Janey Wiggs

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    J Glaucoma 22:517-25. 2013
  2. pmc The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    PLoS ONE 7:e45613. 2012
  3. pmc Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002654. 2012
  4. pmc DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    BMC Med Genet 9:5. 2008
  5. pmc Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA
    Janey L Wiggs
    Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hum Mol Genet 20:4707-13. 2011
  6. doi request reprint Association Between LOXL1 and pseudoexfoliation
    Janey L Wiggs
    Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 126:420-1. 2008
  7. ncbi request reprint Macular degeneration: risk factors for progression
    Janey L Wiggs
    Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Arch Ophthalmol 125:1264-5. 2007
  8. ncbi request reprint Genetic etiologies of glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
    Arch Ophthalmol 125:30-7. 2007
  9. ncbi request reprint Molecular and clinical evaluation of a patient hemizygous for TIGR/MYOC
    J L Wiggs
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St, Boston, MA 02114
    Arch Ophthalmol 119:1674-8. 2001
  10. ncbi request reprint Genes associated with human glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Ophthalmol Clin North Am 18:335-43, v. 2005

Research Grants

  1. Genetic Studies of Pseudoexfoliation Glaucoma
    Janey Wiggs; Fiscal Year: 2004
  2. LINKAGE STUDY OF JUVENILE GLAUCOMA
    Janey Wiggs; Fiscal Year: 2007
  3. LINKAGE STUDY OF JUVENILE GLAUCOMA
    Janey Wiggs; Fiscal Year: 2003
  4. FAMILIAL PRIMARY OPEN ANGLE GLAUCOMA
    Janey Wiggs; Fiscal Year: 2004
  5. Genetic Etiologies of Primary Open Angle Glaucoma
    Janey Wiggs; Fiscal Year: 2009

Detail Information

Publications27

  1. pmc The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    J Glaucoma 22:517-25. 2013
    ..In this report we describe the formation of the NEIGHBOR consortium, the harmonized case control definitions used for a POAG GWAS, the clinical features of the cases and controls, and the rationale for the GWAS study design. ..
  2. pmc The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    PLoS ONE 7:e45613. 2012
    ..In this study we evaluate the association between a p53 variant functionally known to influence apoptosis (codon 72 Pro/Arg) and the subset of primary open angle glaucoma (POAG) patients with early loss of central visual field...
  3. pmc Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002654. 2012
    ..009). These results suggest that neuro-protective therapies targeting TGF-beta signaling could be effective for multiple forms of glaucoma...
  4. pmc DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    BMC Med Genet 9:5. 2008
    ....
  5. pmc Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA
    Janey L Wiggs
    Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hum Mol Genet 20:4707-13. 2011
    ..We also present data suggesting that associations with several CAV1/CAV2 SNPs are significant mostly in women...
  6. doi request reprint Association Between LOXL1 and pseudoexfoliation
    Janey L Wiggs
    Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 126:420-1. 2008
  7. ncbi request reprint Macular degeneration: risk factors for progression
    Janey L Wiggs
    Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Arch Ophthalmol 125:1264-5. 2007
  8. ncbi request reprint Genetic etiologies of glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
    Arch Ophthalmol 125:30-7. 2007
    ....
  9. ncbi request reprint Molecular and clinical evaluation of a patient hemizygous for TIGR/MYOC
    J L Wiggs
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St, Boston, MA 02114
    Arch Ophthalmol 119:1674-8. 2001
    ..To determine if a patient with an interstitial deletion of chromosome 1 is hemizygous for the TIGR/MYOC gene and if that patient has glaucoma...
  10. ncbi request reprint Genes associated with human glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Ophthalmol Clin North Am 18:335-43, v. 2005
    ..Glaucoma patients who are identified early and treated appropriately have the best chance of maintaining useful sight...
  11. pmc A genomewide scan identifies novel early-onset primary open-angle glaucoma loci on 9q22 and 20p12
    J L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Am J Hum Genet 74:1314-20. 2004
    ..Markers located on chromosomes 9q22 and 20p12 showed evidence for linkage, identifying two novel loci for early-onset open-angle glaucoma...
  12. ncbi request reprint Distribution of optineurin sequence variations in an ethnically diverse population of low-tension glaucoma patients from the United States
    Michael A Hauser
    Center for Human Genetics Duke School of Medicine, Harvard Medical School, Boston, MA 02114, USA
    J Glaucoma 15:358-63. 2006
    ....
  13. doi request reprint Lack of association of polymorphisms in elastin with pseudoexfoliation syndrome and glaucoma
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Glaucoma 19:432-6. 2010
    ..To evaluate the elastin gene (ELN) as a secondary risk factor for pseudoexfoliation syndrome (PXFS) and the associated glaucoma pseudoexfoliation glaucoma (PXFG)...
  14. ncbi request reprint Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma
    Michael A Hauser
    Center for Human Genetics, Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA
    Invest Ophthalmol Vis Sci 47:2542-6. 2006
    ..To determine the distribution of WDR36 sequence variants in a cohort of patients with primary open-angle glaucoma (POAG) in the United States...
  15. pmc The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
    Genet Epidemiol 34:364-72. 2010
    ..By maximizing knowledge obtained through collaborative GWAS incorporating environmental exposure information, GENEVA aims to enhance our understanding of disease etiology, potentially identifying opportunities for intervention...
  16. pmc Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 51:971-9. 2010
    ..To evaluate the association between the nitric oxide synthase gene (NOS3) variants and primary open-angle glaucoma (POAG)...
  17. ncbi request reprint DNA sequence variants in the tyrosinase-related protein 1 (TYRP1) gene are not associated with human pigmentary glaucoma
    Sean Lynch
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA
    Mol Vis 8:127-9. 2002
    ..Abnormalities in the mouse Tyrp1 gene contribute to this condition. The purpose of this study was to determine if DNA sequence variants in the human TYRP1 gene are associated with pigmentary glaucoma in humans...
  18. pmc Feasibility of High-Throughput Genome-Wide Genotyping using DNA from Stored Buccal Cell Samples
    Stephanie J Loomis
    Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Biomark Insights 5:49-55. 2010
    ..7 ng/ul, discordant genotyping calls did not cluster in any particular chromosome. Buccal cell-derived DNA represents a viable alternative to blood DNA for genotyping on a high-density platform...
  19. pmc Glaucoma: genes, phenotypes, and new directions for therapy
    Bao Jian Fan
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:3064-72. 2010
    ..This review summarizes the human genetics and genomic approaches that have shed light on the complex inheritance of glaucoma genes and the potential for gene-based and cellular therapies that this research makes possible...
  20. pmc Lack of association of mutations in optineurin with disease in patients with adult-onset primary open-angle glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    Arch Ophthalmol 121:1181-3. 2003
    ..To determine whether mutations in the optineurin gene contribute to susceptibility to adult-onset primary open-angle glaucoma...
  21. ncbi request reprint Clinical and molecular characterization of a patient with an interstitial deletion of chromosome 12q15-q23 and peripheral corneal abnormalities
    Mary Lillian Tocyap
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Am J Ophthalmol 141:566-567. 2006
    ..To describe the ocular features of a patient with an interstitial deletion of chromosome 12 and to determine the molecular boundaries of the deletion...
  22. ncbi request reprint Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice
    Michael G Anderson
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    Nat Genet 30:81-5. 2002
    ..The fact that hypopigmentation profoundly alleviates the D2 disease indicates that therapeutic strategies designed to decrease pigment production may be beneficial in human pigmentary glaucoma...
  23. pmc Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations
    Yutao Liu
    Center for Human Genetics, Duke University Eye Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 49:3465-8. 2008
    ..The purpose of this study was to investigate whether XFG-associated variants of LOXL1 play a significant role in primary open-angle glaucoma in the Caucasian, African-American, and Ghanaian (West-African) populations...
  24. pmc Early adult-onset POAG linked to 15q11-13 using ordered subset analysis
    R Rand Allingham
    Duke University Eye Center and the Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 46:2002-5. 2005
    ..Ordered subset analysis (OSA) is a recently described method that utilizes the variability of phenotypic traits to determine underlying genetic heterogeneity...
  25. ncbi request reprint No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations
    Yutao Liu
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Mol Vis 13:2137-41. 2007
    ....
  26. pmc Investigation of founder effects for the Thr377Met Myocilin mutation in glaucoma families from differing ethnic backgrounds
    Alex W Hewitt
    Department of Ophthalmology, Flinders University, Adelaide, Australia
    Mol Vis 13:487-92. 2007
    ..The aim of this study was to determine if there is a common founder for the Thr377Met myocilin mutation in primary open angle glaucoma (POAG) families with various ethnic backgrounds...
  27. ncbi request reprint Complement factor H and macular degeneration: the genome yields an important clue
    Janey L Wiggs
    Arch Ophthalmol 124:577-8. 2006

Research Grants24

  1. Genetic Studies of Pseudoexfoliation Glaucoma
    Janey Wiggs; Fiscal Year: 2004
    ....
  2. LINKAGE STUDY OF JUVENILE GLAUCOMA
    Janey Wiggs; Fiscal Year: 2007
    ..3) Screen candidate genes located in the RIEG2 region on chromosome 13q14. 4) Correlate mutations in genes known to cause glaucoma with clinical phenotypes. ..
  3. LINKAGE STUDY OF JUVENILE GLAUCOMA
    Janey Wiggs; Fiscal Year: 2003
    ..Newly ascertained pedigrees will be used for further studies to confirm existing loci, to identify new loci and to correlate specific genetic defects with important aspects of the clinical phenotype. ..
  4. FAMILIAL PRIMARY OPEN ANGLE GLAUCOMA
    Janey Wiggs; Fiscal Year: 2004
    ..Initial genome screens to identify genes responsible for two POAG risk factors, ocular hypertension (OHT) and pseudoexfoliation (PEX), will be performed. ..
  5. Genetic Etiologies of Primary Open Angle Glaucoma
    Janey Wiggs; Fiscal Year: 2009
    ..Specific genetic defects will be correlated with clinical phenotype by investigating familial aggregation of clinical parameters and looking for evidence of gene/gene interactions and how these interactions may influence phenotype. ..