Kana Wu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Interactions between plasma levels of 25-hydroxyvitamin D, insulin-like growth factor (IGF)-1 and C-peptide with risk of colorectal cancer
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS ONE 6:e28520. 2011
  2. ncbi request reprint Meat mutagens and risk of distal colon adenoma in a cohort of U.S. men
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Building 2, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:1120-5. 2006
  3. ncbi request reprint Dietary patterns and risk of colon cancer and adenoma in a cohort of men (United States)
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Boston, MA 02115, USA
    Cancer Causes Control 15:853-62. 2004
  4. ncbi request reprint A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg 2, Boston, MA 02115, USA
    J Natl Cancer Inst 99:1120-9. 2007
  5. ncbi request reprint Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control study
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:260-9. 2004
  6. pmc Meat mutagens and breast cancer in postmenopausal women--a cohort analysis
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, and Department of Medicine, Brigham and Women s Hospital, 665 Huntington Avenue, Building 2, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:1301-10. 2010
  7. ncbi request reprint Dietary patterns and risk of prostate cancer in U.S. men
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:167-71. 2006
  8. ncbi request reprint Variations in plasma lycopene and specific isomers over time in a cohort of U.S. men
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA
    J Nutr 133:1930-6. 2003
  9. ncbi request reprint A prospective study on supplemental vitamin e intake and risk of colon cancer in women and men
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1298-304. 2002
  10. pmc A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 90:1623-31. 2009

Detail Information

Publications50

  1. pmc Interactions between plasma levels of 25-hydroxyvitamin D, insulin-like growth factor (IGF)-1 and C-peptide with risk of colorectal cancer
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS ONE 6:e28520. 2011
    ..Vitamin D status and levels of insulin-like growth factor (IGF)-1 and C-peptide have been implicated in colorectal carcinogenesis. However, in contrast to vitamin D IGF-1 is not an easily modifiable risk factor...
  2. ncbi request reprint Meat mutagens and risk of distal colon adenoma in a cohort of U.S. men
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Building 2, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:1120-5. 2006
    ..Because mutagens other than heterocyclic amines also contribute to MDM, our results suggest that mutagens other than heterocyclic amines in cooked meats may also play a role in increasing the risk of distal adenoma...
  3. ncbi request reprint Dietary patterns and risk of colon cancer and adenoma in a cohort of men (United States)
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Boston, MA 02115, USA
    Cancer Causes Control 15:853-62. 2004
    ..Examining the effects of dietary patterns on cancer risk may provide insights beyond the assessment of individual foods or nutrients...
  4. ncbi request reprint A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg 2, Boston, MA 02115, USA
    J Natl Cancer Inst 99:1120-9. 2007
    ..We investigated this relationship in a nested case-control study within the Health Professionals Follow-up Study (HPFS), a large ongoing study of male health professionals living in the United States...
  5. ncbi request reprint Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control study
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:260-9. 2004
    ..In addition, our findings also suggest that among younger men, diets rich in beta-carotene may also play a protective role in prostate carcinogenesis...
  6. pmc Meat mutagens and breast cancer in postmenopausal women--a cohort analysis
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, and Department of Medicine, Brigham and Women s Hospital, 665 Huntington Avenue, Building 2, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:1301-10. 2010
    ..Mutagenic compounds produced when meats are cooked at high temperatures have been hypothesized to increase risk of breast cancer...
  7. ncbi request reprint Dietary patterns and risk of prostate cancer in U.S. men
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:167-71. 2006
    ....
  8. ncbi request reprint Variations in plasma lycopene and specific isomers over time in a cohort of U.S. men
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA
    J Nutr 133:1930-6. 2003
    ..Single plasma samples quantitating plasma lycopene are a valid predictor of long-term exposure for epidemiologic studies...
  9. ncbi request reprint A prospective study on supplemental vitamin e intake and risk of colon cancer in women and men
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1298-304. 2002
    ..Considering the paucity of epidemiological data on this association, further studies of vitamin E and colon cancer are warranted...
  10. pmc A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 90:1623-31. 2009
    ..Evidence from observational studies suggests that inadequate folate status enhances colorectal carcinogenesis, but results from some randomized trials do not support this hypothesis...
  11. pmc The joint association of eating frequency and diet quality with colorectal cancer risk in the Health Professionals Follow-up Study
    Rania A Mekary
    Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Am J Epidemiol 175:664-72. 2012
    ..01, P for trend = 0.01). There was an implied protective association between increased eating frequency of healthy meals and colorectal cancer risk and in men with factors associated with higher insulin sensitivity...
  12. pmc Long-term colorectal-cancer incidence and mortality after lower endoscopy
    Reiko Nishihara
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    N Engl J Med 369:1095-105. 2013
    ..Colonoscopy and sigmoidoscopy provide protection against colorectal cancer, but the magnitude and duration of protection, particularly against cancer of the proximal colon, remain uncertain...
  13. pmc Prospective cohort studies of vitamin B-6 intake and colorectal cancer incidence: modification by time?
    Xuehong Zhang
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 96:874-81. 2012
    ..The relation between vitamin B-6 intake and colorectal cancer risk remains uncertain...
  14. pmc Associations of self-reported sleep duration and snoring with colorectal cancer risk in men and women
    Xuehong Zhang
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Sleep 36:681-8. 2013
    ..We assessed the relationship between sleep duration, snoring and colorectal cancer risk...
  15. pmc Aspirin use, body mass index, physical activity, plasma C-peptide, and colon cancer risk in US health professionals
    Xuehong Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 174:459-67. 2011
    ..10) for the low and 0.65 (95% CI: 0.46, 0.92) for the high group. Reductions in colon cancer risk associated with aspirin use were not significantly modified by body mass index, physical activity, or plasma C-peptide level in this study...
  16. pmc Dietary intakes of red meat, poultry, and fish during high school and risk of colorectal adenomas in women
    Katharina Nimptsch
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Am J Epidemiol 178:172-83. 2013
    ..Our findings do not suggest an association between red meat intake during adolescence and colorectal adenomas later in life, but higher poultry intake during this time was associated with a lower risk of colorectal adenomas. ..
  17. ncbi request reprint Dairy foods, calcium, and colorectal cancer: a pooled analysis of 10 cohort studies
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 96:1015-22. 2004
    ..Studies in animals have suggested that calcium may reduce the risk of colorectal cancer. However, results from epidemiologic studies of intake of calcium or dairy foods and colorectal cancer risk have been inconclusive...
  18. doi request reprint Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer
    Kimmie Ng
    Division of Medical Oncology, Dana Farber Cancer Institute Boston, MA 02115, USA
    J Clin Oncol 26:2984-91. 2008
    ..Higher plasma 25-hydroxyvitamin D(3) (25(OH)D) levels are associated with a decreased incidence of colorectal cancer, but the influence of plasma 25(OH)D on the outcome of patients with established colorectal cancer is unknown...
  19. ncbi request reprint Body mass index and risk of prostate cancer in U.S. health professionals
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 95:1240-4. 2003
    ....
  20. pmc Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:2335-40. 2008
    ..On the other hand, some epidemiologic studies suggest that the Ala allele is associated with a higher risk of cancer, including prostate cancer...
  21. pmc Dietary choline and betaine and the risk of distal colorectal adenoma in women
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 99:1224-31. 2007
    ..No epidemiologic study has examined the association of intake of these nutrients and colorectal adenoma risk...
  22. ncbi request reprint Dietary patterns and pancreatic cancer risk in men and women
    Dominique S Michaud
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 97:518-24. 2005
    ..Dietary patterns have been associated with fasting insulin levels and risk of diabetes. To determine whether dietary patterns are associated with pancreatic cancer risk, we analyzed data from two large prospective cohort studies...
  23. pmc Prospective cohort studies of bowel movement frequency and laxative use and colorectal cancer incidence in US women and men
    Xuehong Zhang
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Causes Control 24:1015-24. 2013
    ..The associations between bowel movement frequency, laxative use, and colorectal cancer incidence remain uncertain. No published studies have accounted for potential latency between these factors and colorectal cancer onset...
  24. ncbi request reprint Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 28:1510-9. 2007
    ..Further investigation is required to validate the association of the polymorphisms in the one-carbon metabolic genes and risk of colorectal adenoma...
  25. pmc Carotenoid intake and risk of colorectal adenomas in a cohort of male health professionals
    Seungyoun Jung
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Cancer Causes Control 24:705-17. 2013
    ..Carotenoids have been hypothesized to prevent carcinogenesis through their antioxidant and pro-vitamin A properties. We examined associations between intakes of specific carotenoids and risk of colorectal adenomas...
  26. pmc A prospective study of intakes of zinc and heme iron and colorectal cancer risk in men and women
    Xuehong Zhang
    Channing Laboratory at Landmark Center West Wing, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 401 Park Drive, Boston, MA 02115, USA
    Cancer Causes Control 22:1627-37. 2011
    ..Our study does not support strong roles of zinc and heme iron intake in colorectal cancer risk; however, a suggestive inverse association of dietary zinc intake with rectal cancer risk in women requires further study...
  27. pmc Body fatness during childhood and adolescence, adult height, and risk of colorectal adenoma in women
    Katharina Nimptsch
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 4:1710-8. 2011
    ..Higher height and body fatness during childhood was associated with increased risk of distal adenoma later in life, independent of adult body weight...
  28. pmc Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 27:176-85. 2009
    ..Excess energy balance leads to increased circulating insulin and depressed levels of circulating insulin-like growth factor binding protein (IGFBP) -1, which promote cancer cell growth in preclinical models...
  29. pmc The Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets and colorectal cancer
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA, USA
    Am J Clin Nutr 92:1429-35. 2010
    ....
  30. pmc Total antioxidant capacity intake and colorectal cancer risk in the Health Professionals Follow-up Study
    Rania A Mekary
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Bldg 2, Rm 355A, Boston, MA 02115, USA
    Cancer Causes Control 21:1315-21. 2010
    ..To examine the association between total antioxidant capacity (TAC) intake and colorectal cancer incidence...
  31. ncbi request reprint Intake of dairy products, calcium, and vitamin d and risk of breast cancer
    Myung Hee Shin
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 94:1301-11. 2002
    ..We examined data from a large, long-term cohort study to evaluate whether high intake of dairy products, calcium, or vitamin D is associated with reduced risk of breast cancer...
  32. doi request reprint Dietary patterns during high school and risk of colorectal adenoma in a cohort of middle-aged women
    Katharina Nimptsch
    Department of Nutrition, Harvard School of Public Health, Boston, MA Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
    Int J Cancer 134:2458-67. 2014
    ..Our results support the hypothesis that diet during early life may influence colorectal carcinogenesis. ..
  33. pmc Blood donation and colorectal cancer incidence and mortality in men
    Xuehong Zhang
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e39319. 2012
    ..Although blood donations may reduce body iron stores, to date, prospective data on frequent blood donation and colorectal cancer risk are limited...
  34. pmc Determinants of plasma 25-hydroxyvitamin D and development of prediction models in three US cohorts
    Kimberly A Bertrand
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Br J Nutr 108:1889-96. 2012
    ....
  35. doi request reprint Alcohol intake and colorectal cancer: a comparison of approaches for including repeated measures of alcohol consumption
    Lau Caspar Thygesen
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 19:258-64. 2008
    ..In numerous studies, alcohol intake has been found to be positively associated with colorectal cancer risk. However, the majority of studies included only one exposure measurement, which may bias the results if long-term intake is relevant...
  36. ncbi request reprint Calcium intake and risk of colon cancer in women and men
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Building 2, Boston, MA 02115, USA
    J Natl Cancer Inst 94:437-46. 2002
    ..We examined the association between calcium intake and colon cancer risk in two prospective cohorts, the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS)...
  37. pmc Comparison of risk factors for colon and rectal cancer
    Esther K Wei
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 108:433-42. 2004
    ..Future investigations of colon or rectal cancer should take into consideration risk factor differences by subsite...
  38. pmc Aspirin dose and duration of use and risk of colorectal cancer in men
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Gastroenterology 134:21-8. 2008
    ..Long-term data on the risk of colorectal cancer according to dose, duration, and consistency of aspirin therapy are limited...
  39. pmc Association between sex hormones and colorectal cancer risk in men and women
    Jennifer H Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Gastroenterol Hepatol 11:419-424.e1. 2013
    ..There is observational and clinical evidence that indicates that sex hormones affect development of colorectal cancer in men and women. However, the relationship between endogenous sex hormone levels and colorectal cancer is unclear...
  40. ncbi request reprint Flavonoid intake and colorectal cancer risk in men and women
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 164:644-51. 2006
    ..These data provide little support for the hypothesis of an association between flavonoid intake and colorectal cancer risk, at least within the ranges of intakes consumed in the populations studied...
  41. pmc Plasma adiponectin and soluble leptin receptor and risk of colorectal cancer: a prospective study
    Mingyang Song
    Division of Nutrition, Harvard Medical School, Boston, MA 02114, USA
    Cancer Prev Res (Phila) 6:875-85. 2013
    ..These findings support a role for adiponectin in colorectal carcinogenesis in men. Further studies are warranted to confirm these associations and elucidate potential underlying mechanisms...
  42. pmc Pre-diagnostic leukocyte genomic DNA methylation and the risk of colorectal cancer in women
    Hongmei Nan
    Division of Cancer Epidemiology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 8:e59455. 2013
    ..Abnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia...
  43. pmc Polymorphisms in xenobiotic metabolizing genes, intakes of heterocyclic amines and red meat, and postmenopausal breast cancer
    Hae Jeung Lee
    a Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nutr Cancer 65:1122-31. 2013
    ..These results do not support the hypothesis that genetic polymorphisms of xenobiotic enzymes involved in the metabolism of HCAs may modify the associations between intakes of red meat or meat-related mutagens and breast cancer risk. ..
  44. pmc Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies
    Jung Eun Lee
    Department of Food and Nutrition, Sookmyung Women s University, Seoul, Republic of Korea
    Cancer Prev Res (Phila) 4:735-43. 2011
    ..77; 95% CI, 0.56-1.07; P value for difference between colon and rectal cancer = 0.20). These data suggest an inverse association between circulating 25(OH)D levels and colorectal cancer, with a stronger association for rectal cancer...
  45. doi request reprint Total calcium intake and colorectal adenoma in young women
    Jennifer Massa
    Departments of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA
    Cancer Causes Control 25:451-60. 2014
    ..We examined fine categories of calcium intake in relation to occurrence of first colorectal adenoma in a cohort of mostly premenopausal (88 %) women aged 26-60 at time of endoscopy...
  46. pmc Physical activity, tumor PTGS2 expression, and survival in patients with colorectal cancer
    Mai Yamauchi
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 22:1142-52. 2013
    ....
  47. doi request reprint Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women
    Sylvia H Ley
    Departments of Nutrition SHL, QS, WCW, KW, AP, and FBH and Epidemiology WCW, FG, and FBH, Harvard School of Public Health, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School QS, WCW, AHE, FG, and FBH, Boston, MA and the Saw Swee Hock School of Public Health and Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore AP
    Am J Clin Nutr 99:352-60. 2014
    ..Greater red meat intake is associated with an increased type 2 diabetes and cardiovascular disease risk. However, the relation of red meat intake to biomarkers of inflammation and glucose metabolism has not been investigated thoroughly...
  48. pmc Insulin-like growth factor 2 messenger RNA binding protein 3 (IGF2BP3) is a marker of unfavourable prognosis in colorectal cancer
    Paul Lochhead
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, United States
    Eur J Cancer 48:3405-13. 2012
    ..However, the clinical, pathological, molecular and prognostic features of IGF2BP3-positive colorectal cancers remain uncertain...
  49. ncbi request reprint Calcium and vitamin D intakes in relation to risk of distal colorectal adenoma in women
    Kyungwon Oh
    Division of Chronic Disease Surveillance, Korea Centers for Disease Control and Prevention, Seoul, Korea
    Am J Epidemiol 165:1178-86. 2007
    ..Higher total calcium and vitamin D intakes were associated with reduced risk, and the actions of vitamin D may be attenuated by high retinol intake...
  50. ncbi request reprint Zinc supplement use and risk of prostate cancer
    Michael F Leitzmann
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:1004-7. 2003
    ....