Daniel M Weinreich

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Perspective: Sign epistasis and genetic constraint on evolutionary trajectories
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Evolution 59:1165-74. 2005
  2. ncbi request reprint Rapid evolutionary escape by large populations from local fitness peaks is likely in nature
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Evolution 59:1175-82. 2005
  3. ncbi request reprint Darwinian evolution can follow only very few mutational paths to fitter proteins
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 312:111-4. 2006
  4. pmc The rank ordering of genotypic fitness values predicts genetic constraint on natural selection on landscapes lacking sign epistasis
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 171:1397-405. 2005
  5. ncbi request reprint Mutational reversions during adaptive protein evolution
    Mark A DePristo
    Department of Organismic and Evolutionary Biology, Harvard University, MA, USA
    Mol Biol Evol 24:1608-10. 2007
  6. pmc Temporal constraints on the incorporation of regulatory mutants in evolutionary pathways
    Kyle M Brown
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA
    Mol Biol Evol 26:2455-62. 2009
  7. ncbi request reprint Missense meanderings in sequence space: a biophysical view of protein evolution
    Mark A DePristo
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Genet 6:678-87. 2005
  8. pmc Patterns and mechanisms of genetic and phenotypic differentiation in marine microbes
    Martin F Polz
    Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Philos Trans R Soc Lond B Biol Sci 361:2009-21. 2006
  9. pmc Stepwise acquisition of pyrimethamine resistance in the malaria parasite
    Elena R Lozovsky
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 106:12025-30. 2009
  10. pmc Widespread genetic exchange among terrestrial bacteriophages
    Olin K Silander
    Department of Biological Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 102:19009-14. 2005

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Perspective: Sign epistasis and genetic constraint on evolutionary trajectories
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Evolution 59:1165-74. 2005
    ..These theoretical and empirical considerations imply that strong genetic constraint on the selective accessibility of trajectories to high fitness genotypes may exist and suggest specific areas of investigation for future research...
  2. ncbi request reprint Rapid evolutionary escape by large populations from local fitness peaks is likely in nature
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Evolution 59:1175-82. 2005
    ..Thus, counterintuitively, mass selection alone offers a biologically realistic resolution to the problem of evolutionary escape from local fitness peaks in natural populations...
  3. ncbi request reprint Darwinian evolution can follow only very few mutational paths to fitter proteins
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 312:111-4. 2006
    ..This implies that the protein tape of life may be largely reproducible and even predictable...
  4. pmc The rank ordering of genotypic fitness values predicts genetic constraint on natural selection on landscapes lacking sign epistasis
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 171:1397-405. 2005
    ..This statistical association is robust to population size, permitting general inferences about some of the characteristics of fitness rank orderings responsible for genetic constraint on natural selection...
  5. ncbi request reprint Mutational reversions during adaptive protein evolution
    Mark A DePristo
    Department of Organismic and Evolutionary Biology, Harvard University, MA, USA
    Mol Biol Evol 24:1608-10. 2007
    ..Altogether, this discovery highlights the unusual and potentially circuitous routes natural selection can follow during adaptation...
  6. pmc Temporal constraints on the incorporation of regulatory mutants in evolutionary pathways
    Kyle M Brown
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA
    Mol Biol Evol 26:2455-62. 2009
    ..A mathematical model of beta-lactam resistance is examined in detail and shown to be consistent with the observed results...
  7. ncbi request reprint Missense meanderings in sequence space: a biophysical view of protein evolution
    Mark A DePristo
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Genet 6:678-87. 2005
    ..We then advance a biophysical model of protein evolution that helps us to understand phenomena that range from the dynamics of molecular adaptation to the clock-like rate of protein evolution...
  8. pmc Patterns and mechanisms of genetic and phenotypic differentiation in marine microbes
    Martin F Polz
    Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Philos Trans R Soc Lond B Biol Sci 361:2009-21. 2006
    ....
  9. pmc Stepwise acquisition of pyrimethamine resistance in the malaria parasite
    Elena R Lozovsky
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 106:12025-30. 2009
    ..Our results also suggest an explanation for why I164L is detected in Southeast Asia and South America, but not at significant frequencies in Africa...
  10. pmc Widespread genetic exchange among terrestrial bacteriophages
    Olin K Silander
    Department of Biological Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 102:19009-14. 2005
    ..This extraordinary rate of genetic exchange between highly unrelated individuals is unprecedented in any taxa. We discuss our results in light of the biological species concept applied to viruses...
  11. ncbi request reprint Empirical fitness landscapes reveal accessible evolutionary paths
    Frank J Poelwijk
    FOM Institute AMOLF, Kruislaan 407, 1098 SJ, Amsterdam, The Netherlands
    Nature 445:383-6. 2007
    ..With this first view on empirical evolutionary landscapes, we can now finally start asking why particular evolutionary paths are taken...