
    ..We sought to identify whether the proportion of initially ischemic to eventually infarcted tissue was different between men and women with ischemic stroke...
  19. ncbi request reprint Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study
    Rick M Dijkhuizen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 23:510-7. 2003
    ....
  20. doi request reprint Reliability of cerebral blood volume maps as a substitute for diffusion-weighted imaging in acute ischemic stroke
    Amy R Deipolyi
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Magn Reson Imaging 36:1083-7. 2012
    ..Some propose using perfusion imaging, specifically CBV maps, in place of DWI. We examined whether CBV maps can reliably subsitute for DWI, and assessed the effect of scan duration on calculated CBV...
  21. pmc Lower hemoglobin correlates with larger stroke volumes in acute ischemic stroke
    W Taylor Kimberly
    Department of Neurology, Massachusetts General Hospital, Boston, Mass, USA
    Cerebrovasc Dis Extra 1:44-53. 2011
    ..Hemoglobin tetramers are the major oxygen-carrying molecules within the blood. We hypothesized that a lower hemoglobin level and its reduced oxygen-carrying capacity would associate with larger infarction in acute ischemic stroke patients...
  22. pmc Evaluating effects of normobaric oxygen therapy in acute stroke with MRI-based predictive models
    Ona Wu
    Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston MA 02114, USA
    Med Gas Res 2:5. 2012
    ..abstract:..
  23. pmc MR perfusion imaging in acute ischemic stroke
    William A Copen
    Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, GRB 273A, 55 Fruit Street, Boston, MA 02114, USA
    Neuroimaging Clin N Am 21:259-83, x. 2011
    ..This review discusses the basic pathophysiology of acute stroke, the utility of different kinds of perfusion images, and research on the continually evolving role of MR perfusion imaging in acute stroke care...
  24. ncbi request reprint Technical aspects of perfusion-weighted imaging
    Ona Wu
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimaging Clin N Am 15:623-37, xi. 2005
    ..Understanding the technical aspects of PWI may improve comprehension of the capabilities and limitations of this technique...
  25. pmc Early time points perfusion imaging
    Kenneth K Kwong
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 54:1070-82. 2011
    ..A recipe to run ET was presented, with attention paid to the noise problem around the time of arrival (TOA) of the contrast agent...
  26. doi request reprint Acute stroke imaging research roadmap
    Max Wintermark
    University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
    Stroke 39:1621-8. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...
  27. ncbi request reprint Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy
    Kei Yamada
    Massachusetts General Hospital NMR Center, Harvard Medical School, Boston, USA
    Stroke 33:87-94. 2002
    ..Steno-occlusive disease in the parent vessels is another factor that may affect the results of the PWI. The purpose of this study was to elucidate the effect of the calculation methods and underlying vasculopathy on PWI...
  28. ncbi request reprint Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury
    Thierry A G M Huisman
    MGH NMR Center, Division of Neuroradiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    AJNR Am J Neuroradiol 25:370-6. 2004
    ..Our objective was to determine if changes in anisotropic diffusion in TBI correlate with acute Glasgow coma scale (GCS) and/or Rankin scores at discharge...
  29. pmc Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders
    Brian L Edlow
    Department of Neurology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Neuropathol Exp Neurol 71:531-46. 2012
    ....
  30. ncbi request reprint Diffusion magnetic resonance imaging of acute ischemic stroke
    Pamela W Schaefer
    Neuroradiology Division, Stroke Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Semin Roentgenol 37:219-29. 2002
  31. ncbi request reprint Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model
    Rick M Dijkhuizen
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass, USA
    Stroke 33:2100-4. 2002
    ..Our aim was to characterize acute effects of rtPA administration on the integrity of microvascular barriers...
  32. ncbi request reprint Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
    Neurobiol Aging 28:1556-67. 2007
    ..To our knowledge this is the first investigation reporting such alterations in the aging monkey...
  33. doi request reprint Functional MRI and outcome in traumatic coma
    Brian L Edlow
    Department of Neurology, Massachusetts General Hospital, 55 Fruit Street Lunder 650, Boston, MA, 02114, USA
    Curr Neurol Neurosci Rep 13:375. 2013
    ..We also discuss future strategies for overcoming the current barriers to clinical implementation. ..
  34. pmc Advanced neuroimaging in traumatic brain injury
    Brian L Edlow
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Semin Neurol 32:374-400. 2012
    ..Finally, given the vast amounts of advanced imaging data that will soon be available to clinicians, we discuss strategies for optimizing data integration, visualization, and interpretation...
  35. ncbi request reprint Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI
    Ona Wu
    Center for Functionally Integrative Neuroscience, Department of Neuroradiology, Arhus University Hospital, Arhus C, Denmark
    Brain 129:2384-93. 2006
    ..MRI-based algorithms may therefore provide a more sensitive means for monitoring therapeutic effects on a voxel-wise basis...
  36. ncbi request reprint Changes in neuronal connectivity after stroke in rats as studied by serial manganese-enhanced MRI
    Jet P van der Zijden
    Image Sciences Institute, University Medical Center Utrecht, Bolognalaan 50, 3584 CJ, Utrecht, The Netherlands
    Neuroimage 34:1650-7. 2007
    ..This study demonstrates that MEMRI enables in vivo assessment of spatiotemporal alterations in neuronal connectivity after stroke, which may lead to improved insights in mechanisms underlying functional loss and recovery after stroke...
  37. ncbi request reprint Manganese-enhanced MRI of brain plasticity in relation to functional recovery after experimental stroke
    Jet P van der Zijden
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 28:832-40. 2008
    ..Our data suggest that the plateau stage of functional recovery is associated with restoration of ipsilateral sensorimotor pathways and enhanced interhemispheric connectivity...
  38. ncbi request reprint Applying instance-based techniques to prediction of final outcome in acute stroke
    Christian Gottrup
    DIMAC A S, Højbjerg, Denmark
    Artif Intell Med 33:223-36. 2005
    ..This requires an accurate prediction of the extent of infarction if untreated. In this study, we investigate the applicability of highly flexible instance-based (IB) methods for such predictions...
  39. ncbi request reprint Ischemic injury detected by diffusion imaging 11 minutes after stroke
    Niels Hjort
    Department of Neuroradiology, Center for Functionally Integrative Neuroscience, Arhus University Hospital, Arhus, Denmark
    Ann Neurol 58:462-5. 2005
    ..The data show early, abrupt diffusion changes in hypoperfused tissue, adding to our understanding of the progression of microstructural abnormalities in the hyperacute phase of stroke...
  40. doi request reprint Inferring origin of vascular supply from tracer arrival timing patterns using bolus tracking MRI
    Søren Christensen
    Center for Functionally Integrative Neuroscience, Arhus University Hospital, Arhus, Denmark
    J Magn Reson Imaging 27:1371-81. 2008
    ..Collateral blood supply is believed to be of paramount importance in acute stroke, yet clinical evaluation is challenging as the gold standard digital subtraction angiography is often not feasible in the acute scenario...
  41. ncbi request reprint Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models
    Ona Wu
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 27:196-204. 2007
    ..Our study shows that predictive algorithms are promising metrics for diagnosis, prognosis and therapeutic evaluation after acute stroke that can translate readily from preclinical to clinical settings...
  42. doi request reprint MRI detection of early blood-brain barrier disruption: parenchymal enhancement predicts focal hemorrhagic transformation after thrombolysis
    Niels Hjort
    Stroke 39:1025-8. 2008
    ..Blood-brain barrier disruption may be a predictor of hemorrhagic transformation (HT) in ischemic stroke. We hypothesize that parenchymal enhancement (PE) on postcontrast T1-weighted MRI predicts and localizes subsequent HT...
  43. ncbi request reprint Model of the human vasculature for studying the influence of contrast injection speed on cerebral perfusion MRI
    Matthias J P van Osch
    Department of Radiology, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Magn Reson Med 50:614-22. 2003
    ..Additionally, it was determined that decreasing the temporal resolution of the acquisition results in an underestimation of the CBF values, and an increase of the standard deviation (SD) of CBF measurements...
  44. ncbi request reprint In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat
    Pieter van Eijsden
    Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain Res 1030:11-8. 2004
    ..These pathological phenomena are the first to contribute to the pathophysiology of spontaneous recurrent seizures in a later stage in this animal model...
  45. ncbi request reprint Evolution of water diffusion and anisotropy in hyperacute stroke: significant correlation between fractional anisotropy and T2
    Yelda Ozsunar
    Department of Radiology, School of Medicine, Adnan Menderes University, Aydin, Turkey
    AJNR Am J Neuroradiol 25:699-705. 2004
    ..Our purpose was to correlate fractional anisotropy (FA) measurements with the clinical time of stroke onset, apparent diffusion coefficients (ADC), and T2 signal intensity...

Research Grants3

  1. Quantitative MRI-based metrics for multi-center stroke treatment assessment
    Ona Wu; Fiscal Year: 2009
    ..This quantitative assessment of patient's infarction risk can be used for the objective evaluation of efficacy of novel therapies, thereby speeding the development of much-needed new stroke therapies. ..
  2. Quantitative MRI-based metrics for multi-center stroke treatment assessment
    Ona Wu; Fiscal Year: 2010
    ..This quantitative assessment of patient's infarction risk can be used for the objective evaluation of efficacy of novel therapies, thereby speeding the development of much-needed new stroke therapies. ..