W C Willett

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Consumption and acceptability of whole grain staples for lowering markers of diabetes risk among overweight and obese Tanzanian adults
    Alfa Muhihi
    Clinical Trial Unit, Africa Academy for Public Health, Dar es Salaam, Tanzania
    Global Health 9:26. 2013
  2. pmc Green tea drinking and subsequent risk of breast cancer in a population-based cohort of Japanese women
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Chuo Ku, Tokyo, Japan
    Breast Cancer Res 12:R88. 2010
  3. pmc Nondense mammographic area and risk of breast cancer
    Andreas Pettersson
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 13:R100. 2011
  4. pmc The combined influence of multiple sex and growth hormones on risk of postmenopausal breast cancer: a nested case-control study
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 13:R99. 2011
  5. pmc Milk consumption and the prepubertal somatotropic axis
    Janet W Rich-Edwards
    Connors Center for Women s Health and Gender Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nutr J 6:28. 2007
  6. pmc Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study II
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Breast Cancer Res 13:R50. 2011
  7. pmc Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study
    Heather J Baer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Breast Cancer Res 7:R314-25. 2005
  8. pmc Gender-related differences in the prevalence of cardiovascular disease risk factors and their correlates in urban Tanzania
    Marina A Njelekela
    Department of Physiology, Muhimbili University of Health and Allied Sciences, PO Box 65001, Dar es Salaam, Tanzania
    BMC Cardiovasc Disord 9:30. 2009
  9. ncbi request reprint Dietary fat plays a major role in obesity: no
    W C Willett
    Departments of Epidemiology and Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Obes Rev 3:59-68. 2002
  10. ncbi request reprint The scientific basis for TFA regulations-is it sufficient? Comments from the USA
    W C Willett
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Atheroscler Suppl 7:69-71. 2006

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. pmc Consumption and acceptability of whole grain staples for lowering markers of diabetes risk among overweight and obese Tanzanian adults
    Alfa Muhihi
    Clinical Trial Unit, Africa Academy for Public Health, Dar es Salaam, Tanzania
    Global Health 9:26. 2013
    ..We assessed the preferences and acceptability of unrefined whole grain carbohydrate staples (i.e., brown rice, unrefined maize and unrefined sorghum ugali) as substitutes for commonly consumed refined carbohydrates in Tanzania...
  2. pmc Green tea drinking and subsequent risk of breast cancer in a population-based cohort of Japanese women
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Chuo Ku, Tokyo, Japan
    Breast Cancer Res 12:R88. 2010
    ....
  3. pmc Nondense mammographic area and risk of breast cancer
    Andreas Pettersson
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 13:R100. 2011
    ..We investigated separately the absolute dense area and the absolute nondense area on mammograms in relation to breast cancer risk...
  4. pmc The combined influence of multiple sex and growth hormones on risk of postmenopausal breast cancer: a nested case-control study
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 13:R99. 2011
    ..Sex and growth hormones are positively associated with postmenopausal breast cancer risk. However, few studies have evaluated the influence of multiple hormones simultaneously...
  5. pmc Milk consumption and the prepubertal somatotropic axis
    Janet W Rich-Edwards
    Connors Center for Women s Health and Gender Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nutr J 6:28. 2007
    ..We conducted pilot studies in Mongolia and Massachusetts to test the extent to which milk intake raised somatotropic hormone concentrations in prepubertal children...
  6. pmc Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study II
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Breast Cancer Res 13:R50. 2011
    ..Vitamin D comes from dietary intake and sun exposure and plasma levels of 25-hydroxyvitamin D (25(OH)D) are considered the best measure of vitamin D status...
  7. pmc Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study
    Heather J Baer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Breast Cancer Res 7:R314-25. 2005
    ..We examined prospectively the relation between body fatness during childhood and adolescence and the incidence of breast cancer in premenopausal women...
  8. pmc Gender-related differences in the prevalence of cardiovascular disease risk factors and their correlates in urban Tanzania
    Marina A Njelekela
    Department of Physiology, Muhimbili University of Health and Allied Sciences, PO Box 65001, Dar es Salaam, Tanzania
    BMC Cardiovasc Disord 9:30. 2009
    ..Results of this study will help inform future research and potential preventive and therapeutic interventions against such chronic diseases...
  9. ncbi request reprint Dietary fat plays a major role in obesity: no
    W C Willett
    Departments of Epidemiology and Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Obes Rev 3:59-68. 2002
    ..The emphasis on total fat reduction has been a serious distraction in efforts to control obesity and improve health in general...
  10. ncbi request reprint The scientific basis for TFA regulations-is it sufficient? Comments from the USA
    W C Willett
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Atheroscler Suppl 7:69-71. 2006
    ..Thus, the present US Food and Drug Administration position of allowing TFA in the food supply is indefensible, and large numbers of Americans are dying prematurely because of its failure to act to responsibly...
  11. ncbi request reprint Trans fatty acids and cardiovascular disease-epidemiological data
    W C Willett
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Atheroscler Suppl 7:5-8. 2006
    ..The apparent gap between the epidemiologic findings and effects of TFA on LDL:HDL has been bridged, at least in part, by recent metabolic studies showing effects of TFA on inflammatory factors and other indicators of insulin resistance...
  12. ncbi request reprint Adherence to the Dietary Guidelines for Americans and risk of major chronic disease in men
    M L McCullough
    Departments of Nutrition, Epidemiology, and Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 72:1223-31. 2000
    ..The healthy eating index (HEI) measures the concordance of dietary patterns with these guidelines...
  13. ncbi request reprint A prospective study of body mass index, weight change, and risk of stroke in women
    K M Rexrode
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    JAMA 277:1539-45. 1997
    ..To examine the associations of body mass index (BMI) and weight change with risk of stroke in women...
  14. ncbi request reprint Dietary carotenoids and vitamins A, C, and E and risk of breast cancer
    S Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 91:547-56. 1999
    ..Furthermore, studies of vitamins A, C, and E in relation to breast cancer risk are inconclusive. We have conducted a large, prospective study to evaluate long-term intakes of these nutrients and breast cancer risk...
  15. ncbi request reprint A prospective study of carotenoid intake and risk of cataract extraction in US men
    L Brown
    Departments of Epidemiology, Nutrition, and Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 70:517-24. 1999
    ..However, prospective epidemiologic data concerning this phenomenon are limited...
  16. ncbi request reprint Dietary fat and protein in relation to risk of non-Hodgkin's lymphoma among women
    S Zhang
    Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 91:1751-8. 1999
    ..In this study, we examined the intake of specific types of dietary fat and protein in relation to the risk of non-Hodgkin's lymphoma...
  17. ncbi request reprint Dietary fiber, glycemic load, and risk of NIDDM in men
    J Salmeron
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Diabetes Care 20:545-50. 1997
    ..Intake of carbohydrates that provide a large glycemic response has been hypothesized to increase the risk of NIDDM, whereas dietary fiber is suspected to reduce incidence. These hypotheses have not been evaluated prospectively...
  18. ncbi request reprint Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus
    C G Solomon
    Division of Women s Health, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 102:494-9. 2000
    ..We assessed prospectively the association between moderate alcohol intake and CHD risk in women with type 2 diabetes mellitus, a group at high risk for cardiovascular disease...
  19. ncbi request reprint Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women
    E B Rimm
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 279:359-64. 1998
    ..Hyperhomocysteinemia is caused by genetic and lifestyle influences, including low intakes of folate and vitamin B6. However, prospective data relating intake of these vitamins to risk of coronary heart disease (CHD) are not available...
  20. ncbi request reprint Physical activity and benign prostatic hyperplasia
    E A Platz
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA
    Arch Intern Med 158:2349-56. 1998
    ..Therefore, we assessed whether physical activity leads to fewer lower urinary tract symptoms in the Health Professionals Follow-up Study...
  21. ncbi request reprint A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women
    S Liu
    Departments of Epidemiology and Nutrition, The Harvard School of Public Health, Boston, MA 02215, USA
    Am J Clin Nutr 71:1455-61. 2000
    ..Little is known about the effects of the amount and type of carbohydrates on risk of coronary heart disease (CHD)...
  22. ncbi request reprint Birth weight and adult hypertension, diabetes mellitus, and obesity in US men
    G C Curhan
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 94:3246-50. 1996
    ..Further study of these diseases in a large cohort with information on a wide variety of risk factors is essential to determine more precisely the risks associated with birth weight...
  23. ncbi request reprint Fruit and vegetable intake and risk of cardiovascular disease: the Women's Health Study
    S Liu
    Division of Preventive Medicine and Channing Laboratory, The Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 72:922-8. 2000
    ..Prospective data relating fruit and vegetable intake to cardiovascular disease (CVD) risk are sparse, particularly for women...
  24. ncbi request reprint A prospective study of folate intake and the risk of breast cancer
    S Zhang
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    JAMA 281:1632-7. 1999
    ..Folate is involved in DNA synthesis and methylation and may reduce breast cancer risk, particularly among women with greater alcohol consumption...
  25. ncbi request reprint Vitamin supplement use and the risk of non-Hodgkin's lymphoma among women and men
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 153:1056-63. 2001
    ..Because an elevated risk among multivitamin users was not observed consistently in the two cohorts and the pooled data were not significant, the elevated risk among women may be the result of chance...
  26. ncbi request reprint Trends in the incidence of coronary heart disease and changes in diet and lifestyle in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 343:530-7. 2000
    ..However, the effects of changes in diet and lifestyle on trends in coronary disease are largely unknown...
  27. ncbi request reprint Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 345:790-7. 2001
    ..Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown...
  28. pmc A prospective study of whole-grain intake and risk of type 2 diabetes mellitus in US women
    S Liu
    Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Am J Public Health 90:1409-15. 2000
    ..This study examined the association between intake of whole vs refined grain and the risk of type 2 diabetes mellitus...
  29. ncbi request reprint Intake of fruits and vegetables and risk of breast cancer: a pooled analysis of cohort studies
    S A Smith-Warner
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    JAMA 285:769-76. 2001
    ..CONCLUSION: These results suggest that fruit and vegetable consumption during adulthood is not significantly associated with reduced breast cancer risk...
  30. ncbi request reprint A prospective study of egg consumption and risk of cardiovascular disease in men and women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 281:1387-94. 1999
    ..Reduction in egg consumption has been widely recommended to lower blood cholesterol levels and prevent coronary heart disease (CHD). Epidemiologic studies on egg consumption and risk of CHD are sparse...
  31. ncbi request reprint Smoking and risk of total and fatal prostate cancer in United States health professionals
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 8:277-82. 1999
    ..Our results indicate that although smoking was unrelated to prostate cancer incidence, recent tobacco use had a substantial impact on the occurrence of fatal prostate cancer...
  32. ncbi request reprint Fruit and vegetable intake in relation to risk of ischemic stroke
    K J Joshipura
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    JAMA 282:1233-9. 1999
    ..Few studies have evaluated the relationship between fruit and vegetable intake and cardiovascular disease...
  33. pmc Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976
    J W Rich-Edwards
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    BMJ 315:396-400. 1997
    ..To examine the association between birth weight and non-fatal adult cardiovascular disease while controlling for potential confounders such as socioeconomic group and adult lifestyle...
  34. ncbi request reprint N-acetyl transferase 2 genotypes, meat intake and breast cancer risk
    D M Gertig
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Int J Cancer 80:13-7. 1999
    ..We observed no evidence of differential susceptibility to these exposures by NAT2 genotype...
  35. pmc Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    BMJ 317:1341-5. 1998
    ..To examine the relation between nut consumption and risk of coronary heart disease in a cohort of women from the Nurses' Health Study...
  36. ncbi request reprint Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women
    D Feskanich
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 92:1812-23. 2000
    ..beta-Carotene was hypothesized to be largely responsible for the apparent protective effect, but this hypothesis was not supported by clinical trials...
  37. ncbi request reprint Being breastfed in infancy and breast cancer incidence in adult life: results from the two nurses' health studies
    K B Michels
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 153:275-83. 2001
    ..11 (95% CI: 0.88, 1.39) for women who were breastfed compared with those who were not. Data from these two large cohorts do not support the hypothesis that being breastfed confers protection against subsequent breast cancer...
  38. ncbi request reprint Prospective study of fat and protein intake and risk of intraparenchymal hemorrhage in women
    H Iso
    Channing Laboratory, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Circulation 103:856-63. 2001
    ..The increased risk with low intake of saturated fat and trans unsaturated fat is compatible with the reported association between low serum total cholesterol and risk...
  39. ncbi request reprint Physical activity and risk for cardiovascular events in diabetic women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Ann Intern Med 134:96-105. 2001
    ..Increased physical activity has been associated with reduced risk for cardiovascular disease in the general population, but data are limited on its role among persons with type 2 diabetes mellitus...
  40. ncbi request reprint Dietary glycemic load assessed by food-frequency questionnaire in relation to plasma high-density-lipoprotein cholesterol and fasting plasma triacylglycerols in postmenopausal women
    S Liu
    Division of Preventive Medicine and the Channing Laboratory, The Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 73:560-6. 2001
    ..In epidemiologic studies, dietary glycemic load (GL) is positively associated with risk of coronary artery disease and type 2 diabetes...
  41. ncbi request reprint Prospective study of cataract extraction and risk of coronary heart disease in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 153:875-81. 2001
    ..84, 95% CI: 1.29, 2.64). These findings are compatible with current hypotheses relating oxidative damage and tissue aging to the development of cataract and CHD...
  42. ncbi request reprint Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts
    D S Michaud
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:429-37. 2001
    ..Data from these two large cohorts do not support any overall association between coffee intake or alcohol intake and risk of pancreatic cancer...
  43. ncbi request reprint A prospective study of risk factors for pulmonary embolism in women
    S Z Goldhaber
    Channing Laboratory, Boston, Mass, USA
    JAMA 277:642-5. 1997
    ..To investigate risk factors for pulmonary embolism in women...
  44. ncbi request reprint Intake of vitamins B6 and C and the risk of kidney stones in women
    G C Curhan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 10:840-5. 1999
    ..06 (95% confidence interval, 0.69 to 1.64). Large doses of vitamin B6 may reduce the risk of kidney stone formation in women. Routine restriction of vitamin C to prevent stone formation appears unwarranted...
  45. ncbi request reprint Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women
    F B Hu
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Hospital
    Am J Clin Nutr 70:1001-8. 1999
    ..Metabolic studies suggest that saturated fatty acids differ in their effects on blood lipids...
  46. ncbi request reprint Whole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study
    S Liu
    Division of Preventive Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 70:412-9. 1999
    ..Although current dietary guidelines for Americans recommend increased intake of grain products to prevent coronary heart disease (CHD), epidemiologic data relating whole-grain intake to the risk of CHD are sparse...
  47. ncbi request reprint A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women
    J E Manson
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 341:650-8. 1999
    ..The role of walking, as compared with vigorous exercise, in the prevention of coronary heart disease remains controversial, and data for women on this topic are sparse...
  48. ncbi request reprint Recreational physical activity and the risk of cholecystectomy in women
    M F Leitzmann
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 341:777-84. 1999
    ..Physical activity may be an important determinant of the risk of gallstone disease in women, both independently and as a result of its role in maintaining body weight...
  49. ncbi request reprint A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men
    M F Leitzmann
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 281:2106-12. 1999
    ..Coffee has several metabolic effects that could reduce the risk of gallstone formation...
  50. ncbi request reprint Prospective study of dietary fat and the risk of age-related macular degeneration
    E Cho
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 73:209-18. 2001
    ..The relation between intakes of total fat and specific types of fat and age-related macular degeneration (AMD) remains unclear...
  51. ncbi request reprint Blood donations and risk of coronary heart disease in men
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 103:52-7. 2001
    ..In experimental animals, iron overload appears to promote atherosclerosis and ischemic myocardial damage, but the results of epidemiological studies that relate iron stores to risk of coronary heart disease (CHD) have been inconsistent...
  52. ncbi request reprint Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men
    F B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 161:1542-8. 2001
    ..Television (TV) watching, a major sedentary behavior in the United States, has been associated with obesity. We hypothesized that prolonged TV watching may increase risk for type 2 diabetes...
  53. ncbi request reprint Snoring and risk of cardiovascular disease in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 35:308-13. 2000
    ..To examine prospectively the association between snoring and incidence of cardiovascular disease (CVD) in women...
  54. ncbi request reprint Fluid intake and the risk of bladder cancer in men
    D S Michaud
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 340:1390-7. 1999
    ..The data on fluid intake in relation to the risk of bladder cancer are inconclusive...
  55. ncbi request reprint Birth weight and adult hypertension and obesity in women
    G C Curhan
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 94:1310-5. 1996
    ..Low birth weight has been associated with an increased risk of hypertension, and high birth weight has been associated with increased adult body mass index. Published studies on adults have included only a small number of women...
  56. ncbi request reprint Long-term nutrient intake and early age-related nuclear lens opacities
    P F Jacques
    Laboratory for Nutrition and Vision, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arch Ophthalmol 119:1009-19. 2001
    ..CONCLUSION: These results provide additional evidence that antioxidant nutrients play a role in the prevention of age-related nuclear lens opacities...
  57. pmc Magnesium intake, plasma C-peptide, and colorectal cancer incidence in US women: a 28-year follow-up study
    X Zhang
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 401 Park Drive, Boston, MA 02115, USA
    Br J Cancer 106:1335-41. 2012
    ..Laboratory studies suggest a possible role of magnesium intake in colorectal carcinogenesis but epidemiological evidence is inconclusive...
  58. ncbi request reprint Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 282:1433-9. 1999
    ..Although many studies suggest that physical activity may reduce risk of type 2 diabetes, the role of moderate-intensity activity such as walking is not well understood...
  59. ncbi request reprint Risk of ovarian carcinoma and consumption of vitamins A, C, and E and specific carotenoids: a prospective analysis
    K M Fairfield
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer 92:2318-26. 2001
    ..Antioxidant vitamins may decrease risk of cancer by limiting oxidative DNA damage leading to cancer initiation. Few prospective studies have assessed relations between antioxidant vitamins and ovarian carcinoma...
  60. ncbi request reprint Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Ann Intern Med 130:963-70. 1999
    ..Antioxidants increase the resistance of low-density lipoprotein to oxidation and may thereby reduce risk for atherosclerosis...
  61. ncbi request reprint Prospective study of zinc intake and the risk of age-related macular degeneration
    E Cho
    Departments of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Epidemiol 11:328-36. 2001
    ..Zinc is found in high concentrations in the retina and is hypothesized to reduce the risk of age-related macular degeneration (AMD). Any long-term benefit associated with dietary zinc intake has not been evaluated...
  62. ncbi request reprint A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 58:3307-11. 1998
    ..02). These prospective data, which need to be confirmed in other studies, suggest that polymorphisms in the NAT genes confer differential susceptibility to the effect of red meat consumption on colorectal cancer risk...
  63. ncbi request reprint Racial variation in prostate cancer incidence and in hormonal system markers among male health professionals
    E A Platz
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 92:2009-17. 2000
    ..Whether differences in the distribution of known or suspected risk factors among racial groups explain this variation is unknown...
  64. ncbi request reprint Racial variation in insulin-like growth factor-1 and binding protein-3 concentrations in middle-aged men
    E A Platz
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 8:1107-10. 1999
    ..Although differences in circulating IGF-1 do not seem to account for the greater prostate cancer risk among African-American men, their absolute lower levels of IGFBP-3 may be contributory...
  65. ncbi request reprint Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk
    T T Fung
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    Am J Clin Nutr 73:61-7. 2001
    ..Although the effects of individual foods or nutrients on the development of diseases and their risk factors have been investigated in many studies, little attention has been given to the effect of overall dietary patterns...
  66. ncbi request reprint Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 69:890-7. 1999
    ..Experimental studies in laboratory animals and humans suggest that alpha-linolenic acid (18:3n-3) may reduce the risk of arrhythmia...
  67. ncbi request reprint Physical activity and breast cancer risk in a cohort of young women
    B Rockhill
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Natl Cancer Inst 90:1155-60. 1998
    ..Increased physical activity has been hypothesized to be a means of breast cancer prevention. We examined the associations between physical activity at two different times in life and breast cancer risk...
  68. ncbi request reprint Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 57:75-80. 2001
    ..Antioxidant nutrients may reduce the risk of MS. In a recent case-control study, vitamin C intake was significantly inversely associated with MS risk among women. However, no prospective data are available...
  69. ncbi request reprint Intakes of fruits, vegetables, and related nutrients and the risk of non-Hodgkin's lymphoma among women
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:477-85. 2000
    ..Higher intake of vegetables, particularly cruciferous vegetables, may reduce the risk of non-Hodgkin's lymphoma among women...
  70. ncbi request reprint Dietary fat intake and risk of type 2 diabetes in women
    J Salmeron
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston 02115, USA
    Am J Clin Nutr 73:1019-26. 2001
    ..The long-term relations between specific types of dietary fat and risk of type 2 diabetes remain unclear...
  71. ncbi request reprint Prospective study of alcohol consumption and the risk of age-related macular degeneration
    E Cho
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    Arch Ophthalmol 118:681-8. 2000
    ..To describe the relationship between alcohol consumption and the incidence of age-related macular degeneration (AMD)...
  72. ncbi request reprint A prospective study of passive smoking and coronary heart disease
    I Kawachi
    Channing Laboratory, Boston, MA 02115, USA
    Circulation 95:2374-9. 1997
    ..Additionally, several studies have been unable to control for the full range of potential confounding factors. We examined prospectively the relationship of passive smoking with risk of CHD in a cohort of women...
  73. ncbi request reprint Diet and cancer: one view at the start of the millennium
    W C Willett
    Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:3-8. 2001
    ....
  74. ncbi request reprint Risk of bladder cancer by geographic region in a U.S. cohort of male health professionals
    D S Michaud
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 12:719-26. 2001
    ..77, 95% CI = 1.15-2.71, adjusted for smoking). Diet and other known characteristics do not appear to be responsible for the regional variations in bladder cancer rates in the United States...
  75. ncbi request reprint Fruit and vegetable consumption and colorectal cancer incidence
    K B Michels
    Harvard University, Boston, MA, USA
    IARC Sci Publ 156:139-40. 2002
  76. pmc Oral contraceptive use and risk of melanoma in premenopausal women
    D Feskanich
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Br J Cancer 81:918-23. 1999
    ..Further research is needed to determine whether low-dose oestrogen pills in particular are associated with an increase in risk and to describe possible interactions between OC use and sun exposure or other risk factors for melanoma...
  77. ncbi request reprint Dietary patterns and the risk of coronary heart disease in women
    T T Fung
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Arch Intern Med 161:1857-62. 2001
    ..Although substantial information on individual nutrients or foods and risk of coronary heart disease (CHD) is available, little is known about the role of overall eating pattern...
  78. ncbi request reprint The effect of fruit and vegetable intake on risk for coronary heart disease
    K J Joshipura
    Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Ann Intern Med 134:1106-14. 2001
    ..CONCLUSIONS: Consumption of fruits and vegetables, particularly green leafy vegetables and vitamin C-rich fruits and vegetables, appears to have a protective effect against coronary heart disease...
  79. pmc Aspirin use and lung cancer in men
    C N Holick
    Department of Nutrition, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Br J Cancer 89:1705-8. 2003
    ..64), and results remained null when consistent use of aspirin over time was examined. These findings do not suggest that regular aspirin use is associated with a reduced lung cancer risk...
  80. pmc Bidi and cigarette smoking and risk of acute myocardial infarction among males in urban India
    T Rastogi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Tob Control 14:356-8. 2005
    ..1 (95% CI 4.7 to 17.7) and 8.1 (95% CI 4.3 to 15.3), respectively. It is estimated that smoking may cause 53% (95% CI 47% to 64%) of MIs among urban males in India...
  81. ncbi request reprint A prospective study of dairy foods intake and anovulatory infertility
    J E Chavarro
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Hum Reprod 22:1340-7. 2007
    ..Yet, few studies have been conducted in humans and their results are inconsistent. We evaluated whether intake of dairy foods was associated with anovulatory infertility and whether this association differed according to fat content...
  82. pmc A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility
    J E Chavarro
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Eur J Clin Nutr 63:78-86. 2009
    ..To evaluate whether the amount or quality of carbohydrate in diet is associated with ovulatory infertility...
  83. ncbi request reprint A longitudinal study of infant feeding and obesity throughout life course
    K B Michels
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Int J Obes (Lond) 31:1078-85. 2007
    ..We evaluated the relation between infant feeding and the development of overweight and obesity throughout life course...
  84. doi request reprint Health effects of trans-fatty acids: experimental and observational evidence
    D Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Clin Nutr 63:S5-21. 2009
    ..As part of the World Health Organization (WHO) Scientific Update on TFA, we reviewed the evidence for effects of TFA consumption on coronary heart disease (CHD)...
  85. ncbi request reprint A prospective study of the relationship between body mass index and cataract extraction among US women and men
    J M Weintraub
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Int J Obes Relat Metab Disord 26:1588-95. 2002
    ..Obesity may influence several physiologic processes involved in cataract formation such as oxidative stress, glycosylation and osmotic stress...
  86. ncbi request reprint Processed meat intake and incidence of Type 2 diabetes in younger and middle-aged women
    M B Schulze
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetologia 46:1465-73. 2003
    ..The aim of this study was to investigate the association between processed and other meat intake and incidence of Type 2 diabetes in a large cohort of women...
  87. ncbi request reprint Physical activity and risk of stroke in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115
    JAMA 283:2961-7. 2000
    ..Persuasive evidence has demonstrated that increased physical activity is associated with substantial reduction in risk of coronary heart disease. However, the role of physical activity in the prevention of stroke is less well established...
  88. ncbi request reprint Types of dietary fat and breast cancer: a pooled analysis of cohort studies
    S A Smith-Warner
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Int J Cancer 92:767-74. 2001
    ....
  89. ncbi request reprint Whole grain consumption and risk of ischemic stroke in women: A prospective study
    S Liu
    Division of Preventive Medicine, Bringham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 284:1534-40. 2000
    ..Although increased intake of grain products has been recommended to prevent cardiovascular disease (CVD), prospective data examining the relation of whole grain intake to risk of ischemic stroke are sparse, especially among women...
  90. pmc Polymorphic repeat in AIB1 does not alter breast cancer risk
    C A Haiman
    Channing Laboratory, Department of Medicine, Harvard School of Public Health, 191 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 2:378-85. 2000
    ..These findings suggest that AIB1 repeat genotype does not influence postmenopausal breast cancer risk among Caucasian women in the general population...
  91. ncbi request reprint A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women
    I Baik
    Harvard School of Public Health, Department of Nutrition, 665 Huntington Ave, Bldg 2, Room 329, Boston, MA 02115, USA
    Arch Intern Med 160:3082-8. 2000
    ..We examined the associations of age, smoking status, body mass index (BMI), weight change during adulthood, physical activity, and alcohol intake with risk of CAP among men and women...
  92. ncbi request reprint Prospective study of body mass index, weight change, and risk of adult-onset asthma in women
    C A Camargo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Arch Intern Med 159:2582-8. 1999
    ....
  93. ncbi request reprint Relationship of a large weight loss to long-term weight change among young and middle-aged US women
    A E Field
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Int J Obes Relat Metab Disord 25:1113-21. 2001
    ..To assess the prevalence of clinically significant weight loss among women and whether this is associated with smaller long-term weight gains...
  94. ncbi request reprint Prospective study of oral contraceptives and hypertension among women in the United States
    L Chasan-Taber
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 94:483-9. 1996
    ..However, neither the responsible hormone in the oral contraceptive nor particular subgroups of women who might be susceptible to the hypertensive effect of oral contraceptives have been identified...
  95. ncbi request reprint Prospective study of calcium channel blocker use, cardiovascular disease, and total mortality among hypertensive women: the Nurses' Health Study
    K B Michels
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass 02115 USA
    Circulation 97:1540-8. 1998
    ..We explored these associations in the Nurses' Health Study...
  96. ncbi request reprint Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus
    C G Solomon
    Division of Women s Health, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 286:2421-6. 2001
    ..Although oligomenorrhea has been associated cross-sectionally with insulin resistance and glucose intolerance, it is not known whether oligomenorrhea is a marker for increased future risk of type 2 diabetes mellitus (DM)...
  97. ncbi request reprint Abdominal adiposity and coronary heart disease in women
    K M Rexrode
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02215, USA
    JAMA 280:1843-8. 1998
    ..Obesity is a well-established risk factor for coronary heart disease (CHD), but whether regional fat distribution contributes independently to risk remains unclear...
  98. ncbi request reprint Alcohol consumption and risk of coronary heart disease among men with type 2 diabetes mellitus
    M Tanasescu
    Nutrition, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 38:1836-42. 2001
    ..The goal of this study was to examine the relationship between alcohol intake and risk of coronary heart disease (CHD) among men with type 2 diabetes...
  99. pmc Stress and suicide in the Nurses' Health Study
    D Feskanich
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Epidemiol Community Health 56:95-8. 2002
    ..This study examined prospectively the associations between self perceived stress, diazepam use, and death from suicide among adult women...
  100. ncbi request reprint Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers
    K B Michels
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 92:1740-52. 2000
    ..Frequent consumption of fruit and vegetables has been associated with a reduced risk of colorectal cancer in many observational studies...
  101. ncbi request reprint Intake of fish and omega-3 fatty acids and risk of stroke in women
    H Iso
    Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave, Third Floor, Boston, MA 02215, USA
    JAMA 285:304-12. 2001
    ....