Genomes and Genes
Affiliation: Harvard University
- Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activationLizi Wu
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
EMBO J 24:2391-402. 2005..This study has identified a novel, critical mechanism of transformation for an oncogene associated very specifically with salivary gland tumors, and identified potential targets for the development of novel therapies...
- Cloning and functional characterization of the murine mastermind-like 1 (Maml1) geneLizi Wu
Department of Medical Oncology, Mayer 540, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Gene 328:153-65. 2004..There seems to be close correlation of the spatial and temporal expression among Maml1, Notch1 and Hes1 in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis...
- Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptorsLizi Wu
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Mol Cell Biol 22:7688-700. 2002..Thus, MAML proteins may modify Notch signaling in different cell types based on their own expression levels and differential activities and thereby contribute to the diversity of the biological effects resulting from Notch activation...
- The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesisHuangxuan Shen
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 20:675-88. 2006..Mechanistically, MAML1 appears to mediate cross-talk between Notch and MEF2 to influence myogenic differentiation...
- The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell developmentLizi Wu
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Blood 110:3618-23. 2007..Moreover, the number of MZB cells correlated with Maml1 gene dosage. Since all 3 Maml genes were expressed in MZB cells and their precursors, these results suggest that Maml1 is specifically required for Notch2 signaling in MZB cells...
- Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complexTao Sun
Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 23:9547-56. 2003..2 that helps to establish the pMN-p3 boundary in the developing spinal cord...
- Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesisLizi Wu
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Semin Cancer Biol 14:348-56. 2004..The mounting biochemical and functional evidence indicate that the MAML genes are critical components of the Notch signaling pathway, likely regulating cellular events involved in both normal development and oncogenesis...
- Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheresJie Chen
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
Genes Cancer 1:822-35. 2010..Our overall data indicate that Notch signaling contributes significantly to optimal GBM growth, strongly supporting that the Notch pathway is a promising therapeutic target for GBM...
- t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathwayGiovanni Tonon
Genetics Branch, Center for Cancer Research, National Cancer Institute and the National Naval Medical Center, Bethesda, Maryland 20889, USA
Nat Genet 33:208-13. 2003..These data suggest a new mechanism to disrupt the function of a Notch co-activator in a common type of malignant salivary gland tumor...
- The notch regulator MAML1 interacts with p53 and functions as a coactivatorYongtong Zhao
Division of Cancer Biology, Department of Medicine, ENH Research Institute, Feinberg School of Medicine, Northwestern University, Evanston, Illinois 60201, USA
J Biol Chem 282:11969-81. 2007..elegans p53 homolog Cep-1. Thus, we present evidence for a novel coactivator function of MAML1 for p53, independent of its function as a coactivator of Notch signaling pathway...