Rachel I Wilson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Origins of correlated activity in an olfactory circuit
    Hokto Kazama
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 12:1136-44. 2009
  2. pmc Biophysical mechanisms underlying olfactory receptor neuron dynamics
    Katherine I Nagel
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 14:208-16. 2011
  3. pmc Asymmetric neurotransmitter release enables rapid odour lateralization in Drosophila
    Quentin Gaudry
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 493:424-8. 2013
  4. pmc Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe
    Ya Hui Chou
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, USA
    Nat Neurosci 13:439-49. 2010
  5. doi request reprint Early olfactory processing in Drosophila: mechanisms and principles
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Neurosci 36:217-41. 2013
  6. ncbi request reprint Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 25:9069-79. 2005
  7. ncbi request reprint Early events in olfactory processing
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Neurosci 29:163-201. 2006
  8. pmc Understanding the functional consequences of synaptic specialization: insight from the Drosophila antennal lobe
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, MA 02115, United States
    Curr Opin Neurobiol 21:254-60. 2011
  9. pmc Eppendorf 2007 winner. Neural circuits underlying chemical perception
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 318:584-5. 2007
  10. pmc Neural and behavioral mechanisms of olfactory perception
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, United States
    Curr Opin Neurobiol 18:408-12. 2008

Research Grants

Collaborators

Detail Information

Publications33

  1. pmc Origins of correlated activity in an olfactory circuit
    Hokto Kazama
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 12:1136-44. 2009
    ..PN axons from the same glomerulus reconverge in the lateral horn, where pooling redundant signals may allow lateral horn neurons to average out noise that arises independently in these PNs...
  2. pmc Biophysical mechanisms underlying olfactory receptor neuron dynamics
    Katherine I Nagel
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 14:208-16. 2011
    ..However, in the presence of rapidly fluctuating natural stimuli, spiking simply increases the speed and sensitivity of encoding...
  3. pmc Asymmetric neurotransmitter release enables rapid odour lateralization in Drosophila
    Quentin Gaudry
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 493:424-8. 2013
    ..Our data also show that small differences in spike timing and spike rate can produce reliable differences in olfactory behaviour...
  4. pmc Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe
    Ya Hui Chou
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, USA
    Nat Neurosci 13:439-49. 2010
    ..Our results reveal an unexpected degree of complexity and individual variation in an invertebrate neural circuit, a result that creates challenges for solving the Drosophila connectome...
  5. doi request reprint Early olfactory processing in Drosophila: mechanisms and principles
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Neurosci 36:217-41. 2013
    ..These findings suggest some general principles with broad relevance to early sensory processing in other modalities. ..
  6. ncbi request reprint Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 25:9069-79. 2005
    ....
  7. ncbi request reprint Early events in olfactory processing
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Neurosci 29:163-201. 2006
    ..Recent findings in synaptic physiology, neural coding, and psychophysics are discussed, with reference to both vertebrate and insect model systems...
  8. pmc Understanding the functional consequences of synaptic specialization: insight from the Drosophila antennal lobe
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, MA 02115, United States
    Curr Opin Neurobiol 21:254-60. 2011
    ..Specifically, many of these properties appear to promote odor detection when odor concentrations are low, while promoting adaptive gain control when odor concentrations are high...
  9. pmc Eppendorf 2007 winner. Neural circuits underlying chemical perception
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 318:584-5. 2007
  10. pmc Neural and behavioral mechanisms of olfactory perception
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, United States
    Curr Opin Neurobiol 18:408-12. 2008
    ..Other recent studies highlight the role of active sensing (sniffing) in shaping odor-evoked neural activity and perception...
  11. pmc Olfactory processing and behavior downstream from highly selective receptor neurons
    Michelle L Schlief
    Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Neurosci 10:623-30. 2007
    ....
  12. pmc Electrical coupling between olfactory glomeruli
    Emre Yaksi
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 67:1034-47. 2010
    ..We propose that when stimuli are weak, lateral excitation promotes sensitivity, whereas when stimuli are strong, lateral excitation helps recruit inhibitory gain control...
  13. pmc Divisive normalization in olfactory population codes
    Shawn R Olsen
    Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA
    Neuron 66:287-99. 2010
    ....
  14. pmc Lateral presynaptic inhibition mediates gain control in an olfactory circuit
    Shawn R Olsen
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 452:956-60. 2008
    ..A substantial portion of this interglomerular inhibition acts at a presynaptic locus, and our results imply that this is mediated by both ionotropic and metabotropic receptors on the same nerve terminal...
  15. pmc Excitatory interactions between olfactory processing channels in the Drosophila antennal lobe
    Shawn R Olsen
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 54:89-103. 2007
    ..Thus, a dense network of lateral connections distributes odor-evoked excitation between channels in the first brain region of the olfactory processing stream...
  16. pmc Cell death triggers olfactory circuit plasticity via glial signaling in Drosophila
    Hokto Kazama
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 31:7619-30. 2011
    ..By strengthening excitatory interactions between neurons in a deafferented brain region, this mechanism might help boost activity to compensate for lost sensory input...
  17. pmc Sensory processing in the Drosophila antennal lobe increases reliability and separability of ensemble odor representations
    Vikas Bhandawat
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 10:1474-82. 2007
    ..Finally, we show that a linear discriminator classifies odors more accurately using PN spike trains than using an equivalent number of ORN spike trains...
  18. pmc Homeostatic matching and nonlinear amplification at identified central synapses
    Hokto Kazama
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston MA 02115, USA
    Neuron 58:401-13. 2008
    ..Finally, strong stimuli produce short-term depression at this synapse. This helps explain why PN odor responses are transient, and why strong ORN odor responses are not amplified as powerfully as weak responses...
  19. doi request reprint Stereotyped connectivity and computations in higher-order olfactory neurons
    Mehmet Fisek
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 17:280-8. 2014
    ..The biased stereotyped connectivity of the lateral horn contrasts with the probabilistic wiring of the mushroom body, reflecting the distinct roles of these regions in innate as compared to learned behaviors. ..
  20. pmc Glutamate is an inhibitory neurotransmitter in the Drosophila olfactory system
    Wendy W Liu
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:10294-9. 2013
    ..Thus, the existence of two parallel inhibitory transmitter systems may increase the range and flexibility of synaptic inhibition...
  21. pmc Signal propagation in Drosophila central neurons
    Nathan W Gouwens
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:6239-49. 2009
    ..Our results also have important consequences for the design and interpretation of experiments aimed at understanding Drosophila neurons and neural circuits...
  22. pmc Olfactory modulation of flight in Drosophila is sensitive, selective and rapid
    Vikas Bhandawat
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    J Exp Biol 213:3625-35. 2010
    ..This makes these behaviors a useful paradigm for studying the relationship between sensory neuron activity and behavioral decision-making in a simple and genetically tractable organism...
  23. pmc Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila
    Shawn R Olsen
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Trends Neurosci 31:512-20. 2008
    ....
  24. pmc Transient and specific inactivation of Drosophila neurons in vivo using a native ligand-gated ion channel
    Wendy W Liu
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 23:1202-8. 2013
    ..Ort also performed favorably in comparison to the available alternative effector transgenes. Thus, Ort misexpression is a useful tool for probing functional connectivity among Drosophila neurons...
  25. pmc Smelling on the fly: sensory cues and strategies for olfactory navigation in Drosophila
    Quentin Gaudry
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, United States
    Curr Opin Neurobiol 22:216-22. 2012
    ..Finally, we highlight future research directions that will be important in understanding the neural circuits that underlie these behaviors...
  26. pmc Transduction in Drosophila olfactory receptor neurons is invariant to air speed
    Yi Zhou
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurophysiol 108:2051-9. 2012
    ..Thus, for the fly, invariance to air speed may be adaptive because it confers robustness to changing wind conditions...
  27. pmc Distinct roles of TRP channels in auditory transduction and amplification in Drosophila
    Brendan P Lehnert
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 77:115-28. 2013
    ..Thus, transduction and active amplification are genetically separable processes in Drosophila hearing...
  28. doi request reprint Olfactory neuroscience: normalization is the norm
    Elizabeth J Hong
    Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, MA 02115, USA Electronic address
    Curr Biol 23:R1091-3. 2013
    ..A recent study shows that neural circuits from vertebrates and invertebrates use common strategies to stabilize odor representations across a wide range of concentrations. ..
  29. ncbi request reprint painless, a Drosophila gene essential for nociception
    W Daniel Tracey
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 113:261-73. 2003
    ..An antibody to Painless binds to localized dendritic structures that we hypothesize are involved in nociceptive signaling...
  30. ncbi request reprint Transformation of olfactory representations in the Drosophila antennal lobe
    Rachel I Wilson
    Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Science 303:366-70. 2004
    ..This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe...
  31. ncbi request reprint Neurobiology: scent secrets of insects
    Rachel I Wilson
    Nature 445:30-1. 2007
  32. ncbi request reprint Oscillations and sparsening of odor representations in the mushroom body
    Javier Perez-Orive
    Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Science 297:359-65. 2002
    ..These results provide direct support for the functional relevance of correlation codes and shed some light on the role of oscillatory synchronization in sensory networks...
  33. ncbi request reprint Endocannabinoid signaling in the brain
    Rachel I Wilson
    Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Science 296:678-82. 2002
    ..Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism...

Research Grants5

  1. Synaptic and circuit mechanisms of olfactory processing
    Rachel Wilson; Fiscal Year: 2007
    ..These sensors have important applications in medical diagnosis and biodefense, and have shown particular promise in diagnosing stage 1 lung cancer by measuring the chemicals present in a subject's breath ..
  2. Synaptic and circuit mechanisms of olfactory processing
    Rachel Wilson; Fiscal Year: 2010
    ..These sensors have important applications in medical diagnosis and biodefense, and have shown particular promise in diagnosing stage 1 lung cancer by measuring the chemicals present in a subject's breath. ..