Robert O Wright

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Association between the plasma/whole blood lead ratio and history of spontaneous abortion: a nested cross-sectional study
    Hector Lamadrid-Figueroa
    Division of Program Evaluation and Biostatistics, Center for Research in Evaluation and Surveys, National Institute of Public Health, Cuernavaca, Mexico
    BMC Pregnancy Childbirth 7:22. 2007
  2. pmc Association between iron deficiency and low-level lead poisoning in an urban primary care clinic
    R O Wright
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Public Health 89:1049-53. 1999
  3. ncbi request reprint Apolipoprotein E genotype predicts 24-month bayley scales infant development score
    Robert O Wright
    Department of Pediatrics, Children s Hospital, Boston, Massachusett 02115, USA
    Pediatr Res 54:819-25. 2003
  4. ncbi request reprint Lead exposure biomarkers and mini-mental status exam scores in older men
    Robert O Wright
    Division of Emergency Medicine, Department of Pediatrics, Boston Children s Hospital, Boston, MA, USA
    Epidemiology 14:713-8. 2003
  5. pmc Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study
    Robert O Wright
    Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115, USA
    Environ Health Perspect 112:746-50. 2004
  6. ncbi request reprint Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site
    Robert O Wright
    Harvard School of Public Health, USA
    Neurotoxicology 27:210-6. 2006
  7. pmc Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study
    Pradeep Rajan
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Occup Environ Med 50:1053-61. 2008
  8. pmc Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline
    Florence T Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 115:1210-5. 2007
  9. pmc Association between blood pressure and DNA methylation of retrotransposons and pro-inflammatory genes
    Stacey E Alexeeff
    Department of Environmental Health, Harvard School of Public Health, Boston MA 02215, USA
    Int J Epidemiol 42:270-80. 2013
  10. pmc Arsenic exposure and DNA methylation among elderly men
    Angeliki Lambrou
    Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 23:668-76. 2012

Research Grants

  1. NEUROCHEMICAL AND GENETIC MARKERS OF LEAD TOXICITY
    Robert Wright; Fiscal Year: 2004
  2. Metal Mixtures and Neurodevelopment
    Robert O Wright; Fiscal Year: 2010
  3. Stress, Lead, Iron Deficiency and Neurodevelopment
    Robert O Wright; Fiscal Year: 2010
  4. Metal Mixtures and Neurodevelopment
    Robert Wright; Fiscal Year: 2009
  5. Stress, Lead, Iron Deficiency and Neurodevelopment
    Robert Wright; Fiscal Year: 2009
  6. Metal Mixtures and Neurodevelopment
    Robert Wright; Fiscal Year: 2007
  7. Stress, Lead, Iron Deficiency and Neurodevelopment
    Robert Wright; Fiscal Year: 2007
  8. Metal Mixtures and Neurodevelopment
    Robert Wright; Fiscal Year: 2006
  9. Stress, Lead, Iron Deficiency and Neurodevelopment
    Robert O Wright; Fiscal Year: 2011

Detail Information

Publications77

  1. pmc Association between the plasma/whole blood lead ratio and history of spontaneous abortion: a nested cross-sectional study
    Hector Lamadrid-Figueroa
    Division of Program Evaluation and Biostatistics, Center for Research in Evaluation and Surveys, National Institute of Public Health, Cuernavaca, Mexico
    BMC Pregnancy Childbirth 7:22. 2007
    ..Women with a tendency to have a higher plasma/whole blood Pb ratio could tend towards an elevated risk of miscarriage due to a higher plasma Pb for a given whole blood Pb and would consequently have a history of spontaneous abortion...
  2. pmc Association between iron deficiency and low-level lead poisoning in an urban primary care clinic
    R O Wright
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Public Health 89:1049-53. 1999
    ..The purpose of this study was to examine the association between iron deficiency and low-level lead poisoning...
  3. ncbi request reprint Apolipoprotein E genotype predicts 24-month bayley scales infant development score
    Robert O Wright
    Department of Pediatrics, Children s Hospital, Boston, Massachusett 02115, USA
    Pediatr Res 54:819-25. 2003
    ..These results suggest that subjects with the E4 isoform of APOE may have advantages over those with the E2 or E3 isoforms with respect to early life neuronal/brain development...
  4. ncbi request reprint Lead exposure biomarkers and mini-mental status exam scores in older men
    Robert O Wright
    Division of Emergency Medicine, Department of Pediatrics, Boston Children s Hospital, Boston, MA, USA
    Epidemiology 14:713-8. 2003
    ..We studied whether lead exposure biomarkers are associated with cognitive test scores, as well as the modifying effects of age on the lead-cognition relationship...
  5. pmc Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study
    Robert O Wright
    Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115, USA
    Environ Health Perspect 112:746-50. 2004
    ..Among elderly men, subjects with HFE variants had lower patella lead levels. These effects may be mediated by alterations in lead toxicokinetics via iron metabolic pathways regulated by the HFE gene product and body iron stores...
  6. ncbi request reprint Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site
    Robert O Wright
    Harvard School of Public Health, USA
    Neurotoxicology 27:210-6. 2006
    ..No other significant relationships were found. These results suggest the need to study further the neuropsychological correlates of developmental exposure to Mn and As, particularly as a mixture...
  7. pmc Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study
    Pradeep Rajan
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Occup Environ Med 50:1053-61. 2008
    ..We evaluated the modifying influence of a delta-aminolevulinic acid dehydratase (ALAD) polymorphism on the relation between lead burden and cognition among older men...
  8. pmc Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline
    Florence T Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 115:1210-5. 2007
    ..As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship...
  9. pmc Association between blood pressure and DNA methylation of retrotransposons and pro-inflammatory genes
    Stacey E Alexeeff
    Department of Environmental Health, Harvard School of Public Health, Boston MA 02215, USA
    Int J Epidemiol 42:270-80. 2013
    ..We examined the relation of BP to the methylation of retrotransposon sequences of DNA and of selected candidate genes...
  10. pmc Arsenic exposure and DNA methylation among elderly men
    Angeliki Lambrou
    Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 23:668-76. 2012
    ..This association has also been explored in highly exposed human populations, but studies among populations environmentally exposed to low arsenic levels are lacking...
  11. pmc Associations of early childhood manganese and lead coexposure with neurodevelopment
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, Boston, MA 02215, USA
    Environ Health Perspect 120:126-31. 2012
    ..Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals...
  12. pmc Air pollution, obesity, genes and cellular adhesion molecules
    Jaime Madrigano
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Occup Environ Med 67:312-7. 2010
    ..We examined the association between particulate matter and cell adhesion molecules. We also investigated the modifying effect of genotype and phenotype variation to gain insight into the relevant biological pathways for this association...
  13. pmc Early postnatal blood manganese levels and children's neurodevelopment
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 21:433-9. 2010
    ..Previous studies have addressed the effects of prenatal exposure, but little is known about developmental effects of early postnatal exposure...
  14. pmc Lead concentrations in relation to multiple biomarkers of cardiovascular disease: the Normative Aging Study
    Junenette L Peters
    Department of Environment Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:361-6. 2012
    ..However, the mechanisms of action have not been fully elucidated. We therefore examined the relationship between lead and multiple biomarkers of CVD...
  15. pmc Variants in iron metabolism genes predict higher blood lead levels in young children
    Marianne R Hopkins
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 116:1261-6. 2008
    ..Given the association between iron deficiency and lead absorption, we hypothesized that variants in iron metabolism genes would predict higher blood lead levels in young children...
  16. ncbi request reprint Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution
    Cizao Ren
    Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 21:198-206. 2010
    ..nondeletion), and HMOX-1 (any short vs. both long). We attempted to replicate identified genes in an analysis of heart rate variability and in other outcomes reported in the literature...
  17. pmc Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism: the VA Normative Aging Study
    Pradeep Rajan
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 166:1400-8. 2007
    ..004). These results augment evidence of a deleterious association between lead and psychiatric symptoms...
  18. pmc Biomarkers of lead exposure and DNA methylation within retrotransposons
    Robert O Wright
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 118:790-5. 2010
    ..Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a marker of cumulative exposure, may therefore better predict DNA methylation than does blood lead...
  19. pmc Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 10:97. 2011
    ..Given mounting evidence for adverse effects from excess manganese exposure, it is critical to understand host factors, such as genetics, that affect manganese metabolism...
  20. ncbi request reprint Cumulative lead exposure and cognitive performance among elderly men
    Marc G Weisskopf
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Epidemiology 18:59-66. 2007
    ..Recent evidence suggests that cumulative lead exposure among adults in nonoccupational settings can adversely affect cognitive function. Which cognitive domains are affected has not been explored in detail...
  21. pmc Prolonged exposure to particulate pollution, genes associated with glutathione pathways, and DNA methylation in a cohort of older men
    Jaime Madrigano
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 119:977-82. 2011
    ..Exposure to particulate air pollution has been associated with increased cardiovascular morbidity and mortality, and lower blood DNA methylation has been found in processes related to cardiovascular morbidity...
  22. doi request reprint Associations between arrhythmia episodes and temporally and spatially resolved black carbon and particulate matter in elderly patients
    Antonella Zanobetti
    Environmental Epidemiology and Risk Program, Harvard School of Public Health, Boston, Massachusetts, USA
    Occup Environ Med 71:201-7. 2014
    ..Defibrillator discharge studies have examined the association of air pollution with arrhythmias in sensitive populations. No studies have assessed this association using residence-specific estimates of air pollution exposure...
  23. pmc Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu
    Heather H Burris
    Department of Neonatology, Beth Israel Deaconess Medical Center and Division of Newborn Medicine, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA
    Epigenomics 5:271-81. 2013
    ..We examined the association between birth weight and methylation in the imprinted IGF/H19 loci, the nonimprinted gene NR3C1 and repetitive element DNA (LINE-1 and Alu)...
  24. pmc A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the Food for Thought Study
    Emily Oken
    Department of Population Medicine, Harvard Medical School and the Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, Boston, MA 02215, USA
    Nutr J 12:33. 2013
    ..However, concern exists that this advice will lead to excess intake of methylmercury, a developmental neurotoxicant...
  25. pmc Assessing windows of susceptibility to lead-induced cognitive deficits in Mexican children
    Joe M Braun
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 33:1040-7. 2012
    ..The identification of susceptible periods to Pb-induced decrements in childhood cognitive abilities remains elusive...
  26. pmc Stress as a potential modifier of the impact of lead levels on blood pressure: the normative aging study
    Junenette L Peters
    Department of Environmental Health, Harvard Shool of Public Health, Boston, MA 02215, USA
    Environ Health Perspect 115:1154-9. 2007
    ..Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated...
  27. pmc Association of cumulative lead exposure with Parkinson's disease
    Marc G Weisskopf
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 118:1609-13. 2010
    ....
  28. pmc Longitudinal changes in bone lead levels: the VA Normative Aging Study
    Elissa Wilker
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Occup Environ Med 53:850-5. 2011
    ..We examined repeated measures of bone lead over 11 years to characterize long-term changes and identify predictors of tibia and patella lead stores in an elderly male population...
  29. pmc Interaction of stress, lead burden, and age on cognition in older men: the VA Normative Aging Study
    Junenette L Peters
    Department of Environment Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 118:505-10. 2010
    ..However, the modifying potential of psychosocial stress on the neurotoxicity of lead and their combined relationship to aging-associated decline have not been fully examined...
  30. pmc Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Am J Epidemiol 167:1171-81. 2008
    ..3, -0.9) for the WRAVMA. Fish consumption of < or =2 servings/week was not associated with a benefit. Dietary recommendations for pregnant women should incorporate the nutritional benefits as well as the risks of fish intake...
  31. pmc Associations between traffic-related black carbon exposure and attention in a prospective birth cohort of urban children
    Yueh Hsiu Mathilda Chiu
    Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Environ Health Perspect 121:859-64. 2013
    ..Ambient air pollution may have neurotoxic effects in children. Data examining associations between traffic-related air pollution and attention domains remain sparse...
  32. pmc Modification by hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in older men: a cohort study
    Melinda C Power
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Environ Health 12:16. 2013
    ....
  33. pmc Maternal self-esteem, exposure to lead, and child neurodevelopment
    Pamela J Surkan
    Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 29:278-85. 2008
    ..Moreover, there was evidence that maternal self-esteem attenuated the negative effects of lead exposure, although the interaction fell short of conventional levels of statistical significance...
  34. pmc Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging Study
    Junenette L Peters
    Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Am J Epidemiol 174:1345-53. 2011
    ..Results demonstrate an interrelated role of lead burden and SES over the life course in relation to psychological functioning in older age...
  35. ncbi request reprint HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction
    Sung Kyun Park
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass, USA
    Circulation 114:2798-805. 2006
    ..Two HFE polymorphisms (C282Y and H63D) associated with increased iron uptake may modify the effect of metal-rich particles on the cardiovascular system...
  36. ncbi request reprint Cumulative lead exposure and prospective change in cognition among elderly men: the VA Normative Aging Study
    Marc G Weisskopf
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Landmark Center, 401 Park Drive, PO Box 15697, Boston, MA 02215, USA
    Am J Epidemiol 160:1184-93. 2004
    ..The data suggest that higher patella bone lead levels, a marker of mobilizable accumulated lead burden, are associated with a steeper decline over time in performance on the MMSE test among nonoccupationally exposed elderly men...
  37. pmc Maternal blood manganese levels and infant birth weight
    Ami R Zota
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 20:367-73. 2009
    ..High manganese exposures have been associated with negative reproductive outcomes in animals, but few epidemiologic studies have examined the effects of human fetal manganese exposure...
  38. pmc Proton magnetic resonance spectroscopic evidence of glial effects of cumulative lead exposure in the adult human hippocampus
    Marc G Weisskopf
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, 401 Park Drive, Boston, MA 02215, USA
    Environ Health Perspect 115:519-23. 2007
    ..Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans...
  39. pmc Lead levels and ischemic heart disease in a prospective study of middle-aged and elderly men: the VA Normative Aging Study
    Nitin B Jain
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Environ Health Perspect 115:871-5. 2007
    ..Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes...
  40. pmc Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes
    Elissa H Wilker
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 118:943-8. 2010
    ..MicroRNAs (miRNAs) are emerging as key regulators of gene expression, but whether polymorphisms in genes involved in processing of miRNAs to maturity influence susceptibility to BC has not been elucidated...
  41. pmc Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
    Teresa Chahine
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:1617-22. 2007
    ..We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter...
  42. pmc Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging Study
    Cizao Ren
    Department of Environmental Health, Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
    Occup Environ Med 68:562-9. 2011
    ..Studies show that exposure to air pollution damages human health, but the mechanisms are not fully understood. One suggested pathway is via oxidative stress...
  43. pmc Interpersonal trauma exposure and cognitive development in children to age 8 years: a longitudinal study
    Michelle Bosquet Enlow
    Department of Psychiatry, Children s Hospital Boston, Boston, MA 02115, USA
    J Epidemiol Community Health 66:1005-10. 2012
    ..The impact of exposure in early development has been especially under-investigated. This study examined the impact of interpersonal trauma exposure (IPT) in the first years of life on childhood cognitive functioning...
  44. pmc Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter
    Elissa Wilker
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:935-40. 2009
    ..Fine particulate matter [aerodynamic diameter </= 2.5 mum (PM(2.5))] has been associated with autonomic dysregulation...
  45. pmc Maternal dietary intake of polyunsaturated fatty acids modifies the relationship between lead levels in bone and breast milk
    Manish Arora
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 138:73-9. 2008
    ..Monounsaturated fatty acids did not modify the relationship between lead levels in patella and breast milk. In conclusion, higher maternal dietary intake of PUFA may limit the transfer of lead from bone to breast milk...
  46. ncbi request reprint Association between iron deficiency and blood lead level in a longitudinal analysis of children followed in an urban primary care clinic
    Robert O Wright
    Department of Pediatrics, Children s Hospital, The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr 142:9-14. 2003
    ..To determine if iron deficiency (ID) is longitudinally associated with lead poisoning...
  47. pmc Cadmium exposure and neurodevelopmental outcomes in U.S. children
    Timothy Ciesielski
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:758-63. 2012
    ..Low-level environmental cadmium exposure in children may be associated with adverse neurodevelopmental outcomes...
  48. pmc Low-level lead exposure, metabolic syndrome, and heart rate variability: the VA Normative Aging Study
    Sung Kyun Park
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:1718-24. 2006
    ..Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure...
  49. pmc Association between lung function and cognition among children in a prospective birth cohort study
    Shakira Franco Suglia
    Department of Environmental Health, Harvard School of Public Health, Landmark 415W, 401 Park Drive, Boston, MA 02215, USA
    Psychosom Med 70:356-62. 2008
    ..A number of studies have demonstrated a relationship between lung function and cognition among adults, but this relationship has not been studied among children...
  50. pmc Modifying roles of glutathione S-transferase polymorphisms on the association between cumulative lead exposure and cognitive function
    Ki Do Eum
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 39:65-71. 2013
    ..We investigated whether the GSTP1 Val105 and GSTM1 deletion polymorphisms modify the lead-cognitive function association...
  51. pmc Predictors of virtual radial arm maze performance in adolescent Italian children
    Joe M Braun
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 33:1203-11. 2012
    ..The radial arm maze (RAM), a rodent visuospatial learning and memory task, has a computerized version for use in children, which may help improve comparisons between animal and human studies...
  52. pmc A qualitative study of fish consumption during pregnancy
    Arienne Bloomingdale
    Department of Population Medicine, Harvard Medical School and the Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Am J Clin Nutr 92:1234-40. 2010
    ....
  53. pmc Maternal arsenic exposure and impaired glucose tolerance during pregnancy
    Adrienne S Ettinger
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:1059-64. 2009
    ..Accumulating evidence has shown an increased risk of type 2 diabetes in general populations exposed to arsenic, but little is known about exposures during pregnancy and the association with gestational diabetes (GD)...
  54. pmc Association of environmental cadmium exposure with pediatric dental caries
    Manish Arora
    Environmental and Occupational Medicine and Epidemiology, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 116:821-5. 2008
    ..Although animal experiments have shown that cadmium exposure results in severe dental caries, limited epidemiologic data are available on this issue...
  55. ncbi request reprint Environmental neurotoxins
    Bruce P Lanphear
    Department of Pediatrics, Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital, Medical Center University of Cincinnati, Cincinnati, Ohio, USA
    Pediatr Rev 26:191-7; quiz 198. 2005
  56. pmc Metal sources and exposures in the homes of young children living near a mining-impacted Superfund site
    Ami R Zota
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Expo Sci Environ Epidemiol 21:495-505. 2011
    ..These findings suggest that nearby outdoor sources of metal contaminants from mine waste may migrate indoors. Populations farther away from the mining site may also be exposed if secondary uses of chat are in close proximity to the home...
  57. pmc Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides
    Maryse F Bouchard
    Department of Environmental Health, School of Public Health, Harvard University, Boston, MA, USA
    Pediatrics 125:e1270-7. 2010
    ..The goal was to examine the association between urinary concentrations of dialkyl phosphate metabolites of organophosphates and attention-deficit/hyperactivity disorder (ADHD) in children 8 to 15 years of age...
  58. pmc Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning
    Marc G Weisskopf
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Landmark Center, 401 Park Drive, PO Box 15697, Boston, MA 02215, USA
    Environ Health Perspect 112:620-5. 2004
    ..Nevertheless, the results point to the potential utility of MRS in determining mechanisms of neurotoxicity not only for lead but also for other neurotoxicants as well...
  59. pmc Maternal fish consumption, hair mercury, and infant cognition in a U.S. Cohort
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Environ Health Perspect 113:1376-80. 2005
    ..Women should continue to eat fish during pregnancy but choose varieties with lower mercury contamination...
  60. pmc Racial/ethnic disparities in preterm birth: clues from environmental exposures
    Heather H Burris
    Department of Neonatology, Division of Newborn Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, and Division of Emergency Medicine, Children s Hospital Boston, Boston, Massachusetts 02215, USA
    Curr Opin Pediatr 23:227-32. 2011
    ..Despite advances in medical care, preterm birth and its associated racial/ethnic disparities remain major public health issues. Environmental exposures may contribute to racial disparities in preterm birth...
  61. pmc Association of environmental cadmium exposure with periodontal disease in U.S. adults
    Manish Arora
    Population Oral Health, Faculty of Dentistry, Westmead Centre for Oral Health, University of Sydney, Sydney, New South Wales, Australia
    Environ Health Perspect 117:739-44. 2009
    ..Cadmium adversely affects bone remodeling, and it is therefore possible that environmental Cd exposure may be a risk factor for periodontal-disease-related bone loss...
  62. doi request reprint Ambient particulate air pollution and microRNAs in elderly men
    Serena Fossati
    From the Departments of aEnvironmental Health and cEpidemiology, Harvard School of Public Health, Boston, MA bDepartment of Biomedical and Clinical Sciences Luigi Sacco, University of Milan, Milan, Italy dLaboratory of Environmental Epigenetics, Department of Environmental and Occupational Health, University of Milan, Milan, Italy eVA Normative Aging Study, Veterans Affairs Boston Healthcare System and the Department of Medicine, Boston University School of Medicine, Boston, MA and fGenetic Epidemiology Unit, Channing Laboratory, Brigham and Women s Hospital, Boston, MA
    Epidemiology 25:68-78. 2014
    ..Polymorphisms in microRNA-related genes could influence response to PM...
  63. pmc Cumulative exposure to lead and cognition in persons with Parkinson's disease
    Jennifer Weuve
    Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 28:176-82. 2013
    ..06). Patella bone lead concentration was not consistently associated with performance on the tests. These data provide evidence suggesting that cumulative exposure to lead may result in worsened cognition among persons with PD...
  64. pmc Environmental epigenetics: a role in endocrine disease?
    Abby F Fleisch
    Department of Endocrinology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Mol Endocrinol 49:R61-7. 2012
    ..Current evidence suggests that environmental exposures may significantly impact expression of endocrine-related genes and thereby affect clinical endocrine outcomes...
  65. ncbi request reprint Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy
    Rosalind J Wright
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 113:1051-7. 2004
    ..Psychologic stress modifies immune function and cytokine production...
  66. ncbi request reprint End-tidal carbon dioxide as a measure of acidosis among children with gastroenteritis
    Joshua Nagler
    Division of Emergency Medicine, Children s Hospital and Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115, USA
    Pediatrics 118:260-7. 2006
    ....
  67. ncbi request reprint Metals and neurotoxicology
    Robert O Wright
    Department of Pediatrics, Children s Hospital, Boston Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 137:2809-13. 2007
    ..Parallel work in metals demonstrates that epigenetics may be a critical pathway by which metals produce health effects...
  68. pmc Correlation of global and gene-specific DNA methylation in maternal-infant pairs
    Molly L Kile
    Environmental Health Department, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13730. 2010
    ..Future studies should also use a multi-generational family-based design that would quantify both maternal and paternal contributions to DNA methylation in offspring across more than one generation...
  69. pmc Design and analysis issues in gene and environment studies
    Chen Yu Liu
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 11:93. 2012
    ..Future research directions are also discussed...
  70. pmc Gene-environment interaction and children's health and development
    Robert O Wright
    Department of Pediatrics, Children s Hospital, Harvard School of Public Health, Boston, Massachusetts, USA
    Curr Opin Pediatr 22:197-201. 2010
    ....
  71. pmc Air pollution and heart rate variability: effect modification by chronic lead exposure
    Sung Kyun Park
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Epidemiology 19:111-20. 2008
    ..Outdoor air pollution and lead exposure can disturb cardiac autonomic function, but the effects of both these exposures together have not been studied...
  72. pmc The challenge posed to children's health by mixtures of toxic waste: the Tar Creek superfund site as a case-study
    Howard Hu
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Room 1518, Vaughan Building SPH I, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
    Pediatr Clin North Am 54:155-75, x. 2007
    ..This article discusses the issue of toxic mixtures and children's health by focusing on the specific example of mining waste at the Tar Creek Superfund Site in Northeast Oklahoma...
  73. ncbi request reprint Longitudinal associations between blood lead concentrations lower than 10 microg/dL and neurobehavioral development in environmentally exposed children in Mexico City
    Martha M Téllez-Rojo
    Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    Pediatrics 118:e323-30. 2006
    ..Using data from a prospective study conducted in Mexico City, Mexico, we evaluated the dose-effect relationship between blood lead levels and neurodevelopment at 12 and 24 months of age...
  74. pmc Phthalates in food and medical devices
    Karen Chou
    Environmental Science and Policy Program, Department of Animal Science, Michigan State University, MI, USA
    J Med Toxicol 2:126-35. 2006
  75. doi request reprint Therapeutics and toxicology
    Robert O Wright
    Curr Opin Pediatr 20:171. 2008
  76. ncbi request reprint Bispectral analysis during deep sedation of pediatric oral surgery patients
    Frank L Overly
    Emergency Medicine and Pediatrics, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island, RI 02903, USA
    J Oral Maxillofac Surg 63:215-9. 2005
    ..Our objective was to determine the correlation between clinical sedation scales and BIS index in pediatric patients undergoing sedation in an outpatient oral surgery setting...
  77. pmc Neurotoxicology: what can context teach us?
    Robert O Wright
    J Pediatr 152:155-7. 2008

Research Grants11

  1. NEUROCHEMICAL AND GENETIC MARKERS OF LEAD TOXICITY
    Robert Wright; Fiscal Year: 2004
    ....
  2. Metal Mixtures and Neurodevelopment
    Robert O Wright; Fiscal Year: 2010
    ..Furthermore, our pilot data suggest that exposure to Mn, As and Pb are elevated in the target population, and that biomarkers of internal dose may be associated with poorer developmental outcomes. ..
  3. Stress, Lead, Iron Deficiency and Neurodevelopment
    Robert O Wright; Fiscal Year: 2010
    ..abstract_text> ..
  4. Metal Mixtures and Neurodevelopment
    Robert Wright; Fiscal Year: 2009
    ..Furthermore, our pilot data suggest that exposure to Mn, As and Pb are elevated in the target population, and that biomarkers of internal dose may be associated with poorer developmental outcomes. ..
  5. Stress, Lead, Iron Deficiency and Neurodevelopment
    Robert Wright; Fiscal Year: 2009
    ..abstract_text> ..
  6. Metal Mixtures and Neurodevelopment
    Robert Wright; Fiscal Year: 2007
    ..Furthermore, our pilot data suggest that exposure to Mn, As and Pb are elevated in the target population, and that biomarkers of internal dose may be associated with poorer developmental outcomes. ..
  7. Stress, Lead, Iron Deficiency and Neurodevelopment
    Robert Wright; Fiscal Year: 2007
    ....
  8. Metal Mixtures and Neurodevelopment
    Robert Wright; Fiscal Year: 2006
    ..Furthermore, our pilot data suggest that exposure to Mn, As and Pb are elevated in the target population, and that biomarkers of internal dose may be associated with poorer developmental outcomes. ..
  9. Stress, Lead, Iron Deficiency and Neurodevelopment
    Robert O Wright; Fiscal Year: 2011
    ..abstract_text> ..