Henry Yim Wu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Histone peptide-induced nasal tolerance: suppression of murine lupus
    Henry Yim Wu
    Infection and Immunity Research Group, Division of Life Sciences, King s College London, London, United Kingdom
    J Immunol 169:1126-34. 2002
  2. pmc Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells
    H Y Wu
    Brigham and Women s Hospital and Harvard Medical School Boston, Massachusetts, USA
    Lupus 18:586-96. 2009
  3. ncbi request reprint A deficiency of CD4+CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen
    H Y Wu
    The Infection and Immunity Research Group, Franklin Wilkins Building, King s College London, London, UK
    Lupus 13:192-200. 2004
  4. ncbi request reprint The mechanism of nasal tolerance in lupus prone mice is T-cell anergy induced by immature B cells that lack B7 expression
    Henry Yim Wu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Autoimmun 26:116-26. 2006
  5. pmc Induction of mucosal tolerance in SLE: a sniff or a sip away from ameliorating lupus?
    Henry Yim Wu
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 130:111-22. 2009
  6. pmc Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells
    Henry Yim Wu
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:6038-50. 2008
  7. ncbi request reprint Oral tolerance
    Henry Yim Wu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunol Res 28:265-84. 2003
  8. pmc Mucosal anti-CD3 monoclonal antibody attenuates collagen-induced arthritis that is associated with induction of LAP+ regulatory T cells and is enhanced by administration of an emulsome-based Th2-skewing adjuvant
    Henry Yim Wu
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:3401-7. 2010
  9. pmc In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling
    Henry Yim Wu
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23618. 2011
  10. pmc Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
    Yaron Ilan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:9765-70. 2010

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Histone peptide-induced nasal tolerance: suppression of murine lupus
    Henry Yim Wu
    Infection and Immunity Research Group, Division of Life Sciences, King s College London, London, United Kingdom
    J Immunol 169:1126-34. 2002
    ..Finally, chronic nasal instillation of mice with the H471 peptide not only suppressed the development of autoantibodies, but also altered the severity of glomerulonephritis in lupus-prone SNF(1) mice...
  2. pmc Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells
    H Y Wu
    Brigham and Women s Hospital and Harvard Medical School Boston, Massachusetts, USA
    Lupus 18:586-96. 2009
    ..Our results show that oral anti-CD3 induces CD4+CD25-LAP+ regulatory T cells that suppress lupus in mice and is associated with downregulation of T cell help for autoantibody production...
  3. ncbi request reprint A deficiency of CD4+CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen
    H Y Wu
    The Infection and Immunity Research Group, Franklin Wilkins Building, King s College London, London, UK
    Lupus 13:192-200. 2004
    ..As such transmucosal treatment may ameliorate disease, we conclude that a deficiency in the CD4+CD25+ T cell pool contributes to a susceptibility to develop spontaneous lupus disease...
  4. ncbi request reprint The mechanism of nasal tolerance in lupus prone mice is T-cell anergy induced by immature B cells that lack B7 expression
    Henry Yim Wu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Autoimmun 26:116-26. 2006
    ..The anergic T cells do not possess suppressive function in coculture with naïve responder T cells nor produce suppressive cytokines interleukin 10 and transforming growth factor-beta in vitro...
  5. pmc Induction of mucosal tolerance in SLE: a sniff or a sip away from ameliorating lupus?
    Henry Yim Wu
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 130:111-22. 2009
    ..Here I review studies on mucosal tolerance in autoimmune diseases and discuss the therapeutic potential of inducing tolerance for the treatment of SLE...
  6. pmc Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells
    Henry Yim Wu
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:6038-50. 2008
    ..Our results demonstrate that nasal anti-CD3 induces CD4(+)CD25(-)LAP(+) regulatory T cells that suppress lupus in mice and that it is associated with down-regulation of T cell help for autoantibody production...
  7. ncbi request reprint Oral tolerance
    Henry Yim Wu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunol Res 28:265-84. 2003
    ..This type of immunological event is termed oral tolerance. In this review, we examine the mechanisms behind the induction of oral tolerance and provide findings from its use as a form of treatment for autoimmune diseases...
  8. pmc Mucosal anti-CD3 monoclonal antibody attenuates collagen-induced arthritis that is associated with induction of LAP+ regulatory T cells and is enhanced by administration of an emulsome-based Th2-skewing adjuvant
    Henry Yim Wu
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:3401-7. 2010
    ..These results demonstrate that mucosal anti-CD3 therapy may serve as a therapeutic approach in arthritis and that the biologic effect is enhanced by an emulsome-based adjuvant...
  9. pmc In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling
    Henry Yim Wu
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23618. 2011
    ..However, effective strategies that specifically induce Tr1 cells in vivo are limited. Furthermore, the pathways controlling the induction of these cells in vivo are not well understood...
  10. pmc Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
    Yaron Ilan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:9765-70. 2010
    ..Our results demonstrate the importance of inflammation in T2D and identify a unique immunological approach for treatment of T2D by the induction of Tregs...