Research Topics
Species | Marc WeisskopfSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Polychlorinated biphenyls in prospectively collected serum and Parkinson's disease riskMarc G Weisskopf
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Mov Disord 27:1659-65. 2012..34 (95% confidence interval, 0.13-0.90; P trend = .05). These results do not support an increased risk of PD from polychlorinated biphenyl exposure and instead suggest a possible protective effect of polychlorinated biphenyl exposure...- Heat wave morbidity and mortality, Milwaukee, Wis, 1999 vs 1995: an improved response?Marc G Weisskopf
Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA, USA
Am J Public Health 92:830-3. 2002.... 
Smoking and cognitive function in Parkinson's diseaseMarc G Weisskopf
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Mov Disord 22:660-5. 2007..Analyses of pack-years of smoking prior to disease onset gave similar results. These findings, nested in prospective cohort studies, suggest that cigarette smoking prior to disease onset is associated with worse cognitive function in PD...- Magnetic resonance spectroscopy and environmental toxicant exposureMarc G Weisskopf
Department of Environmental Health, Harvard School of Public Health, Occupational Health Program, Landmark Center, 401 Park Dr, P O Box 15697, Boston, MA 02215, USA
Ann N Y Acad Sci 1097:179-82. 2007..MRS showed lower N-acetylaspartate/creatine ratios in JG. The findings illustrate the potential utility of MRS in assessing impacts of not only lead, but other toxicants as well... - Proton magnetic resonance spectroscopic evidence of glial effects of cumulative lead exposure in the adult human hippocampusMarc G Weisskopf
Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, 401 Park Drive, Boston, MA 02215, USA
Environ Health Perspect 115:519-23. 2007..Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans... - Plasma urate and risk of Parkinson's diseaseM G Weisskopf
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Am J Epidemiol 166:561-7. 2007.... - Prospective study of chemical exposures and amyotrophic lateral sclerosisM G Weisskopf
Harvard School of Public Health, Department of Environmental Health, Boston, MA 02215, USA
J Neurol Neurosurg Psychiatry 80:558-61. 2009..This study assessed the association between exposure to chemicals and risk of ALS in a prospective cohort study... - A prospective study of bone lead concentration and death from all causes, cardiovascular diseases, and cancer in the Department of Veterans Affairs Normative Aging StudyMarc G Weisskopf
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Circulation 120:1056-64. 2009..The association between bone lead levels and mortality has not been explored... - Persistent organochlorine pesticides in serum and risk of Parkinson diseaseM G Weisskopf
Harvard School of Public Health, Department of Environmental Health, Landmark Center, Boston, MA 02215, USA
Neurology 74:1055-61. 2010..No prior studies of pesticide exposure and PD used biomarkers of exposure collected before the onset of PD. Our investigation examined the association between prospective serum biomarkers of organochlorine pesticides and PD... - Association of cumulative lead exposure with Parkinson's diseaseMarc G Weisskopf
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 118:1609-13. 2010.... - Cumulative lead exposure and cognitive performance among elderly menMarc G Weisskopf
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Epidemiology 18:59-66. 2007..Recent evidence suggests that cumulative lead exposure among adults in nonoccupational settings can adversely affect cognitive function. Which cognitive domains are affected has not been explored in detail... - Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoningMarc G Weisskopf
Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Landmark Center, 401 Park Drive, PO Box 15697, Boston, MA 02215, USA
Environ Health Perspect 112:620-5. 2004..Nevertheless, the results point to the potential utility of MRS in determining mechanisms of neurotoxicity not only for lead but also for other neurotoxicants as well... - Prospective study of phobic anxiety and risk of Parkinson's diseaseMarc G Weisskopf
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Mov Disord 18:646-51. 2003..Our results suggest that anxiety is a risk factor for PD. Whether this association is causal or the result of shared underlying biology remains a question... - Maternal exposure to Great Lakes sport-caught fish and dichlorodiphenyl dichloroethylene, but not polychlorinated biphenyls, is associated with reduced birth weightMarc G Weisskopf
Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, 1600 Clifton Rd MS D18, Atlanta, GA 30333, USA
Environ Res 97:149-62. 2005..The data suggest that fetal DDE exposure (as indicated by maternal serum DDE concentration) may decrease birth weight and that decreased birth weight effects associated with GLSCF consumption have decreased over time... - Decreased sex ratio following maternal exposure to polychlorinated biphenyls from contaminated Great Lakes sport-caught fish: a retrospective cohort studyMarc G Weisskopf
Bureau of Environmental Health, Wisconsin Department of Health and Family Services, Madison, WI, USA
Environ Health 2:2. 2003..Several environmental contaminants have been found to alter the sex ratio of offspring at birth, but the evidence of such an effect of polychlorinated biphenyls has been inconsistent... - Prospective study of occupation and amyotrophic lateral sclerosis mortalityM G Weisskopf
Department of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
Am J Epidemiol 162:1146-52. 2005..04). Results, which suggest that male programmers and laboratory technicians and female machine assemblers may be at increased risk of death from ALS, should be interpreted cautiously, however, because they are based on small numbers... - Hazardous ammonia releases: public health consequences and risk factors for evacuation and injury, United States, 1993-1998Marc G Weisskopf
Harvard School of Public Health, Department of Environmental Health, OHP, 665 Huntington Avenue, Boston, MA, USA
J Occup Environ Med 45:197-204. 2003..Indoor release was a consistent risk factor, whereas quantity of ammonia released was not always a risk factor. Preventive maintenance and worker training may be effective tools to reduce the burdens of hazardous ammonia releases... - Low-level lead exposure, metabolic syndrome, and heart rate variability: the VA Normative Aging StudySung Kyun Park
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 114:1718-24. 2006..Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure... - Arsenic exposure and DNA methylation among elderly menAngeliki Lambrou
Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Epidemiology 23:668-76. 2012..This association has also been explored in highly exposed human populations, but studies among populations environmentally exposed to low arsenic levels are lacking... - Smoking and risk of amyotrophic lateral sclerosis: a pooled analysis of 5 prospective cohortsHao Wang
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Arch Neurol 68:207-13. 2011..Cigarette smoking has been proposed as a risk factor for amyotrophic lateral sclerosis (ALS), but epidemiological studies supporting this hypothesis have been small and mostly retrospective... - Plasma urate and Parkinson's disease in womenEilis J O'Reilly
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Am J Epidemiol 172:666-70. 2010..Unlike in men, these findings do not support the hypothesis that urate is strongly associated with lower rates of Parkinson's disease among women... - Assessment of occupational exposure to manganese and other metals in welding fumes by portable X-ray fluorescence spectrometerWisanti Laohaudomchok
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
J Occup Environ Hyg 7:456-65. 2010..41 for zinc to 0.97 for iron). Such strong correlations and comparable results suggested that the portable XRF could be used as an effective and reliable tool for exposure assessment in many studies... - Interaction of stress, lead burden, and age on cognition in older men: the VA Normative Aging StudyJunenette L Peters
Department of Environment Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 118:505-10. 2010..However, the modifying potential of psychosocial stress on the neurotoxicity of lead and their combined relationship to aging-associated decline have not been fully examined... - Cumulative lead exposure and tooth loss in men: the normative aging studyManish Arora
Environmental and Occupational Medicine and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 117:1531-4. 2009..Individuals previously exposed to lead remain at risk because of endogenous release of lead stored in their skeletal compartments. However, it is not known if long-term cumulative lead exposure is a risk factor for tooth loss... - Pesticide exposure and risk for Parkinson's diseaseAlberto Ascherio
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Ann Neurol 60:197-203. 2006..Chronic, low-dose exposure to pesticides is suspected to increase the risk for Parkinson's disease (PD), but data are inconclusive... 
Bone lead and endogenous exposure in an environmentally exposed elderly population: the normative aging studyHuiling Nie
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
J Occup Environ Med 51:848-57. 2009..The objective of this study is to investigate the mobilization of lead from bone to blood (endogenous exposure) in a large epidemiologic population...- Cumulative lead exposure and prospective change in cognition among elderly men: the VA Normative Aging StudyMarc G Weisskopf
Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Landmark Center, 401 Park Drive, PO Box 15697, Boston, MA 02215, USA
Am J Epidemiol 160:1184-93. 2004..The data suggest that higher patella bone lead levels, a marker of mobilizable accumulated lead burden, are associated with a steeper decline over time in performance on the MMSE test among nonoccupationally exposed elderly men... - Vitamin E intake and risk of amyotrophic lateral sclerosisAlberto Ascherio
Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Building 2, Boston, MA 02115, USA
Ann Neurol 57:104-10. 2005..004). In contrast, no significant associations were found for use of vitamin C or multivitamins. These results suggest that vitamin E supplementation could have a role in ALS prevention... - Diet and amyotrophic lateral sclerosisNatalia Morozova
Departments of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
Epidemiology 19:324-37. 2008..Several dietary factors have been associated with risk of amyotrophic lateral sclerosis (ALS) in case-control studies, but no prospective studies have investigated diet and ALS... - Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging studyPradeep Rajan
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
J Occup Environ Med 50:1053-61. 2008..We evaluated the modifying influence of a delta-aminolevulinic acid dehydratase (ALAD) polymorphism on the relation between lead burden and cognition among older men... - Coffee consumption, gender, and Parkinson's disease mortality in the cancer prevention study II cohort: the modifying effects of estrogenAlberto Ascherio
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 160:977-84. 2004..75, 2.30; p = 0.34) among users. These results suggest that caffeine reduces the risk of Parkinson's disease but that this hypothetical beneficial effect may be prevented by use of estrogen replacement therapy... - Cumulative exposure to lead in relation to cognitive function in older womenJennifer Weuve
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 117:574-80. 2009..Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women... - Neuropsychological effects of low-level manganese exposure in weldersWisanti Laohaudomchok
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Neurotoxicology 32:171-9. 2011..04), adjusting for age and time between the 2 tests. Our study suggests that even at relatively low Mn exposure levels neuropsychological effects may manifest particularly with respect to attention, mood, and fine motor control... - Cumulative lead exposure in community-dwelling adults and fine motor function: comparing standard and novel tasks in the VA normative aging studyRachel Grashow
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
Neurotoxicology 35:154-61. 2013.... - Maternal lead exposure and the secondary sex ratioJohn F Jarrell
Harvard School of Public Health, Harvard University, Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Hum Reprod 21:1901-6. 2006..A reduction in the secondary sex ratio may be associated with exposure to environmental toxicants. Little data exists relating this outcome to lead exposure, a well-known reproductive toxicant... - Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticidesMaryse F Bouchard
Department of Environmental Health, School of Public Health, Harvard University, Boston, MA, USA
Pediatrics 125:e1270-7. 2010..The goal was to examine the association between urinary concentrations of dialkyl phosphate metabolites of organophosphates and attention-deficit/hyperactivity disorder (ADHD) in children 8 to 15 years of age... - Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone leadRegina A Shih
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892, USA
Environ Health Perspect 115:483-92. 2007..We review empirical evidence for the relations of recent and cumulative lead dose with cognitive function in adults... - Cumulative effect of lead on cognition: is bone more revealing than blood?Marc G Weisskopf
Neurology 67:1536-7. 2006
Research Grants
- NEW BIOMARKERS OF NEUROTOXICITYMarc Weisskopf; Fiscal Year: 2007..abstract_text> ..
- LEAD-GENE INTERACTIONS AND CONGNITIONMarc Weisskopf; Fiscal Year: 2007..Results of this research promise to shed further light on lead's potential impact on society and may also give rise to tools for identifying susceptible individuals as well as early brain effects. ..
- Population-Based Study of Environmental Risk Factors for ALSMarc G Weisskopf; Fiscal Year: 2010..In, particular, we will focus on lead and formaldehyde exposure, trauma, and use of statin and hormone replacement therapy medications. Furthermore, we will assess whether these factors affect the survival of patients with ALS. ..