Research Topics
Genomes and Genes
| D R WeaverSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
A1-adenosine receptor gene expression in fetal rat brainD R Weaver
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114, USA
Brain Res Dev Brain Res 94:205-23. 1996....- Definition of the developmental transition from dopaminergic to photic regulation of c-fos gene expression in the rat suprachiasmatic nucleusD R Weaver
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114, USA
Brain Res Mol Brain Res 33:136-48. 1995..The developmental transition from dopaminergic to photic regulation of c-fos gene expression roughly parallels the developmental transition from maternal to photic entrainment of the developing biological clock... - Interacting molecular loops in the mammalian circadian clockL P Shearman
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
Science 288:1013-9. 2000..PERIOD2 is a positive regulator of the Bmal1 loop, and CRYPTOCHROMES are the negative regulators of the Period and Cryptochrome cycles... - mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loopK Kume
Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Cell 98:193-205. 1999..Luciferase reporter gene assays show that mCRY1 or mCRY2 alone abrogates CLOCK:BMAL1-E box-mediated transcription. The mPER and mCRY proteins appear to inhibit the transcriptional complex differentially... - Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clockK Bae
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and, Harvard Medical School, 02114, Boston, MA, USA
Neuron 30:525-36. 2001..Thus, mPER1 influences rhythmicity primarily through interaction with other clock proteins, while mPER2 positively regulates rhythmic gene expression, and there is partial compensation between products of these two genes... - A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clockX Jin
Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Cell 96:57-68. 1999..These data indicate that the transcriptional machinery of the core clockwork directly regulates a clock-controlled output rhythm... 
Targeted disruption of the mPer3 gene: subtle effects on circadian clock functionL P Shearman
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Mol Cell Biol 20:6269-75. 2000..5 h) shorter than that in controls. The results demonstrate that mPer3 is not necessary for circadian rhythms in mice...- Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brainM J Zylka
Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Neuron 20:1103-10. 1998..The results highlight the differential light responses among the three mammalian Per genes in the SCN and raise the possibility of circadian oscillators in mammals outside of brain and retina... - A time-less function for mouse timelessA L Gotter
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nat Neurosci 3:755-6. 2000..A putative mouse homolog, mTimeless (mTim), has been difficult to place in the circadian clock of mammals. Here we show that mTim is essential for embryonic development, but does not have substantiated circadian function... - Photic induction of Period gene expression is reduced in Clock mutant miceL P Shearman
Pediatric Service, Massachusetts General Hospital, Boston 02114, USA
Neuroreport 10:613-8. 1999..Clock appears to play a role in circadian photoreception that is distinct from its role in the circadian oscillatory mechanism... - Molecular analysis of mammalian timelessM J Zylka
Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Neuron 21:1115-22. 1998..The data suggest that PER-PER interactions have replaced the function of PER-TIM dimers in the molecular workings of the mammalian circadian clock... - Cloning of a melatonin-related receptor from human pituitaryS M Reppert
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114
FEBS Lett 386:219-24. 1996..H9 mRNA is expressed in hypothalamus and pituitary, suggesting that the encoded receptor and its natural ligand are involved in neuroendocrine function... - Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responsesS M Reppert
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114
Neuron 13:1177-85. 1994..The cloned high affinity receptor likely mediates the reproductive and circadian actions of melatonin in mammals... - Molecular cloning and characterization of a rat A1-adenosine receptor that is widely expressed in brain and spinal cordS M Reppert
Laboratory of Developmental Chronobiology, Children s Service, Massachusetts General Hospital, Boston
Mol Endocrinol 5:1037-48. 1991..The cloned A1-adenosine receptor may thus mediate many of the modulatory actions of adenosine in neural and endocrine systems... - Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clockC Liu
Laboratory of Developmental Chronobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Neuron 19:91-102. 1997..The results provide a molecular basis for two distinct, mechanistically separable effects of melatonin on SCN physiology... - Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brainS M Reppert
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Neuron 15:1003-15. 1995..Expression of CKA and CKB results in similar ligand binding and functional characteristics. The widespread distribution of CKA and CKB mRNA in brain provides a molecular substrate for the profound actions of melatonin in birds... - Molecular analysis of mammalian circadian rhythmsS M Reppert
Laboratory of Developmental Chronobiology, Mass General Hospital for Children, and Harvard Medical School, Boston, Massachusetts 02114, USA
Annu Rev Physiol 63:647-76. 2001..Greater understanding of the cellular and molecular mechanisms of the SCN clockwork provides opportunities for pharmacological manipulation of circadian timing... - Two period homologs: circadian expression and photic regulation in the suprachiasmatic nucleiL P Shearman
Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Neuron 19:1261-9. 1997..Both Per1 and Per2 RNAs in the SCN are increased by light exposure during subjective night but not during subjective day. The results advance our knowledge of candidate clock elements in mammals... - Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamstersD R Weaver
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, USA
Mol Endocrinol 10:1478-87. 1996..These data support the hypothesis that the Mel1a receptor, which does encode a functional receptor in this species, mediates reproductive and circadian responses to melatonin... - Postmortem stability of melatonin receptor binding and clock-relevant mRNAs in mouse suprachiasmatic nucleusD R Weaver
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Boston, MA 02114, USA
J Biol Rhythms 16:216-23. 2001..The relative stability of melatonin receptor binding in the SCN also suggests that receptor binding may be a reliable marker for the location of the SCN in studies assessing clock gene expression in postmortem material... - Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptorA L Roca
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114, USA
Endocrinology 137:3469-77. 1996..These results provide information on Mel1a receptor gene structure essential for designing transgenic and gene knock-out studies and analyzing the transcriptional regulation of receptor gene expression... - Distinct pharmacological mechanisms leading to c-fos gene expression in the fetal suprachiasmatic nucleusL P Shearman
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Boston, MA 02114, USA
J Biol Rhythms 16:531-40. 2001..The present work shows that stimulant drugs influence the fetal brain through multiple transmitter systems and further suggests that there may be multiple pathways leading to entrainment of the fetal biological clock... - Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptorS M Reppert
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 92:8734-8. 1995..The Mel1b melatonin receptor may mediate the reported actions of melatonin in retina and participate in some of the neurobiological effects of melatonin in mammals... - c-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulationD R Weaver
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114, USA
Brain Res Dev Brain Res 85:293-7. 1995..In mice, the D1-dopamine agonist, SKF 38393, induced c-fos and jun-B mRNAs in the fetal SCN and striatum. Regulated expression of immediate early genes in the fetal SCN may play a role in entrainment of the fetal clock... - Haloperidol regulates neurotensin gene expression in striatum of c-fos-deficient miceL P Shearman
Massachusetts General Hospital, Department of Pediatrics, Harvard Medical School, Boston 02114, USA
Brain Res Mol Brain Res 47:275-85. 1997..These findings indicate that reliance on c-fos may be greater earlier in development and that redundant molecular pathways can lead to induction of NT/N mRNA in mouse striatum... - Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtypeJ H Stehle
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114
Mol Endocrinol 6:384-93. 1992..In situ hybridization studies of RFL9 mRNA showed no specific hybridization pattern in brain, but a hybridization signal was readily observed in the hypophyseal pars tuberalis. Thus, RFL9 encodes a novel A2-adenosine receptor subtype... - Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: new insights into a core clock mechanismM H Hastings
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
J Neurosci 19:RC11. 1999.... - Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatumJ S Fink
Laboratory of Molecular Neurobiology, Massachusetts General Hospital, Charlestown 02129
Brain Res Mol Brain Res 14:186-95. 1992..The co-expression of D2 dopamine and A2 adenosine receptors in a subset of striatal cells provides an anatomical basis for dopaminergic-adenosinergic interactions on motor behavior...