James B Whitney

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Evolutionary mechanisms of retroviral persistence
    James B Whitney
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    AIDS Rev 13:234-9. 2011
  2. pmc Impaired RNA incorporation and dimerization in live attenuated leader-variants of SIVmac239
    James B Whitney
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada
    Retrovirology 3:96. 2006
  3. pmc Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV
    James B Whitney
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Immune Based Ther Vaccines 9:2. 2011
  4. pmc Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genome
    James B Whitney
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada
    Retrovirology 4:44. 2007
  5. pmc Genital tract sequestration of SIV following acute infection
    James B Whitney
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    PLoS Pathog 7:e1001293. 2011
  6. pmc T-cell vaccination reduces simian immunodeficiency virus levels in semen
    James B Whitney
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Virol 83:10840-3. 2009
  7. pmc The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys
    Wendy W Yeh
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Virol 85:10389-98. 2011
  8. pmc Autologous neutralizing antibodies to the transmitted/founder viruses emerge late after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys
    Wendy W Yeh
    Division of Viral Pathogenesis, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Virol 84:6018-32. 2010
  9. pmc Monitoring HIV vaccine trial participants for primary infection: studies in the SIV/macaque model
    James B Whitney
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    AIDS 23:1453-60. 2009
  10. pmc In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes
    Mohammed Asmal
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e48234. 2012

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Evolutionary mechanisms of retroviral persistence
    James B Whitney
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    AIDS Rev 13:234-9. 2011
    ..Understanding the dynamic mechanisms that contribute to the establishment and maintenance of retroviral persistence is critical toward the goal of attaining HIV-1 eradication...
  2. pmc Impaired RNA incorporation and dimerization in live attenuated leader-variants of SIVmac239
    James B Whitney
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada
    Retrovirology 3:96. 2006
    ..We also assessed the impact of these deletions upon viral infectiousness, replication kinetics and gene expression in cell lines and monkey peripheral blood mononuclear cells (PBMC)...
  3. pmc Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV
    James B Whitney
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Immune Based Ther Vaccines 9:2. 2011
    ..abstract:..
  4. pmc Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genome
    James B Whitney
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada
    Retrovirology 4:44. 2007
    ..These findings indicate that viral reversion that overcomes a genetic bottleneck is not limited to a single pathway, and illustrates the remarkable adaptability of lentiviruses...
  5. pmc Genital tract sequestration of SIV following acute infection
    James B Whitney
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    PLoS Pathog 7:e1001293. 2011
    ..These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves...
  6. pmc T-cell vaccination reduces simian immunodeficiency virus levels in semen
    James B Whitney
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Virol 83:10840-3. 2009
    ..A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS...
  7. pmc The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys
    Wendy W Yeh
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Virol 85:10389-98. 2011
    ..In addition, we used our understanding of TRIM5 to establish a novel nonhuman primate penile transmission model for AIDS mucosal pathogenesis and vaccine research...
  8. pmc Autologous neutralizing antibodies to the transmitted/founder viruses emerge late after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys
    Wendy W Yeh
    Division of Viral Pathogenesis, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Virol 84:6018-32. 2010
    ..They also illustrate the capacity of the SIVmac quasispecies to modify antigenic determinants in response to very modest titers of neutralizing antibodies...
  9. pmc Monitoring HIV vaccine trial participants for primary infection: studies in the SIV/macaque model
    James B Whitney
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    AIDS 23:1453-60. 2009
    ..We have utilized the SIV/rhesus monkey model to evaluate whether samples more easily obtained than peripheral blood might be used for intensive monitoring of vaccine trial participants...
  10. pmc In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes
    Mohammed Asmal
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e48234. 2012
    ..Ultimately, understanding how serpins, such as hep-ATIII, regulate host responses during HIV infection may reveal new avenues for therapeutic intervention...
  11. pmc Envelope vaccination shapes viral envelope evolution following simian immunodeficiency virus infection in rhesus monkeys
    Aravind Basavapathruni
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Virol 84:953-63. 2010
    ..These data show that env vaccination altered the focus of the antibody-mediated selection pressure on the evolution of envelope following SIV challenge...
  12. pmc The M184V mutation in reverse transcriptase can delay reversion of attenuated variants of simian immunodeficiency virus
    James B Whitney
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 76:8958-62. 2002
    ..We also observed that M184V significantly impaired the potential for both compensatory mutagenesis and reversion in these mutants both in cell lines and in peripheral blood mononuclear cells...
  13. pmc Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys
    So yon Lim
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1000997. 2010
    ..34 or 0.36, respectively. These findings call into question the premise that CCL3L CNV is important in HIV/SIV pathogenesis...
  14. pmc Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys
    Norman L Letvin
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Sci Transl Med 3:81ra36. 2011
    ..This study begins to elucidate the mechanisms of vaccine protection against immunodeficiency viruses and highlights the need to analyze these immune and genetic correlates of protection in future trials of HIV vaccine strategies...
  15. pmc TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys
    So yon Lim
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 6:e1000738. 2010
    ..These findings demonstrate a central role for TRIM5alpha in limiting the replication of an immunodeficiency virus infection in a primate host...
  16. pmc Important role for the CA-NC spacer region in the assembly of bovine immunodeficiency virus Gag protein
    Xiaofeng Guo
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 78:551-60. 2004
    ..Taken together, these data suggest a pivotal role for the CA-NC spacer region in the assembly of BIV Gag; however, the mechanism involved therein may differ from that for the HIV-1 CA-NC spacer...
  17. pmc Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
    Dan H Barouch
    1 Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA 2 Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts 02139, USA
    Nature 503:224-8. 2013
    ..Our findings strongly encourage the investigation of monoclonal antibody therapy for HIV-1 in humans. ..
  18. pmc Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys
    Sallie R Permar
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:3643-50. 2008
    ..This robust viral-specific cellular immune response in breast milk may contribute to control of breast milk virus replication...
  19. ncbi request reprint Live attenuated HIV vaccines: pitfalls and prospects
    James B Whitney
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Curr Opin Infect Dis 17:17-26. 2004
    ..safety, (2). efficacy, (3). the correlates of immune protection, and (4) the molecular determinants for lentiviral virulence or attenuation...
  20. pmc A structurally disordered region at the C terminus of capsid plays essential roles in multimerization and membrane binding of the gag protein of human immunodeficiency virus type 1
    Chen Liang
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    J Virol 77:1772-83. 2003
    ....
  21. doi request reprint Overlapping synthetic peptides encoding TPD52 as breast cancer vaccine in mice: prolonged survival
    Saied Mirshahidi
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, United States
    Vaccine 27:1825-33. 2009
    ..We show that an OSP vaccination approach can assist in the disruption of self-tolerance and conclude that our approach may hold promise for immunoprevention of early-stage cancers in a general population...
  22. pmc Serpin induced antiviral activity of prostaglandin synthetase-2 against HIV-1 replication
    James B Whitney
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18589. 2011
    ..These findings suggest a central role for serpins in the host innate anti-viral response. Host factors such as PTGS2 elicited by ATIII treatment could be exploited in the development of novel anti-viral interventions...
  23. ncbi request reprint Molecular cloning and in vitro evaluation of an infectious simian-human immunodeficiency virus containing env of a primary Chinese HIV-1 subtype C isolate
    YingYun Wu
    College of Life Sciences, Nankai University, Tianjin, China
    J Med Primatol 34:101-7. 2005
    ..The resulting chimeric SHIV-XJ02170 was infectious in human, rhesus monkey and cynomolgus monkey peripheral blood mononuclear cells (PBMC) and used CCR5 exclusively as coreceptor...