Genomes and Genes
Affiliation: Harvard University
- What is this thing called pain?Clifford J Woolf
Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 120:3742-4. 2010....
- Activity-dependent silencing reveals functionally distinct itch-generating sensory neuronsDavid P Roberson
FM Kirby Neurobiology Center and Department of Neurology, Children s Hospital, Boston, Massachusetts, USA
Nat Neurosci 16:910-8. 2013....
- Bacteria activate sensory neurons that modulate pain and inflammationIsaac M Chiu
Kirby Neurobiology Center, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 501:52-7. 2013..Thus, bacterial pathogens produce pain by directly activating sensory neurons that modulate inflammation, an unsuspected role for the nervous system in host-pathogen interactions. ..
- Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammationChristian Brenneis
Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt, Germany
Mol Pain 7:78. 2011..Three of the EETs (i.e., 8,9-, 11,12- and 14,15-EET) are rapidly hydrolysed by the enzyme soluble epoxide hydrolase (sEH). Here, we investigated the role of sEH in nociceptive processing during peripheral inflammation...
- Overcoming obstacles to developing new analgesicsClifford J Woolf
Neurobiology Center and Program in Neurobiology, Department of Neurology, Children s Hospital Boston, Boston, Massachusetts, USA
Nat Med 16:1241-7. 2010..Nevertheless, the chances of success could increase if analgesic drug development strategy changed. To achieve such a paradigm shift we must understand why development of drugs for pain relief is so challenging...
- Central sensitization: implications for the diagnosis and treatment of painClifford J Woolf
FM Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA
Pain 152:S2-15. 2011....