Research Topics
| Sabine WilhelmSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Motor inhibition in trichotillomania and obsessive-compulsive disorderAntje Bohne
Massachusetts General Hospital Harvard Medical School, OCD Clinic, Simches Research Building, 2nd Floor, 185 Cambridge Street, Boston, MA 02114, USA
J Psychiatr Res 42:141-50. 2008..There was no evidence for motor inhibition deficits in OCD. Based on our data, a subgroup of TTM sufferers seems to be characterized by motor inhibition deficits...
Randomized trial of behavior therapy for adults with Tourette syndromeSabine Wilhelm
Massachusetts General Hospital Harvard Medical School, Boston, 02114, USA
Arch Gen Psychiatry 69:795-803. 2012..Medications for tics are often effective but can cause adverse effects. Behavior therapy may offer an alternative but has not been examined in a large-scale controlled trial in adults...- Habit reversal versus supportive psychotherapy for Tourette's disorder: a randomized controlled trialSabine Wilhelm
Massachusett General Hospital, MA 02129, USA
Am J Psychiatry 160:1175-7. 2003..The authors investigated the efficacy of habit reversal for Tourette's disorder, which is characterized by multiple motor and vocal tics... - Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorderSabine Wilhelm
Obsessive Compulsive Disorder Clinic, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 165:335-41; quiz 409. 2008..This study examined whether d-cycloserine, a partial agonist at the N-methyl-D-aspartate (NMDA) glutamatergic receptor, enhances the efficacy of behavior therapy for obsessive-compulsive disorder (OCD)... - Challenges in treating obsessive-compulsive disorder: introductionSabine Wilhelm
Department of Psychiatry, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
J Clin Psychol 60:1127-32. 2004..The final article describes pharmacotherapy for OCD. All articles feature case vignettes and provide practitioners with clinical recommendations... - Prevalence of body dysmorphic disorder in patients with anxiety disordersS Wilhelm
OCD Clinic and Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
J Anxiety Disord 11:499-502. 1997..In all cases, onset of social phobia preceded onset of BDD. Our findings draw attention to the prevalence of BDD in patients with social phobia. The potential etiologic significance of our findings is discussed... 
Modular cognitive-behavioral therapy for body dysmorphic disorderSabine Wilhelm
Massachusetts General Hospital, Boston, MA 02114, USA
Behav Ther 42:624-33. 2011..To our knowledge, this represents the first test of a broadly applicable, individual psychosocial treatment for BDD...- Cognitive behavior group therapy for body dysmorphic disorder: a case seriesS Wilhelm
Massachusetts General Hospital, Charlestown, USA
Behav Res Ther 37:71-5. 1999..This finding adds to a nascent literature documenting the potential efficacy of short-term cognitive-behavior therapy for patients suffering from BDD... - Self-injurious skin picking: clinical characteristics and comorbidityS Wilhelm
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
J Clin Psychiatry 60:454-9. 1999..The authors examined the demographics, phenomenology, and associated psychopathology in a series of 31 subjects with this problem... - Role of medial cortical networks for anticipatory processing in obsessive-compulsive disorderKristina T Ciesielski
Department of Radiology, MGH MIT HMS A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and McLean Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
Hum Brain Mapp 33:2125-34. 2012.... - Visuospatial abilities, memory, and executive functioning in trichotillomania and obsessive-compulsive disorderAntje Bohne
Massachusetts General Hospital/Harvard Medical School, OCD Clinic, Charlestown, MA 02129, USA
J Clin Exp Neuropsychol 27:385-99. 2005..Other executive functions, as well as memory and visuospatial abilities were unimpaired in TTM and OCD. Our data suggest that TTM and OCD are characterized by different patterns of neuropsychological dysfunction... - Cognitive retraining for organizational impairment in obsessive-compulsive disorderUlrike Buhlmann
Department of Psychiatry OCD Clinic, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
Psychiatry Res 144:109-16. 2006..These findings support a distinction in OCD between failure to utilize a strategy and incapacity to implement a strategy... - Prevalence of symptoms of body dysmorphic disorder and its correlates: a cross-cultural comparisonAntje Bohne
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Psychosomatics 43:486-90. 2002..Body image concerns and preoccupation were significantly greater in American than in German students, although the prevalence of probable body dysmorphic disorder was not... - Skin picking in German students. Prevalence, phenomenology, and associated characteristicsAntje Bohne
Massachusetts General Hospital, Harvard Medical School, USA
Behav Modif 26:320-39. 2002..6%). About 20% (n = 26) ate the picked tissue afterward. Results suggest SP is an underrecognized problem that occurs on a continuum ranging from mild to severe with generally stable clinical characteristics across cultures... - Open-label escitalopram treatment for pathological skin pickingNancy J Keuthen
Massachusetts General Hospital Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
Int Clin Psychopharmacol 22:268-74. 2007..These results suggest that escitalopram can be an effective agent in reducing pathological skin picking. The lack of medication response in a subset of our sample suggests the possibility of pathological skin picking subtypes... - Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorderScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Biol Psychiatry 61:330-6. 2007..Here, we used the SRT and functional magnetic resonance imaging (fMRI) to replicate prior results in a larger sample and to test for relationships between regional activation and OCD symptom dimensions... - Need for speed: evaluating slopes of OCD recovery in behavior therapy enhanced with d-cycloserineGregory S Chasson
Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Behav Res Ther 48:675-9. 2010..Ultimately, DCS may provide a means for curtailing treatment costs, decreasing treatment dropout and refusal rates, and enhancing access to care... - Predictors of treatment outcome in modular cognitive therapy for obsessive-compulsive disorderGail Steketee
Boston University Schoolof Social Work, 264 Bay State Road, Boston, MA 02215, USA
Depress Anxiety 28:333-41. 2011..The present study sought to identify predictors of outcome for a comprehensive cognitive therapy (CT) developed for patients with obsessive-compulsive disorder (OCD)... - Cognitive-behavior therapy for self-injurious skin picking. A case seriesThilo Deckersbach
Harvard Medical School, Cognitive-Behavior Therapy Program, Obsessive-Compulsive Disorder Clinic, Psychiatric Neuroscience Program, Massachusetts General Hospital, USA
Behav Modif 26:361-77. 2002..In the current article, the authors describe the implementation and outcome of cognitive-behavior therapy for three patients with severe self-injurious skin picking, two of which had psychiatric comorbidity... - Comorbid posttraumatic stress disorder: impact on treatment outcome for obsessive-compulsive disorderBeth S Gershuny
OCD Clinic and Research Unit, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, 02129, USA
Am J Psychiatry 159:852-4. 2002..The study tested the effect of comorbid posttraumatic stress disorder (PTSD) on behavior therapy outcome for obsessive-compulsive disorder (OCD)... - Cognitive inhibition in trichotillomania and obsessive-compulsive disorderAntje Bohne
Massachusetts General Hospital, Harvard Medical School, OCD Clinic, 9th Floor, 149 Thirteenth Street, Charlestown, MA 02129, USA
Behav Res Ther 43:923-42. 2005..In conclusion, although attention was disproportionately directed towards negative information in both disorders, cognitive inhibition deficits appeared specific to OCD... - Prevalence of body dysmorphic disorder in a German college student sampleAntje Bohne
Massachusetts General Hospital-East/Harvard Medical School, OCD Clinic, 149 Thirteenth Street, Charlestown, MA 02129, USA
Psychiatry Res 109:101-4. 2002..One student with BDD also reported severe skin picking. In conclusion, BDD is a common psychiatric disorder in college students... - The relationship between perceived social support and severity of body dysmorphic disorder symptoms: the role of genderLuana Marques
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Rev Bras Psiquiatr 33:238-44. 2011..To address this gap in the literature, the present study aims to examine the association between three domains of perceived social support (i.e., family, friends, and significant others) and severity of body dysmorphic disorder symptoms... - Habit reversal versus supportive psychotherapy in Tourette's disorder: a randomized controlled trial and predictors of treatment responseThilo Deckersbach
OCD Clinic Psychiatric Neuroscience Division, Department of Psychiatry, 149 2611, Massachusetts General Hospital, Charlestown, MA 02129, USA
Behav Res Ther 44:1079-90. 2006..Assessments of response inhibition may be of value for predicting treatment response to HR... - Facial attractiveness ratings and perfectionism in body dysmorphic disorder and obsessive-compulsive disorderUlrike Buhlmann
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
J Anxiety Disord 22:540-7. 2008..These findings mostly support cognitive-behavioral models of BDD that suggest that individuals with BDD exhibit perfectionistic thinking and maladaptive attractiveness beliefs... - Correlates of quality of life and functional disability in individuals with body dysmorphic disorderLuana Marques
Massachusetts General Hospital Department of Psychiatry and Harvard Medical School, Boston, MA 02114, USA
Psychosomatics 52:245-54. 2011..The present study was designed to examine sociodemographic and clinical correlates of quality of life and disability (work, social, and family) in a sample of individuals with moderately severe BDD symptoms... - Dissociation between MEG alpha modulation and performance accuracy on visual working memory task in obsessive compulsive disorderKristina T Ciesielski
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Hum Brain Mapp 28:1401-14. 2007.... - Reality monitoring in patients with body dysmorphic disorderHannah E Reese
Harvard University, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Behav Ther 42:387-98. 2011..The results suggest that impairments in reality monitoring do not contribute to the development or maintenance of appearance-related beliefs in BDD... - Clinical considerations for the treatment of body dysmorphic disorder with cognitive-behavioral therapyUlrike Buhlmann
Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Body Image 5:39-49. 2008..The aim of this review is to provide a treatment aid to clinicians by offering specific recommendations for improved care based on the available literature as well as our clinical experience... - A study of parallel implicit and explicit information processing in patients with obsessive-compulsive disorderThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital-East, Building 149, 13th Street, 9th Floor, Charlestown, MA 02129, USA
Am J Psychiatry 159:1780-2. 2002..CONCLUSIONS: These results are consistent with the hypothesis that concurrent explicit and implicit information-processing demands interfere with implicit learning in OCD patients... - A diffusion tensor imaging study of white matter in obsessive-compulsive disorderPaul A Cannistraro
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Depress Anxiety 24:440-6. 2007..This could explain why surgically severing these tracts is therapeutic. Additional studies are needed to replicate these findings and to clarify their pathological and clinical significance... - Body dysmorphic disorder and obsessive-compulsive disorder: similarities, differences and the classification debateAnne Chosak
OCD and Related Disorders Program, Simches Research Building, Massachusetts General Hospital, 185 Cambridge Street, Boston MA 02114, USA
Expert Rev Neurother 8:1209-18. 2008..This article describes the association between obsessive-compulsive disorder and body dysmorphic disorder as evidenced by the emerging literature, and presents theoretical and clinical implications of this association... - Emotion recognition bias for contempt and anger in body dysmorphic disorderUlrike Buhlmann
Body Dysmorphic Disorder Clinic, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Psychiatr Res 40:105-11. 2006..Perceiving others as rejecting might reinforce concerns about one's personal perceived ugliness and social desirability... - Is age at symptom onset associated with severity of memory impairment in adults with obsessive-compulsive disorder?A Henin
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129 2060, USA
Am J Psychiatry 158:137-9. 2001..Age at onset is a potentially important marker for neurobiological features of obsessive-compulsive disorder (OCD). This study examined the relationship between age at symptom onset and memory impairment in adults with OCD... - The prevalence of body dysmorphic disorder: a population-based surveyWinfried Rief
Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
Psychol Med 36:877-85. 2006..Well designed studies on its prevalence and on base rates for diagnostic criteria are rare. Therefore this study aimed to reveal prevalence rates of BDD in the general population and to examine clinical features associated with BDD... - Treatment utilization and barriers to treatment engagement among people with body dysmorphic symptomsLuana Marques
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Psychosom Res 70:286-93. 2011..The present study sought to examine rates and patterns of treatment utilization as well as barriers to treatment among individuals with body dysmorphic symptoms... - Body dysmorphic symptoms: phenomenology and ethnicityLuana Marques
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Body Image 8:163-7. 2011..Although most clinical features of BDD appear similar across ethnic groups, results showed some differences in body parts and behaviors between Caucasians and Asian Americans with BDD symptoms... - Amygdala responses to human faces in obsessive-compulsive disorderPaul A Cannistraro
Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital, Building 149, Thirteenth Street, Charlestown, MA 02129, USA
Biol Psychiatry 56:916-20. 2004..Therefore, the present findings are consistent with abnormal amygdala function in OCD and are of a character that may distinguish OCD from other anxiety disorders... - Physiologic responses to loud tones in individuals with obsessive-compulsive disorderUlrike Buhlmann
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Psychosom Med 69:166-72. 2007..To determine if individuals with obsessive-compulsive disorder (OCD) are characterized by larger eyeblink and/or autonomic responses to sudden, loud (startling) tones... - Selective processing of emotional information in body dysmorphic disorderUlrike Buhlmann
University of Marburg, Germany
J Anxiety Disord 16:289-98. 2002..Results suggest that BDD may indeed be related to anxiety disorders such as social phobia... - Facial asymmetry detection in patients with body dysmorphic disorderHannah E Reese
Harvard University, Cambridge, MA, USA
Behav Res Ther 48:936-40. 2010..Taken together, our results do not support a heightened perceptual ability or evaluative preference for symmetry among individuals with BDD... - The Skin Picking Impact Scale (SPIS): scale development and psychometric analysesN J Keuthen
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129 2060, USA
Psychosomatics 42:397-403. 2001..Sensitivity and specificity analyses indicate that a scale cutoff score of 7 optimally discriminates individuals with self-injurious skin picking from those with non-self-injurious skin picking... - The Skin Picking Scale: scale construction and psychometric analysesN J Keuthen
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129 2060, USA
J Psychosom Res 50:337-41. 2001..This paper reports on the development of the Skin Picking Scale (SPS), a six-item paper-and-pencil measure for the assessment of skin picking... - Strategic processing and episodic memory impairment in obsessive compulsive disorderC R Savage
Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129 2060, USA
Neuropsychology 14:141-51. 2000..Therefore, verbal and nonverbal episodic memory deficits in OCD are affected by impaired strategic processing. Results are consistent with neurobiological models proposing frontal-striatal system dysfunction in OCD... - Expression of AE2 anion exchanger in mouse intestineS L Alper
Molecular Medicine and Renal Units, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Physiol 277:G321-32. 1999..These localization studies will aid in the interpretation of anion exchanger function measured in epithelial sheets, isolated cells, and membrane vesicles... - Emotion recognition deficits in body dysmorphic disorderUlrike Buhlmann
Department of Psychiatry, OCD Clinic, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, MA 02129, USA
J Psychiatr Res 38:201-6. 2004..Perceiving others as angry and rejecting might reinforce concerns about one's personal ugliness and social desirability... - Barriers to treatment and service utilization in an internet sample of individuals with obsessive-compulsive symptomsLuana Marques
Obsessive Compulsive and Related Disorders Program, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Depress Anxiety 27:470-5. 2010..This study examined rates of treatment utilization and barriers to treatment in an internet sample of individuals with self-reported OCD... - Prevalence of body dysmorphic disorder in a community sample of womenM W Otto
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 158:2061-3. 2001..In a large population-based study, the authors examined the prevalence and correlates of body dysmorphic disorder, a debilitating and chronic condition characterized by an imagined defect in appearance... - Traumatic experiences in individuals with body dysmorphic disorderUlrike Buhlmann
Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
J Nerv Ment Dis 200:95-8. 2012..Surprisingly, there was no significant group difference in reports of emotional abuse in early life. This study provides preliminary evidence of the importance of examining abuse as a potential risk factor in the development of BDD... - Regulation of AE2-mediated Cl- transport by intracellular or by extracellular pH requires highly conserved amino acid residues of the AE2 NH2-terminal cytoplasmic domainA K Stewart
Department of Medicine, Harvard Medical School, Molecular Medicine and Renal Units, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Gen Physiol 120:707-22. 2002..Conserved, individual amino acid residues of the AE2 cytoplasmic domain contribute to independent regulation of anion exchange activity by pH(o) as well as pH(i)... - The cytoplasmic C-terminal fragment of polycystin-1 regulates a Ca2+-permeable cation channelD H Vandorpe
Molecular Medicine and Renal Units, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 276:4093-101. 2001..Dysregulation of these or similar channels in autosomal dominant polycystic kidney disease may contribute to cyst formation or expansion... - Do dysfunctional beliefs play a role in all types of obsessive-compulsive disorder?Steven Taylor
Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
J Anxiety Disord 20:85-97. 2006..These results are consistent with the view that dysfunctional beliefs may play a role in only some types of OCD... - Body dysmorphic disorder: treating an underrecognized disorderKatharine A Phillips
Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
Am J Psychiatry 165:1111-8. 2008 - Severe obsessive-compulsive disorder with and without body dysmorphic disorder: clinical correlates and implicationsS Evelyn Stewart
McLean Hospital Obsessive Compulsive Disorder Institute, Belmont, MA, USA
Ann Clin Psychiatry 20:33-8. 2008..This exploratory study systematically examined prevalence and clinical correlates of Body Dysmorphic Disorder (BDD) comorbidity in an inpatient Obsessive-Compulsive Disorder (OCD) population... - Perceived teasing experiences in body dysmorphic disorderUlrike Buhlmann
Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, United States
Body Image 4:381-5. 2007..The group comprising individuals with BDD reported more appearance- and competency-related teasing than did control participants. This study provides preliminary evidence for the association between perceived teasing and BDD... - Pathologic hairpulling, skin picking, and nail bitingAntje Bohne
Institute of Psychology I, University of Muenster, Muenster, Germany
Ann Clin Psychiatry 17:227-32. 2005..To date, HP, SP, and NB have received little attention in the psychiatric literature despite being widespread behaviors... - No disgust recognition deficit in obsessive-compulsive disorderHolly A Parker
Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA
J Behav Ther Exp Psychiatry 35:183-92. 2004..In light of the deficits exhibited by one subject with severe OCD, disgust recognition deficits may be confined to an unidentified subset of people with OCD... - A critical evaluation of obsessive-compulsive disorder subtypes: symptoms versus mechanismsDean McKay
Department of Psychology, Fordham University, 441 East Fordham Road, Bronx, NY 10458 5198, USA
Clin Psychol Rev 24:283-313. 2004..The research is critically examined and implications for treatment are discussed. Recommendations for future investigations are offered...
Research Grants
- CBT Treatment Development for Body Dysmorphic DisorderSabine Wilhelm; Fiscal Year: 2006..abstract_text> ..
- COGNITIVE THERAPY IN OBSESSSIVE-COMPULSIVE DISORDERSabine Wilhelm; Fiscal Year: 2002..Using a combined sample of 30 patients we will study the influence of a small number of possible predictors of posttest outcome. ..
- Behavior Therapy for Adults with Tourette SyndromeSabine Wilhelm; Fiscal Year: 2009..The Informatics group at Yale University will provide data management services. ..
- Pharmacotherapy Prevention in Body Dysmorphic DisorderSabine Wilhelm; Fiscal Year: 2007..This study will yield unique and clinically important data, and will fill gaps in knowledge about this relatively common, severe, and understudied illness. ..
- Pharmacotherapy Relapse Prevention in Body Dysmorphic DisorderSabine Wilhelm; Fiscal Year: 2009..This study will yield unique and clinically important data, and will fill gaps in knowledge about this relatively common, severe, and understudied illness. ..