Francine Welty

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Frequency of ApoB and ApoE gene mutations as causes of hypobetalipoproteinemia in the framingham offspring population
    F K Welty
    Lipid Metabolism Laboratory, Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 18:1745-51. 1998
  2. ncbi Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women
    Francine K Welty
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Intern Med 167:1060-7. 2007
  3. ncbi Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women
    Francine K Welty
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Metabolism 56:910-4. 2007
  4. ncbi Effect of onsite dietitian counseling on weight loss and lipid levels in an outpatient physician office
    Francine K Welty
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 100:73-5. 2007
  5. ncbi The association between soy nut consumption and decreased menopausal symptoms
    Francine K Welty
    Division of Cardiology, Beth Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Womens Health (Larchmt) 16:361-9. 2007
  6. ncbi Interrelationships between human apolipoprotein A-I and apolipoproteins B-48 and B-100 kinetics using stable isotopes
    Francine K Welty
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 24:1703-7. 2004
  7. ncbi Nutrition and Women's Health Symposium. Introduction
    Francine K Welty
    Cardiovascular Care for Women, Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Womens Health (Larchmt) 12:105-8. 2003
  8. ncbi TRL, IDL, and LDL apolipoprotein B-100 and HDL apolipoprotein A-I kinetics as a function of age and menopausal status
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:1691-6. 2005
  9. ncbi Role of the estrogen and progestin in hormonal replacement therapy on apolipoprotein A-I kinetics in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 26:385-91. 2006
  10. ncbi Effect of soy nuts on adhesion molecules and markers of inflammation in hypertensive and normotensive postmenopausal women
    Melita M Nasca
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Cardiol 102:84-6. 2008

Research Grants

  1. MECHANISMS OF LOW LEVELS OF APOLIPOPROTEIN B
    Francine Welty; Fiscal Year: 2000
  2. Periodontal Disease and Coronary Artery Remodeling in CHD and Metabolic Syndrome
    Francine Welty; Fiscal Year: 2009
  3. Periodontal Disease and Coronary Artery Remodeling in CHD and Metabolic Syndrome
    Francine Welty; Fiscal Year: 2007
  4. ApoB and ApoA-I Kinetics in the ApoB-67 Mutation
    Francine Welty; Fiscal Year: 2006
  5. TEACHING NUTRITION TO PREVENT CARDIOVASCULAR DISEASES
    Francine Welty; Fiscal Year: 2004
  6. Periodontal Disease and Coronary Artery Remodeling in CHD and Metabolic Syndrome
    Francine K Welty; Fiscal Year: 2010

Detail Information

Publications28

  1. ncbi Frequency of ApoB and ApoE gene mutations as causes of hypobetalipoproteinemia in the framingham offspring population
    F K Welty
    Lipid Metabolism Laboratory, Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 18:1745-51. 1998
    ..21). In conclusion, a truncated apoB was a rare cause of HBLP, whereas the E2/E3 genotype was a much more common cause. A large prospective study is needed to evaluate the incidence of cancer and atherosclerosis in subjects with HBLP...
  2. ncbi Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women
    Francine K Welty
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Intern Med 167:1060-7. 2007
    ..For people aged 40 to 70 years, each increment of 20 mm Hg in systolic blood pressure (BP) or 10 mm Hg in diastolic BP doubles the risk of cardiovascular disease for BPs of 115/75 to 185/115 mm Hg...
  3. ncbi Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women
    Francine K Welty
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Metabolism 56:910-4. 2007
    ..Sixty-two percent of the variability in PR and 71% of the variability in FCR were due to BMI in men and only 3% and 23%, respectively, in women. In conclusion, BMI has a significant effect on apo A-I PR and FCR in men but not in women...
  4. ncbi Effect of onsite dietitian counseling on weight loss and lipid levels in an outpatient physician office
    Francine K Welty
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 100:73-5. 2007
    ..003). In conclusion, having a dietitian counsel patients concurrently with a physician in the outpatient setting is effective in achieving and maintaining weight loss and is fully reimbursable...
  5. ncbi The association between soy nut consumption and decreased menopausal symptoms
    Francine K Welty
    Division of Cardiology, Beth Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Womens Health (Larchmt) 16:361-9. 2007
    ..Epidemiological studies suggest a low incidence of hot flashes in populations that consume dietary soy. The present study examined the effect of soy nuts on hot flashes and menopausal symptoms...
  6. ncbi Interrelationships between human apolipoprotein A-I and apolipoproteins B-48 and B-100 kinetics using stable isotopes
    Francine K Welty
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 24:1703-7. 2004
    ..Our purpose was to determine the relationship between apolipoprotein (apo) A-I and apoB-48 and apoB-100 metabolism in moderately hypercholesterolemic humans...
  7. ncbi Nutrition and Women's Health Symposium. Introduction
    Francine K Welty
    Cardiovascular Care for Women, Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Womens Health (Larchmt) 12:105-8. 2003
  8. ncbi TRL, IDL, and LDL apolipoprotein B-100 and HDL apolipoprotein A-I kinetics as a function of age and menopausal status
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:1691-6. 2005
    ..To determine mechanisms contributing to the altered lipoprotein profile associated with aging and menopause, apolipoprotein B-100 (apoB-100) and apoA-I kinetic behavior was assessed...
  9. ncbi Role of the estrogen and progestin in hormonal replacement therapy on apolipoprotein A-I kinetics in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 26:385-91. 2006
    ..Hormonal replacement therapy (HRT) affects plasma HDL cholesterol levels, with estrogen increasing HDL cholesterol levels and progestins blunting this effect. This study was designed to assess the mechanism responsible for these effects...
  10. ncbi Effect of soy nuts on adhesion molecules and markers of inflammation in hypertensive and normotensive postmenopausal women
    Melita M Nasca
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Cardiol 102:84-6. 2008
    ....
  11. ncbi Measuring noncalcified coronary atherosclerotic plaque using voxel analysis with MDCT angiography: a pilot clinical study
    Melvin E Clouse
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, WCC 302, Boston, MA 02215, USA
    AJR Am J Roentgenol 190:1553-60. 2008
    ..The purpose of our study was to evaluate a new method using voxel analysis for quantifying noncalcified plaque in coronary arteries using MDCT angiography (MDCTA) compared with luminal stenosis by catheter coronary arteriography...
  12. ncbi Alternative hormone replacement regimens: is there a need for further clinical trials?
    Francine K Welty
    Division of Cardiology, Beth Israel Deaconess Medical Center, One Autumn Street, 5th Floor, Boston, MA 02215, USA
    Curr Opin Lipidol 14:585-91. 2003
    ..To review the randomized trials of hormone replacement therapy...
  13. ncbi Effect of addition of exercise to therapeutic lifestyle changes diet in enabling women and men with coronary heart disease to reach Adult Treatment Panel III low-density lipoprotein cholesterol goal without lowering high-density lipoprotein cholesterol
    Francine K Welty
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Cardiol 89:1201-4. 2002
  14. ncbi Influence of the DASH diet and other low-fat, high-carbohydrate diets on blood pressure
    Helen K Delichatsios
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Curr Atheroscler Rep 7:446-54. 2005
    ..Because many hypertensive subjects are overweight, hypocaloric versions of DASH geared toward weight loss are appropriate. Mechanisms for dietary beneficial effects are related to inflammation and insulin sensitivity...
  15. ncbi Preventing clinically evident coronary heart disease in the postmenopausal woman
    Francine K Welty
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
    Menopause 11:484-94. 2004
    ..This review summarizes data on the prevalent coronary heart disease risk factors of postmenopausal women and the pharmacologic and nonpharmacologic therapies available for preventing or treating them...
  16. ncbi Apolipoprotein A-I, B-100, and B-48 metabolism in subjects with chronic kidney disease, obesity, and the metabolic syndrome
    Marcelo C Batista
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Metabolism 53:1255-61. 2004
    ....
  17. ncbi Outcomes of using high- or low-dose atorvastatin in patients 65 years of age or older with stable coronary heart disease
    Nanette K Wenger
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Ann Intern Med 147:1-9. 2007
    ..Increased life expectancy is associated with an increase in the burden of chronic cardiovascular disease...
  18. ncbi The metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein (a) in human beings
    Jennifer L Jenner
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 54:361-9. 2005
    ....
  19. ncbi Apolipoprotein B metabolism in humans: studies with stable isotope-labeled amino acid precursors
    Julian B Marsh
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 162:227-44. 2002
    ..Because of the advances which have been made in mass spectrometry techniques, the advantages of using non-radioactive tracers in humans have made stable isotope kinetic studies the present day standard in this area of research...
  20. ncbi LC-MS-based method for the qualitative and quantitative analysis of complex lipid mixtures
    Ulf Sommer
    Mass Spectrometry Resource, Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    J Lipid Res 47:804-14. 2006
    ..The methods described should be easily adaptable to most modern MS instrumentation...
  21. ncbi Atorvastatin and cardiovascular risk in the elderly--patient considerations
    Subroto Acharjee
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Clin Interv Aging 3:299-314. 2008
    ....
  22. ncbi Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion
    Margaret E Brousseau
    Lipid Metabolism Laboratory, JM USDA HNRCA at Tufts University and Tufts New England Medical Center, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 25:1057-64. 2005
    ..The present study was designed to address these issues...
  23. ncbi Stable isotopes in obesity research
    Gregory G Dolnikowski
    Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    Mass Spectrom Rev 24:311-27. 2005
    ....
  24. ncbi Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism in humans
    John S Millar
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 26:1350-6. 2006
    ..The goal of the present study was to define the kinetic mechanism(s) by which CETP inhibition reduces levels of apoB-containing lipoproteins...
  25. ncbi Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on VLDL apolipoprotein E metabolism
    John S Millar
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Lipid Res 49:543-9. 2008
    ..Adding torcetrapib to atorvastatin treatment increases the VLDL apoE content, likely leading to decreased conversion of VLDL to LDL, reduced LDL production, and lower levels of circulating VLDL and LDL...
  26. ncbi Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston Mass 02111, USA
    Arterioscler Thromb Vasc Biol 24:1092-7. 2004
    ....
  27. ncbi Lipoprotein metabolism in subjects with hepatic lipase deficiency
    Marju Tilly-Kiesi
    Helsinki University Central Hospital, Helsinki, Finland
    Metabolism 53:520-5. 2004
    ..HL deficiency may result in a lipoprotein pattern associated with low heart disease risk...
  28. ncbi Aggressive versus moderate lipid-lowering therapy in hypercholesterolemic postmenopausal women: Beyond Endorsed Lipid Lowering with EBT Scanning (BELLES)
    Paolo Raggi
    Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Circulation 112:563-71. 2005
    ..We used sequential electron-beam tomography (EBT) scanning to quantify changes in coronary artery calcium (CAC) as a measure of atherosclerosis burden in patients treated with statins...

Research Grants12

  1. MECHANISMS OF LOW LEVELS OF APOLIPOPROTEIN B
    Francine Welty; Fiscal Year: 2000
    ..In specific aim 4, size and composition of VLDL will be compared in apoB-67 subjects and controls to determine if larger size or compositional changes account for the faster catabolism of VLDL apoB-100. ..
  2. Periodontal Disease and Coronary Artery Remodeling in CHD and Metabolic Syndrome
    Francine Welty; Fiscal Year: 2009
    ..This study may also show that salsalate improves oral and periodontal health. ..
  3. Periodontal Disease and Coronary Artery Remodeling in CHD and Metabolic Syndrome
    Francine Welty; Fiscal Year: 2007
    ..If this project shows that periodontal disease is related to the progression of coronary plaque, the public would benefit by more aggressive oral health care. This study may also show that salsalate improves oral and periodontal health. ..
  4. ApoB and ApoA-I Kinetics in the ApoB-67 Mutation
    Francine Welty; Fiscal Year: 2006
    ..The apoB-67 mutation may provide insights into mechanisms of low LDL-C and high HDL-C levels and new and better therapies to lower cholesterol. ..
  5. TEACHING NUTRITION TO PREVENT CARDIOVASCULAR DISEASES
    Francine Welty; Fiscal Year: 2004
    ..This career award will establish Dr. Walker as a leader in medical education in nutrition, his long-term career goal. ..
  6. Periodontal Disease and Coronary Artery Remodeling in CHD and Metabolic Syndrome
    Francine K Welty; Fiscal Year: 2010
    ..This study may also show that salsalate improves oral and periodontal health. ..