Van Wedeen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Phase contrast MRI of myocardial 3D strain by encoding contiguous slices in a single shot
    Timothy G Reese
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Magn Reson Med 47:665-76. 2002
  2. ncbi Cardiac diffusion MRI without motion effects
    Jiangang Dou
    MGH NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 48:105-14. 2002
  3. pmc Response to comment on "the geometric structure of the brain fiber pathways"
    Van J Wedeen
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School and the Martinos Center for Biomedical Imaging, Building 129 13th Street, 2nd Floor, Charlestown, MA 02129, USA
    Science 337:1605. 2012
  4. pmc The geometric structure of the brain fiber pathways
    Van J Wedeen
    Department of Radiology, Massachusetts General Hospital MGH, Harvard Medical School and the MGH Massachussetts Institute of Technology, Charlestown, MA 02129, USA
    Science 335:1628-34. 2012
  5. pmc Diffusion MR tractography of the heart
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA
    J Cardiovasc Magn Reson 11:47. 2009
  6. doi Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers
    V J Wedeen
    Department of Radiology, MGH Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 41:1267-77. 2008
  7. pmc Demonstration of primary and secondary muscle fiber architecture of the bovine tongue by diffusion tensor magnetic resonance imaging
    V J Wedeen
    NMR Center and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biophys J 80:1024-8. 2001
  8. ncbi Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging
    Van J Wedeen
    Department of Radiology, MGH Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 54:1377-86. 2005
  9. ncbi Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imaging
    Mette R Wiegell
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neuroimage 19:391-401. 2003
  10. pmc Development of cerebral fiber pathways in cats revealed by diffusion spectrum imaging
    Emi Takahashi
    Department of Radiology, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 49:1231-40. 2010

Research Grants

Detail Information

Publications35

  1. ncbi Phase contrast MRI of myocardial 3D strain by encoding contiguous slices in a single shot
    Timothy G Reese
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Magn Reson Med 47:665-76. 2002
    ..Two-slices-in-one-shot spatial encoding permits a complete quantitative survey of ventricular 3D strain in under a minute, with routine patient supervision and turnkey image processing...
  2. ncbi Cardiac diffusion MRI without motion effects
    Jiangang Dou
    MGH NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 48:105-14. 2002
    ..These results demonstrate the technique's ability to measure myocardial diffusion accurately at any point in the cardiac cycle free of measurable motion effect, as if the heart were frozen at the point of acquisition...
  3. pmc Response to comment on "the geometric structure of the brain fiber pathways"
    Van J Wedeen
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School and the Martinos Center for Biomedical Imaging, Building 129 13th Street, 2nd Floor, Charlestown, MA 02129, USA
    Science 337:1605. 2012
    ..Thus, the geometric thesis gives the best account of the available evidence...
  4. pmc The geometric structure of the brain fiber pathways
    Van J Wedeen
    Department of Radiology, Massachusetts General Hospital MGH, Harvard Medical School and the MGH Massachussetts Institute of Technology, Charlestown, MA 02129, USA
    Science 335:1628-34. 2012
    ..This architecture naturally supports functional spatio-temporal coherence, developmental path-finding, and incremental rewiring with correlated adaptation of structure and function in cerebral plasticity and evolution...
  5. pmc Diffusion MR tractography of the heart
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA
    J Cardiovasc Magn Reson 11:47. 2009
    ..The application of DSI in ischemic heart disease is reviewed, and the requisites for widespread clinical translation of diffusion MR tractography in the heart are discussed...
  6. doi Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers
    V J Wedeen
    Department of Radiology, MGH Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 41:1267-77. 2008
    ..These findings indicate that DSI tractography is able to image crossing fibers in neural tissue, an essential step toward non-invasive imaging of connectional neuroanatomy...
  7. pmc Demonstration of primary and secondary muscle fiber architecture of the bovine tongue by diffusion tensor magnetic resonance imaging
    V J Wedeen
    NMR Center and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biophys J 80:1024-8. 2001
    ..These findings suggest that three-dimensional analysis of diffusion tensor magnetic resonance imaging provides a structural basis for understanding the micromechanics of the mammalian tongue...
  8. ncbi Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging
    Van J Wedeen
    Department of Radiology, MGH Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 54:1377-86. 2005
    ..Finally, the relation between the presented model-free imaging technique and other available diffusion MRI schemes is discussed...
  9. ncbi Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imaging
    Mette R Wiegell
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neuroimage 19:391-401. 2003
    ..The ability to resolve thalamic nuclei with DTI will allow for morphometric analysis of specific nuclei and improved anatomical localization of functional activation in the thalamus...
  10. pmc Development of cerebral fiber pathways in cats revealed by diffusion spectrum imaging
    Emi Takahashi
    Department of Radiology, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 49:1231-40. 2010
    ..The technique may also be applicable to the study of other forms of brain plasticity, including future studies in vivo...
  11. pmc Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Cardiovasc Imaging 2:206-12. 2009
    ..Unlike diffusion tensor imaging, DSI tractography resolves multiple myofiber populations per voxel, thus generating accurate 3D tractograms, which we present in the myocardium for the first time...
  12. pmc Developing neocortex organization and connectivity in cats revealed by direct correlation of diffusion tractography and histology
    Emi Takahashi
    Division of Newborn Medicine, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cereb Cortex 21:200-11. 2011
    ..These results suggest that diffusion tractography can differentially characterize internal and external SP zones and their transition into mature cortical pathways...
  13. pmc Derivation of a finite-element model of lingual deformation during swallowing from the mechanics of mesoscale myofiber tracts obtained by MRI
    Srboljub M Mijailovich
    Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Appl Physiol 109:1500-14. 2010
    ....
  14. ncbi Combined diffusion and strain MRI reveals structure and function of human myocardial laminar sheets in vivo
    Jiangang Dou
    MGH NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 50:107-13. 2003
    ..The study demonstrates that noninvasive NMR imaging is a promising tool for investigations of myocardial sheet architecture and function, and is particularly suited to the evident complexity of this field of study...
  15. pmc A novel approach for reducing ischemic mitral regurgitation by injection of a polymer to reverse remodel and reposition displaced papillary muscles
    Judy Hung
    Massachusetts General Hospital, Cardiac Ultrasound Laboratory, Blake 256, 55 Fruit Street, Boston, MA 02114, USA
    Circulation 118:S263-9. 2008
    ..The purpose is to materially support the infarcted myocardium while at the same time repositioning the papillary muscles that become apically tethered in MR...
  16. doi Halving imaging time of whole brain diffusion spectrum imaging and diffusion tractography using simultaneous image refocusing in EPI
    Timothy G Reese
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Magn Reson Imaging 29:517-22. 2009
    ....
  17. ncbi Diffusion MRI of complex neural architecture
    David S Tuch
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neuron 40:885-95. 2003
    ..The ability of q-ball imaging to resolve complex intravoxel fiber architecture eliminates a key obstacle to mapping neural connectivity in the human brain noninvasively...
  18. ncbi Cylindrical meanderline radiofrequency coil for intravascular magnetic resonance studies of atherosclerotic plaque
    Christian T Farrar
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Magn Reson Med 53:226-30. 2005
    ..This radically new RF coil geometry offers the potential to improve the efficiency of MR data acquisition in medical applications in which curved surfaces or slabs contain the material of interest...
  19. ncbi Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Brain 130:630-53. 2007
    ..By replicating the major features of these tracts identified by histological techniques in monkey, we show that DSI has the potential to cast new light on the organization of the human brain in the normal state and in clinical disorders...
  20. pmc Mapping the structural core of human cerebral cortex
    Patric Hagmann
    Department of Radiology, University Hospital Center and University of Lausanne CHUV, Lausanne, Switzerland
    PLoS Biol 6:e159. 2008
    ..The spatial and topological centrality of the core within cortex suggests an important role in functional integration...
  21. doi Associating the mesoscale fiber organization of the tongue with local strain rate during swallowing
    Samuel M Felton
    Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Biomech 41:1782-9. 2008
    ..These data demonstrate that lingual deformation during swallowing involves complex interactions involving intrinsic and extrinsic muscles, whose contractility is directed by the alignment of mesoscale fiber tracts...
  22. doi Resolving the three-dimensional myoarchitecture of bovine esophageal wall with diffusion spectrum imaging and tractography
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell Tissue Res 332:461-8. 2008
    ....
  23. ncbi Representing diffusion MRI in 5-D simplifies regularization and segmentation of white matter tracts
    Lisa Jonasson
    Signal Processing Institute ITS, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    IEEE Trans Med Imaging 26:1547-54. 2007
    ..These results will lead us to the conclusion that this new high-dimensional representation indeed simplifies the problem of segmentation and regularization...
  24. ncbi Three dimensional myoarchitecture of the human tongue determined in vivo by diffusion tensor imaging with tractography
    Terry A Gaige
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Magn Reson Imaging 26:654-61. 2007
    ..To study the anatomical relationships involving the intrinsic and extrinsic myofiber populations of the human tongue employing diffusion tensor imaging (DTI) with tractography...
  25. ncbi Diffusion tensor MRI of myocardial fibers and sheets: correspondence with visible cut-face texture
    Wen Yih I Tseng
    Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan
    J Magn Reson Imaging 17:31-42. 2003
    ....
  26. ncbi High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity
    David S Tuch
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown 02129, USA
    Magn Reson Med 48:577-82. 2002
    ..The multitensor reconstruction resolved multiple intravoxel fiber populations corresponding to known fiber anatomy. Ma..
  27. ncbi Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond
    Patric Hagmann
    Department of Radiology, Lausanne University Hospital, Rue du Bugnon, 46, CH 1011 Lausanne, Switzerland
    Radiographics 26:S205-23. 2006
    ..Knowledge of the technique-specific requirements with regard to hardware and acquisition time, as well as the advantages, limitations, and potential interpretation pitfalls of each technique, is especially useful...
  28. ncbi Three-dimensional myoarchitecture of the bovine tongue demonstrated by diffusion spectrum magnetic resonance imaging with tractography
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:1173-82. 2006
    ..We postulate that the properties associated with these myofiber tracts predict the mechanical behavior of the tissue and thus constitute a method to relate structure and function for anatomically complex muscular tissues...
  29. ncbi Imaging myocardial fiber disarray and intramural strain hypokinesis in hypertrophic cardiomyopathy with MRI
    Wen Yih I Tseng
    Center for Optoelectronic Biomedicine, National Taiwan University Medical College, Taipai, Taiwan
    J Magn Reson Imaging 23:1-8. 2006
    ..To examine the relationship between myofiber disarray and myocardial hypokinesis in human hypertrophic cardiomyopathy (HCM) using noninvasive cardiac diffusion and strain MRI...
  30. ncbi Fibertract segmentation in position orientation space from high angular resolution diffusion MRI
    Patric Hagmann
    Department of Radiology, Lausanne University Hospital CHUV, Switzerland
    Neuroimage 32:665-75. 2006
    ..Potential advantages and drawbacks as compared to classical tractography are discussed; for example, it appears that our formulation handles naturally crossing tracts and is not biased by human intervention...
  31. pmc Mapping complex myoarchitecture in the bovine tongue with diffusion-spectrum magnetic resonance imaging
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Biophys J 91:1014-22. 2006
    ..We conclude that DSI has the capacity to determine three-dimensional fiber orientation in structurally complex muscular tissues...
  32. ncbi Simultaneous echo refocusing in EPI
    David A Feinberg
    Advanced MRI Technologies, LLC, Sebastopol, California 95472, USA
    Magn Reson Med 48:1-5. 2002
    ....
  33. ncbi Diffusion tensor magnetic resonance imaging mapping the fiber architecture remodeling in human myocardium after infarction: correlation with viability and wall motion
    Ming Ting Wu
    Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Circulation 114:1036-45. 2006
    ....
  34. ncbi Mechanical basis for lingual deformation during the propulsive phase of swallowing as determined by phase-contrast magnetic resonance imaging
    Samuel M Felton
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Appl Physiol 103:255-65. 2007
    ..These data support the concept that propulsive lingual deformation is due to complex muscular interactions involving both extrinsic and intrinsic muscles...
  35. ncbi Maturation-dependent microstructure length scale in the corpus callosum of fixed rat brains by magnetic resonance diffusion-diffraction
    Jun Cheng Weng
    Department of Electrical Engineering, National Taiwan University, Interdisciplinary MRI MRS Laboratory, Taipei, Taiwan, Republic of China
    Magn Reson Imaging 25:78-86. 2007
    ..In conclusion, MR diffusion-diffraction can be observed in the corpus callosum of fixed rat brains. This technique might be useful in probing the status of myelination in the development of disease...

Research Grants5

  1. Diffusion MRI of Complex White Matter and Connectivity
    Van Wedeen; Fiscal Year: 2005
    ..To measure the accuracy of DSI computation of large scale white matter trajectories, by correlation with known neural pathways defined by functional magnetic resonance imaging (fMRI) in the human visual system. ..