Research Topics
| James B WhitneySummaryAffiliation: Harvard University Country: USA Publications
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Publications
Evolutionary mechanisms of retroviral persistenceJames B Whitney
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
AIDS Rev 13:234-9. 2011..Understanding the dynamic mechanisms that contribute to the establishment and maintenance of retroviral persistence is critical toward the goal of attaining HIV-1 eradication...
Impaired RNA incorporation and dimerization in live attenuated leader-variants of SIVmac239James B Whitney
McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada
Retrovirology 3:96. 2006..We also assessed the impact of these deletions upon viral infectiousness, replication kinetics and gene expression in cell lines and monkey peripheral blood mononuclear cells (PBMC)...- Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genomeJames B Whitney
McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada
Retrovirology 4:44. 2007..These findings indicate that viral reversion that overcomes a genetic bottleneck is not limited to a single pathway, and illustrates the remarkable adaptability of lentiviruses... - Genital tract sequestration of SIV following acute infectionJames B Whitney
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
PLoS Pathog 7:e1001293. 2011..These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves... - Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIVJames B Whitney
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
J Immune Based Ther Vaccines 9:2. 2011..abstract:.. - T-cell vaccination reduces simian immunodeficiency virus levels in semenJames B Whitney
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Virol 83:10840-3. 2009..A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS... - The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeysWendy W Yeh
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Virol 85:10389-98. 2011..In addition, we used our understanding of TRIM5 to establish a novel nonhuman primate penile transmission model for AIDS mucosal pathogenesis and vaccine research... - Autologous neutralizing antibodies to the transmitted/founder viruses emerge late after simian immunodeficiency virus SIVmac251 infection of rhesus monkeysWendy W Yeh
Division of Viral Pathogenesis, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Virol 84:6018-32. 2010..They also illustrate the capacity of the SIVmac quasispecies to modify antigenic determinants in response to very modest titers of neutralizing antibodies... - Monitoring HIV vaccine trial participants for primary infection: studies in the SIV/macaque modelJames B Whitney
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
AIDS 23:1453-60. 2009..We have utilized the SIV/rhesus monkey model to evaluate whether samples more easily obtained than peripheral blood might be used for intensive monitoring of vaccine trial participants... - Envelope vaccination shapes viral envelope evolution following simian immunodeficiency virus infection in rhesus monkeysAravind Basavapathruni
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
J Virol 84:953-63. 2010..These data show that env vaccination altered the focus of the antibody-mediated selection pressure on the evolution of envelope following SIV challenge... - The M184V mutation in reverse transcriptase can delay reversion of attenuated variants of simian immunodeficiency virusJames B Whitney
McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
J Virol 76:8958-62. 2002..We also observed that M184V significantly impaired the potential for both compensatory mutagenesis and reversion in these mutants both in cell lines and in peripheral blood mononuclear cells... - Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeysSo yon Lim
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 6:e1000997. 2010..34 or 0.36, respectively. These findings call into question the premise that CCL3L CNV is important in HIV/SIV pathogenesis... 
Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in MonkeysNorman L Letvin
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Sci Transl Med 3:81ra36. 2011..This study begins to elucidate the mechanisms of vaccine protection against immunodeficiency viruses and highlights the need to analyze these immune and genetic correlates of protection in future trials of HIV vaccine strategies...- TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus MonkeysSo yon Lim
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Pathog 6:e1000738. 2010..These findings demonstrate a central role for TRIM5alpha in limiting the replication of an immunodeficiency virus infection in a primate host... - Important role for the CA-NC spacer region in the assembly of bovine immunodeficiency virus Gag proteinXiaofeng Guo
McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
J Virol 78:551-60. 2004..Taken together, these data suggest a pivotal role for the CA-NC spacer region in the assembly of BIV Gag; however, the mechanism involved therein may differ from that for the HIV-1 CA-NC spacer... - In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomesMohammed Asmal
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
PLoS ONE 7:e48234. 2012..Ultimately, understanding how serpins, such as hep-ATIII, regulate host responses during HIV infection may reveal new avenues for therapeutic intervention... - A structurally disordered region at the C terminus of capsid plays essential roles in multimerization and membrane binding of the gag protein of human immunodeficiency virus type 1Chen Liang
McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
J Virol 77:1772-83. 2003.... - Live attenuated HIV vaccines: pitfalls and prospectsJames B Whitney
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Curr Opin Infect Dis 17:17-26. 2004..safety, (2). efficacy, (3). the correlates of immune protection, and (4) the molecular determinants for lentiviral virulence or attenuation... - Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeysSallie R Permar
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
J Immunol 181:3643-50. 2008..This robust viral-specific cellular immune response in breast milk may contribute to control of breast milk virus replication... - Overlapping synthetic peptides encoding TPD52 as breast cancer vaccine in mice: prolonged survivalSaied Mirshahidi
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, United States
Vaccine 27:1825-33. 2009..We show that an OSP vaccination approach can assist in the disruption of self-tolerance and conclude that our approach may hold promise for immunoprevention of early-stage cancers in a general population... - Serpin induced antiviral activity of prostaglandin synthetase-2 against HIV-1 replicationJames B Whitney
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
PLoS ONE 6:e18589. 2011..These findings suggest a central role for serpins in the host innate anti-viral response. Host factors such as PTGS2 elicited by ATIII treatment could be exploited in the development of novel anti-viral interventions... - Molecular cloning and in vitro evaluation of an infectious simian-human immunodeficiency virus containing env of a primary Chinese HIV-1 subtype C isolateYingYun Wu
College of Life Sciences, Nankai University, Tianjin, China
J Med Primatol 34:101-7. 2005..The resulting chimeric SHIV-XJ02170 was infectious in human, rhesus monkey and cynomolgus monkey peripheral blood mononuclear cells (PBMC) and used CCR5 exclusively as coreceptor...