Gregory A Wellenius

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Air pollution and hospital admissions for ischemic and hemorrhagic stroke among medicare beneficiaries
    Gregory A Wellenius
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Stroke 36:2549-53. 2005
  2. ncbi request reprint Particulate air pollution and hospital admissions for congestive heart failure in seven United States cities
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 97:404-8. 2006
  3. ncbi request reprint Effects of ambient particles and carbon monoxide on supraventricular arrhythmias in a rat model of myocardial infarction
    Gregory A Wellenius
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Inhal Toxicol 18:1077-82. 2006
  4. pmc Effects of ambient air pollution on functional status in patients with chronic congestive heart failure: a repeated-measures study
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Environ Health 6:26. 2007
  5. pmc Depressive symptoms and the risk of atherosclerotic progression among patients with coronary artery bypass grafts
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Circulation 117:2313-9. 2008
  6. pmc Particulate air pollution and the rate of hospitalization for congestive heart failure among medicare beneficiaries in Pittsburgh, Pennsylvania
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Epidemiol 161:1030-6. 2005
  7. pmc Disparities in myocardial infarction case fatality rates among the elderly: the 20-year Medicare experience
    Gregory A Wellenius
    Department of Medicine, Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am Heart J 156:483-90. 2008
  8. ncbi request reprint Renal dysfunction increases the risk of saphenous vein graft occlusion: results from the Post-CABG trial
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Deaconess 306, Boston, MA 02215, USA
    Atherosclerosis 193:414-20. 2007
  9. ncbi request reprint Cardiac effects of carbon monoxide and ambient particles in a rat model of myocardial infarction
    Gregory A Wellenius
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Toxicol Sci 80:367-76. 2004
  10. pmc Mechanisms of inhaled fine particulate air pollution-induced arterial blood pressure changes
    Carlo R Bartoli
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Environ Health Perspect 117:361-6. 2009

Research Grants

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Air pollution and hospital admissions for ischemic and hemorrhagic stroke among medicare beneficiaries
    Gregory A Wellenius
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Stroke 36:2549-53. 2005
    ..The association between short-term elevations in ambient air particles and increased cardiovascular morbidity and mortality is well documented. Ambient particles may similarly increase the risk of stroke...
  2. ncbi request reprint Particulate air pollution and hospital admissions for congestive heart failure in seven United States cities
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 97:404-8. 2006
    ....
  3. ncbi request reprint Effects of ambient particles and carbon monoxide on supraventricular arrhythmias in a rat model of myocardial infarction
    Gregory A Wellenius
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Inhal Toxicol 18:1077-82. 2006
    ..Thus, the results of this study do not support the hypothesis that exposure to ambient air pollution increases the risk or frequency of supraventricular arrhythmias...
  4. pmc Effects of ambient air pollution on functional status in patients with chronic congestive heart failure: a repeated-measures study
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Environ Health 6:26. 2007
    ..We tested the hypothesis that BNP levels would be positively associated with short-term changes in ambient pollution levels among 28 patients with chronic stable HF and impaired systolic function...
  5. pmc Depressive symptoms and the risk of atherosclerotic progression among patients with coronary artery bypass grafts
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Circulation 117:2313-9. 2008
    ....
  6. pmc Particulate air pollution and the rate of hospitalization for congestive heart failure among medicare beneficiaries in Pittsburgh, Pennsylvania
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Epidemiol 161:1030-6. 2005
    ....
  7. pmc Disparities in myocardial infarction case fatality rates among the elderly: the 20-year Medicare experience
    Gregory A Wellenius
    Department of Medicine, Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am Heart J 156:483-90. 2008
    ..Accordingly, we sought to assess long-term temporal trends in mortality after hospitalization for MI and to assess whether these trends differ by sex, race, or age in a cohort of elderly patients...
  8. ncbi request reprint Renal dysfunction increases the risk of saphenous vein graft occlusion: results from the Post-CABG trial
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Deaconess 306, Boston, MA 02215, USA
    Atherosclerosis 193:414-20. 2007
    ..Saphenous vein grafts are common among patients with a history of coronary artery bypass graft (CABG) surgery. Chronic kidney disease (CKD) is an established cardiovascular risk factor, but its role in graft disease has not been evaluated...
  9. ncbi request reprint Cardiac effects of carbon monoxide and ambient particles in a rat model of myocardial infarction
    Gregory A Wellenius
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Toxicol Sci 80:367-76. 2004
    ..No significant interactions were observed between the effects of CO and CAPs. In this animal model, the responses to CO and CAPs are distinctly different...
  10. pmc Mechanisms of inhaled fine particulate air pollution-induced arterial blood pressure changes
    Carlo R Bartoli
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Environ Health Perspect 117:361-6. 2009
    ..Epidemiologic studies suggest a positive association between fine particulate matter and arterial blood pressure, but the results have been inconsistent...
  11. pmc Modeling the association between particle constituents of air pollution and health outcomes
    Elizabeth Mostofsky
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 176:317-26. 2012
    ..5. Although the different methods yield results with different interpretations, the relative rankings of the association between constituents and ischemic stroke were fairly consistent across models...
  12. ncbi request reprint Structural equation modeling of parasympathetic and sympathetic response to traffic air pollution in a repeated measures study
    Emmanuel S Baja
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 12:81. 2013
    ..In a Bayesian framework, we examined the effect of traffic pollution on HRV using structural equation models (SEMs) and looked at effect modification by participant characteristics...
  13. doi request reprint Cardiac oxidative stress and electrophysiological changes in rats exposed to concentrated ambient particles are mediated by TRP-dependent pulmonary reflexes
    Elisa Ghelfi
    Harvard School of Public Health, Department of Environmental Health, Boston, Massachusetts, USA
    Toxicol Sci 102:328-36. 2008
    ....
  14. doi request reprint Residential proximity to major roadways and renal function
    Shih Ho Lue
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Epidemiol Community Health 67:629-34. 2013
    ..Living near major roadways has been associated with increased risk of cardiovascular events, but little is known about its impact on renal function...
  15. pmc Concentrated ambient particles alter myocardial blood flow during acute ischemia in conscious canines
    Carlo R Bartoli
    Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Environ Health Perspect 117:333-7. 2009
    ..Experimental and observational studies have demonstrated that short-term exposure to ambient particulate matter (PM) exacerbates myocardial ischemia...
  16. doi request reprint Structural equation modeling of the inflammatory response to traffic air pollution
    Emmanuel S Baja
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Expo Sci Environ Epidemiol 23:268-74. 2013
    ..Traffic pollution adversely impacts inflammation in the elderly. SEMs in a Bayesian framework can comprehensively incorporate multiple pollutants and health outcomes simultaneously in air pollution-cardiovascular epidemiological studies...
  17. pmc Traffic-related air pollution and QT interval: modification by diabetes, obesity, and oxidative stress gene polymorphisms in the normative aging study
    Emmanuel S Baja
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 118:840-6. 2010
    ..Acute exposure to ambient air pollution has been associated with acute changes in cardiac outcomes, often within hours of exposure...
  18. pmc The toxicological evaluation of realistic emissions of source aerosols study: statistical methods
    Brent A Coull
    Department of Biostatistics and Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Inhal Toxicol 23:31-41. 2011
    ..Peak expiratory flow (PEF) is used to demonstrate how the multiple levels of the analysis complement each other to assess constituents most strongly associated with health effects...
  19. pmc Cardiac oxidative stress and dysfunction by fine concentrated ambient particles (CAPs) are mediated by angiotensin-II
    Elisa Ghelfi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Inhal Toxicol 22:963-72. 2010
    ..These results show that ambient fine particles can increase plasma levels of angiotensin-II and suggest a role of the renin-angiotensin system in the development of particle-related acute cardiac events...
  20. pmc Weather and air pollution as triggers of severe headaches
    Kenneth J Mukamal
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurology 72:922-7. 2009
    ..The roles of weather conditions and air pollution as triggers of headache have been inconsistent in previous, generally small studies...
  21. pmc Crescendo in depolarization and repolarization heterogeneity heralds development of ventricular tachycardia in hospitalized patients with decompensated heart failure
    Bruce D Nearing
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 3908, USA
    Circ Arrhythm Electrophysiol 5:84-90. 2012
    ..We used a new quantitative method to track interlead heterogeneity of depolarization and repolarization to detect premonitory changes before ventricular tachycardia (VT) in hospitalized patients with acute decompensated heart failure...
  22. pmc Inhalation of concentrated ambient air particles exacerbates myocardial ischemia in conscious dogs
    Gregory A Wellenius
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 111:402-8. 2003
    ..Heart rate was not affected by CAPs exposure. These results suggest that exacerbation of myocardial ischemia during coronary artery occlusion may be an important mechanism of environmentally related acute cardiac events...
  23. ncbi request reprint Residential proximity to high-traffic roadways and poststroke mortality
    Elissa H Wilker
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts Environmental Epidemiology and Risk Program, Harvard School of Public Health, Boston, Massachusetts Electronic address
    J Stroke Cerebrovasc Dis 22:e366-72. 2013
    ....
  24. pmc Air pollution and risk of stroke: underestimation of effect due to misclassification of time of event onset
    R Peter Lokken
    Department of Medicine, Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Epidemiology 20:137-42. 2009
    ..Epidemiologic studies linking ambient air pollution to the onset of acute cardiovascular events often rely on date of hospital admission for exposure assessment...
  25. doi request reprint Hematologic parameters, atherosclerotic progression, and prognosis in patients with previous coronary artery bypass grafting (from the Post CABG Trial)
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Cardiol 103:328-32. 2009
    ..In conclusion, WBC count is associated with a graded increase in cardiovascular events in patients with coronary artery bypass grafts...
  26. pmc Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone
    Asghar A Fakhri
    Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:1287-92. 2009
    ....
  27. ncbi request reprint PM-induced cardiac oxidative stress and dysfunction are mediated by autonomic stimulation
    Claudia R Rhoden
    Department of Environmental Health, Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    Biochim Biophys Acta 1725:305-13. 2005
    ..These data indicate that PM exposure increases cardiac oxidants via autonomic signals and the resulting oxidative stress is associated with significant functional alterations in the heart...
  28. pmc Ambient temperature and biomarkers of heart failure: a repeated measures analysis
    Elissa H Wilker
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Environ Health Perspect 120:1083-7. 2012
    ....
  29. pmc Self-reported anxiety and the risk of clinical events and atherosclerotic progression among patients with Coronary Artery Bypass Grafts (CABG)
    Joshua I Rosenbloom
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am Heart J 158:867-73. 2009
    ....
  30. pmc Renal function predicts survival in patients with acute ischemic stroke
    Elizabeth Mostofsky
    Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Cerebrovasc Dis 28:88-94. 2009
    ..Among patients with acute ischemic stroke, impaired kidney function has been shown to increase the mortality risk, but the shape of this relationship has not been evaluated in detail...
  31. ncbi request reprint Electrocardiographic changes during exposure to residual oil fly ash (ROFA) particles in a rat model of myocardial infarction
    Gregory A Wellenius
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Toxicol Sci 66:327-35. 2002
    ....
  32. pmc Holiday review. Early to bed and early to rise: does it matter?
    Kenneth J Mukamal
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    CMAJ 175:1560-2. 2006
    ..Controversy remains about whether early to bed and early to rise makes a man healthy, wealthy and wise (the Ben Franklin hypothesis), or healthy, wealthy and dead (the James Thurber hypothesis)...
  33. ncbi request reprint Potent antifibrillatory effects of intrapericardial nitroglycerin in the ischemic porcine heart
    Kapil Kumar
    Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 41:1831-7. 2003
    ..We investigated the antiarrhythmic effects of intrapericardial nitroglycerin (NTG) during acute myocardial ischemia in the porcine heart...
  34. pmc Gender differences in presenting and prodromal stroke symptoms
    Eileen M Stuart-Shor
    ANP, Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Stroke 40:1121-6. 2009
    ..Prompt recognition of stroke symptoms is critical to timely treatment and women have increased delay to treatment. Women may be more likely to present with atypical symptoms, but this hypothesis has not been extensively evaluated...
  35. pmc Seasonality and coronary heart disease deaths in United States firefighters
    Ibeawuchi Mbanu
    Department of Environmental Health Occupational Health Program, Harvard School of Public Health, Boston, MA, USA
    Chronobiol Int 24:715-26. 2007
    ..The seasonal pattern was also found to be independent of duty-related risks...
  36. ncbi request reprint It's not the heat, it's the humidity: wet weather increases legionellosis risk in the greater Philadelphia metropolitan area
    David N Fisman
    School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA
    J Infect Dis 192:2066-73. 2005
    ..Increases in cases of community-acquired legionellosis in the greater Philadelphia metropolitan area (GPMA) led to concern that changing environmental factors could influence occurrence of disease...

Research Grants3

  1. Particulate Air Pollution and Acute Ischemic Stroke
    Gregory Wellenius; Fiscal Year: 2006
    ..These hypotheses will be tested in patient populations with complimentary strengths. ..
  2. Mechanisms of Air Pollution Health Effects in Subjects with Heart Failure
    Gregory Wellenius; Fiscal Year: 2007
    ..Understanding the underlying mechanisms may lead to new preventative strategies, new treatments, or improved air quality. ..