Research Topics
| Van WedeenSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Phase contrast MRI of myocardial 3D strain by encoding contiguous slices in a single shotTimothy G Reese
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
Magn Reson Med 47:665-76. 2002..Two-slices-in-one-shot spatial encoding permits a complete quantitative survey of ventricular 3D strain in under a minute, with routine patient supervision and turnkey image processing...- Cardiac diffusion MRI without motion effectsJiangang Dou
MGH-NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Magn Reson Med 48:105-14. 2002..These results demonstrate the technique's ability to measure myocardial diffusion accurately at any point in the cardiac cycle free of measurable motion effect, as if the heart were frozen at the point of acquisition... - Response to comment on "the geometric structure of the brain fiber pathways"Van J Wedeen
Department of Radiology, Massachusetts General Hospital, Harvard Medical School and the Martinos Center for Biomedical Imaging, Building 129 13th Street, 2nd Floor, Charlestown, MA 02129, USA
Science 337:1605. 2012..Thus, the geometric thesis gives the best account of the available evidence... 
The geometric structure of the brain fiber pathwaysVan J Wedeen
Department of Radiology, Massachusetts General Hospital MGH, Harvard Medical School and the MGH Massachussetts Institute of Technology, Charlestown, MA 02129, USA
Science 335:1628-34. 2012..This architecture naturally supports functional spatio-temporal coherence, developmental path-finding, and incremental rewiring with correlated adaptation of structure and function in cerebral plasticity and evolution...
Diffusion MR tractography of the heartDavid E Sosnovik
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA
J Cardiovasc Magn Reson 11:47. 2009..The application of DSI in ischemic heart disease is reviewed, and the requisites for widespread clinical translation of diffusion MR tractography in the heart are discussed...- Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibersV J Wedeen
Department of Radiology, MGH Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 41:1267-77. 2008..These findings indicate that DSI tractography is able to image crossing fibers in neural tissue, an essential step toward non-invasive imaging of connectional neuroanatomy... - Demonstration of primary and secondary muscle fiber architecture of the bovine tongue by diffusion tensor magnetic resonance imagingV J Wedeen
NMR Center and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biophys J 80:1024-8. 2001..These findings suggest that three-dimensional analysis of diffusion tensor magnetic resonance imaging provides a structural basis for understanding the micromechanics of the mammalian tongue... - Mapping complex tissue architecture with diffusion spectrum magnetic resonance imagingVan J Wedeen
Department of Radiology, MGH Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Magn Reson Med 54:1377-86. 2005..Finally, the relation between the presented model-free imaging technique and other available diffusion MRI schemes is discussed... - Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imagingMette R Wiegell
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Neuroimage 19:391-401. 2003..The ability to resolve thalamic nuclei with DTI will allow for morphometric analysis of specific nuclei and improved anatomical localization of functional activation in the thalamus... - Development of cerebral fiber pathways in cats revealed by diffusion spectrum imagingEmi Takahashi
Department of Radiology, Harvard Medical School, Charlestown, MA, USA
Neuroimage 49:1231-40. 2010..The technique may also be applicable to the study of other forms of brain plasticity, including future studies in vivo... - Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardiumDavid E Sosnovik
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
Circ Cardiovasc Imaging 2:206-12. 2009..Unlike diffusion tensor imaging, DSI tractography resolves multiple myofiber populations per voxel, thus generating accurate 3D tractograms, which we present in the myocardium for the first time... - Developing neocortex organization and connectivity in cats revealed by direct correlation of diffusion tractography and histologyEmi Takahashi
Division of Newborn Medicine, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Cereb Cortex 21:200-11. 2011..These results suggest that diffusion tractography can differentially characterize internal and external SP zones and their transition into mature cortical pathways... - Derivation of a finite-element model of lingual deformation during swallowing from the mechanics of mesoscale myofiber tracts obtained by MRISrboljub M Mijailovich
Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
J Appl Physiol 109:1500-14. 2010.... - Combined diffusion and strain MRI reveals structure and function of human myocardial laminar sheets in vivoJiangang Dou
MGH-NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Magn Reson Med 50:107-13. 2003..The study demonstrates that noninvasive NMR imaging is a promising tool for investigations of myocardial sheet architecture and function, and is particularly suited to the evident complexity of this field of study... - A novel approach for reducing ischemic mitral regurgitation by injection of a polymer to reverse remodel and reposition displaced papillary musclesJudy Hung
Massachusetts General Hospital, Cardiac Ultrasound Laboratory, Blake 256, 55 Fruit Street, Boston, MA 02114, USA
Circulation 118:S263-9. 2008..The purpose is to materially support the infarcted myocardium while at the same time repositioning the papillary muscles that become apically tethered in MR... - Halving imaging time of whole brain diffusion spectrum imaging and diffusion tractography using simultaneous image refocusing in EPITimothy G Reese
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
J Magn Reson Imaging 29:517-22. 2009.... - Diffusion MRI of complex neural architectureDavid S Tuch
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Neuron 40:885-95. 2003..The ability of q-ball imaging to resolve complex intravoxel fiber architecture eliminates a key obstacle to mapping neural connectivity in the human brain noninvasively... - Cylindrical meanderline radiofrequency coil for intravascular magnetic resonance studies of atherosclerotic plaqueChristian T Farrar
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Magn Reson Med 53:226-30. 2005..This radically new RF coil geometry offers the potential to improve the efficiency of MR data acquisition in medical applications in which curved surfaces or slabs contain the material of interest... - Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiographyJeremy D Schmahmann
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
Brain 130:630-53. 2007..By replicating the major features of these tracts identified by histological techniques in monkey, we show that DSI has the potential to cast new light on the organization of the human brain in the normal state and in clinical disorders... - Mapping the structural core of human cerebral cortexPatric Hagmann
Department of Radiology, University Hospital Center and University of Lausanne CHUV, Lausanne, Switzerland
PLoS Biol 6:e159. 2008..The spatial and topological centrality of the core within cortex suggests an important role in functional integration... - Associating the mesoscale fiber organization of the tongue with local strain rate during swallowingSamuel M Felton
Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
J Biomech 41:1782-9. 2008..These data demonstrate that lingual deformation during swallowing involves complex interactions involving intrinsic and extrinsic muscles, whose contractility is directed by the alignment of mesoscale fiber tracts... - Resolving the three-dimensional myoarchitecture of bovine esophageal wall with diffusion spectrum imaging and tractographyRichard J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell Tissue Res 332:461-8. 2008.... - Representing diffusion MRI in 5-D simplifies regularization and segmentation of white matter tractsLisa Jonasson
Signal Processing Institute ITS, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
IEEE Trans Med Imaging 26:1547-54. 2007..These results will lead us to the conclusion that this new high-dimensional representation indeed simplifies the problem of segmentation and regularization... - Three dimensional myoarchitecture of the human tongue determined in vivo by diffusion tensor imaging with tractographyTerry A Gaige
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Magn Reson Imaging 26:654-61. 2007..To study the anatomical relationships involving the intrinsic and extrinsic myofiber populations of the human tongue employing diffusion tensor imaging (DTI) with tractography... - Diffusion tensor MRI of myocardial fibers and sheets: correspondence with visible cut-face textureWen-Yih I Tseng
Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan
J Magn Reson Imaging 17:31-42. 2003..Specifically, the first, second and third eigenvectors correspond to the fiber, sheet, and sheet normal directions, respectively... - High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneityDavid S Tuch
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown 02129, USA
Magn Reson Med 48:577-82. 2002..The multitensor reconstruction resolved multiple intravoxel fiber populations corresponding to known fiber anatomy. Ma.. - Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyondPatric Hagmann
Department of Radiology, Lausanne University Hospital, Rue du Bugnon, 46, CH 1011 Lausanne, Switzerland
Radiographics 26:S205-23. 2006..Knowledge of the technique-specific requirements with regard to hardware and acquisition time, as well as the advantages, limitations, and potential interpretation pitfalls of each technique, is especially useful... - Three-dimensional myoarchitecture of the bovine tongue demonstrated by diffusion spectrum magnetic resonance imaging with tractographyRichard J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
Anat Rec A Discov Mol Cell Evol Biol 288:1173-82. 2006..We postulate that the properties associated with these myofiber tracts predict the mechanical behavior of the tissue and thus constitute a method to relate structure and function for anatomically complex muscular tissues... - Imaging myocardial fiber disarray and intramural strain hypokinesis in hypertrophic cardiomyopathy with MRIWen-Yih I Tseng
Center for Optoelectronic Biomedicine, National Taiwan University Medical College, Taipai, Taiwan
J Magn Reson Imaging 23:1-8. 2006..CONCLUSION: Myofiber disarray in HCM is correlated with abnormalities of both passive and active myocardial function, and the normal patterns of fiber shortening and wall thickening are deranged in HCM... - Fibertract segmentation in position orientation space from high angular resolution diffusion MRIPatric Hagmann
Department of Radiology, Lausanne University Hospital CHUV, Switzerland
Neuroimage 32:665-75. 2006..Potential advantages and drawbacks as compared to classical tractography are discussed; for example, it appears that our formulation handles naturally crossing tracts and is not biased by human intervention... - Mapping complex myoarchitecture in the bovine tongue with diffusion-spectrum magnetic resonance imagingRichard J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
Biophys J 91:1014-22. 2006..We conclude that DSI has the capacity to determine three-dimensional fiber orientation in structurally complex muscular tissues... - Simultaneous echo refocusing in EPIDavid A Feinberg
Advanced MRI Technologies, LLC, Sebastopol, California 95472, USA
Magn Reson Med 48:1-5. 2002.... - Diffusion tensor magnetic resonance imaging mapping the fiber architecture remodeling in human myocardium after infarction: correlation with viability and wall motionMing Ting Wu
Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
Circulation 114:1036-45. 2006.... - Mechanical basis for lingual deformation during the propulsive phase of swallowing as determined by phase-contrast magnetic resonance imagingSamuel M Felton
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Appl Physiol 103:255-65. 2007..These data support the concept that propulsive lingual deformation is due to complex muscular interactions involving both extrinsic and intrinsic muscles... - Maturation-dependent microstructure length scale in the corpus callosum of fixed rat brains by magnetic resonance diffusion-diffractionJun Cheng Weng
Department of Electrical Engineering, National Taiwan University, Interdisciplinary MRI MRS Laboratory, Taipei, Taiwan, Republic of China
Magn Reson Imaging 25:78-86. 2007..In conclusion, MR diffusion-diffraction can be observed in the corpus callosum of fixed rat brains. This technique might be useful in probing the status of myelination in the development of disease...
Research Grants
- Diffusion MRI of Complex White Matter and ConnectivityVan Wedeen; Fiscal Year: 2005..To measure the accuracy of DSI computation of large scale white matter trajectories, by correlation with known neural pathways defined by functional magnetic resonance imaging (fMRI) in the human visual system. ..