Research Topics
Genomes and GenesSpecies | Gregory A WelleniusSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Disparities in myocardial infarction case fatality rates among the elderly: the 20-year Medicare experienceGregory A Wellenius
Department of Medicine, Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am Heart J 156:483-90. 2008..Accordingly, we sought to assess long-term temporal trends in mortality after hospitalization for MI and to assess whether these trends differ by sex, race, or age in a cohort of elderly patients...- Effects of ambient air pollution on functional status in patients with chronic congestive heart failure: a repeated-measures studyGregory A Wellenius
Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Environ Health 6:26. 2007..We tested the hypothesis that BNP levels would be positively associated with short-term changes in ambient pollution levels among 28 patients with chronic stable HF and impaired systolic function... - Effects of ambient particles and carbon monoxide on supraventricular arrhythmias in a rat model of myocardial infarctionGregory A Wellenius
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Inhal Toxicol 18:1077-82. 2006..Thus, the results of this study do not support the hypothesis that exposure to ambient air pollution increases the risk or frequency of supraventricular arrhythmias... - Renal dysfunction increases the risk of saphenous vein graft occlusion: results from the Post-CABG trialGregory A Wellenius
Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Deaconess 306, Boston, MA 02215, USA
Atherosclerosis 193:414-20. 2007..Saphenous vein grafts are common among patients with a history of coronary artery bypass graft (CABG) surgery. Chronic kidney disease (CKD) is an established cardiovascular risk factor, but its role in graft disease has not been evaluated... - Particulate air pollution and hospital admissions for congestive heart failure in seven United States citiesGregory A Wellenius
Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Am J Cardiol 97:404-8. 2006.... - Air pollution and hospital admissions for ischemic and hemorrhagic stroke among medicare beneficiariesGregory A Wellenius
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Stroke 36:2549-53. 2005..The association between short-term elevations in ambient air particles and increased cardiovascular morbidity and mortality is well documented. Ambient particles may similarly increase the risk of stroke... - Depressive symptoms and the risk of atherosclerotic progression among patients with coronary artery bypass graftsGregory A Wellenius
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Circulation 117:2313-9. 2008.... - Particulate air pollution and the rate of hospitalization for congestive heart failure among medicare beneficiaries in Pittsburgh, PennsylvaniaGregory A Wellenius
Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Epidemiol 161:1030-6. 2005.... - Mechanisms of inhaled fine particulate air pollution-induced arterial blood pressure changesCarlo R Bartoli
Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Environ Health Perspect 117:361-6. 2009..Epidemiologic studies suggest a positive association between fine particulate matter and arterial blood pressure, but the results have been inconsistent... - Cardiac effects of carbon monoxide and ambient particles in a rat model of myocardial infarctionGregory A Wellenius
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Toxicol Sci 80:367-76. 2004..No significant interactions were observed between the effects of CO and CAPs. In this animal model, the responses to CO and CAPs are distinctly different... - Cardiac oxidative stress and electrophysiological changes in rats exposed to concentrated ambient particles are mediated by TRP-dependent pulmonary reflexesElisa Ghelfi
Harvard School of Public Health, Department of Environmental Health, Boston, Massachusetts, USA
Toxicol Sci 102:328-36. 2008.... - Concentrated ambient particles alter myocardial blood flow during acute ischemia in conscious caninesCarlo R Bartoli
Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Environ Health Perspect 117:333-7. 2009..Experimental and observational studies have demonstrated that short-term exposure to ambient particulate matter (PM) exacerbates myocardial ischemia... - The toxicological evaluation of realistic emissions of source aerosols study: statistical methodsBrent A Coull
Department of Biostatistics and Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Inhal Toxicol 23:31-41. 2011..Peak expiratory flow (PEF) is used to demonstrate how the multiple levels of the analysis complement each other to assess constituents most strongly associated with health effects... - Cardiac oxidative stress and dysfunction by fine concentrated ambient particles (CAPs) are mediated by angiotensin-IIElisa Ghelfi
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Inhal Toxicol 22:963-72. 2010..These results show that ambient fine particles can increase plasma levels of angiotensin-II and suggest a role of the renin-angiotensin system in the development of particle-related acute cardiac events... - Traffic-related air pollution and QT interval: modification by diabetes, obesity, and oxidative stress gene polymorphisms in the normative aging studyEmmanuel S Baja
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Environ Health Perspect 118:840-6. 2010..Acute exposure to ambient air pollution has been associated with acute changes in cardiac outcomes, often within hours of exposure... - Modeling the association between particle constituents of air pollution and health outcomesElizabeth Mostofsky
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Am J Epidemiol 176:317-26. 2012..5. Although the different methods yield results with different interpretations, the relative rankings of the association between constituents and ischemic stroke were fairly consistent across models... - Weather and air pollution as triggers of severe headachesKenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Neurology 72:922-7. 2009..The roles of weather conditions and air pollution as triggers of headache have been inconsistent in previous, generally small studies... - Crescendo in depolarization and repolarization heterogeneity heralds development of ventricular tachycardia in hospitalized patients with decompensated heart failureBruce D Nearing
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 3908, USA
Circ Arrhythm Electrophysiol 5:84-90. 2012..We used a new quantitative method to track interlead heterogeneity of depolarization and repolarization to detect premonitory changes before ventricular tachycardia (VT) in hospitalized patients with acute decompensated heart failure... - Inhalation of concentrated ambient air particles exacerbates myocardial ischemia in conscious dogsGregory A Wellenius
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Environ Health Perspect 111:402-8. 2003..Heart rate was not affected by CAPs exposure. These results suggest that exacerbation of myocardial ischemia during coronary artery occlusion may be an important mechanism of environmentally related acute cardiac events... - Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozoneAsghar A Fakhri
Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Environ Health Perspect 117:1287-92. 2009.... - Hematologic parameters, atherosclerotic progression, and prognosis in patients with previous coronary artery bypass grafting (from the Post CABG Trial)Kenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
Am J Cardiol 103:328-32. 2009..In conclusion, WBC count is associated with a graded increase in cardiovascular events in patients with coronary artery bypass grafts... - Air pollution and risk of stroke: underestimation of effect due to misclassification of time of event onsetR Peter Lokken
Department of Medicine, Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Epidemiology 20:137-42. 2009..Epidemiologic studies linking ambient air pollution to the onset of acute cardiovascular events often rely on date of hospital admission for exposure assessment... - PM-induced cardiac oxidative stress and dysfunction are mediated by autonomic stimulationClaudia R Rhoden
Department of Environmental Health, Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
Biochim Biophys Acta 1725:305-13. 2005..These data indicate that PM exposure increases cardiac oxidants via autonomic signals and the resulting oxidative stress is associated with significant functional alterations in the heart... - Self-reported anxiety and the risk of clinical events and atherosclerotic progression among patients with Coronary Artery Bypass Grafts (CABG)Joshua I Rosenbloom
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am Heart J 158:867-73. 2009.... - Electrocardiographic changes during exposure to residual oil fly ash (ROFA) particles in a rat model of myocardial infarctionGregory A Wellenius
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Toxicol Sci 66:327-35. 2002.... - Renal function predicts survival in patients with acute ischemic strokeElizabeth Mostofsky
Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Cerebrovasc Dis 28:88-94. 2009..Among patients with acute ischemic stroke, impaired kidney function has been shown to increase the mortality risk, but the shape of this relationship has not been evaluated in detail... - Potent antifibrillatory effects of intrapericardial nitroglycerin in the ischemic porcine heartKapil Kumar
Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 41:1831-7. 2003..012). CONCLUSIONS: Intrapericardial NTG exerts a robust antifibrillatory action. Potential mechanisms include reduction in electrical instability and blunting of adrenergic effects... - Holiday review. Early to bed and early to rise: does it matter?Kenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
CMAJ 175:1560-2. 2006..INTERPRETATION: Our results refute both the Franklin and Thurber hypotheses. Early to bed and early to rise is not associated with health, wealth or wisdom... - Gender differences in presenting and prodromal stroke symptomsEileen M Stuart-Shor
ANP, Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Stroke 40:1121-6. 2009..Prompt recognition of stroke symptoms is critical to timely treatment and women have increased delay to treatment. Women may be more likely to present with atypical symptoms, but this hypothesis has not been extensively evaluated... - Ambient temperature and biomarkers of heart failure: a repeated measures analysisElissa H Wilker
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Environ Health Perspect 120:1083-7. 2012..Conclusions: Among patients undergoing treatment for heart failure, we observed positive associations between temperature and both BNP and CRP-predictors of heart failure prognosis and severity... - Seasonality and coronary heart disease deaths in United States firefightersIbeawuchi Mbanu
Department of Environmental Health Occupational Health Program, Harvard School of Public Health, Boston, MA, USA
Chronobiol Int 24:715-26. 2007..The seasonal pattern was also found to be independent of duty-related risks... - It's not the heat, it's the humidity: wet weather increases legionellosis risk in the greater Philadelphia metropolitan areaDavid N Fisman
School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA
J Infect Dis 192:2066-73. 2005..Increases in cases of community-acquired legionellosis in the greater Philadelphia metropolitan area (GPMA) led to concern that changing environmental factors could influence occurrence of disease...
Research Grants
- Particulate Air Pollution and Acute Ischemic StrokeGregory Wellenius; Fiscal Year: 2006..These hypotheses will be tested in patient populations with complimentary strengths. ..
- Mechanisms of Air Pollution Health Effects in Subjects with Heart FailureGregory Wellenius; Fiscal Year: 2007..Understanding the underlying mechanisms may lead to new preventative strategies, new treatments, or improved air quality. ..