Gordon Weir

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes
    Lorella Marselli
    Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 5:e11499. 2010
  2. pmc Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes
    Aileen J F King
    Diabetes Research Group, King s College London, London, United Kingdom Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e77452. 2013
  3. pmc Protective unfolded protein response in human pancreatic beta cells transplanted into mice
    Jeffrey Kennedy
    Section on Islet Cell Biology and Regenerative Medicine, Research Division, Joslin Diabetes Center, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11211. 2010
  4. pmc The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs
    Tova Neufeld
    Technology Department, Beta O2 Technologies, Rosh Haayin, Israel
    PLoS ONE 8:e70150. 2013
  5. pmc Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration
    Claudia Cavelti-Weder
    Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215
    Endocrinology 154:4493-502. 2013
  6. pmc Islet β cell mass in diabetes and how it relates to function, birth, and death
    Gordon C Weir
    Section on Islet Cell Biology and Regenerative Medicine, Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Ann N Y Acad Sci 1281:92-105. 2013
  7. doi request reprint Islet encapsulation: advances and obstacles
    G C Weir
    Section on Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetologia 56:1458-61. 2013
  8. doi request reprint Cellular transplantation into lymph nodes may not be such a crazy idea
    Gordon C Weir
    Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA Department of Medicine, Harvard Medical School, Boston, MA 02115, USA Electronic address
    Cell Stem Cell 11:587-8. 2012
  9. pmc Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion
    Hitoshi Katsuta
    Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 153:5180-7. 2012
  10. pmc Single pancreatic beta cells co-express multiple islet hormone genes in mice
    H Katsuta
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetologia 53:128-38. 2010

Collaborators

Detail Information

Publications62

  1. pmc Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes
    Lorella Marselli
    Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 5:e11499. 2010
    ..Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D) should provide insights into their abnormal insulin secretion and turnover...
  2. pmc Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes
    Aileen J F King
    Diabetes Research Group, King s College London, London, United Kingdom Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e77452. 2013
    ....
  3. pmc Protective unfolded protein response in human pancreatic beta cells transplanted into mice
    Jeffrey Kennedy
    Section on Islet Cell Biology and Regenerative Medicine, Research Division, Joslin Diabetes Center, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11211. 2010
    ..There is great interest about the possible contribution of ER stress to the apoptosis of pancreatic beta cells in the diabetic state and with islet transplantation...
  4. pmc The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs
    Tova Neufeld
    Technology Department, Beta O2 Technologies, Rosh Haayin, Israel
    PLoS ONE 8:e70150. 2013
    ....
  5. pmc Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration
    Claudia Cavelti-Weder
    Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215
    Endocrinology 154:4493-502. 2013
    ..We conclude that β-cells and acinar cells, although originating from the same precursors during development, have very distinct regenerative potentials in our PDL model in adult rats. ..
  6. pmc Islet β cell mass in diabetes and how it relates to function, birth, and death
    Gordon C Weir
    Section on Islet Cell Biology and Regenerative Medicine, Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Ann N Y Acad Sci 1281:92-105. 2013
    ..Learning more about the relationships between β cell mass, turnover, and function and finding ways to restore β cell mass are among the most urgent priorities for diabetes research...
  7. doi request reprint Islet encapsulation: advances and obstacles
    G C Weir
    Section on Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetologia 56:1458-61. 2013
    ..Many obstacles must still be overcome, but this technology has the potential to safely protect transplanted beta cells from autoimmunity and allorejection...
  8. doi request reprint Cellular transplantation into lymph nodes may not be such a crazy idea
    Gordon C Weir
    Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA Department of Medicine, Harvard Medical School, Boston, MA 02115, USA Electronic address
    Cell Stem Cell 11:587-8. 2012
    ..A study published in Nature Biotechnology by Komori and colleagues (Komori et al., 2012) has identified the surprising potential of lymph nodes as sites for cellular transplants...
  9. pmc Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion
    Hitoshi Katsuta
    Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 153:5180-7. 2012
    ..The three populations from the youngest had larger cells (forward scatter) and less granularity (side scatter) than those from the adults. This approach opens up new ways to advance knowledge about β-cell heterogeneity...
  10. pmc Single pancreatic beta cells co-express multiple islet hormone genes in mice
    H Katsuta
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetologia 53:128-38. 2010
    ..We examined whether beta cells express other genes encoding islet hormones...
  11. ncbi request reprint Can we make surrogate beta-cells better than the original?
    Gordon C Weir
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Semin Cell Dev Biol 15:347-57. 2004
    ..Bioengineering can be used to improve secretory performance and strengthen cells to better withstand the challenges of transplantation. Strategies include protection against hypoxia, inflammation, and immune attack...
  12. ncbi request reprint Five stages of evolving beta-cell dysfunction during progression to diabetes
    Gordon C Weir
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 53:S16-21. 2004
    ..For type 1 diabetes, as remission develops, progression from stage 4 to stage 2 is typically found. Delineation of these stages provides insight into the pathophysiology of both progression and remission of diabetes...
  13. pmc A dominant role for glucose in beta cell compensation of insulin resistance
    Gordon C Weir
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 117:81-3. 2007
    ..The study also provides strong evidence that insulin receptor substrate 2 (Irs2), which is known to have major effects on beta cell growth and survival, is a key downstream mediator of the effects of glucose found in this study...
  14. ncbi request reprint Beta-cell adaptation and decompensation during the progression of diabetes
    G C Weir
    Joslin Diabetes Center, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 50:S154-9. 2001
    ..Arguments are developed that the beta-cell changes found in diabetes are better correlated with increased glucose levels than with non-esterified fatty acid levels, thus supporting the importance of glucose toxicity...
  15. doi request reprint Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes
    G C Weir
    Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Diabetes Obes Metab 11:82-90. 2009
    ....
  16. pmc Finally! A human pancreatic β cell line
    Gordon C Weir
    Section on Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 121:3395-7. 2011
    ....
  17. ncbi request reprint Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function
    Sunmin Park
    Howard Hughes Medical Institute, Division of Endocrinology, Department of Medicine, Children s Hospital Boston, MA 02215, USA
    J Biol Chem 281:1159-68. 2006
    ....
  18. ncbi request reprint Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice
    Abdulkadir Omer
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 52:69-75. 2003
    ..In conclusion, NPCCs encapsulated with simple barium alginate can differentiate into beta-cells and reverse high blood glucose levels in immunocompetent mice without immunosuppression for >20 weeks...
  19. pmc p38 MAPK is a major regulator of MafA protein stability under oxidative stress
    Takuma Kondo
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 23:1281-90. 2009
    ..Therefore, preventing p38 MAPK-mediated degradation of MafA represents a novel approach to improve beta-cell function...
  20. ncbi request reprint New sources of pancreatic beta-cells
    Susan Bonner-Weir
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Nat Biotechnol 23:857-61. 2005
    ..Recent progress in the search for new sources of beta-cells has opened promising new opportunities and spawned clinical trials...
  21. ncbi request reprint Exercise induces hypoglycemia in rats with islet transplantation
    Abdulkadir Omer
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 53:360-5. 2004
    ..C-peptide and glucagon responses to exercise were very different in rats with transplanted islets compared with controls. This islet dysfunction led to exercise-induced hypoglycemia...
  22. ncbi request reprint Islet transplantation: progress and challenge
    Jason L Gaglia
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Arch Med Res 36:273-80. 2005
    ..In this review, we describe details of the evolution of modern islet transplantation and provide insight into ongoing clinical and basic research efforts to overcome current obstacles for this promising therapy...
  23. ncbi request reprint Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes
    D Ross Laybutt
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 51:1793-804. 2002
    ....
  24. ncbi request reprint Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats
    Emi Arikawa
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 56:1410-20. 2007
    ..Thus, PKCbeta or ACE inhibitors may ameliorate cardiac metabolism and function in diabetes partly by normalization of fuel metabolic gene expression directly in the myocardium...
  25. ncbi request reprint Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation
    Aileen J F King
    Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes 56:2312-8. 2007
    ..It is therefore likely that islet non-beta-cells are not essential for successful islet transplantation...
  26. doi request reprint Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice
    Tomoyuki Akashi
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes Metab Res Rev 24:585-90. 2008
    ..In this study, we carried out bone marrow and foetal liver cell transplantation to determine if these cells could differentiate into pancreatic beta-cells or promote regeneration...
  27. ncbi request reprint Long-term normoglycemia in rats receiving transplants with encapsulated islets
    Abdulkadir Omer
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Transplantation 79:52-8. 2005
    ....
  28. ncbi request reprint Suppression of beta cell energy metabolism and insulin release by PGC-1alpha
    J Cliff Yoon
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA
    Dev Cell 5:73-83. 2003
    ..These results strongly suggest that PGC-1alpha plays a key functional role in the beta cell and is involved in the pathogenesis of the diabetic phenotype...
  29. pmc In vivo imaging of autologous islet grafts in the liver and under the kidney capsule in non-human primates
    Zdravka Medarova
    Department of Radiology, Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Transplantation 87:1659-66. 2009
    ..The potential translation of these findings to the clinical situation requires validation of our methodology in a non-human primate model, which we have now carried out in baboons (Papio hamadryas) and reported here...
  30. ncbi request reprint Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes
    D Ross Laybutt
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 278:2997-3005. 2003
    ..Thus, both the severity and duration of hyperglycemia appear to contribute to the deterioration of the beta-cell phenotype found in diabetes...
  31. pmc Prediction of marginal mass required for successful islet transplantation
    Klearchos K Papas
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Invest Surg 23:28-34. 2010
    ..Because human clinical islet preparations in a previous study had OCR/DNA...
  32. ncbi request reprint Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture
    Krystyna Tatarkiewicz
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Dev Growth Differ 45:39-50. 2003
    ..Furthermore, in such a culture setting, precursor duct cells have a high rate of proliferation and are more efficiently transduced with a retrovirus-based reporter gene than are beta cells...
  33. ncbi request reprint Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia
    D Ross Laybutt
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 277:10912-21. 2002
    ..This global maladaptation in gene expression at the time of increased secretory demand may contribute to the beta-cell dysfunction found in diabetes...
  34. ncbi request reprint Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells
    Hideaki Kaneto
    Section on Islet Transplantation and Cell Biology and Section on Vascular Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 277:3680-5. 2002
    ..These results suggest that at least some of the reduction of insulin gene transcription found in the diabetic state is mediated by PKC beta2 regulation of c-myc expression...
  35. ncbi request reprint Induced pluripotent stem cells generated without viral integration
    Matthias Stadtfeld
    Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, 185 Cambridge Street, Boston, MA 02114, USA
    Science 322:945-9. 2008
    ..Adenoviral reprogramming may provide an improved method for generating and studying patient-specific stem cells and for comparing embryonic stem cells and iPS cells...
  36. pmc Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells
    Keiji Isshiki
    Research Division, Joslin Diabetes Center, One Joslin Place, Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 74:1434-43. 2008
    ..Insulin deficiency may contribute to the mesangial expansion found in diabetes through reduced STAT5/SOCS2 expression...
  37. ncbi request reprint Induction of Mad expression leads to augmentation of insulin gene transcription
    Giovanni Patanè
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, MA 02215, USA
    Biochem Biophys Res Commun 303:1199-208. 2003
    ..Such regulation of insulin expression by Mad with modulation of PDX-1 expression and DNA binding activity could offer useful therapeutic and/or experimental tools to promote insulin production in appropriate cell types...
  38. ncbi request reprint PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells
    Hirofumi Noguchi
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 52:1732-7. 2003
    ....
  39. ncbi request reprint Differentiation of affinity-purified human pancreatic duct cells to beta-cells
    Shigeru Yatoh
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 56:1802-9. 2007
    ..Thus, purified duct cells from adult human pancreas can differentiate to insulin-producing cells...
  40. ncbi request reprint Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
    Hideaki Kaneto
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 277:30010-8. 2002
    ..In conclusion, activation of JNK is involved in the reduction of insulin gene expression by oxidative stress, and suppression of the JNK pathway protects beta-cells from oxidative stress...
  41. ncbi request reprint Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells
    Akari Inada
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Biochem Biophys Res Commun 329:925-9. 2005
    ..Since ICER Igamma is greatly increased in diabetes as well as in FFA- or high glucose-treated islets, this effect may in part exacerbate diabetes by limiting beta-cell proliferation...
  42. ncbi request reprint Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation
    Hideaki Kaneto
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Biol Chem 277:12998-3006. 2002
    ..This mechanism may explain some of the beta-cell dysfunction found in diabetes...
  43. ncbi request reprint Importance of hyperglycemia on the primary function of allogeneic islet transplants
    Leila Makhlouf
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Transplantation 76:657-64. 2003
    ..In this study, we investigated the influence of hyperglycemia on primary function of allogeneic islets transplanted into spontaneously diabetic recipients (NOD) or streptozotocin-induced diabetic mice (BALB/c)...
  44. ncbi request reprint Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats
    Abdulkadir Omer
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Xenotransplantation 10:240-51. 2003
    ..In this study, the effect of peritoneal macrophage depletion on the biocompatibility of alginate macrocapsules and function of macroencapsulated porcine neonatal pancreatic cell clusters (NPCCs) was investigated...
  45. ncbi request reprint Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia
    D Ross Laybutt
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 51:413-23. 2002
    ..In conclusion, beta-cell adaptation to chronic hyperglycemia and, hence, increased insulin demand is accompanied by the induction of protective stress genes that may contribute to the survival of hypertrophied beta-cells...
  46. doi request reprint Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells
    Masaki Nagaya
    Research Division, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Endocrinol 201:37-47. 2009
    ..This approach may lead to a new source of beta-cells that can be used for transplantation in diabetes...
  47. ncbi request reprint Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors
    Justin R Fernandes
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Room 535, Boston, MA 02215, USA
    Transpl Immunol 13:191-200. 2004
    ..The purpose of this study was to see if lentiviral (LV) vectors would provide superior results compared with adenoviral vectors...
  48. doi request reprint Pig islet xenograft rejection in a mouse model with an established human immune system
    Noriko Tonomura
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Xenotransplantation 15:129-35. 2008
    ..A better understanding of the human immune response to pig islets would help develop effective strategies for preventing graft rejection...
  49. ncbi request reprint Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets
    Maria D Lopez-Avalos
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Diabetes 55:1223-31. 2006
    ....
  50. ncbi request reprint NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes
    Shigeru Yatoh
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes Metab Res Rev 23:239-49. 2007
    ..Our goal was to convert adult mouse hepatocytes to pancreatic beta-cells...
  51. ncbi request reprint Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes
    Gang Xu
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 56:1551-8. 2007
    ..Taken together, GLP-1 and GIP receptor expression is decreased with chronic hyperglycemia, and this decrease likely contributes to the impaired incretin effects found in diabetes...
  52. ncbi request reprint Beta-cell precursors--a work in progress
    Gordon C Weir
    Nat Biotechnol 22:1095-6. 2004
  53. ncbi request reprint The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation
    Kenji Fukui
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita Osaka 565 0871, Japan
    Cell Metab 2:373-84. 2005
    ..Therefore, collectrin is a regulator of SNARE complex function, which thereby controls insulin exocytosis...
  54. pmc The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
    Jonathan C Schisler
    Department of Pharmacology, Sarah W Stedman Nutrition and Metabolism Center, Durham, NC 27704, USA
    Proc Natl Acad Sci U S A 102:7297-302. 2005
    ..1 mRNA in primary rat islets was accompanied by a significant decrease in GSIS relative to control cells. In sum, our studies have revealed roles for Nkx6.1 in suppression of glucagon expression and control of GSIS in islet beta cells...
  55. ncbi request reprint GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts
    Gang Xu
    Diabetes Res Clin Pract 73:107-10. 2006
  56. ncbi request reprint Survival of microencapsulated adult pig islets in mice in spite of an antibody response
    Valerie F Duvivier-Kali
    Diabetes and Obesity Unit, Sanofi Synthelabo, Rueil Malmaison, France
    Am J Transplant 4:1991-2000. 2004
    ..In conclusion, alginate capsules can prolong the survival of adult pig islets transplanted into diabetic mice for up to 190 days, even in the presence of an antibody response...
  57. doi request reprint A model for diabetic nephropathy: advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin-induced diabetic mouse
    Akari Inada
    SSP Stem Cell Unit, Kyushu University Graduate School of Medicine, Fukuoka, Japan
    J Cell Physiol 215:383-91. 2008
    ..Thus, ICER Igamma Tg mouse has advantages for examining diabetic renal disease, and offers unique and very different perspectives compared to STZ model...
  58. ncbi request reprint Islet transplantation under the kidney capsule corrects the defects in glycogen metabolism in both liver and muscle of streptozocin-diabetic rats
    Margherita Matarazzo
    Department of Internal Medicine and Cardiovascular Sciences, University of Federico II School of Medicine, Napoli, Italy
    Cell Transplant 11:103-12. 2002
    ..In conclusion, islet transplantation under the kidney capsule corrects the diabetes-induced abnormalities in glycogen and glucose-6-phosphate content and glycogen synthase activity in both liver and skeletal muscle...
  59. pmc Establishment of a diabetic mouse model with progressive diabetic nephropathy
    Akari Inada
    Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Pathol 167:327-36. 2005
    ..Thus, similar to human diabetic nephropathy, ICER Igamma transgenic mice exhibit a stable and progressive phenotype of diabetic kidney disease due solely to chronic hyperglycemia without other modulating factors...
  60. ncbi request reprint Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes
    Tessy Iype
    Department of Internal Medicine and the Diabetes Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 280:16798-807. 2005
    ..This complex leads to enhancement of elongation by the basal transcriptional machinery...
  61. pmc A stirred microchamber for oxygen consumption rate measurements with pancreatic islets
    Klearchos K Papas
    Department of Chemical Engineering, Massachusetts Institute of Technology, 25 Ames St, Cambridge, Massachusetts 02139, USA
    Biotechnol Bioeng 98:1071-82. 2007
    ....

Research Grants19

  1. DIABETES AND ENDOCRINOLOGY RESEARCH CENTER
    Gordon Weir; Fiscal Year: 2007
    ..The Enrichment Program continues to enhance the research environment for students, post-doctoral fellows and investigators by supporting a valuable array of academic exercises and visiting speakers. ..
  2. Islet Transplantation - Protection by Immunobarriers
    Gordon Weir; Fiscal Year: 2006
    ..This work should serve as a guide for the encapsulation and transplantation of xenogeneic islets cells or insulin-producing cells that should eventually be produced from precursor/stem cells. ..
  3. ISLET TRANSPLANTATION--FUNCTION AND ANGIOGENESIS
    Gordon Weir; Fiscal Year: 1999
    ..IRAP will be overexpressed in beta cells by the genetic manipulations of transfection and the production of transgenic mice to determine if transplanted islets can be protected at the site of attack from immune injury. ..
  4. ISLET TRANSPLANTATION-- PROTECTION BY IMMUNOBARRIERS
    Gordon Weir; Fiscal Year: 2001
    ..The other is to engineer the islets to secrete peptides, in particular CTLA4 and TGF-p, that may modulate the immune attack surrounding the capsules. ..
  5. ISLET TRANSPLANTATION-- PROTECTION BY IMMUNOBARRIERS
    Gordon Weir; Fiscal Year: 2002
    ..The other is to engineer the islets to secrete peptides, in particular CTLA4 and TGF-p, that may modulate the immune attack surrounding the capsules. ..
  6. ISLET TRANSPLANTATION-- PROTECTION BY IMMUNOBARRIERS
    Gordon Weir; Fiscal Year: 2003
    ..The other is to engineer the islets to secrete peptides, in particular CTLA4 and TGF-p, that may modulate the immune attack surrounding the capsules. ..
  7. Islet Transplantation - Protection by Immunobarriers
    Gordon Weir; Fiscal Year: 2007
    ..This work should serve as a guide for the encapsulation and transplantation of xenogeneic islets cells or insulin-producing cells that should eventually be produced from precursor/stem cells. ..
  8. Islet Transplantation - Protection by Immunobarriers
    Gordon Weir; Fiscal Year: 2005
    ..This work should serve as a guide for the encapsulation and transplantation of xenogeneic islets cells or insulin-producing cells that should eventually be produced from precursor/stem cells. ..
  9. DIABETES AND ENDOCRINOLOGY RESEARCH CENTER
    Gordon Weir; Fiscal Year: 2007
    ..The Enrichment Program continues to enhance the research environment for students, post-doctoral fellows and investigators by supporting a valuable array of academic exercises and visiting speakers. ..
  10. ISLET TRANSPLANTATION-- PROTECTION BY IMMUNOBARRIERS
    Gordon Weir; Fiscal Year: 2004
    ..The other is to engineer the islets to secrete peptides, in particular CTLA4 and TGF-p, that may modulate the immune attack surrounding the capsules. ..