CLIFFORD WOOLF

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc What is this thing called pain?
    Clifford J Woolf
    Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3742-4. 2010
  2. pmc Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation
    Christian Brenneis
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Mol Pain 7:78. 2011
  3. doi request reprint Overcoming obstacles to developing new analgesics
    Clifford J Woolf
    Neurobiology Center and Program in Neurobiology, Department of Neurology, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Med 16:1241-7. 2010
  4. pmc Central sensitization: implications for the diagnosis and treatment of pain
    Clifford J Woolf
    FM Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA
    Pain 152:S2-15. 2011

Research Grants

  1. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    Clifford J Woolf; Fiscal Year: 2010
  2. Tetrahydrobiopterin and pain
    Clifford J Woolf; Fiscal Year: 2010
  3. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
  4. Microglia, Complement, and Pain
    Clifford J Woolf; Fiscal Year: 2010
  5. Tetrahydrobiopterin and pain
    CLIFFORD WOOLF; Fiscal Year: 2009
  6. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    Clifford J Woolf; Fiscal Year: 2010
  7. Microglia, Complement, and Pain
    Clifford J Woolf; Fiscal Year: 2009
  8. Microglia, Complement, and Pain
    Clifford J Woolf; Fiscal Year: 2009
  9. Neural Plasticity and Inflammatory Pain
    CLIFFORD WOOLF; Fiscal Year: 2007
  10. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    CLIFFORD WOOLF; Fiscal Year: 2003

Collaborators

  • Christian Brenneis
  • Klaus Scholich
  • Kai Altenrath
  • Ovidiu Coste
  • Ingrid Fleming
  • Michael J Fischer
  • Marco Sisignano
  • Carlo Angioni
  • Gerd Geisslinger
  • Peter W Reeh
  • Ralf P Brandes

Detail Information

Publications4

  1. pmc What is this thing called pain?
    Clifford J Woolf
    Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3742-4. 2010
    ....
  2. pmc Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation
    Christian Brenneis
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Mol Pain 7:78. 2011
    ..Three of the EETs (i.e., 8,9-, 11,12- and 14,15-EET) are rapidly hydrolysed by the enzyme soluble epoxide hydrolase (sEH). Here, we investigated the role of sEH in nociceptive processing during peripheral inflammation...
  3. doi request reprint Overcoming obstacles to developing new analgesics
    Clifford J Woolf
    Neurobiology Center and Program in Neurobiology, Department of Neurology, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Med 16:1241-7. 2010
    ..Nevertheless, the chances of success could increase if analgesic drug development strategy changed. To achieve such a paradigm shift we must understand why development of drugs for pain relief is so challenging...
  4. pmc Central sensitization: implications for the diagnosis and treatment of pain
    Clifford J Woolf
    FM Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA
    Pain 152:S2-15. 2011
    ....

Research Grants36

  1. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    Clifford J Woolf; Fiscal Year: 2010
    ....
  2. Tetrahydrobiopterin and pain
    Clifford J Woolf; Fiscal Year: 2010
    ..This grant aims both to understand the mechanisms responsible for pain, and validate a particular enzyme, GCH1, as a target for developing novel analgesics. ..
  3. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
    ..Understanding the molecular mechanisms involved will help reveal targets for developing novel analgesics. ..
  4. Microglia, Complement, and Pain
    Clifford J Woolf; Fiscal Year: 2010
    ..We will use this information to devise and test novel treatment strategies for somatic and facial neuropathic pain based either on blocking complement gene induction in microglia or complement cascade activation in the nervous system. ..
  5. Tetrahydrobiopterin and pain
    CLIFFORD WOOLF; Fiscal Year: 2009
    ..This grant aims both to understand the mechanisms responsible for pain, and validate a particular enzyme, GCH1, as a target for developing novel analgesics. ..
  6. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    Clifford J Woolf; Fiscal Year: 2010
    ....
  7. Microglia, Complement, and Pain
    Clifford J Woolf; Fiscal Year: 2009
    ..We will use this information to devise and test novel treatment strategies for somatic and facial neuropathic pain based either on blocking complement gene induction in microglia or complement cascade activation in the nervous system. ..
  8. Microglia, Complement, and Pain
    Clifford J Woolf; Fiscal Year: 2009
    ..We will use this information to devise and test novel treatment strategies for somatic and facial neuropathic pain based either on blocking complement gene induction in microglia or complement cascade activation in the nervous system. ..
  9. Neural Plasticity and Inflammatory Pain
    CLIFFORD WOOLF; Fiscal Year: 2007
    ..Understanding the molecular mechanisms involved will help reveal targets for developing novel analgesics. ..
  10. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    CLIFFORD WOOLF; Fiscal Year: 2003
    ....
  11. SEMAPHORIN ACTIVATION AND ROLE IN NEURONAL REGENERATION
    CLIFFORD WOOLF; Fiscal Year: 2004
    ..This work will improve our understanding of the structure function relationship of the secreted semaphorins. This work should also advance our knowledge of the response to injury in the adult central nervous system. ..
  12. Neural Plasticity and Inflammatory Pain
    CLIFFORD WOOLF; Fiscal Year: 2005
    ..Prevention of posttranslational changes may, in addition, offer new approaches for treatment of inflammatory pain hypersensitivity, a major health problem, and we need, therefore, to acquire an integrated view of these phenomena. ..
  13. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    CLIFFORD WOOLF; Fiscal Year: 2007
    ..Absence of these intrinsic survival genes contributes to cell death after nerve injury/lesions. ..
  14. Tetrahydrobiopterin and pain
    Clifford J Woolf; Fiscal Year: 2009
    ..The proposal is designed to explore the molecular mechanisms responsible for pain and identify novel targets for the development of new analgesics. Project Description Page 7 ..