G M Whitesides

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Don't forget long-term fundamental research in energy
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 315:796-8. 2007
  2. doi request reprint Integrated fabrication and magnetic positioning of metallic and polymeric nanowires embedded in thin epoxy slabs
    Darren J Lipomi
    Harvard University, Department of Chemistry and Chemical Biology, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    ACS Nano 3:3315-25. 2009
  3. ncbi request reprint A microfluidic apparatus for the study of ice nucleation in supercooled water drops
    Claudiu A Stan
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 01238, USA
    Lab Chip 9:2293-305. 2009
  4. pmc Using ion channel-forming peptides to quantify protein-ligand interactions
    Michael Mayer
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 130:1453-65. 2008
  5. ncbi request reprint Density-based diamagnetic separation: devices for detecting binding events and for collecting unlabeled diamagnetic particles in paramagnetic solutions
    Adam Winkleman
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Anal Chem 79:6542-50. 2007
  6. doi request reprint Rapid fabrication of pressure-driven open-channel microfluidic devices in omniphobic R(F) paper
    Ana C Glavan
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Lab Chip 13:2922-30. 2013
  7. doi request reprint Is the focus on "molecules" obsolete?
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Anal Chem (Palo Alto Calif) 6:1-29. 2013
  8. ncbi request reprint Optically controlled collisions of biological objects to evaluate potent polyvalent inhibitors of virus-cell adhesion
    M Mammen
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Chem Biol 3:757-63. 1996
  9. ncbi request reprint The 'right' size in nanobiotechnology
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Nat Biotechnol 21:1161-5. 2003
  10. ncbi request reprint Assumptions: taking chemistry in new directions
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138 2902, USA
    Angew Chem Int Ed Engl 43:3632-41. 2004

Research Grants

  1. Multivalency: Mechanisms and Applications
    George Whitesides; Fiscal Year: 2009
  2. Nano-Scale Tools for Use in Cell Biology
    George M Whitesides; Fiscal Year: 2010
  3. Tools To Study Cell Motility and Ion Channels
    George Whitesides; Fiscal Year: 2006
  4. Capillary Electrophoresis and Protein Biophysics
    George Whitesides; Fiscal Year: 2005
  5. Multivalency: Mechanisms and Applications
    George Whitesides; Fiscal Year: 2004
  6. Nano-Scale Tools for Use in Cell Biology
    George Whitesides; Fiscal Year: 2007
  7. Capillary Electrophoresis and Protein Biophysics
    George Whitesides; Fiscal Year: 2007
  8. Multivalency: Mechanisms and Applications
    George Whitesides; Fiscal Year: 2007
  9. Multivalency: Mechanisms and Applications
    George M Whitesides; Fiscal Year: 2010
  10. Capillary Electrophoresis and Protein Biophysics
    George M Whitesides; Fiscal Year: 2010

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Don't forget long-term fundamental research in energy
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 315:796-8. 2007
    ....
  2. doi request reprint Integrated fabrication and magnetic positioning of metallic and polymeric nanowires embedded in thin epoxy slabs
    Darren J Lipomi
    Harvard University, Department of Chemistry and Chemical Biology, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    ACS Nano 3:3315-25. 2009
    ..Single-crystalline Au nanowires can be placed on glass wool fibers or on microfabricated polymeric waveguides, with which the nanowire can be addressed optically...
  3. ncbi request reprint A microfluidic apparatus for the study of ice nucleation in supercooled water drops
    Claudiu A Stan
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 01238, USA
    Lab Chip 9:2293-305. 2009
    ..The dendritic growth of ice in 150-microm drops of supercooled water at -35 degrees C was observed and imaged at a rate of 16 000 frames/s...
  4. pmc Using ion channel-forming peptides to quantify protein-ligand interactions
    Michael Mayer
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 130:1453-65. 2008
    ....
  5. ncbi request reprint Density-based diamagnetic separation: devices for detecting binding events and for collecting unlabeled diamagnetic particles in paramagnetic solutions
    Adam Winkleman
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Anal Chem 79:6542-50. 2007
    ..This device requires no power, has no moving parts, and may be suitable for use in resource-poor environments...
  6. doi request reprint Rapid fabrication of pressure-driven open-channel microfluidic devices in omniphobic R(F) paper
    Ana C Glavan
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Lab Chip 13:2922-30. 2013
    ..The combination of omniphobic paper and a craft cutter enables the development of new types of valves and switches, such as "fold valves" and "porous switches," which provide new methods to control fluid flow. ..
  7. doi request reprint Is the focus on "molecules" obsolete?
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Anal Chem (Palo Alto Calif) 6:1-29. 2013
    ....
  8. ncbi request reprint Optically controlled collisions of biological objects to evaluate potent polyvalent inhibitors of virus-cell adhesion
    M Mammen
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Chem Biol 3:757-63. 1996
    ..We wished to develop an assay in which all the relevant factors, including the components of the solution, the relative orientation and the relative collision velocity, are under the user's control...
  9. ncbi request reprint The 'right' size in nanobiotechnology
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Nat Biotechnol 21:1161-5. 2003
    ....
  10. ncbi request reprint Assumptions: taking chemistry in new directions
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138 2902, USA
    Angew Chem Int Ed Engl 43:3632-41. 2004
  11. pmc Designing ligands to bind proteins
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Q Rev Biophys 38:385-95. 2005
    ..The counterintuitive thermodynamic results observed serve to illustrate that, even in relatively simple systems, understanding protein-ligand association is challenging...
  12. ncbi request reprint Molecular engineering of surfaces using self-assembled monolayers
    George M Whitesides
    Harvard University, Department of Chemistry and Chemical Biology, Cambridge, MA 02138 2902, USA
    Sci Prog 88:17-48. 2005
    ..Understanding the principles by which they form, and connecting molecular-level structure with macroscopic properties, opens a wide range of areas to study and exploitation...
  13. pmc Microfabricated teflon membranes for low-noise recordings of ion channels in planar lipid bilayers
    Michael Mayer
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Biophys J 85:2684-95. 2003
    ..The low-noise properties of bilayer recordings on micropores in Teflon AF films were exploited to record the smallest conductance state of alamethicin (24 pS) at an unprecedentedly high bandwidth of 10.7 kHz...
  14. ncbi request reprint Complexity in chemistry
    G M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 284:89-92. 1999
    ..Historically, chemistry has emphasized the approximation of complex nonlinear processes by simpler linear ones. Complexity is becoming a profitable approach to a wide range of problems, especially the understanding of life...
  15. pmc Beyond molecules: self-assembly of mesoscopic and macroscopic components
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 99:4769-74. 2002
    ..These larger systems also offer a level of control over the characteristics of the components and over the interactions among them that makes fundamental investigations especially tractable...
  16. ncbi request reprint Self-assembly at all scales
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 295:2418-21. 2002
    ..The concept of self-assembly is used increasingly in many disciplines, with a different flavor and emphasis in each...
  17. ncbi request reprint Soft lithography in biology and biochemistry
    G M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Biomed Eng 3:335-73. 2001
    ..Self-assembled monolayers of alkanethiolates on gold are particularly easy to pattern by soft lithography, and they provide exquisite control over surface biochemistry...
  18. ncbi request reprint Bubbles navigating through networks of microchannels
    Wonjae Choi
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Lab Chip 11:3970-8. 2011
    ....
  19. ncbi request reprint Nanoscience, nanotechnology, and chemistry
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Small 1:172-9. 2005
  20. doi request reprint Millimeter-scale contact printing of aqueous solutions using a stamp made out of paper and tape
    Chao Min Cheng
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Lab Chip 10:3201-5. 2010
    ..By patterning the paper to which the transfer occurs using wax printing or an equivalent technique, accuracy increases substantially...
  21. doi request reprint Fabrication of arrays of metal and metal oxide nanotubes by shadow evaporation
    Michael D Dickey
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    ACS Nano 2:800-8. 2008
    ....
  22. ncbi request reprint Fabrication of thin, metallic films along the sidewalls of a topographically patterned stamp and their application in charge printing
    Tingbing Cao
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Small 1:1191-5. 2005
  23. ncbi request reprint Fabrication of large-area patterned nanostructures for optical applications by nanoskiving
    Qiaobing Xu
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts, 02138, USA
    Nano Lett 7:2800-5. 2007
    ....
  24. pmc Thermodynamic parameters for the association of fluorinated benzenesulfonamides with bovine carbonic anhydrase II
    Vijay M Krishnamurthy
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Chem Asian J 2:94-105. 2007
    ..Calorimetry revealed that all of the ligands studied bind in a 1:1 stoichiometry with BCA; this result was confirmed by 19F NMR spectroscopy and X-ray crystallography (for complexes with human carbonic anhydrase II)...
  25. ncbi request reprint Flowing lattices of bubbles as tunable, self-assembled diffraction gratings
    Michinao Hashimoto
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA, USA
    Small 2:1292-8. 2006
    ..For our devices, we achieved tunable ranges in pitch from 12 to 51 microm, corresponding to first-order diffraction angles from 3.2 degrees to 0.7 degrees for light with a wavelength of 632 nm...
  26. ncbi request reprint Water-soluble sacrificial layers for surface micromachining
    Vincent Linder
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA 02138, USA
    Small 1:730-6. 2005
    ....
  27. pmc Fabrication of high-aspect-ratio metallic nanostructures using nanoskiving
    Qiaobing Xu
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Nano Lett 6:2163-5. 2006
    ..The dimensions of the metal structures are determined by the thickness of the metal film and the thickness of the epoxy sections. The shape of the resulting nanostructure is defined by the cross section of the original template...
  28. pmc Swimming in circles: motion of bacteria near solid boundaries
    Eric Lauga
    Division of Engineering and Applied Sciences, and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02139, USA
    Biophys J 90:400-12. 2006
    ..We compare the results of the model with experimental data and obtain reasonable agreement. In particular, the radius of curvature of the trajectory is observed to increase with the length of the bacterium body...
  29. ncbi request reprint Micropatterning tractional forces in living cells
    Ning Wang
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cell Motil Cytoskeleton 52:97-106. 2002
    ....
  30. ncbi request reprint Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up
    Piotr Garstecki
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA 02138, USA
    Lab Chip 6:437-46. 2006
    ....
  31. pmc A technique to transfer metallic nanoscale patterns to small and non-planar surfaces
    Elizabeth J Smythe
    School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, Massachusetts 02138, USA
    ACS Nano 3:59-65. 2009
    ..A distinguishing feature of this technique is the use of a thin, sacrificial film to strip and transfer metallic nanopatterns and its ability to directly transfer metallic structures produced by conventional lithography...
  32. pmc Folding of electrostatically charged beads-on-a-string as an experimental realization of a theoretical model in polymer science
    Meital Reches
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 106:17644-9. 2009
    ....
  33. ncbi request reprint The origins and the future of microfluidics
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138
    Nature 442:368-73. 2006
    ..The solutions to these problems will require imagination and ingenuity...
  34. pmc Core-shell and segmented polymer-metal composite nanostructures
    Michal Lahav
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nano Lett 6:2166-71. 2006
    ..In the segmented structures, a self-assembled monolayer (SAM) of thioaniline nucleated the growth of PANI on top of metal nanorods and acted as an adhesion layer between the metal and PANI components...
  35. ncbi request reprint Chaotic mixer for microchannels
    Abraham D Stroock
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 295:647-51. 2002
    ..This method uses bas-relief structures on the floor of the channel that are easily fabricated with commonly used methods of planar lithography...
  36. ncbi request reprint A general method for patterning gradients of biomolecules on surfaces using microfluidic networks
    Xingyu Jiang
    Department of Chemistry and Chemical Biology, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Anal Chem 77:2338-47. 2005
    ..In this procedure, the relative amount of each protein, at saturation on the surface, depends only on its concentration.)...
  37. doi request reprint Nanoskiving: a new method to produce arrays of nanostructures
    Qiaobing Xu
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, Massachusetts 02138, USA
    Acc Chem Res 41:1566-77. 2008
    ..This Account discusses a new fabrication method (nanoskiving) that produces arrays of metal nanostructures. The defining process in nanoskiving is cutting slabs from a polymeric matrix containing embedded, more extended metal structures...
  38. ncbi request reprint The force acting on a superparamagnetic bead due to an applied magnetic field
    Sergey S Shevkoplyas
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA 02138, USA
    Lab Chip 7:1294-302. 2007
    ..The derivation of the force on a magnetic bead due to a magnetic field also identifies the correct treatment to use for this interaction, and resolves discrepancies present throughout the literature...
  39. ncbi request reprint Patterning multiple aligned self-assembled monolayers using light
    Declan Ryan
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Langmuir 20:9080-8. 2004
    ..The ability to produce multiple, aligned patterns of SAMs in a single step, without alignment of photomasks in separate steps, increases the versatility of SAMs for studying a range of physical phenomena...
  40. pmc Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery
    Qiaobing Xu
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachussets Avenue, Cambridge, MA 02139, USA
    Small 5:1575-81. 2009
    ..These results demonstrate the utility of microfluidic FF for the generation of homogenous systems of particles for the delivery of drugs...
  41. ncbi request reprint Self-assembled monolayers of thiolates on metals as a form of nanotechnology
    J Christopher Love
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Chem Rev 105:1103-69. 2005
  42. ncbi request reprint Electrostatic self-assembly of macroscopic crystals using contact electrification
    Bartosz A Grzybowski
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Nat Mater 2:241-5. 2003
    ..We suggest that the stability of these unusual structures can be explained by accounting for the interactions between electric dipoles that the particles in the aggregates induce in their neighbours...
  43. ncbi request reprint Combining microscience and neurobiology
    Douglas B Weibel
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Curr Opin Neurobiol 15:560-7. 2005
    ..The major impediment to the development of a field of 'microfabrication and measurement' in neuroscience is the absence of effective collaborative interactions between the communities of fabricators and neurobiologists...
  44. pmc Increasing the net charge and decreasing the hydrophobicity of bovine carbonic anhydrase decreases the rate of denaturation with sodium dodecyl sulfate
    Katherine L Gudiksen
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Biophys J 91:298-310. 2006
    ..At the high numbers of acylations, hydrophobic interactions cause the hexanoyl-modified BCA to denature nearly three orders of magnitude more rapidly than the acetyl-modified BCA...
  45. ncbi request reprint Mechanical anisotropy of adherent cells probed by a three-dimensional magnetic twisting device
    Shaohua Hu
    Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Physiol Cell Physiol 287:C1184-91. 2004
    ..Deformation patterns of the cytoskeleton and the nucleolus were sensitive to loading direction, suggesting anisotropic mechanical signaling. This technology may be useful for elucidating the structural basis of mechanotransduction...
  46. ncbi request reprint Components for integrated poly(dimethylsiloxane) microfluidic systems
    Jessamine M K Ng
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Electrophoresis 23:3461-73. 2002
    ..Several components are described in detail: a passive chaotic mixer, pneumatically actuated switches and valves, a magnetic filter, functional membranes, and optical components...
  47. doi request reprint Rapid prototyping of microstructures by soft lithography for biotechnology
    Daniel B Wolfe
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA
    Methods Mol Biol 583:81-107. 2010
    ..Here we describe the procedures for fabricating microstructures with lateral dimensions as small as 1 mum. These types of microstructures are useful for microfluidic devices, cell-based assays, and bioengineered surfaces...
  48. doi request reprint Thread as a matrix for biomedical assays
    Meital Reches
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    ACS Appl Mater Interfaces 2:1722-8. 2010
    ....
  49. ncbi request reprint Muscular thin films for building actuators and powering devices
    Adam W Feinberg
    Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
    Science 317:1366-70. 2007
    ..These centimeter-scale constructs perform functions as diverse as gripping, pumping, walking, and swimming with fine spatial and temporal control and generating specific forces as high as 4 millinewtons per square millimeter...
  50. pmc Dependence of effective molarity on linker length for an intramolecular protein-ligand system
    Vijay M Krishnamurthy
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 129:1312-20. 2007
    ....
  51. pmc Controlling the orientation and synaptic differentiation of myotubes with micropatterned substrates
    Jacinthe Gingras
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    Biophys J 97:2771-9. 2009
    ..Our results represent what we believe is a new approach for musculoskeletal tissue engineering, and our model sheds light on mechanisms of myotube alignment in vivo...
  52. pmc Electrochemical sensing in paper-based microfluidic devices
    Zhihong Nie
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Lab Chip 10:477-83. 2010
    ..g., heavy-metal ions and glucose) in aqueous solutions. This low-cost analytical device should be useful for applications in public health, environmental monitoring, and the developing world...
  53. ncbi request reprint New approaches to nanofabrication: molding, printing, and other techniques
    Byron D Gates
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Chem Rev 105:1171-96. 2005
  54. ncbi request reprint Electrochemical desorption of self-assembled monolayers noninvasively releases patterned cells from geometrical confinements
    Xingyu Jiang
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    J Am Chem Soc 125:2366-7. 2003
    ..This straightforward technique is useful in bioassays for drug screening and for fundamental studies in cell biology...
  55. ncbi request reprint Modeling the anodic half-cell of a low-temperature coal fuel cell
    Douglas B Weibel
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Angew Chem Int Ed Engl 44:5682-6. 2005
  56. ncbi request reprint Prototyping of microfluidic devices in poly(dimethylsiloxane) using solid-object printing
    J Cooper McDonald
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Anal Chem 74:1537-45. 2002
    ..The capabilities of this method are demonstrated by fabricating devices that contain multilevel and tall features, devices that cover a large area (approximately 150 cm2), and devices that contain nonintersecting, crossing channels...
  57. pmc The paradoxical thermodynamic basis for the interaction of ethylene glycol, glycine, and sarcosine chains with bovine carbonic anhydrase II: an unexpected manifestation of enthalpy/entropy compensation
    Vijay M Krishnamurthy
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 128:5802-12. 2006
    ..Thus, this study demonstrates a surprising example of enthalpy/entropy compensation in a well-defined system. Understanding this compensation is integral to the rational design of high-affinity ligands for proteins...
  58. ncbi request reprint Patterning flows using grooved surfaces
    Abraham D Stroock
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge Massachusetts 02138, USA
    Anal Chem 74:5306-12. 2002
    ..g., to control the position of streams in the cross section of a channel or to promote mixing. Potential applications in microfluidics are outlined...
  59. ncbi request reprint Effects of surface charge on denaturation of bovine carbonic anhydrase
    Irina Gitlin
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Chembiochem 7:1241-50. 2006
    ....
  60. ncbi request reprint Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies
    Samuel K Sia
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Electrophoresis 24:3563-76. 2003
    ..The review emphasizes the advantages of miniaturization for biological analysis, such as efficiency of the device and special insights into cell biology...
  61. pmc Combinatorial computational method gives new picomolar ligands for a known enzyme
    Bartosz A Grzybowski
    Harvard University, Department of Chemistry and Chemical Biology, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 99:1270-3. 2002
    ..The designed R isomer is the best-known inhibitor (K(d) approximately 30 pM) of human carbonic anhydrase II...
  62. pmc Cofabrication: a strategy for building multicomponent microsystems
    Adam C Siegel
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Acc Chem Res 43:518-28. 2010
    ....
  63. ncbi request reprint Potentiometric titrations in a poly(dimethylsiloxane)-based microfluidic device
    Rosaria Ferrigno
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Anal Chem 76:2273-80. 2004
    ..These potentials are probed by microelectrodes that are integrated into the chip; the measured potentials were used to produce a titration curve from which the end point of a reaction was measured...
  64. ncbi request reprint Fabrication of complex three-dimensional microchannel systems in PDMS
    Hongkai Wu
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 125:554-9. 2003
    ..The channels can be used as templates to form 3D structures in other materials...
  65. ncbi request reprint Why are proteins charged? Networks of charge-charge interactions in proteins measured by charge ladders and capillary electrophoresis
    Irina Gitlin
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA 02138, USA
    Angew Chem Int Ed Engl 45:3022-60. 2006
    ..By studying the influence of charge on the properties of proteins using charge ladders, it is possible to estimate the net charge and hydrodynamic radius and to infer the role of charged residues in ligand binding and protein folding...
  66. ncbi request reprint Cofabrication of electromagnets and microfluidic systems in poly(dimethylsiloxane)
    Adam C Siegel
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Angew Chem Int Ed Engl 45:6877-82. 2006
  67. ncbi request reprint Approaching zero: using fractured crystals in metrology for replica molding
    Qiaobing Xu
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 127:854-5. 2005
    ..4 nm could be reproduced; these features approach the dimensions of atoms...
  68. ncbi request reprint Selective chemical treatment of cellular microdomains using multiple laminar streams
    Shuichi Takayama
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Chem Biol 10:123-30. 2003
    ..This technique does not require microinjection or immobilization of reagents onto nondiffusive objects; it opens a new window into cell biology...
  69. doi request reprint Formation of bubbles and droplets in parallel, coupled flow-focusing geometries
    Michinao Hashimoto
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Small 4:1795-805. 2008
    ..g., the gas or liquid), and on variations in pressure at the flow-focusing orifices induced by the breakup of bubbles or droplets...
  70. ncbi request reprint Molecule-mimetic chemistry and mesoscale self-assembly
    N B Bowden
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Acc Chem Res 34:231-8. 2001
    ..The properties of these aggregates--that is, their "chemistry"--mimic aspects of the chemistry of molecules...
  71. ncbi request reprint Self-assembly of 10-microm-sized objects into ordered three-dimensional arrays
    T D Clark
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 123:7677-82. 2001
    ..This work validates the use of capillary interactions for three-dimensional mesoscale self-assembly in the 10-microm-size regime and opens new avenues for the fabrication of complex, three-dimensional microscructures...
  72. doi request reprint Paper-based piezoresistive MEMS sensors
    Xinyu Liu
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Lab Chip 11:2189-96. 2011
    ..We applied this sensor to characterizing the mechanical properties of a soft material. Leveraging the same sensing concept, we also developed a paper-based balance with a measurement range of 15 g, and a resolution of 0.39 g...
  73. ncbi request reprint Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device
    Noo Li Jeon
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospitals for Children, Boston, MA 02114, USA
    Nat Biotechnol 20:826-30. 2002
    ..The technique described in this paper provides a robust method to investigate migratory cells under a variety of conditions not accessible to study by earlier techniques...
  74. ncbi request reprint Analysis by capillary electrophoresis of the kinetics of charge ladder formation for bovine carbonic anhydrase
    Janelle R Anderson
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Anal Chem 74:1870-8. 2002
    ....
  75. ncbi request reprint Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces
    Kevin Kit Parker
    Department of Pathology and Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 16:1195-204. 2002
    ..When cell tension was dissipated, lamellipodia extension ceased. Mechanical interactions between cells and ECM that modulate cytoskeletal tension may therefore play a key role in the control of directional cell motility...
  76. ncbi request reprint Molecular rectification in a metal-insulator-metal junction based on self-assembled monolayers
    Michael L Chabinyc
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    J Am Chem Soc 124:11730-6. 2002
    ....
  77. ncbi request reprint Propagation of viruses on micropatterned host cells
    Elizabeth E Endler
    Department of Chemical Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, Wisconsin 53706 1691, USA
    Biotechnol Bioeng 81:719-25. 2003
    ..This work sets a foundation for parallel, high-throughput characterization of viral and cellular processes...
  78. ncbi request reprint Coding/decoding and reversibility of droplet trains in microfluidic networks
    Michael J Fuerstman
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Science 315:828-32. 2007
    ..The encoding/decoding device is a functional microfluidic system that requires droplets to navigate a network in a precise manner without the use of valves, switches, or other means of external control...
  79. ncbi request reprint Shear patterning of microdominos: a new class of procedures for making micro- and nanostructures
    Byron D Gates
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Angew Chem Int Ed Engl 43:2780-3. 2004
  80. ncbi request reprint Geometric confinement influences cellular mechanical properties I -- adhesion area dependence
    Judith Su
    Department of Mechanical Engineering, MIT, USA
    Mol Cell Biomech 4:87-104. 2007
    ....
  81. ncbi request reprint Synthesis of monodisperse polymers from proteins
    Jerry Yang
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 125:12392-3. 2003
    ..Modification of lysozyme on a gram scale demonstrated that the method can generate useful quantities of material...
  82. ncbi request reprint Cell shape provides global control of focal adhesion assembly
    Christopher S Chen
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 2120, USA
    Biochem Biophys Res Commun 307:355-61. 2003
    ..This complex interplay between cell morphology, mechanics, and adhesion may be critical to how cells integrate from and function in living tissues...
  83. pmc Partitioning microfluidic channels with hydrogel to construct tunable 3-D cellular microenvironments
    Amy P Wong
    Harvard Biophysics Program, Harvard Medical School, Boston, MA 02115, USA
    Biomaterials 29:1853-61. 2008
    ..This pair of cell lines represents a simple model system for intercellular communication: the LADMAC cells produce colony-stimulating factor 1 (CSF-1), which is required by the BAC cells for survival...
  84. ncbi request reprint Combined microfluidic-micromagnetic separation of living cells in continuous flow
    Nan Xia
    Vascular Biology Program, Department of Pathology, Karp Family Research Laboratories, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Biomed Microdevices 8:299-308. 2006
    ..This on-chip HGMC-microfluidic separator technology may potentially allow cell separations to be carried out in the field outside of hospitals and clinical laboratories...
  85. ncbi request reprint Formation and structure of self-assembled monolayers of alkanethiolates on palladium
    J Christopher Love
    Department of Chemistry and the Fredrick Seitz Materials Research Laboratory at the University of Illinois Urbana Champaign, Urbana, IL 61801, USA
    J Am Chem Soc 125:2597-609. 2003
    ..The differences in chain organization between SAMs formed by microcontact printing and by solution deposition are also examined by RAIRS and XPS...
  86. ncbi request reprint Geometric confinement influences cellular mechanical properties II -- intracellular variances in polarized cells
    Judith Su
    Department of Mechanical Engineering, MIT, USA
    Mol Cell Biomech 4:105-18. 2007
    ..9 times higher shear modulus than the trailing edge and that this increase in shear modulus correlates with a greater density of filamentous actin, as measured by phalloidin-staining observed through quantitative 3D microscopy...

Research Grants42

  1. Multivalency: Mechanisms and Applications
    George Whitesides; Fiscal Year: 2009
    ....
  2. Nano-Scale Tools for Use in Cell Biology
    George M Whitesides; Fiscal Year: 2010
    ....
  3. Tools To Study Cell Motility and Ion Channels
    George Whitesides; Fiscal Year: 2006
    ..The work spans biology, microfabrication, and biophysics, and an important product of the research will be students broadly trained in biological and physical sciences. ..
  4. Capillary Electrophoresis and Protein Biophysics
    George Whitesides; Fiscal Year: 2005
    ..The research will provide understanding useful in rationalizing and predicting interactions between proteins and ligands, and ultimately in the rational design of drugs. ..
  5. Multivalency: Mechanisms and Applications
    George Whitesides; Fiscal Year: 2004
    ..coli, pseudomonas, B. anthracis, and influenza are of particular interest. It will also develop new analytical systems that are tailored to the special requirements of multivalency. ..
  6. Nano-Scale Tools for Use in Cell Biology
    George Whitesides; Fiscal Year: 2007
    ....
  7. Capillary Electrophoresis and Protein Biophysics
    George Whitesides; Fiscal Year: 2007
    ....
  8. Multivalency: Mechanisms and Applications
    George Whitesides; Fiscal Year: 2007
    ....
  9. Multivalency: Mechanisms and Applications
    George M Whitesides; Fiscal Year: 2010
    ....
  10. Capillary Electrophoresis and Protein Biophysics
    George M Whitesides; Fiscal Year: 2010
    ....
  11. Nano-Scale Tools for Use in Cell Biology
    George Whitesides; Fiscal Year: 2009
    ....
  12. AFFINITY CAPILLARY ELECTROPHORESIS AND PROTEIN BINDING
    George Whitesides; Fiscal Year: 2000
    ..The research will also apply ACE to problems in biomolecular recognition that do not explicitly involve electrostatic interactions: polyvalency will be the most important of these problems. ..
  13. ENZYMES AS CATALYSTS IN ORGANIC SYNTHESIS
    George Whitesides; Fiscal Year: 1990
    ..5) Exploration of techniques for assembling and controlling complex synthetic systems involving eight or more cooperating enzymes capable of performing both synthetic and cofactor-regenerating functions ("artificial metabolism")...