MALCOLM R WHITMAN

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells
    Yana G Kamberov
    Genetics Department, Harvard Medical School, Boston, MA, USA
    BMC Res Notes 4:381. 2011
  2. ncbi request reprint TGFbeta signaling at the summit
    Malcolm Whitman
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Development 132:4205-10. 2005
  3. ncbi request reprint Nodal signaling in early vertebrate embryos: themes and variations
    M Whitman
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 1:605-17. 2001
  4. ncbi request reprint Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development
    S Faure
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Development 127:2917-31. 2000
  5. ncbi request reprint A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis
    E Weisberg
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mech Dev 79:17-27. 1998
  6. ncbi request reprint Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms
    C Yeo
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 7:949-57. 2001
  7. ncbi request reprint The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis
    C Y Yeo
    Department of Cell Biology and Graduate Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:26584-90. 1999
  8. ncbi request reprint Timing of endogenous activin-like signals and regional specification of the Xenopus embryo
    M A Lee
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Development 128:2939-52. 2001
  9. ncbi request reprint A transcriptional partner for MAD proteins in TGF-beta signalling
    X Chen
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 383:691-6. 1996
  10. ncbi request reprint Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1
    S I Osada
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Development 127:2503-14. 2000

Collaborators

Detail Information

Publications15

  1. pmc Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells
    Yana G Kamberov
    Genetics Department, Harvard Medical School, Boston, MA, USA
    BMC Res Notes 4:381. 2011
    ..abstract:..
  2. ncbi request reprint TGFbeta signaling at the summit
    Malcolm Whitman
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Development 132:4205-10. 2005
    ..This meeting highlighted the ongoing interplay between advances in our understanding of the molecular biology of TGFbeta family signaling and in investigations into its roles in specific developmental events...
  3. ncbi request reprint Nodal signaling in early vertebrate embryos: themes and variations
    M Whitman
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 1:605-17. 2001
    ..Recent studies in mice, fish, and frogs of nodals and their intracellular transducers allow a comparison of how this signaling pathway is used in the patterning of early embryos of these different vertebrates...
  4. ncbi request reprint Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development
    S Faure
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Development 127:2917-31. 2000
    ..We discuss the implications of our results for endogenous functions of BMP and activin-like signals as candidate morphogens regulating primary germ layer formation and dorsoventral patterning of the early Xenopus embryo...
  5. ncbi request reprint A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis
    E Weisberg
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mech Dev 79:17-27. 1998
    ..We propose that mouse Fast1, like Xenopus FAST-1, mediates TGF beta superfamily signals specifying developmental fate during early embryogenesis...
  6. ncbi request reprint Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms
    C Yeo
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 7:949-57. 2001
    ..Inhibition appears to be mediated by heterodimerization between Nodal and BMPs, indicating that antagonism between Nodal and BMPs can occur at the level of dimeric ligand production...
  7. ncbi request reprint The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis
    C Y Yeo
    Department of Cell Biology and Graduate Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:26584-90. 1999
    ..These observations elucidate how broadly expressed signal transducers (Smads) regulate a developmentally specific transcriptional response in conjunction with a temporally restricted transcription factor, FAST-1...
  8. ncbi request reprint Timing of endogenous activin-like signals and regional specification of the Xenopus embryo
    M A Lee
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Development 128:2939-52. 2001
    ..These observations suggest that the timing of endogenous activin-like signaling is a determinant of patterning in the early Xenopus embryo...
  9. ncbi request reprint A transcriptional partner for MAD proteins in TGF-beta signalling
    X Chen
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 383:691-6. 1996
    ..A model is proposed to explain how TGF-beta superfamily signals might regulate the expression of specific genes in the early embryo...
  10. ncbi request reprint Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1
    S I Osada
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Development 127:2503-14. 2000
    ..Thus, an evolutionarily conserved intronic enhancer in Xnr1 is involved in both mesendoderm induction and asymmetric expression during left-right axis formation...
  11. ncbi request reprint Smad4 and FAST-1 in the assembly of activin-responsive factor
    X Chen
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 5730, USA
    Nature 389:85-9. 1997
    ..These results indicate that Smad4 stabilizes a ligand-stimulated Smad2-FAST-1 complex as an active DNA-binding factor...
  12. pmc Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo
    H C Huang
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 14:5965-73. 1995
    ..Characterization of this factor provides a powerful tool for studying the early steps in the induction of mesoderm by members of the activin/TGF-beta superfamily...
  13. ncbi request reprint FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo
    M Watanabe
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA
    Development 126:5621-34. 1999
    ..In intact embryos, this antibody can prevent the expression of early mesodermal markers and inhibit axis formation, demonstrating that FAST-1 is a necessary component of the first steps in the specification of mesoderm...
  14. ncbi request reprint The role of transcription factors involved in TGFbeta superfamily signaling during development
    M Watanabe
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Mol Biol (Noisy-le-grand) 45:537-43. 1999
    ..Therefore the developmental specificity of TGF-beta signaling may be, at least in part, determined by cell-type specific transcription factors...
  15. ncbi request reprint TGF-beta superfamily signaling and left-right asymmetry
    M Whitman
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Sci STKE 2001:re1. 2001
    ..Also discussed is the problem of how signal transduction mediated by the Smad proteins can pattern LR asymmetry without interfering with coincident dorsoventral patterning, which relies on the same Smad proteins...

Research Grants18

  1. Regulation of Xenopus Embryonic Development by TGFbeta Superfamily Ligands and SM
    MALCOLM R WHITMAN; Fiscal Year: 2010
    ..The study of TGF superfamily ligands provides a common approach, and a common set of molecular tools, with which to understand the regulation of these important physiological processes. ..
  2. MECHANISM OF ACTION OF HALOFUGINONE AS A NOVEL THERAPEUTIC
    MALCOLM R WHITMAN; Fiscal Year: 2010
    ..We plan to characterize the mechanism of action of this molecule as a new class of disease therapeutic. ..
  3. Regulation of Xenopus Embryonic Development by TGFbeta Superfamily Ligands and SM
    Malcolm Whitman; Fiscal Year: 2009
    ..The study of TGF superfamily ligands provides a common approach, and a common set of molecular tools, with which to understand the regulation of these important physiological processes. ..
  4. Regulation of Xenopus Embryonic Development by TGFbeta Superfamily Ligands and SM
    Malcolm Whitman; Fiscal Year: 2007
    ..The study of TGF¿ superfamily ligands provides a common approach, and a common set of molecular tools, with which to understand the regulation of these important physiological processes. ..
  5. SMAD AND FAST-1 SIGNALS IN EARLY XENOPUS DEVELOPMENT
    Malcolm Whitman; Fiscal Year: 2005
    ..Investigation of the regulation of endogenous Smad activity will allow us to critically test a variety of hypotheses concerning the role of TGFBs in early development. ..
  6. INTRACELLULAR SIGNALS DURING EARLY DEVELOPMENT
    Malcolm Whitman; Fiscal Year: 1993
    ..This technique will be used to study patterns of signalling during normal and experimentally manipulated early development...
  7. INTRACELLULAR SIGNALS DURING EARLY DEVELOPMENT
    Malcolm Whitman; Fiscal Year: 1999
    ..Receptor depleted embryos will then be analyzed for responsiveness to exogenous and endogenous inducing signals and for specific types of transcriptional responses. ..
  8. Regulation of Xenopus Embryonic Development by TGFbeta Superfamily Ligands and SM
    MALCOLM R WHITMAN; Fiscal Year: 2010
    ..The study of TGF superfamily ligands provides a common approach, and a common set of molecular tools, with which to understand the regulation of these important physiological processes. ..