CLIFFORD WOOLF

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc What is this thing called pain?
    Clifford J Woolf
    Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3742-4. 2010
  2. pmc Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons
    David P Roberson
    FM Kirby Neurobiology Center and Department of Neurology, Children s Hospital, Boston, Massachusetts, USA
    Nat Neurosci 16:910-8. 2013
  3. pmc Bacteria activate sensory neurons that modulate pain and inflammation
    Isaac M Chiu
    Kirby Neurobiology Center, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 501:52-7. 2013
  4. pmc Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation
    Christian Brenneis
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Mol Pain 7:78. 2011
  5. doi request reprint Overcoming obstacles to developing new analgesics
    Clifford J Woolf
    Neurobiology Center and Program in Neurobiology, Department of Neurology, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Med 16:1241-7. 2010
  6. pmc Central sensitization: implications for the diagnosis and treatment of pain
    Clifford J Woolf
    FM Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA
    Pain 152:S2-15. 2011

Research Grants

  1. SEMAPHORIN ACTIVATION AND ROLE IN NEURONAL REGENERATION
    CLIFFORD WOOLF; Fiscal Year: 2004
  2. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
  3. Microglia, Complement, and Pain
    Clifford J Woolf; Fiscal Year: 2010

Collaborators

  • Isaac M Chiu
  • David P Roberson
  • Christian Brenneis
  • Victoria K Robson
  • Bruce P Bean
  • Qiufu Ma
  • Sagi Gudes
  • Felix Blasl
  • Haley A W Patoski
  • Alexander M Binshtok
  • Bo Duan
  • Seog Bae Oh
  • Jared M Sprague
  • Klaus Scholich
  • Michael J Fischer
  • Kai Altenrath
  • Peter W Reeh
  • Ingrid Fleming
  • Ralf P Brandes
  • Gerd Geisslinger
  • Ovidiu Coste
  • Marco Sisignano
  • Carlo Angioni

Detail Information

Publications6

  1. pmc What is this thing called pain?
    Clifford J Woolf
    Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3742-4. 2010
    ....
  2. pmc Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons
    David P Roberson
    FM Kirby Neurobiology Center and Department of Neurology, Children s Hospital, Boston, Massachusetts, USA
    Nat Neurosci 16:910-8. 2013
    ....
  3. pmc Bacteria activate sensory neurons that modulate pain and inflammation
    Isaac M Chiu
    Kirby Neurobiology Center, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 501:52-7. 2013
    ..Thus, bacterial pathogens produce pain by directly activating sensory neurons that modulate inflammation, an unsuspected role for the nervous system in host-pathogen interactions. ..
  4. pmc Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation
    Christian Brenneis
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Mol Pain 7:78. 2011
    ..Three of the EETs (i.e., 8,9-, 11,12- and 14,15-EET) are rapidly hydrolysed by the enzyme soluble epoxide hydrolase (sEH). Here, we investigated the role of sEH in nociceptive processing during peripheral inflammation...
  5. doi request reprint Overcoming obstacles to developing new analgesics
    Clifford J Woolf
    Neurobiology Center and Program in Neurobiology, Department of Neurology, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Med 16:1241-7. 2010
    ..Nevertheless, the chances of success could increase if analgesic drug development strategy changed. To achieve such a paradigm shift we must understand why development of drugs for pain relief is so challenging...
  6. pmc Central sensitization: implications for the diagnosis and treatment of pain
    Clifford J Woolf
    FM Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA
    Pain 152:S2-15. 2011
    ....

Research Grants3

  1. SEMAPHORIN ACTIVATION AND ROLE IN NEURONAL REGENERATION
    CLIFFORD WOOLF; Fiscal Year: 2004
    ..This work will improve our understanding of the structure function relationship of the secreted semaphorins. This work should also advance our knowledge of the response to injury in the adult central nervous system. ..
  2. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
    ..Understanding the molecular mechanisms involved will help reveal targets for developing novel analgesics. ..
  3. Microglia, Complement, and Pain
    Clifford J Woolf; Fiscal Year: 2010
    ..We will use this information to devise and test novel treatment strategies for somatic and facial neuropathic pain based either on blocking complement gene induction in microglia or complement cascade activation in the nervous system. ..