Affiliation: Harvard University
Khawaja A, Cooke Bailey J, Wareham N, Scott R, Simcoe M, Igo R, et al
. Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nat Genet. 2018;50:778-782 pubmed publisher
..76 in US NEIGHBORHOOD study participants and 0.74 in independent glaucoma cases from the UK Biobank. Genetic-prediction models for POAG offer an opportunity to target screening and timely therapy to individuals most at risk. ..
Loomis S, Kang J, Weinreb R, Yaspan B, Cooke Bailey J, Gaasterland D, et al
. Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss. Ophthalmology. 2014;121:508-16 pubmed publisher
..These data support a role for caveolin 1, caveolin 2, or both in POAG and suggest that the caveolins particularly may affect POAG pathogenesis in women and in patients with early paracentral VF defects. ..
Fan B, Pasquale L, Kang J, Levkovitch Verbin H, Haines J, Wiggs J. Association of clusterin (CLU) variants and exfoliation syndrome: An analysis in two Caucasian studies and a meta-analysis. Exp Eye Res. 2015;139:115-22 pubmed publisher
..006, I(2)Â =Â 87%). Our results suggest that common CLU variants may contribute to modest XFS risk but even larger datasets are required to confirm these findings. ..
Wiggs J, Hauser M, Abdrabou W, ALLINGHAM R, Budenz D, DelBono E, et al
. The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables. J Glaucoma. 2013;22:517-25 pubmed publisher
..In this report we describe the formation of the NEIGHBOR consortium, the harmonized case control definitions used for a POAG GWAS, the clinical features of the cases and controls, and the rationale for the GWAS study design. ..
Wiggs J. Glaucoma Genes and Mechanisms. Prog Mol Biol Transl Sci. 2015;134:315-42 pubmed publisher
Wiggs J. Mitochondrial Genetics and Optic Neuropathy. Annu Rev Vis Sci. 2015;1:97-124 pubmed publisher
..Identifying new optic neuropathy-causing genes and defining the role of current and novel genes in disease will be important steps toward the development of effective and potentially neuroprotective therapies. ..
Wiggs J. Association Between LOXL1 and pseudoexfoliation. Arch Ophthalmol. 2008;126:420-1 pubmed publisher
Wiggs J, Kang J, Yaspan B, Mirel D, Laurie C, Crenshaw A, et al
. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA. Hum Mol Genet. 2011;20:4707-13 pubmed publisher
..We also present data suggesting that associations with several CAV1/CAV2 SNPs are significant mostly in women. ..
Wiggs J, Yaspan B, Hauser M, Kang J, Allingham R, Olson L, et al
. Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet. 2012;8:e1002654 pubmed publisher
..009). These results suggest that neuro-protective therapies targeting TGF-beta signaling could be effective for multiple forms of glaucoma...