Research Topics
| ROSALIND J contact WRIGHTSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Stress-related programming of autonomic imbalance: role in allergy and asthmaRosalind J Wright
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, and Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Chem Immunol Allergy 98:32-47. 2012..Epigenetic dysregulation of gene expression may be a fundamental mechanism for programming of early neural-immune processes...
Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study IIKarestan C Koenen
Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA 02115, USA
BMC Psychiatry 9:29. 2009..Although twin studies suggest genetic influences account for substantial variance in PTSD risk, little progress has been made in identifying variants in specific genes that influence liability to this common, debilitating disorder...
Response to child abuse in the pediatric emergency department: need for continued educationR J Wright
Beth Israel Deaconess Medical Center, Department of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston 02115, USA
Pediatr Emerg Care 15:376-82. 1999..Pediatric emergency physicians are on the front line to identify and respond to child abuse. The physician's response to suspected child abuse cases is influenced by educational content and experience...- Prenatal maternal stress and early caregiving experiences: implications for childhood asthma riskRosalind J Wright
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Paediatr Perinat Epidemiol 21:8-14. 2007..In addition, social stressors during the early part of a child's life may also affect the HPA axis and thence dysregulation of immune system functioning with implications for the development of asthma... - Transdisciplinary research strategies for understanding socially patterned disease: the Asthma Coalition on Community, Environment, and Social Stress (ACCESS) project as a case studyRosalind J Wright
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Cien Saude Colet 13:1729-42. 2008.... - Health effects of socially toxic neighborhoods: the violence and urban asthma paradigmRosalind J Wright
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Clin Chest Med 27:413-21, v. 2006..This article focuses on violence exposure as a useful paradigm to understand how chronic social stressors may influence asthma expression... - The impact of stress on the development and expression of atopyRosalind J Wright
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Curr Opin Allergy Clin Immunol 5:23-9. 2005..The primary objective is to review recent evidence updating our understanding of the role for psychological stress in atopy... - Alternative modalities for asthma that reduce stress and modify mood states: evidence for underlying psychobiologic mechanismsRosalind J Wright
Department of Medicine, Brigham and Women s Hospital, and the Pulmonary Critical Care Division, Boston s Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Allergy Asthma Immunol 93:S18-23. 2004..To review the evidence supporting a role for psychological interventions in the treatment of asthma, with particular emphasis on underlying psychobiological mechanisms... - Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopyRosalind J Wright
Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
J Allergy Clin Immunol 113:1051-7. 2004..Psychologic stress modifies immune function and cytokine production... - Perinatal stress and early life programming of lung structure and functionRosalind J Wright
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02116, USA
Biol Psychol 84:46-56. 2010..This overview discusses the evidence linking psychological factors to alterations in these interrelated physiological processes that may, in turn, influence childhood lung function and identifies gaps in our understanding... 
Violence: an unrecognized environmental exposure that may contribute to greater asthma morbidity in high risk inner-city populationsR J Wright
Beth Israel Deaconess Medical Center, Pulmonary and Critical Care Division, Harvard Medical School, Boston, MA 02115, USA
Environ Health Perspect 109:1085-9. 2001..Change in policies that address the social, economic, and political factors that contribute to crime and violence in urban America may have broader impact...- Parental stress as a predictor of wheezing in infancy: a prospective birth-cohort studyRosalind J Wright
Department of Pulmonary and Critical Care Medicine, The Beth Israel Deaconess Medical Center, Boston, MA, USA
Am J Respir Crit Care Med 165:358-65. 2002..These findings suggest a more direct mechanism may be operating between stress and wheeze in early childhood. Stress may contribute significantly to the population burden of preventable childhood respiratory illness... - Epidemiology of stress and asthma: from constricting communities and fragile families to epigeneticsRosalind J Wright
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Immunol Allergy Clin North Am 31:19-39. 2011.... - Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic researchRosalind J Wright
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA
Allergy Asthma Clin Immunol 4:29-36. 2008.... - War-related stressors are associated with asthma risk among older Kuwaitis following the 1990 Iraqi invasion and occupationR J Wright
Channing Laboratory 181 Longwood Avenue, Boston, MA 02115, USA
J Epidemiol Community Health 64:630-5. 2010..Associations were examined between war-related stressors and incident asthma in elderly Kuwaiti civilians following the Iraqi invasion... - Stress and atopic disordersRosalind J Wright
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Allergy Clin Immunol 116:1301-6. 2005..Critical periods of development, including in utero environment, are underscored. The role of genetics and gene-by-environment interactions is also discussed... - Community violence and asthma morbidity: the Inner-City Asthma StudyRosalind J Wright
Beth Israel Deaconess Medical Center, Pulmonary and Critical Care Division, and the Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Public Health 94:625-32. 2004..We examined the association between exposure to violence and asthma among urban children... - Advancing a multilevel framework for epidemiologic research on asthma disparitiesRosalind J Wright
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Chest 132:757S-769S. 2007..Is it simply asthma disparities or is it social disparities in asthma?.. - Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESSJunenette L Peters
Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
J Allergy Clin Immunol 123:1041-6. 2009..Whereas some evidence suggests that antigen sensitization may begin prenatally, the influence of maternal allergen exposure during pregnancy has not been fully elucidated... - Witnessing community violence in residential neighborhoods: a mental health hazard for urban womenCheryl Clark
Division of General Medicine and Primary Care, Center for Community Health and Health Equity, Brigham and Women s Hospital, and Department of Biostatistics, Harvard School of Public Health, Boston, MA 02120, USA
J Urban Health 85:22-38. 2008..Community violence interventions must incorporate efforts to protect the mental health of adult women who witness events in their neighborhoods... - Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responsesDiane R Gold
Channing Laboratory, Brigham and Women s Hospital, Boston, Mass, USA
J Allergy Clin Immunol 124:1078-87. 2009.... - Cumulative violence exposure and self-rated health: longitudinal study of adolescents in the United StatesRenée Boynton-Jarrett
Division of General Pediatrics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Pediatrics 122:961-70. 2008..The goal was to determine whether cumulative exposure to violence in childhood and adolescence contributes to disparities in self-rated health among a nationally representative sample of US adolescents... - Caretaker-child concordance for child's exposure to violence in a preadolescent inner-city populationCarey Conley Thomson
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA
Arch Pediatr Adolesc Med 156:818-23. 2002..Screening may be more effective if pediatricians are aware of factors related to increased risk, including immigration status and caretaker marital status... - Violence exposure, a chronic psychosocial stressor, and childhood lung functionShakira Franco Suglia
Harvard School of Public Health, Department of Environmental Health, Landmark 415W, 401 Park Drive, Boston, MA 02215, USA
Psychosom Med 70:160-9. 2008..Chronic psychosocial stressors, including violence, and neuropsychological and behavioral development in children as well as physiologic alterations that may lead to broader health effects... - Moving towards making social toxins mainstream in children's environmental healthRosalind J Wright
The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02067, USA
Curr Opin Pediatr 21:222-9. 2009..Although traditional disciplinary research theory and methods have focused separately on how social and physical environmental factors affect children's health, evolving research underscores important integrated effects... - Posttraumatic stress symptoms related to community violence and children's diurnal cortisol response in an urban community-dwelling sampleShakira Franco Suglia
Department of Environmental Health, Harvard School of Public Health, Landmark 415W, 401 Park Drive, Boston, MA 02215, USA
Int J Behav Med 17:43-50. 2010.... - Domestic violence is associated with adult and childhood asthma prevalence in IndiaS V Subramanian
Department of Society, Human Development and Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Int J Epidemiol 36:569-79. 2007..Little is known on the influence of stressful psychosocial circumstances in predicting asthma. We examine the link between asthma prevalence and domestic violence (DV) in a nationally representative sample of adults and children in India... - Maternal interpersonal trauma and cord blood IgE levels in an inner-city cohort: a life-course perspectiveMichelle Judith Sternthal
Department of Environmental and Occupational Medicine and Epidemiology, Harvard School of Public Health, Boston, Mass 02215, USA
J Allergy Clin Immunol 124:954-60. 2009..Prenatal stress affects immunocompetence in offspring, although the underlying mechanisms are not well understood... - Association between iron deficiency and blood lead level in a longitudinal analysis of children followed in an urban primary care clinicRobert O Wright
Department of Pediatrics, Children's Hospital, The Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Pediatr 142:9-14. 2003..81 (95% CI, 0.10-6.30). CONCLUSIONS: ID is associated with subsequent lead poisoning. These data are consistent with a biological mechanism of increased lead absorption among iron deficient children... - Interaction of stress, lead burden, and age on cognition in older men: the VA Normative Aging StudyJunenette L Peters
Department of Environment Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 118:505-10. 2010..However, the modifying potential of psychosocial stress on the neurotoxicity of lead and their combined relationship to aging-associated decline have not been fully examined... - A matter of life and breath: childhood socioeconomic status is related to young adult pulmonary function in the CARDIA studyBenita Jackson
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Int J Epidemiol 33:271-8. 2004..But prospective studies are sparse across young adulthood, an important phase in pulmonary development... - Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohortRosalind J Wright
The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 182:25-33. 2010..Objectives: Associations among prenatal maternal stress and cord blood mononuclear cell (CBMC) cytokine responses were prospectively examined in the Urban Environment and Childhood Asthma Study (n = 557 families)... - Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 yearsJuan C Celedon
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 167:1239-43. 2003..Our findings suggest that maternal history of asthma influences the relation between day care-related exposures and childhood asthma... - Breathing easy: a prospective study of optimism and pulmonary function in the normative aging studyLaura D Kubzansky
Department of Health and Social Behavior, Harvard School of Public Health, Boston, MA 02115, USA
Ann Behav Med 24:345-53. 2002..These data are the first to link optimism with higher levels of pulmonary function and slower rate of pulmonary function decline in older men, a protective effect that is independent of smoking... - Lifetime maternal experiences of abuse and risk of pre-natal depression in two demographically distinct populations in BostonJanet W Rich-Edwards
Connors Center for Women s Health and Gender Biology, Brigham and Women s Hospital, Boston, MA, USA
Int J Epidemiol 40:375-84. 2011..To investigate lifetime history of interpersonal abuse and risk of pre-natal depression in socio-economically distinct populations in the same city... - Maternal intimate partner violence and increased asthma incidence in children: buffering effects of supportive caregivingShakira Franco Suglia
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Arch Pediatr Adolesc Med 163:244-50. 2009..To examine the relationship between maternal intimate partner violence (IPV) and asthma onset in children and the role of supportive caregiving factors in modifying this relationship... - Social determinants: taking the social context of asthma seriouslyDavid R Williams
Harvard School of Public Health, Department of Society, Human Development, and Health, Harvard University, 677 Huntington Ave, Boston, MA 02115, USA
Pediatrics 123:S174-84. 2009..Effective initiatives for the prevention and treatment of childhood asthma need to address these nonmedical determinants of the prevalence of asthma... - Maternal self-esteem, exposure to lead, and child neurodevelopmentPamela J Surkan
Environmental Health, Harvard School of Public Health, Boston, MA, USA
Neurotoxicology 29:278-85. 2008..Moreover, there was evidence that maternal self-esteem attenuated the negative effects of lead exposure, although the interaction fell short of conventional levels of statistical significance... - Association between lung function and cognition among children in a prospective birth cohort studyShakira Franco Suglia
Department of Environmental Health, Harvard School of Public Health, Landmark 415W, 401 Park Drive, Boston, MA 02215, USA
Psychosom Med 70:356-62. 2008..A number of studies have demonstrated a relationship between lung function and cognition among adults, but this relationship has not been studied among children... - Synergistic effects of traffic-related air pollution and exposure to violence on urban asthma etiologyJane E Clougherty
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Environ Health Perspect 115:1140-6. 2007..Asthma, for example, disproportionately affects lower-income urban communities, where air pollution and social stressors may be elevated... - Land use regression modeling of intra-urban residential variability in multiple traffic-related air pollutantsJane E Clougherty
Harvard School of Public Health, Department of Environmental Health, Landmark Center 4th Floor West, PO Box 15677, Boston, MA 02215, USA
Environ Health 7:17. 2008.... - Child abuse and smoking among young women: the importance of severity, accumulation, and timingHee Jin Jun
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Adolesc Health 43:55-63. 2008..We examined the association between severity, accumulation, and timing of abuse in childhood and adolescence and smoking status among young women... - Intimate partner violence and cigarette smoking: association between smoking risk and psychological abuse with and without co-occurrence of physical and sexual abuseHee Jin Jun
Channing Laboratory, Harvard Medical School Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
Am J Public Health 98:527-35. 2008..We examined the association between psychological abuse in a current relationship and current cigarette smoking among women, with and without the co-occurrence of physical or sexual abuse... - Association between traffic-related black carbon exposure and lung function among urban womenShakira Franco Suglia
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 116:1333-7. 2008..Although a number of studies have documented the relationship between lung function and traffic-related pollution among children, few have focused on adult lung function or examined community-based populations... - Contribution of race/ethnicity and country of origin to variations in lifetime reported asthma: evidence for a nativity advantageS V Subramanian
Department of Society, Harvard School of Public Health, Boston, MA 02115 6096, USA
Am J Public Health 99:690-7. 2009..We assessed the relative contribution of Hispanic ethnicity, country of origin, and nativity to lifetime prevalence of asthma among mothers and children enrolled in the Project on Human Development in Chicago Neighborhoods... - Disparities in child abuse victimization in lesbian, bisexual, and heterosexual women in the Nurses' Health Study IIS Bryn Austin
Division of Adolescent and Young Adult Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
J Womens Health (Larchmt) 17:597-606. 2008..One underlying factor may be heightened risk for abuse victimization in childhood in lesbian and bisexual women... - Associations of maternal lifetime trauma and perinatal traumatic stress symptoms with infant cardiorespiratory reactivity to psychological challengeMichelle Bosquet Enlow
Department of Psychiatry, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Psychosom Med 71:607-14. 2009.... - Creation of a community violence exposure scale: accounting for what, who, where, and how oftenShakira Franco Suglia
Department of Environmental Health, and Department of Epidemiology, Harvard School of Public Health, Boston, MA 02215, USA
J Trauma Stress 21:479-86. 2008..Incorporating detailed event circumstance information that is grounded in traumatic stress theory may reduce measurement error in the assessment of children's community violence exposure... - Association between maternal intimate partner violence and incident obesity in preschool-aged children: results from the Fragile Families and Child Well-being StudyRenée Boynton-Jarrett
Department of General Pediatrics, Boston University School of Medicine, 88 E Newton St, Boston, MA 02118, USA
Arch Pediatr Adolesc Med 164:540-6. 2010..To examine the impact of chronicity of maternal intimate partner violence (IPV) on obesity risk among preschool-aged children... - Biomarkers of lead exposure and DNA methylation within retrotransposonsRobert O Wright
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 118:790-5. 2010..Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a marker of cumulative exposure, may therefore better predict DNA methylation than does blood lead... - Does harboring hostility hurt? Associations between hostility and pulmonary function in the Coronary Artery Risk Development in (Young) Adults (CARDIA) studyBenita Jackson
Department of Psychology, Clark Science Center, Smith College, Northampton, MA 01063, and Brigham and Women s Hospital, Boston, USA
Health Psychol 26:333-40. 2007..To examine the cross-sectional association between hostility and pulmonary function (PF) and its consistency across race/ethnicity-gender groups... - Make no bones about it: increasing epidemiologic evidence links vitamin D to pulmonary function and COPDRosalind J Wright
Chest 128:3781-3. 2005 - Exploring biopsychosocial influences on asthma expression in both the family and community contextRosalind J Wright
Am J Respir Crit Care Med 177:129-30. 2008 - Stressful life events and asthma in adolescentsMary E Turyk
Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL 60612, USA
Pediatr Allergy Immunol 19:255-63. 2008..Assessing and addressing the effects of stressful life events may be helpful in managing asthma in inner city adolescents...
Research Grants
- Impact of Violence on Obesity and Reproductive Axes in YouthRosalind Wright; Fiscal Year: 2007..In addition, salivary cortisol rhythms will be examined in relation to history of violence exposure and as a mediator between violence exposure and the proposed outcomes in a subsample (n=1200). ..
- Stress, Environment, and Genetics in Urban AsthmaRosalind Wright; Fiscal Year: 2009..abstract_text> ..
- Impact of Violence on Obesity & Reproductive Axes in YouthRosalind J Wright; Fiscal Year: 2010..In addition, salivary cortisol rhythms will be examined in relation to history of violence exposure and as a mediator between violence exposure and the proposed outcomes in a subsample (n=1200). ..
- Perinatal Programming of Infant Stress Reactivity and the Atopic PhenotypeROSALIND J contact WRIGHT; Fiscal Year: 2010..Given the enormous cost in the management of atopic patients in the United States, understanding the earliest stages of development offers significant potential benefits to society. ..
- CHRONIC LIFE STRESS AND INCIDENT ASTHMA IN ADULT WOMENRosalind Wright; Fiscal Year: 2003..To our knowledge, this would be the first large-scale (N=64,000) longitudinal study of the association between a specific chronic life stressor (i.e., violence) and the incidence of asthma in adult women. ..
- MULTI-LEVEL ANALYSIS OF URBAN CHILDHOOD ASTHMA RISKRosalind Wright; Fiscal Year: 2004..An additional feature of the proposal is the opportunity to involve under represented minority students (predoctoral and summer interns) from two NIH-funded grants whose principal investigator is a co-investigator on this proposal. ..
- Air pollution, stress and urban child developmentRosalind J Wright; Fiscal Year: 2010..Such knowledge may inform efforts to design programs that improve neurodevelopmental trajectories in high-risk urban populations disproportionately exposed to adverse physical and social environments. ..