Xiao Hong Wen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors
    Xiao Hong Wen
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts, USA
    Biophys J 96:939-50. 2009
  2. pmc S100B serves as a Ca(2+) sensor for ROS-GC1 guanylate cyclase in cones but not in rods of the murine retina
    Xiao Hong Wen
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA 02114, USA
    Cell Physiol Biochem 29:417-30. 2012
  3. ncbi request reprint Effects of low AIPL1 expression on phototransduction in rods
    Clint L Makino
    Howe Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston 02114, USA
    Invest Ophthalmol Vis Sci 47:2185-94. 2006
  4. pmc Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice
    Clint L Makino
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 7:e47637. 2012
  5. pmc AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase
    Xiaoqing Liu
    Berman Gund Laboratory for the Study of Retinal Degenerations, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 101:13903-8. 2004
  6. pmc Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics
    Clint L Makino
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e37832. 2012
  7. pmc Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation-deficient rhodopsin
    Zhongyan Wang
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 280:24293-300. 2005
  8. pmc A role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice
    Clint L Makino
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 283:29135-43. 2008
  9. pmc The ciliary rootlet maintains long-term stability of sensory cilia
    Jun Yang
    The Berman Gund Laboratory for the Study of Retinal Degenerations, Howe Laboratory, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Mol Cell Biol 25:4129-37. 2005
  10. ncbi request reprint Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals
    Jun Yang
    The Berman Gund Laboratory for Study of Retinal Degenerations, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hum Mol Genet 16:1017-29. 2007

Collaborators

Detail Information

Publications11

  1. pmc Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors
    Xiao Hong Wen
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts, USA
    Biophys J 96:939-50. 2009
    ..That feature, as well as an increase in cytosolic volume, was responsible for delaying the onset of the photoresponse and for attenuating its amplification...
  2. pmc S100B serves as a Ca(2+) sensor for ROS-GC1 guanylate cyclase in cones but not in rods of the murine retina
    Xiao Hong Wen
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA 02114, USA
    Cell Physiol Biochem 29:417-30. 2012
    ..The findings define a new cone-specific Ca(2+)-dependent feature of photoreceptors and expand our understanding of the operational principles of phototransduction machinery...
  3. ncbi request reprint Effects of low AIPL1 expression on phototransduction in rods
    Clint L Makino
    Howe Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston 02114, USA
    Invest Ophthalmol Vis Sci 47:2185-94. 2006
    ..To investigate the impact of aryl hydrocarbon receptor-interacting protein-like (AIPL)-1 on photoreception in rods...
  4. pmc Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice
    Clint L Makino
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 7:e47637. 2012
    ....
  5. pmc AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase
    Xiaoqing Liu
    Berman Gund Laboratory for the Study of Retinal Degenerations, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 101:13903-8. 2004
    ..We suggest that AIPL1 is a specialized chaperone required for rod PDE biosynthesis. Thus loss of AIPL1 would result in a condition that phenocopies retinal degenerations in the rd mouse and in a subgroup of human patients...
  6. pmc Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics
    Clint L Makino
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e37832. 2012
    ..The finding that transgenic mice overexpressing rhodopsin have enlarged disks lacking an incisure prompted us to test whether lowered rhodopsin levels constrain disk assembly...
  7. pmc Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation-deficient rhodopsin
    Zhongyan Wang
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 280:24293-300. 2005
    ..Since quench of rhodopsin begins with its phosphorylation, these results suggest that palmitoylation may modulate rod photoreceptor sensitivity by permitting rhodopsin to remain active for a longer period...
  8. pmc A role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice
    Clint L Makino
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 283:29135-43. 2008
    ..Therefore, GCAP2 regulation of guanylyl cyclase activity quickens the recovery of flash and step responses and adjusts the operating range of rods to higher intensities of ambient illumination...
  9. pmc The ciliary rootlet maintains long-term stability of sensory cilia
    Jun Yang
    The Berman Gund Laboratory for the Study of Retinal Degenerations, Howe Laboratory, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Mol Cell Biol 25:4129-37. 2005
    ..Inasmuch as photoreceptors elaborate an exceptionally enlarged sensory cilium, they are especially dependent on the rootlet for structural integrity and long-term survival...
  10. ncbi request reprint Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals
    Jun Yang
    The Berman Gund Laboratory for Study of Retinal Degenerations, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hum Mol Genet 16:1017-29. 2007
    ..We propose that Mpp4 organizes a presynaptic protein complex that includes PMCAs and has a role in modulating Ca(2+) homeostasis and synaptic transmission in rod photoreceptors...
  11. ncbi request reprint Piecing together the timetable for visual transduction with transgenic animals
    Clint L Makino
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Curr Opin Neurobiol 13:404-12. 2003
    ..The timetable for all of these molecular events determines the amplitude, kinetics and reproducibility of the photoresponse...