T W White

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Genetic diseases and gene knockouts reveal diverse connexin functions
    T W White
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 61:283-310. 1999
  2. pmc Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts
    T W White
    Department of Cell Biology and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 143:815-25. 1998
  3. ncbi request reprint Functional characteristics of skate connexin35, a member of the gamma subfamily of connexins expressed in the vertebrate retina
    T W White
    Department of Cell Biology, Harvard Medical School, Boston 02115, USA
    Eur J Neurosci 11:1883-90. 1999
  4. ncbi request reprint Intercellular communication in the eye: clarifying the need for connexin diversity
    T W White
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Brain Res Brain Res Rev 32:130-7. 2000
  5. ncbi request reprint Gap junctions: fates worse than death?
    T W White
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 10:R685-8. 2000
  6. pmc Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70
    T W White
    Program in Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Biol Cell 3:711-20. 1992
  7. ncbi request reprint Functional analysis of human Cx26 mutations associated with deafness
    T W White
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Brain Res Brain Res Rev 32:181-3. 2000
  8. ncbi request reprint Prenatal lens development in connexin43 and connexin50 double knockout mice
    T W White
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794 8661, USA
    Invest Ophthalmol Vis Sci 42:2916-23. 2001
  9. ncbi request reprint Functional defects of Cx26 resulting from a heterozygous missense mutation in a family with dominant deaf-mutism and palmoplantar keratoderma
    G Richard
    Genetics Studies Section, Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 2757, USA
    Hum Genet 103:393-9. 1998
  10. pmc Molecular cloning and functional characterization of chick lens fiber connexin 45.6
    J X Jiang
    Department of Cell Biology, Neurobiology Harvard Medical School, Boston 02115
    Mol Biol Cell 5:363-73. 1994

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Genetic diseases and gene knockouts reveal diverse connexin functions
    T W White
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 61:283-310. 1999
    ..In addition, gene targeting of connexins in mice has provided new insights into connexin function and the significance of connexin diversity...
  2. pmc Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts
    T W White
    Department of Cell Biology and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 143:815-25. 1998
    ..Furthermore, these data indicate that unique functional properties of both Cx46 and Cx50 are required for proper lens development...
  3. ncbi request reprint Functional characteristics of skate connexin35, a member of the gamma subfamily of connexins expressed in the vertebrate retina
    T W White
    Department of Cell Biology, Harvard Medical School, Boston 02115, USA
    Eur J Neurosci 11:1883-90. 1999
    ..Although the cellular localization of Cx35 is unknown, the functional characteristics of Cx35 in Xenopus oocytes are consistent with the hemichannel and intercellular channel properties of skate horizontal cells...
  4. ncbi request reprint Intercellular communication in the eye: clarifying the need for connexin diversity
    T W White
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Brain Res Brain Res Rev 32:130-7. 2000
    ..Secondly, functional characterization of new connexins that are abundantly expressed in the retina has revealed biophysical properties that mimic those recorded from retinal neurons...
  5. ncbi request reprint Gap junctions: fates worse than death?
    T W White
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 10:R685-8. 2000
    ..Functional replacement of one connexin gene with another has now revealed unexpected phenotypes and shows that cellular homeostasis depends not simply on cell-cell communication but also on the correct types of connexin...
  6. pmc Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70
    T W White
    Program in Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Biol Cell 3:711-20. 1992
    ..With the cloning of Cx50, all known participants in gap junction formation between various cell types in the lens are available for study and reconstitution in experimental systems...
  7. ncbi request reprint Functional analysis of human Cx26 mutations associated with deafness
    T W White
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Brain Res Brain Res Rev 32:181-3. 2000
    ..Dominant Cx26 mutations that can cause both PPK and deafness must show some additional alteration of function beyond a simple inhibition of Cx26 activity...
  8. ncbi request reprint Prenatal lens development in connexin43 and connexin50 double knockout mice
    T W White
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794 8661, USA
    Invest Ophthalmol Vis Sci 42:2916-23. 2001
    ..To determine the roles of intercellular communication in embryonic eye growth and development, mice with a targeted deletion of the Cx43 gene were examined, and mice without both Cx43 and Cx50 were generated and analyzed...
  9. ncbi request reprint Functional defects of Cx26 resulting from a heterozygous missense mutation in a family with dominant deaf-mutism and palmoplantar keratoderma
    G Richard
    Genetics Studies Section, Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 2757, USA
    Hum Genet 103:393-9. 1998
    ..These data provide compelling evidence for the serious functional consequences of Cx26 mutations in dominant and recessive deafness...
  10. pmc Molecular cloning and functional characterization of chick lens fiber connexin 45.6
    J X Jiang
    Department of Cell Biology, Neurobiology Harvard Medical School, Boston 02115
    Mol Biol Cell 5:363-73. 1994
    ..6 and ChCx56 were abundant in lens fibers. Treatment of lens membranes with alkaline phosphatase resulted in electrophoretic mobility shifts, demonstrating that both ChCx45.6 and ChCx56 were phosphoproteins in vivo...
  11. ncbi request reprint Molecular cloning, expression analysis, and functional characterization of connexin44.1: a zebrafish lens gap junction protein
    N Cason
    Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada
    Dev Dyn 221:238-47. 2001
    ..Electrophysiological analysis of Cx44.1 channels revealed gating properties that were virtually identical to the mouse and chicken orthologues of Cx44.1...
  12. ncbi request reprint trans-dominant inhibition of connexin-43 by mutant connexin-26: implications for dominant connexin disorders affecting epidermal differentiation
    F Rouan
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA
    J Cell Sci 114:2105-13. 2001
    ..This assumption is further corroborated by our finding that Cx26 and Cx43 focally colocalize at gap junctional plaques in affected skin tissue of two carriers of DeltaE42...
  13. ncbi request reprint Identification and functional expression of HCx31.9, a novel gap junction gene
    N Belluardo
    Department of Experimental Medicine, University of Palermo, Italy
    Cell Commun Adhes 8:173-8. 2001
    ..2 in mouse cerebral cortex, liver and lung. Moreover, preliminary data on the electrophysiological properties of HCx31.9 have been obtained by functional expression in paired Xenopus oocytes and in transfected N2A cells...
  14. ncbi request reprint Functional analysis of a dominant mutation of human connexin26 associated with nonsyndromic deafness
    R Bruzzone
    Unité de Neurovirologie et Régénération du Système Nerveux, Institut Pasteur, Paris, France
    Cell Commun Adhes 8:425-31. 2001
    ....
  15. ncbi request reprint Loss-of-function and residual channel activity of connexin26 mutations associated with non-syndromic deafness
    R Bruzzone
    Departement of Neuroscience, Institut Pasteur, 75015, Paris
    FEBS Lett 533:79-88. 2003
    ....
  16. pmc Gap junctions and cochlear homeostasis
    H B Zhao
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, KY, USA
    J Membr Biol 209:177-86. 2006
    ..These studies elucidate gap junction functions in the cochlea and also provide insight for understanding the pathogenesis of this common hereditary deafness induced by connexin mutations...