Research Topics
| R D WeissSummaryAffiliation: Harvard Medical School Country: USA Publications
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Publications
Group therapy for patients with bipolar disorder and substance dependence: results of a pilot studyR D Weiss
Alcohol and Drug Abuse Program, McLean Hospital, Belmont, Mass 02478, USA
J Clin Psychiatry 61:361-7. 2000..The authors' goal was to pilot test a newly developed manual-based group psychotherapy, called Integrated Group Therapy (IGT), for patients with bipolar disorder and substance dependence...
Substance use and perceived symptom improvement among patients with bipolar disorder and substance dependenceRoger D Weiss
Alcohol and Drug Abuse Program, McLean Hospital, Belmont, MA, USA
J Affect Disord 79:279-83. 2004..We thus investigated reasons for substance use and perceived substance-induced improvement in BPD symptoms among patients with current BPD and substance dependence...
The relationship between cocaine craving, psychosocial treatment, and subsequent cocaine useRoger D Weiss
Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
Am J Psychiatry 160:1320-5. 2003..This study examined the relationship between cocaine craving, psychosocial treatment, and cocaine use in the ensuing week...
Utilization of psychosocial treatments by patients diagnosed with bipolar disorder and substance dependenceR D Weiss
Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
Am J Addict 9:314-20. 2000..These findings point to infrequent utilization over time of psychosocial treatments focusing specifically on bipolar and substance use disorder...
Predictors of self-help group attendance in cocaine dependent patientsR D Weiss
The Alcohol and Drug Abuse Program, McLean Hospital, Belmont, Massachusetts 02478, USA
J Stud Alcohol 61:714-9. 2000..This study examines particular sociodemographic and clinical characteristics as possible predictors of attendance at self-help groups in the National Institute on Drug Abuse Collaborative Cocaine Treatment Study...
Cocaine dependence with and without PTSD among subjects in the National Institute on Drug Abuse Collaborative Cocaine Treatment StudyL M Najavits
Department of Psychiatry, Harvard Medical School, Boston, USA
Am J Psychiatry 155:214-9. 1998....
Therapeutic alliance as a predictor of outcome and retention in the National Institute on Drug Abuse Collaborative Cocaine Treatment StudyJ P Barber
Department of Psychiatry, University of Pennsylvania, USA
J Consult Clin Psychol 69:119-24. 2001..In CT, higher levels of alliance were associated with decreased retention...
Validity of substance use self-reports in dually diagnosed outpatientsR D Weiss
Alcohol and Drug Abuse Program, McLean Hospital, Belmont, MA 02178, USA
Am J Psychiatry 155:127-8. 1998..The purpose of this study was to assess the validity of self-reports of substance use among outpatients dually diagnosed with substance use disorder and either bipolar disorder or posttraumatic stress disorder...
A relapse prevention group for patients with bipolar and substance use disordersR D Weiss
Alcohol and Drug Abuse Program, McLean Hospital, Belmont, MA 02178, USA
J Subst Abuse Treat 16:47-54. 1999..The treatment uses an integrated approach by discussing topics that are relevant to both disorders and by highlighting common aspects of recovery from and relapse to each disorder...
Self-help group attendance and participation among cocaine dependent patientsR D Weiss
Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
Drug Alcohol Depend 60:169-77. 2000..While patterns of attendance were relatively consistent over time, findings suggest that a treatment emphasizing the importance of self-help groups is likely to encourage more self-help group attendance and participation over time...
The use of collateral reports for patients with bipolar and substance use disordersR D Weiss
Alcohol and Drug Abuse Program, McLean Hospital, Belmont, Massachusetts 02478, USA
Am J Drug Alcohol Abuse 26:369-78. 2000..Frequency of contact between informants and patients was associated significantly with the level of agreement. These findings suggest that obtaining collateral informant data when studying this population may be of limited value...
Group cognitive-behavioral therapy for women with PTSD and substance use disorderL M Najavits
Harvard Medical School McLean Hospital, Belmont, MA 02178, USA
J Subst Abuse Treat 13:13-22. 1996....
The link between substance abuse and posttraumatic stress disorder in women. A research reviewL M Najavits
McLean Hospital, Belmont, MA 02178 9106, USA
Am J Addict 6:273-83. 1997..Treatment research on women is limited but suggests the possibility of retaining patients and achieving positive outcomes...
Gender differences in cocaine dependent patients: a 6 month follow-up studyR D Weiss
Alcohol and Drug Abuse Program, McLean Hospital, Belmont, MA 02178, USA
Drug Alcohol Depend 44:35-40. 1997..This replicates previous research showing better treatment outcome for cocaine dependent women. This may be related to specific characteristics of women who enter mixed-gender cocaine treatment programs...
Impact of psychosocial treatments on associated problems of cocaine-dependent patientsP Crits-Christoph
Department of Psychiatry, University of Pennsylvania, USA
J Consult Clin Psychol 69:825-30. 2001..The authors concluded that the superiority of individual drug counseling in modifying cocaine use does not extend broadly to other addiction-associated problems...
Early prediction of initiation of abstinence from cocaine. Use of a craving questionnaireR D Weiss
Alcohol and Drug Abuse Program, McLean Hospital, Belmont, MA 02178, USA
Am J Addict 6:224-31. 1997..The findings suggest that this rapid, easily administered craving questionnaire may have short-term predictive validity...
"Seeking safety": outcome of a new cognitive-behavioral psychotherapy for women with posttraumatic stress disorder and substance dependenceL M Najavits
Harvard Medical School, Boston, Massachusetts 02138, USA
J Trauma Stress 11:437-56. 1998..All results are clearly tentative, however, due to the lack of a control group, multiple comparisons, and absence of assessment of dropouts...
A comparison of alcoholic and nonalcoholic drug abusersR D Weiss
Alcohol and Drug Abuse Treatment Center, McLean Hospital, Belmont, Massachusetts 02178
J Stud Alcohol 49:510-5. 1988..Implications regarding the relationship of alcoholism and other forms of substance abuse are discussed...
Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disordersM W Otto
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Br J Psychiatry 189:20-5. 2006..The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder...
Functional magnetic resonance imaging of human brain activation during cue-induced cocaine cravingL C Maas
Brain Imaging Center, McLean Hospital, Belmont, MA 02178, USA
Am J Psychiatry 155:124-6. 1998..Functional magnetic resonance imaging (MRI) was used to test whether brain activation was detectable in regions previously associated with cocaine cue-induced craving...
3,4-methylenedioxymethamphetamine (MDMA): a reviewG O'Leary
Harvard Medical School, Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Curr Psychiatry Rep 3:477-83. 2001..Finally, the limitations of human research on the effects of MDMA and suggestions for future MDMA research will be discussed...
Opioid antagonists in the treatment of alcohol dependenceG O'Leary
Harvard Medical School, Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Curr Psychiatry Rep 3:484-8. 2001..The role of psychotherapies, particularly coping skills therapy, in combination with opioid antagonists is highlighted in the presentations of the clinical data. Finally, future research directions for opioid antagonists are discussed...
Pharmacotherapies for cocaine dependenceG O'Leary
Harvard Medical School, Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Curr Psychiatry Rep 2:508-13. 2000....
HIV risk behavior among patients with co-occurring bipolar and substance use disorders: associations with mania and drug abuseChristina S Meade
Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Drug Alcohol Depend 92:296-300. 2008..Bipolar and substance use disorders frequently co-occur, and both are associated with impulsivity, impaired judgment, and risk-taking...
Treating patients with bipolar disorder and substance dependence: lessons learnedRoger D Weiss
Alcohol and Drug Abuse Treatment Program, McLean Hospital, Belmont, MA 02478, USA
J Subst Abuse Treat 27:307-12. 2004..Therapeutic aspects involved in addressing these themes are discussed...
Treatment of patients with substance use disorders, second edition. American Psychiatric AssociationHerbert D Kleber
Am J Psychiatry 164:5-123. 2007
A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependenceRoger D Weiss
Department of Psychiatry, Harvard Medical School, Boston, and McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
Am J Psychiatry 164:100-7. 2007..The authors hypothesized that patients receiving integrated group therapy would have fewer days of substance use and fewer weeks ill with bipolar disorder...
Assessment of depressive symptom severity among patients with co-occurring bipolar disorder and substance dependenceMonika E Kolodziej
The Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States
J Affect Disord 106:83-9. 2008....
Validity of the distinction between primary and secondary substance use disorder in patients with bipolar disorder: data from the first 1000 STEP-BD participantsMark D Fossey
Department of Psychiatry, University of Oklahoma College of Medicine Tulsa, Tulsa, Oklahoma 74135, USA
Am J Addict 15:138-43. 2006..The primary/secondary distinction for SUD is not valid when variations in the age of onset of the non-SUD are linked to course characteristics...
Adherence to pharmacotherapy in bipolar disorder patients with and without co-occurring substance use disordersSumita G Manwani
Alcohol and Drug Abuse Treatment Program, McLean Hospital, Belmont, MA, USA
J Clin Psychiatry 68:1172-6. 2007..To examine patterns of adherence to mood stabilizers and reasons for nonadherence in patients with bipolar disorder, with and without substance use disorder (SUD)...
Additional treatment services in a cocaine treatment study: level of services obtained and impact on outcomeMatthew Worley
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Addict 17:209-17. 2008..The results suggest that during uncontrolled follow-up phases, additional non-protocol services may potentially confound the interpretation of treatment group comparisons in drug use outcomes...
Predictors of dropout from group therapy among patients with bipolar and substance use disordersFiona S Graff
Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States
Drug Alcohol Depend 94:272-5. 2008..The current study identified baseline demographic and clinical characteristics that predict treatment dropout among patients with co-occurring bipolar and substance use disorders...
Psychosocial treatments for cocaine dependenceVictoria De Menil
Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Curr Psychiatry Rep 5:362-4. 2003..A number of forms of psychosocial treatment for cocaine dependence have shown promising results, as detailed in the study descriptions...
Cost and cost-effectiveness of the COMBINE study in alcohol-dependent patientsGary A Zarkin
RTI International, 3040 Cornwallis Rd, Research Triangle Park, NC 27709, USA
Arch Gen Psychiatry 65:1214-21. 2008..The costs and cost-effectiveness of these combinations are unknown and of interest to clinicians and policy makers...
Self-harm and suicidal behavior in women with comorbid PTSD and substance dependenceMelanie S Harned
Department of Psychology, University of Washington, Seattle, Washington 98195 5125, USA
Am J Addict 15:392-5. 2006..Women who had and had not engaged in such behavior differed in SD diagnoses and reasons for staying safe, but not in the number or type of traumatic experiences, age at first trauma, or substance abuse diagnoses...
Treatment of patients with substance use disorders, second edition. American Psychiatic AssociationHerbert D Kleber
Am J Psychiatry 163:5-82. 2006
Combining psychosocial treatment with pharmacotherapy for alcohol dependenceRoger D Weiss
Alcohol and Drug Abuse Treatment Program, McLean Hospital, Belmont, MA 02478, USA
J Clin Psychopharmacol 26:S37-42. 2006..Ongoing research examining the optimal combinations of medications with different psychosocial treatments for alcohol dependence may further inform the field...
Response: providing relief, avoiding euphoriaDennis Paul
Addict Sci Clin Pract 4:26-7. 2008
A review of brief medication-adherence instruments used in patients with schizophrenia and bipolar disorderBrian Pomykacz
Harv Rev Psychiatry 15:259-63. 2007
Substance dependence low-density whole genome association study in two distinct American populationsYi Yu
Department of Medicine Genetics Program, Boston University Schools of Medicine and Public Health, Boston, MA, USA
Hum Genet 123:495-506. 2008..Our study provides an initial substance dependence trait-specific blueprint of associated regions for future candidate gene studies...
The validity of cocaine dependence subtypesHenry R Kranzler
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, United States
Addict Behav 33:41-53. 2008..These findings support the validity of the methods used to derive homogeneous subgroups of CD subjects and the resulting CD subtypes. Independent replication of these findings would provide further validation of this approach...
Focus on alcohol & drug abuse: ensuring validity in urine drug testingWilliam B Jaffee
McLean Hospital Alcohol and Drug Abuse Treatment Program, 115 Mill St, Belmont, MA 02478, USA
Psychiatr Serv 59:140-2. 2008....
Assessing negative consequences in patients with substance use and bipolar disorders: psychometric properties of the short inventory of problems (SIP)Rachel E Bender
Alcohol and Drug Abuse Treatment Program, McLean Hospital, Belmont, Massachusetts 02478, USA
Am J Addict 16:503-9. 2007..This modified version of the SIP was psychometrically sound, and may be useful in patients with both disorders. A greater understanding of perceived negative consequences may enhance outcome assessment in dually diagnosed populations...
The relationship between smoking and suicidal behavior, comorbidity, and course of illness in bipolar disorderMichael J Ostacher
Massachusetts General Hospital, Bipolar Clinic and Research Program, Boston, MA 02114, USA
J Clin Psychiatry 67:1907-11. 2006..The purpose of this retrospective study was to examine the relationship between smoking, severity of bipolar disorder, suicidal behavior, and psychiatric and substance use disorder comorbidity...
Seeking safety therapy for adolescent girls with PTSD and substance use disorder: a randomized controlled trialLisa M Najavits
Harvard Medical School, Boston, MA 02445, USA
J Behav Health Serv Res 33:453-63. 2006..Effect sizes were generally in the moderate to high range. Some gains were sustained at follow-up. SS appears a promising treatment for this population, but needs further study and perhaps additional clinical modification...
Seeking Safety plus Exposure Therapy: an outcome study on dual diagnosis menLisa M Najavits
Harvard Medical School, Boston, Massachusetts, USA
J Psychoactive Drugs 37:425-35. 2005..Trends indicating improvement on 11 other outcome variables were also found. Treatment attendance, satisfaction, and alliance were extremely high. The need for further evaluation using more rigorous methodology is discussed...
What general psychiatrists ask addiction psychiatrists: a review of 381 substance abuse consultations in a psychiatric hospitalShelly F Greenfield
McLean Hospital, Belmont, Mass 02478, USA
Am J Addict 12:18-28. 2003..The findings indicate the potential utility of a substance abuse consultation service in a psychiatric hospital...
Past anabolic-androgenic steroid use among men admitted for substance abuse treatment: an underrecognized problem?Gen Kanayama
Alcohol and Drug Abuse Research Center, McLean Hospital, Belmont, Mass 02478, USA
J Clin Psychiatry 64:156-60. 2003..At present, however, little is known about prior AAS use among men entering inpatient substance abuse treatment...
The relationship between educational attainment and relapse among alcohol-dependent men and women: a prospective studyShelly F Greenfield
McLean Hospital, Belmont, MA 02478, USA
Alcohol Clin Exp Res 27:1278-85. 2003..We investigated the relationship between educational attainment and drinking outcomes after discharge from inpatient treatment for alcohol dependence...
Limiting inpatient substance use treatment: what are the consequences?Barbara Dickey
Cambridge Hospital, USA
Med Care Res Rev 60:332-46. 2003..There was no evidence of cost shifting. Although emphasis on outpatient treatment did not result in cost shifting, the combination of substance use disorder and psychiatric illness remains an expensive public health problem...
Mediators of outcome of psychosocial treatments for cocaine dependencePaul Crits-Christoph
Department of Psychiatry, University of Pennsylvania, PA, USA
J Consult Clin Psychol 71:918-25. 2003..In addition, a measure of beliefs about addiction developed to test mediation of outcome of cognitive therapy was found to correlate moderately with drug use outcomes in both cognitive therapy and individual drug counseling...
Domestic violence in women with PTSD and substance abuseLisa M Najavits
Trauma Research Program, Harvard Medical School, McLean Hospital, Proctor III, 115 Mill Street, Belmont, MA 02478, USA
Addict Behav 29:707-15. 2004..The complex dynamics of women as both recipients and enactors of negative relationship behaviors are discussed...
Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BDNaomi M Simon
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 24:512-20. 2004..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity...
Treatment utilization by women with PTSD and substance dependenceLisa M Najavits
McLean Hospital, Belmont, Massachusetts, USA
Am J Addict 13:215-24. 2004..The most common treatments were individual therapy, medication, and hospitalization. Some treatments were perceived as harmful by some participants. The discussion addresses how to help patients obtain needed treatments...
Substance use histories in patients seeking treatment for controlled-release oxycodone dependenceJennifer Sharpe Potter
McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Drug Alcohol Depend 76:213-5. 2004..8 versus illicit=15.8, P<0.05). These findings suggest that a history of substance abuse is common among patients abusing CR oxycodone, including individuals for whom CR oxycodone was initially legitimately prescribed for pain...
Adherence to pharmacotherapy in patients with alcohol and opioid dependenceRoger D Weiss
Alcohol and Drug Abuse Treatment Program, McLean Hospital, Belmont, MA 02478 9106, USA
Addiction 99:1382-92. 2004..This paper presents a review of issues related to medication adherence in patients with these substance use disorders...
The effect of 12-step self-help group attendance and participation on drug use outcomes among cocaine-dependent patientsRoger D Weiss
Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
Drug Alcohol Depend 77:177-84. 2005..Moreover, the distinction between attending meetings and actively participating in 12-step activities has not typically been examined...
Group therapy for substance use disorders: what do we know?Roger D Weiss
Department of Psychiatry, Harvard Medical School, MA, USA
Harv Rev Psychiatry 12:339-50. 2004..Unique methodological and logistical hurdles encountered in research on group therapy for substance use disorders, as well as considerations for future research, are also discussed...
Anxiety disorders among patients with co-occurring bipolar and substance use disordersMonika E Kolodziej
The Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Drug Alcohol Depend 80:251-7. 2005..Our findings point to the importance of further investigating the ramifications of a trauma history among those who are dually diagnosed with bipolar and substance use disorders...
Does recovery from substance use disorder matter in patients with bipolar disorder?Roger D Weiss
Department of Psychiatry, Harvard Medical School, Boston, USA
J Clin Psychiatry 66:730-5; quiz 808-9. 2005..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
Improving the care of individuals with schizophrenia and substance use disorders: consensus recommendationsDouglas M Ziedonis
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 675 Hoes Lane, Rm. D-349, Piscataway, NJ 08854, USA
J Psychiatr Pract 11:315-39. 2005..An algorithm summarizing the consensus recommendations is provided in an appendix...
Readability of patient handout materials in a nationwide sample of alcohol and drug abuse treatment programsShelly F Greenfield
The Alcohol and Drug Abuse Treatment Program, McLean Hospital, Belmont, MA 02478, USA
Am J Addict 14:339-45. 2005..Integrating knowledge regarding program materials' readability level and literacy levels of different populations could be successful aides to substance abuse treatment...
Medical morbidity, mental illness, and substance use disordersBarbara Dickey
Harvard Medical School and the Department of Psychiatry at Cambridge Hospital Cambridge, Massachusetts 02139, USA
Psychiatr Serv 53:861-7. 2002..The authors examined whether certain medical disorders are more prevalent among adults with severe mental illness and whether a comorbid substance use disorder increases prevalence beyond the effect of severe mental illness alone...
Research Grants
- BEHAVIORAL AND PHARMACOLOGIC TREATMENT OF ALCOHOLISMRoger Weiss; Fiscal Year: 2004..However, each study site has provided site-specific information on the budget, budget justifications, listing of key personnel, Consultant/consortium agreements, and human subjects sections of their respective proposals. ..
- TREATMENT OF DRUG DEPENDENCE AND PSYCHIATRIC ILLNESSRoger Weiss; Fiscal Year: 2006..abstract_text> ..
- CTN: Harvard University Northern New England NodeRoger Weiss; Fiscal Year: 2006..The CTN will thus help to bridge the gap between the addiction research and treatment communities, thus improving the overall quality of treatment for drug dependent patients. ..
- Mentoring in Drug Abuse and Dual Diagnosis ResearchRoger Weiss; Fiscal Year: 2007..As part of the K24 Award, Dr. Weiss will receive additional training in the areas of 1) chronic pain, 2) brain imaging, and 3) statistics, which will simultaneously strengthen his own research skills and improve his mentoring abilities. ..
- CTN: Northern New England NodeRoger Weiss; Fiscal Year: 2007....
- CTN: Northern New England NodeRoger Weiss; Fiscal Year: 2007..abstract_text> ..
