J Wozniak

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Parsing the comorbidity between bipolar disorder and anxiety disorders: a familial risk analysis
    Janet Wozniak
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Child Adolesc Psychopharmacol 12:101-11. 2002
  2. ncbi request reprint Examining the association between pediatric bipolar disorder and anxiety disorders in psychiatrically referred children and adolescents
    Terri L Harpold
    Clinical and Research Program in Pediatric Psychopharmacology, Johnson and Johnson Center for the Study of Pediatric Psychopathology, Massachusetts General Hospital and Harvard Medical School, USA
    J Affect Disord 88:19-26. 2005
  3. pmc Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Psychiatry 9:2. 2009
  4. ncbi request reprint Diagnostic and therapeutic dilemmas in the management of pediatric-onset bipolar disorder
    J Wozniak
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Clin Psychiatry 62:10-5. 2001
  5. ncbi request reprint Risperidone treatment for juvenile bipolar disorder: a retrospective chart review
    J A Frazier
    Child Psychiatry Department, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Am Acad Child Adolesc Psychiatry 38:960-5. 1999
  6. ncbi request reprint Systematic chart review of the pharmacologic treatment of comorbid attention deficit hyperactivity disorder in youth with bipolar disorder
    J Biederman
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Child Adolesc Psychopharmacol 9:247-56. 1999
  7. ncbi request reprint Heterogeneity of childhood conduct disorder: further evidence of a subtype of conduct disorder linked to bipolar disorder
    J Wozniak
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Affect Disord 64:121-31. 2001
  8. ncbi request reprint Is bipolar disorder a risk for cigarette smoking in ADHD youth?
    T E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    Am J Addict 9:187-95. 2000
  9. pmc Neurocognitive impairment in unaffected siblings of youth with bipolar disorder
    A E Doyle
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Child Psychiatry Service, 55 Fruit Street, Boston, MA 02114, USA
    Psychol Med 39:1253-63. 2009
  10. ncbi request reprint Parsing pediatric bipolar disorder from its associated comorbidity with the disruptive behavior disorders
    T J Spencer
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114-3139, USA
    Biol Psychiatry 49:1062-70. 2001

Detail Information

Publications40

  1. ncbi request reprint Parsing the comorbidity between bipolar disorder and anxiety disorders: a familial risk analysis
    Janet Wozniak
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Child Adolesc Psychopharmacol 12:101-11. 2002
    ..Thus, we investigated the familial association between BPD and ANX among the first-degree relatives of children with BPD with and without comorbid ANX...
  2. ncbi request reprint Examining the association between pediatric bipolar disorder and anxiety disorders in psychiatrically referred children and adolescents
    Terri L Harpold
    Clinical and Research Program in Pediatric Psychopharmacology, Johnson and Johnson Center for the Study of Pediatric Psychopathology, Massachusetts General Hospital and Harvard Medical School, USA
    J Affect Disord 88:19-26. 2005
    ..To examine the association between anxiety (ANX) and bipolar disorders (BPD) in a clinically referred pediatric sample...
  3. pmc Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Psychiatry 9:2. 2009
    ..In this report we test for association with genes coding brain-derived neurotrophic factor (BDNF), the serotonin transporter (SLC6A4), and catechol-O-methyltransferase (COMT)...
  4. ncbi request reprint Diagnostic and therapeutic dilemmas in the management of pediatric-onset bipolar disorder
    J Wozniak
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Clin Psychiatry 62:10-5. 2001
    ..Treatment requires a combined pharmacotherapy approach to address issues of comorbidity. Atypical antipsychotic medications have provided promising treatment results, but additional controlled clinical trials are needed...
  5. ncbi request reprint Risperidone treatment for juvenile bipolar disorder: a retrospective chart review
    J A Frazier
    Child Psychiatry Department, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Am Acad Child Adolesc Psychiatry 38:960-5. 1999
    ..To investigate the effectiveness and tolerability of the atypical neuroleptic risperidone in the treatment of juvenile mania...
  6. ncbi request reprint Systematic chart review of the pharmacologic treatment of comorbid attention deficit hyperactivity disorder in youth with bipolar disorder
    J Biederman
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Child Adolesc Psychopharmacol 9:247-56. 1999
    ..Although TCAs can be helpful in the management of ADHD children with manic symptoms, these drugs should be used with caution since they can also have a destabilizing effect on manic symptoms...
  7. ncbi request reprint Heterogeneity of childhood conduct disorder: further evidence of a subtype of conduct disorder linked to bipolar disorder
    J Wozniak
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Affect Disord 64:121-31. 2001
    ..Furthermore, they suggest that the comorbid condition of CD+BPD may be a distinct nosological entity. This suggests that clinicians treating CD or BPD children should consider the treatment implications of this comorbid condition...
  8. ncbi request reprint Is bipolar disorder a risk for cigarette smoking in ADHD youth?
    T E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    Am J Addict 9:187-95. 2000
    ..These data coupled with the literature strongly suggest that juveniles with BPD need to be carefully monitored for the early initiation of cigarette smoking and substance abuse...
  9. pmc Neurocognitive impairment in unaffected siblings of youth with bipolar disorder
    A E Doyle
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Child Psychiatry Service, 55 Fruit Street, Boston, MA 02114, USA
    Psychol Med 39:1253-63. 2009
    ..The current study investigated whether these neurocognitive impairments index the familial risk underlying the diagnosis...
  10. ncbi request reprint Parsing pediatric bipolar disorder from its associated comorbidity with the disruptive behavior disorders
    T J Spencer
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114-3139, USA
    Biol Psychiatry 49:1062-70. 2001
    ..What was previously considered refractory ADHD, oppositionality, aggression, and conduct disorder may respond after mood stabilization. We review these issues in this article...
  11. ncbi request reprint Risperidone for the treatment of affective symptoms in children with disruptive behavior disorder: a post hoc analysis of data from a 6-week, multicenter, randomized, double-blind, parallel-arm study
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Clin Ther 28:794-800. 2006
    ..Preliminary data from open-label trials in children suggest that these agents might be effective in treating pediatric bipolar disorder, however...
  12. ncbi request reprint Recognizing and managing bipolar disorder in children
    Janet Wozniak
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02138, USA
    J Clin Psychiatry 66:18-23. 2005
    ....
  13. ncbi request reprint Clinical correlates of bipolar disorder in a large, referred sample of children and adolescents
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    J Psychiatr Res 39:611-22. 2005
    ..To compare the prevalence, clinical correlates, and comorbidity among children and adolescents with bipolar disorder (BPD) assessed in the early 1990s (first cohort) with those evaluated over the last 7 years (second cohort)...
  14. ncbi request reprint Heterogeneity of irritability in attention-deficit/hyperactivity disorder subjects with and without mood disorders
    Eric Mick
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Biol Psychiatry 58:576-82. 2005
    ..We hypothesized that irritability is a heterogeneous symptom distinguished by severity and that attending to this heterogeneity would impact the relationship between irritability and bipolar disorder...
  15. ncbi request reprint How cardinal are cardinal symptoms in pediatric bipolar disorder? An examination of clinical correlates
    Janet Wozniak
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 58:583-8. 2005
    ..The main goal of this study was to test whether the hypothesized cardinal symptom of euphoria results in differences in clinical correlates in bipolar youth ascertained with no a priori assumptions about cardinal symptoms...
  16. ncbi request reprint Open-label, 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder in preschool-age children
    Joseph Biederman
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 58:589-94. 2005
    ..To evaluate short-term safety and efficacy of atypical antipsychotics in a single-site, prospective, open-label, 8-week study of risperidone and olanzapine monotherapy in preschoolers with bipolar disorder (BPD)...
  17. pmc Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 99:19-25. 2007
    ..In this study, we hypothesized that the children with BPD in need of treatment would have lower Glx/Cr compared with the children with BPD being stably treated with risperidone...
  18. ncbi request reprint Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 163:316-8. 2006
    ....
  19. ncbi request reprint Pharmacological management of new-onset bipolar disorder
    Christopher J Kratochvil
    Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE 68198 5581, USA
    J Am Acad Child Adolesc Psychiatry 44:1198-200. 2005
  20. ncbi request reprint The clinical characteristics of unipolar vs. bipolar major depression in ADHD youth
    Janet Wozniak
    Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Affect Disord 82:S59-69. 2004
    ..To investigate the characteristics of unipolar vs. bipolar depression in youth using a sample of children referred for a study on attention deficit hyperactivity disorder (ADHD)...
  21. ncbi request reprint Further evidence of unique developmental phenotypic correlates of pediatric bipolar disorder: findings from a large sample of clinically referred preadolescent children assessed over the last 7 years
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    J Affect Disord 82:S45-58. 2004
    ..A comparison of the prevalence, clinical correlates, and patterns of comorbidity among children with bipolar disorder (BPD) assessed in the early 1990s (1st cohort) with those evaluated over the last 7 years (2nd cohort)...
  22. ncbi request reprint Convergence between structured diagnostic interviews and clinical assessment on the diagnosis of pediatric-onset mania
    Janet Wozniak
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:938-44. 2003
    ..To this end, this study compared structured diagnostic interview based diagnoses of mania in children and adolescents with that of an expert clinician...
  23. ncbi request reprint Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research Program
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 53:952-60. 2003
    ..Our data suggest that when BPD and CD co-occur in children, both are correctly diagnosed. In these comorbid cases, CD symptoms should not be viewed as secondary to BPD, and manic symptoms should not be viewed as secondary to CD...
  24. ncbi request reprint Can adults with attention-deficit/hyperactivity disorder be distinguished from those with comorbid bipolar disorder? Findings from a sample of clinically referred adults
    Timothy E Wilens
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 54:1-8. 2003
    ..We now evaluate the clinical characteristics of referred adults with (n = 24) and without BPD (n = 27)...
  25. ncbi request reprint Current concepts in the validity, diagnosis and treatment of paediatric bipolar disorder
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114 3139, USA
    Int J Neuropsychopharmacol 6:293-300. 2003
    ..The goal of this article is to review our work and the extant literature within this framework to describe the evidence supporting bipolar disorder in children as a valid clinical diagnosis...
  26. doi request reprint Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3)
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1182-5. 2008
    ..These data provide suggestive evidence supporting a role for SLC6A3 in the etiology of pediatric bipolar disorder...
  27. ncbi request reprint Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age at onset
    Eric Mick
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Child Adolesc Psychopharmacol 13:453-62. 2003
    ....
  28. ncbi request reprint A prospective open-label treatment trial of ziprasidone monotherapy in children and adolescents with bipolar disorder
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Research Department, 32 Fruit Street, Yawkey Center for Outpatient Care Yaw 6A, Boston, MA 02114, USA
    Bipolar Disord 9:888-94. 2007
    ..To assess the effectiveness and tolerability of ziprasidone for treating pediatric mania...
  29. ncbi request reprint Olanzapine versus placebo in the treatment of adolescents with bipolar mania
    Mauricio Tohen
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Am J Psychiatry 164:1547-56. 2007
    ..The purpose of this study was to evaluate the efficacy and safety of olanzapine for the treatment of acute manic or mixed episodes associated with bipolar disorder in adolescents...
  30. ncbi request reprint Absence of gender differences in pediatric bipolar disorder: findings from a large sample of referred youth
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology of the Child Psychiatry Service, Massachusetts General Hospital, Pediatric Psychopharmacology Unit WACC 725, 15 Parkman Street, Boston, MA 02114, USA
    J Affect Disord 83:207-14. 2004
    ..Because little is known about gender differences in pediatric bipolar disorder, we evaluated whether gender moderates the expression of pediatric bipolar disorder in a large clinical sample...
  31. ncbi request reprint A prospective follow-up study of pediatric bipolar disorder in boys with attention-deficit/hyperactivity disorder
    Joseph Biederman
    WACC 725, Massachusetts General Hospital, Pediatric Psychopharmacology Unit, MGH, 55 Fruit Street, Boston, MA 02114, USA
    J Affect Disord 82:S17-23. 2004
    ....
  32. ncbi request reprint Can bipolar disorder-specific neuropsychological impairments in children be identified?
    Aude Henin
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Cambridge, MA 02138, USA
    J Consult Clin Psychol 75:210-20. 2007
    ..Thus, comorbidity with ADHD may account for many of the neuropsychological deficits observed in children with bipolar disorder...
  33. ncbi request reprint An open-label trial of aripiprazole monotherapy in children and adolescents with bipolar disorder
    Joseph Biederman
    Joint Program in Pediatric Psychopharmacology Research Office, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Spectr 12:683-9. 2007
    ..Aripiprazole is a novel second-generation antipsychotic approved for the treatment of bipolar disorder in adults but there is no systematic data available in pediatric bipolar disorder...
  34. ncbi request reprint Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial
    Janet Wozniak
    Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Boston, MA 02138, USA
    Eur Neuropsychopharmacol 17:440-7. 2007
    ..To test the effectiveness and safety of omega-3 fatty acids (Omegabrite(R) brand) in the treatment of pediatric bipolar disorder (BPD)...
  35. ncbi request reprint An open-label trial of risperidone in children and adolescents with bipolar disorder
    Joseph Biederman
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 15:311-7. 2005
    ..The aim of this study was to evaluate the potential of risperidone as a treatment of pediatric bipolar disorder...
  36. ncbi request reprint Risk of substance use disorders in adolescents with bipolar disorder
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Child Psychiatric Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 43:1380-6. 2004
    ..Considering the public health importance of this issue, the authors now report on a controlled study of adolescents with and without BPD to evaluate the risk of SUD...
  37. ncbi request reprint Patterns of comorbidity and dysfunction in clinically referred preschool and school-age children with bipolar disorder
    Timothy E Wilens
    Johnson and Johnson Center for the Study of Pediatric Psychopathology, Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 13:495-505. 2003
    ..This study reports on the clinical characteristics, psychiatric comorbidity, and functioning of preschoolers identified with BPD who were referred to a pediatric psychiatric clinic...
  38. ncbi request reprint Pediatric bipolar disorder: the new perspective on severe mood dysfunction in children
    Janet Wozniak
    J Child Adolesc Psychopharmacol 13:449-51. 2003
  39. ncbi request reprint Methodological issues and controversies in clinical trials with child and adolescent patients with bipolar disorder: report of a consensus conference
    Gabrielle A Carlson
    Department of Psychiatry, Stony Brook University Putnam Hall, Stony Brook, NY 11794 8790, USA
    J Child Adolesc Psychopharmacol 13:13-27. 2003
    ..To achieve consensus among researchers, pharmaceutical industry representatives, federal regulatory agency staff, and family advocates on a template for clinical trials of acute mania/bipolar disorder in children and adolescents...
  40. ncbi request reprint Aripiprazole in the treatment of pediatric bipolar disorder: a systematic chart review
    Joseph Biederman
    Pediatric Psychopharmacology Research Office, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Spectr 10:141-8. 2005
    ..Pediatric bipolar disorder is a serious neuropsychiatric disorder associated with high levels of morbidity and disability...