Andrew Wellman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Test of the Starling resistor model in the human upper airway during sleep
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
    J Appl Physiol (1985) 117:1478-85. 2014
  2. pmc A simplified method for determining phenotypic traits in patients with obstructive sleep apnea
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Appl Physiol (1985) 114:911-22. 2013
  3. pmc Ventilatory control and airway anatomy in obstructive sleep apnea
    Andrew Wellman
    Sleep Disorders Program at BI, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1225-32. 2004
  4. pmc A method for measuring and modeling the physiological traits causing obstructive sleep apnea
    Andrew Wellman
    221 Longwood Ave, 036 BLI, Boston, MA 02115, USA
    J Appl Physiol (1985) 110:1627-37. 2011
  5. pmc Chemical control stability in the elderly
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 581:291-8. 2007
  6. doi request reprint Effect of oxygen in obstructive sleep apnea: role of loop gain
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Respir Physiol Neurobiol 162:144-51. 2008
  7. pmc The influence of aging on pharyngeal collapsibility during sleep
    Matthias Eikermann
    Department of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Chest 131:1702-9. 2007
  8. pmc Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea
    Amy S Jordan
    Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
    Sleep 32:361-8. 2009
  9. pmc Model-based characterization of ventilatory stability using spontaneous breathing
    Shamim Nemati
    Massachusetts Institute of Technology, Cambridge, MA, USA
    J Appl Physiol (1985) 111:55-67. 2011
  10. pmc Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans
    Amy S Jordan
    Sleep Disorders Program BIDMC, 75 Francis St, Boston, Massachusetts 02115, USA
    Thorax 62:861-7. 2007

Research Grants

Detail Information

Publications27

  1. doi request reprint Test of the Starling resistor model in the human upper airway during sleep
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
    J Appl Physiol (1985) 117:1478-85. 2014
    ..These findings support the idea that there is not a single model of pharyngeal collapse, but rather that different mechanisms may dominate in different patients. These differences could potentially be exploited for treatment selection...
  2. pmc A simplified method for determining phenotypic traits in patients with obstructive sleep apnea
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Appl Physiol (1985) 114:911-22. 2013
    ..This technique is a relatively simple way of defining mechanisms underlying OSA and could potentially be used in a clinical setting to individualize therapy...
  3. pmc Ventilatory control and airway anatomy in obstructive sleep apnea
    Andrew Wellman
    Sleep Disorders Program at BI, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1225-32. 2004
    ..88, p = 0.0016). We conclude that loop gain has a substantial impact on apnea severity in certain patients with sleep apnea, particularly those with a pharyngeal closing pressure near atmospheric...
  4. pmc A method for measuring and modeling the physiological traits causing obstructive sleep apnea
    Andrew Wellman
    221 Longwood Ave, 036 BLI, Boston, MA 02115, USA
    J Appl Physiol (1985) 110:1627-37. 2011
    ..This technique could conceivably be used clinically to define a patient's physiology and guide therapy based on the traits...
  5. pmc Chemical control stability in the elderly
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 581:291-8. 2007
    ..26). We conclude that the chemical control of breathing does not become unstable with ageing and is thus an unlikely cause of central (and possibly obstructive) apnoeas in this population...
  6. doi request reprint Effect of oxygen in obstructive sleep apnea: role of loop gain
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Respir Physiol Neurobiol 162:144-51. 2008
    ..These data suggest that ventilatory instability is an important mechanism causing obstructive sleep apnea in some patients (those with a relatively high LG), since lowering LG with oxygen in these patients significantly reduces AHI...
  7. pmc The influence of aging on pharyngeal collapsibility during sleep
    Matthias Eikermann
    Department of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Chest 131:1702-9. 2007
    ..We tested the hypotheses that upper airway closing pressure (PCLOSE) and the increase in pharyngeal resistance during sleep (primary outcomes) as well as measures of arousal threshold (secondary outcomes) increase with age...
  8. pmc Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea
    Amy S Jordan
    Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
    Sleep 32:361-8. 2009
    ....
  9. pmc Model-based characterization of ventilatory stability using spontaneous breathing
    Shamim Nemati
    Massachusetts Institute of Technology, Cambridge, MA, USA
    J Appl Physiol (1985) 111:55-67. 2011
    ....
  10. pmc Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans
    Amy S Jordan
    Sleep Disorders Program BIDMC, 75 Francis St, Boston, Massachusetts 02115, USA
    Thorax 62:861-7. 2007
    ..The aims of this study were to compare the ability to recover ventilation and the mechanisms of compensation following a sudden reduction of continuous positive airway pressure (CPAP) in subjects with and without OSA...
  11. pmc Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea
    Amy S Jordan
    Harvard Medical School and Division of Sleep Medicine, Brigham and Women s Hospital, Sleep Disorders Research Program, Boston, MA 02115, USA
    J Appl Physiol (1985) 99:2020-7. 2005
    ..38 +/- 0.02 vs. 0.33 +/- 0.03; P = 0.14). These results suggest that women may be protected from developing OSA by having a less collapsible upper airway for any given degree of obesity...
  12. pmc Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea
    Bradley A Edwards
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Physiol 590:1199-211. 2012
    ..Identification of patients who may benefit from reductions in LG alone or in combination with other therapies to alter the remaining traits may facilitate pharmacological resolution of OSA in the future...
  13. pmc Acetazolamide attenuates the ventilatory response to arousal in patients with obstructive sleep apnea
    Bradley A Edwards
    Division of Sleep Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Sleep 36:281-5. 2013
    ..As acetazolamide can reduce apnea severity in some patients, we examined the effect of acetazolamide on the ventilatory response to spontaneous arousals in CPAP-treated OSA patients...
  14. pmc Termination of respiratory events with and without cortical arousal in obstructive sleep apnea
    Amy S Jordan
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 184:1183-91. 2011
    ..Arousals are thought to predispose to further events by promoting hyperventilation, hypocapnia, and upper-airway dilator muscle hypotonia. Therefore, events terminated without arousal may promote stable breathing...
  15. pmc Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 113:691-9. 2012
    ..These results also highlight the importance of inspiratory collapse in OSA pathogenesis. The cause of negative effort dependence within and across breaths is not known and requires further study...
  16. pmc Influence of pharyngeal muscle activity on inspiratory negative effort dependence in the human upper airway
    Pedro R Genta
    Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA Electronic address
    Respir Physiol Neurobiol 201:55-9. 2014
    ..6±5.8% (p=0.056). In conclusion, phasic EMG(GG) had little effect on NED. This finding suggests that individual differences in phasic EMG(GG) activation do not likely explain the variability in NED found among OSA patients...
  17. ncbi request reprint Respiratory system loop gain in normal men and women measured with proportional-assist ventilation
    Andrew Wellman
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 94:205-12. 2003
    ..We conclude that LG is low in the majority of normal men and women and that higher volume amplification factors are needed to determine whether gender differences exist in this low range...
  18. doi request reprint Quantifying the ventilatory control contribution to sleep apnoea using polysomnography
    Philip I Terrill
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia
    Eur Respir J 45:408-18. 2015
    ..We validated a means to quantify the ventilatory control contribution to OSA pathogenesis using clinical polysomnography, enabling identification of likely responders to therapies targeting ventilatory control. ..
  19. doi request reprint Enhanced upper-airway muscle responsiveness is a distinct feature of overweight/obese individuals without sleep apnea
    Scott A Sands
    1 Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Am J Respir Crit Care Med 190:930-7. 2014
    ..Body habitus is a major determinant of obstructive sleep apnea (OSA). However, many individuals do not have OSA despite being overweight/obese (body mass index > 25 kg/m(2)) for reasons that are not fully elucidated...
  20. doi request reprint Effects of hyperoxia and hypoxia on the physiological traits responsible for obstructive sleep apnoea
    Bradley A Edwards
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Physiol 592:4523-35. 2014
    ..The effects of hypoxia described above may explain the disappearance of OSA and the emergence of central sleep apnoea in conditions such as high altitude. ..
  21. pmc The classical Starling resistor model often does not predict inspiratory airflow patterns in the human upper airway
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Appl Physiol (1985) 116:1105-12. 2014
    ..In contrast to the classical Starling resistor model, the upper airway exhibits marked NED in some subjects. ..
  22. pmc Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold
    Danny J Eckert
    Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Sci (Lond) 120:505-14. 2011
    ..However, additional treatment strategies are probably required to achieve elimination of apnoea...
  23. pmc Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets
    Danny J Eckert
    1 Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Am J Respir Crit Care Med 188:996-1004. 2013
    ..The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among patients but have not been well characterized...
  24. pmc Obstructive sleep apnea in older adults is a distinctly different physiological phenotype
    Bradley A Edwards
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Sleep 37:1227-36. 2014
    ..However, previous studies examining individual physiological traits known to contribute to OSA pathogenesis have been assessed in isolation, primarily in healthy individuals...
  25. pmc Influence of wakefulness on pharyngeal airway muscle activity
    Yu Lun Lo
    Brigham and Women s Hospital, Sleep Disorders Research Program, 75 Francis Street, Boston, Massachusetts 02115, USA
    Thorax 62:799-805. 2007
    ..A study was therefore undertaken to assess the isolated impact of sleep on upper airway muscle activity after minimising respiratory/mechanical inputs...
  26. doi request reprint Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea
    Bradley A Edwards
    1 Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Am J Respir Crit Care Med 190:1293-300. 2014
    ..A low respiratory arousal threshold (ArTH) is one of several traits involved in obstructive sleep apnea pathogenesis and may be a therapeutic target; however, there is no simple way to identify patients without invasive measurements...
  27. pmc Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold
    Danny J Eckert
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program and Harvard Medical School, Boston, MA Neuroscience Research Australia NeuRA, and the School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Sleep 37:811-9. 2014
    ..Secondary aims were to examine the effects of trazodone on upper airway dilator muscle activity, upper airway collapsibility, and breathing during sleep...

Research Grants1

  1. Respiratory Control Stability in Obstructive Sleep Apnea
    David Wellman; Fiscal Year: 2004
    ..b. High LG, independent of upper airway collapsibility, is associated with more severe (more frequently apneas) OSA. c. Lower LG will reduce OSA severity in patients with high LG. ..