P S Wang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Twelve-month use of mental health services in the United States: results from the National Comorbidity Survey Replication
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:629-40. 2005
  2. ncbi Chronic medical conditions and work performance in the health and work performance questionnaire calibration surveys
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Occup Environ Med 45:1303-11. 2003
  3. ncbi Initiation of and adherence to treatment for mental disorders: examination of patient advocate group members in 11 countries
    P S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Care 38:926-36. 2000
  4. ncbi Changing profiles of service sectors used for mental health care in the United States
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 163:1187-98. 2006
  5. ncbi Effects of major depression on moment-in-time work performance
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 161:1885-91. 2004
  6. ncbi Strategies for improving comorbidity measures based on Medicare and Medicaid claims data
    P S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Clin Epidemiol 53:571-8. 2000
  7. ncbi The prevalence and correlates of untreated serious mental illness
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Health Serv Res 36:987-1007. 2001
  8. ncbi Improved comorbidity adjustment for predicting mortality in Medicare populations
    Sebastian Schneeweiss
    Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Health Serv Res 38:1103-20. 2003
  9. ncbi Potential causes of higher mortality in elderly users of conventional and atypical antipsychotic medications
    Soko Setoguchi
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Geriatr Soc 56:1644-50. 2008
  10. ncbi Finding incident breast cancer cases through US claims data and a state cancer registry
    P S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Causes Control 12:257-65. 2001

Research Grants

  1. APPROPRIATENESS AND COMPLIANCE IN DEPRESSION TREATMENT
    Philip Wang; Fiscal Year: 2003
  2. Outreach and Treatment for Depression in the Labor Force
    Philip Wang; Fiscal Year: 2004
  3. Remibursement Limits, Antidepressants, and Outcomes
    Philip Wang; Fiscal Year: 2005

Collaborators

Detail Information

Publications90

  1. ncbi Twelve-month use of mental health services in the United States: results from the National Comorbidity Survey Replication
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:629-40. 2005
    ..Dramatic changes have occurred in mental health treatments during the past decade. Data on recent treatment patterns are needed to estimate the unmet need for services...
  2. ncbi Chronic medical conditions and work performance in the health and work performance questionnaire calibration surveys
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Occup Environ Med 45:1303-11. 2003
    ..Disease management programs for these conditions might have a positive return on investment (ROI). Health and productivity tracking surveys are needed to evaluate ROI and provide quality assurance...
  3. ncbi Initiation of and adherence to treatment for mental disorders: examination of patient advocate group members in 11 countries
    P S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Care 38:926-36. 2000
    ..Greater understanding of the help-seeking process is needed to reduce the level of unmet need for mental health treatment...
  4. ncbi Changing profiles of service sectors used for mental health care in the United States
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 163:1187-98. 2006
    ..Redesigning the fragmented U.S. mental health care system requires knowing how service sectors share responsibility for individuals' mental health needs...
  5. ncbi Effects of major depression on moment-in-time work performance
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 161:1885-91. 2004
    ..The authors used the experience sampling method to address this problem by collecting comparative data on moment-in-time work performance among service workers who were depressed and those who were not depressed...
  6. ncbi Strategies for improving comorbidity measures based on Medicare and Medicaid claims data
    P S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Clin Epidemiol 53:571-8. 2000
    ....
  7. ncbi The prevalence and correlates of untreated serious mental illness
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Health Serv Res 36:987-1007. 2001
    ..Efforts to increase both self-recognition of need for treatment and the patient centeredness of care also are needed...
  8. ncbi Improved comorbidity adjustment for predicting mortality in Medicare populations
    Sebastian Schneeweiss
    Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Health Serv Res 38:1103-20. 2003
    ..80. CONCLUSIONS: We conclude that in epidemiologic studies of the elderly, a modified diagnosis-based score using empirically derived weights provides improved adjustment for comorbidity and enhances the validity of findings...
  9. ncbi Potential causes of higher mortality in elderly users of conventional and atypical antipsychotic medications
    Soko Setoguchi
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Geriatr Soc 56:1644-50. 2008
    ....
  10. ncbi Finding incident breast cancer cases through US claims data and a state cancer registry
    P S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Causes Control 12:257-65. 2001
    ..However, it is crucial to evaluate how completely incident cancer cases can be ascertained using these data sources...
  11. ncbi Hazardous benzodiazepine regimens in the elderly: effects of half-life, dosage, and duration on risk of hip fracture
    P S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 158:892-8. 2001
    ..g., elimination half-life, dosage, duration of use) are most associated with such risks...
  12. ncbi Underuse of ACE inhibitors and angiotensin II receptor blockers in elderly patients with diabetes
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Kidney Dis 46:1080-7. 2005
    ..However, little is known about the adequacy of adherence to these guidelines in elderly patients with diabetes and predictors of such appropriate ACE-inhibitor or ARB use...
  13. ncbi The costs and benefits of enhanced depression care to employers
    Philip S Wang
    Department of Psychiatry, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, USA
    Arch Gen Psychiatry 63:1345-53. 2006
    ..Although outreach and enhanced treatment interventions improve depression outcomes, uptake has been poor in part because purchasers lack information on their return on investment...
  14. ncbi Failure and delay in initial treatment contact after first onset of mental disorders in the National Comorbidity Survey Replication
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:603-13. 2005
    ..An understudied crucial step in the help-seeking process is making prompt initial contact with a treatment provider after first onset of a mental disorder...
  15. ncbi Performance of comorbidity scores to control for confounding in epidemiologic studies using claims data
    S Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 154:854-64. 2001
    ..7% and 6.2%, respectively) for predicting mortality. Generalizability of results may be limited to an elderly, predominantly White population with equal access to state-funded health care...
  16. ncbi Detecting suicide risk in a pediatric emergency department: development of a brief screening tool
    L M Horowitz
    Department of Psychiatry, Children s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 107:1133-7. 2001
    ..To develop a brief screening tool that will allow emergency department (ED) staff to rapidly and accurately detect suicide risk in child and adolescent patients...
  17. ncbi The effects of chronic medical conditions on work loss and work cutback
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA, USA
    J Occup Environ Med 43:218-25. 2001
    ....
  18. ncbi Dopamine antagonists and the development of breast cancer
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:1147-54. 2002
    ..In light of the small hazards and the possibility of residual confounding, these findings should lead to follow-up investigations but not to changes in treatment strategies...
  19. ncbi Predictors of uncontrolled hypertension in ambulatory patients
    E L Knight
    Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Hypertension 38:809-14. 2001
    ..Some of these may be amenable to modification. Further identification of patients at risk of poor control can lead to targeted interventions to improve management...
  20. ncbi HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients
    P S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115
    JAMA 283:3211-6. 2000
    ....
  21. ncbi When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR*D study
    Roy H Perlis
    Center for Human Genetics Research, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropsychopharmacology 34:2227-36. 2009
    ..These circumstances, particularly availability of alternative treatment strategies and test effect sizes, can be estimated and should be considered before these tests are broadly applied in clinical settings...
  22. ncbi Effects of efforts to increase response rates on a workplace chronic condition screening survey
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Care 40:752-60. 2002
    ..Confirmation of these results is required, however, in new samples. Additional research is also needed on innovative and cost-effective strategies to improve HRA response rates...
  23. ncbi Recent care of common mental disorders in the United States : prevalence and conformance with evidence-based recommendations
    P S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
    J Gen Intern Med 15:284-92. 2000
    ..Cost-effective interventions are needed to improve both access to and quality of treatment...
  24. ncbi Comparative safety of antidepressant agents for children and adolescents regarding suicidal acts
    Sebastian Schneeweiss
    Harvard Medical School, Brigham and Women s Hospital, Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, MA 02120, USA
    Pediatrics 125:876-88. 2010
    ..The objective of this study was to assess the risk of suicide attempts and suicides after initiation of antidepressant medication use by children and adolescents, for individual agents...
  25. ncbi Psychotropic medication use for behavioral symptoms of dementia
    Philip S Wang
    Department of Psychiatry, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Curr Neurol Neurosci Rep 6:490-5. 2006
    ..Also, although various psychotropic medications used for behavioral disturbances in dementia patients may be somewhat effective, they have been increasingly associated with important safety risks...
  26. ncbi Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workers
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 163:1561-8. 2006
    ..Bipolar disorder has been overlooked both because of the failure to distinguish between major depressive disorder and bipolar disorder and by the failure to evaluate the workplace costs of mania/hypomania...
  27. ncbi Selective prescribing led to overestimation of the benefits of lipid-lowering drugs
    Robert J Glynn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02120, USA
    J Clin Epidemiol 59:819-28. 2006
    ..Selective use of these drugs in frail people may confound these relationships...
  28. ncbi The prevalence and correlates of workplace depression in the national comorbidity survey replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    J Occup Environ Med 50:381-90. 2008
    ..To review evidence on the workplace prevalence and correlates of major depressive episodes, with a particular focus on the National Comorbidity Survey Replication, the most recent national survey to focus on these issues...
  29. ncbi Instrumental variable analysis of secondary pharmacoepidemiologic data
    M Alan Brookhart
    Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02120, USA
    Epidemiology 17:373-4. 2006
  30. ncbi Assessing health state utilities in elderly patients at cardiovascular risk
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Med Decis Making 26:247-54. 2006
    ..Health state preferences can be a crucial component of cost-effectiveness analyses, but off-the-shelf health state utilities specifically for older people are not available...
  31. ncbi Evaluating short-term drug effects using a physician-specific prescribing preference as an instrumental variable
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02120, USA
    Epidemiology 17:268-75. 2006
    ..Instrumental variable methods have been proposed as a potential approach to control confounding by indication in nonexperimental studies of treatment effects; however, good instruments are hard to find...
  32. ncbi Prescription opioid use among older adults with arthritis or low back pain
    Daniel H Solomon
    Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Ste, 3030, Boston, MA 02120, USA
    Arthritis Rheum 55:35-41. 2006
    ..To examine patterns of chronic opioid use in selected groups with arthritis and low back pain and compare them with patterns among persons with ischemic heart disease...
  33. ncbi Risk of death in elderly users of conventional vs. atypical antipsychotic medications
    Philip S Wang
    Department of Psychiatry, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    N Engl J Med 353:2335-41. 2005
    ..However, the advisory did not apply to conventional antipsychotic medications; the risk of death with these older agents is not known...
  34. ncbi Consistency of performance ranking of comorbidity adjustment scores in Canadian and U.S. utilization data
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Gigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    J Gen Intern Med 19:444-50. 2004
    ..We sought to evaluate and rank the performance of comorbidity scores across selected U.S. and Canadian elderly populations using health care utilization databases...
  35. ncbi Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysis
    Sebastian Schneeweiss
    Harvard Medical School, Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, MA 021205, USA
    Arthritis Rheum 54:3390-8. 2006
    ....
  36. ncbi Adequacy of treatment for serious mental illness in the United States
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Public Health 92:92-8. 2002
    ..The purpose of this study was to assess the prevalence and correlates of treatment for serious mental illness...
  37. ncbi The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Epidemiol Psichiatr Soc 18:23-33. 2009
    ..The paper reviews recent findings from the WHO World Mental Health (WMH) surveys on the global burden of mental disorders...
  38. ncbi Assessing residual confounding of the association between antipsychotic medications and risk of death using survey data
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    CNS Drugs 23:171-80. 2009
    ..Nonrandomised studies on the causal effects of psychotropic medications may be biased by patient characteristics that are not fully adjusted...
  39. ncbi Individual and societal effects of mental disorders on earnings in the United States: results from the national comorbidity survey replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 165:703-11. 2008
    ..The purpose of this report was to update previous estimates of the association between mental disorders and earnings. Current estimates for 2002 are based on data from the National Comorbidity Survey Replication (NCS-R)...
  40. ncbi The descriptive epidemiology of commonly occurring mental disorders in the United States
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Public Health 29:115-29. 2008
    ....
  41. ncbi Disruption of existing mental health treatments and failure to initiate new treatment after Hurricane Katrina
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 165:34-41. 2008
    ..The authors examined the disruption of ongoing treatments among individuals with preexisting mental disorders and the failure to initiate treatment among individuals with new-onset mental disorders in the aftermath of Hurricane Katrina...
  42. ncbi Evaluating the validity of an instrumental variable study of neuroleptics: can between-physician differences in prescribing patterns be used to estimate treatment effects?
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    Med Care 45:S116-22. 2007
    ..We sought to explore the validity of physician-level IV in a comparative study of short-term mortality risk among elderly users of conventional versus atypical antipsychotic medications (APM)...
  43. ncbi Variation in the risk of suicide attempts and completed suicides by antidepressant agent in adults: a propensity score-adjusted analysis of 9 years' data
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Arch Gen Psychiatry 67:497-506. 2010
    ..This prompted a meta-analysis of trials in adults that found no overall increase in risk, but individual agents could not be studied...
  44. ncbi Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Clin Psychol 3:137-58. 2007
    ..The article closes with a discussion of future directions for research...
  45. ncbi Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 021205, USA
    CMAJ 176:627-32. 2007
    ..We assessed the short-term mortality in a population-based cohort of elderly people in British Columbia who were prescribed conventional and atypical antipsychotic medications...
  46. ncbi Restrictions on antidepressant medications for children: a review of Medicaid policy
    Michael A Fischer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont St, Suite 3030, Boston, MA 02120, USA
    Psychiatr Serv 58:135-8. 2007
    ..This study evaluated Medicaid's prior-authorization policies restricting the prescribing of antidepressant medications for children...
  47. ncbi Pharmacogenetic testing in the clinical management of schizophrenia: a decision-analytic model
    Roy H Perlis
    Pharmacogenomics Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 25:427-34. 2005
    ..More consistent reporting of test parameters such as sensitivity and specificity would greatly facilitate assessment of future pharmacogenetic studies...
  48. ncbi Effects of noncardiovascular comorbidities on antihypertensive use in elderly hypertensives
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 46:273-9. 2005
    ..Highly prevalent, noncardiovascular conditions appear to deter use of antihypertensives in elderly with hypertension...
  49. ncbi The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    JAMA 289:3095-105. 2003
    ..Uncertainties exist about prevalence and correlates of major depressive disorder (MDD)...
  50. ncbi Patterns and correlates of contacting clergy for mental disorders in the United States
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Health Serv Res 38:647-73. 2003
    ....
  51. ncbi Should clozapine continue to be restricted to third-line status for schizophrenia?: a decision-analytic model
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030 Boston, MA 02120, USA
    J Ment Health Policy Econ 7:77-85. 2004
    ..Clozapine is currently restricted to patients who have failed at least two trials of other antipsychotic medications because of concerns that its use as a first-line agent would lead to greater mortality, mainly through agranulocytosis...
  52. ncbi Delays in initial treatment contact after first onset of a mental disorder
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Health Serv Res 39:393-415. 2004
    ..Interventions are needed to decrease these delays...
  53. ncbi The economic burden of depression and the cost-effectiveness of treatment
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Methods Psychiatr Res 12:22-33. 2003
    ..Further research is needed to overcome these barriers to providing high-quality care for depression and to ultimately reduce the enormous adverse economic impact of depression disorders...
  54. ncbi Measuring the cost-effectiveness of lipid-lowering drugs in the elderly: the outcomes research and economic analysis components of the PROSPER trial
    Jerry Avorn
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Control Clin Trials 23:757-73. 2002
    ....
  55. ncbi Racial differences in screening for prostate cancer in the elderly
    Timothy Gilligan
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Arch Intern Med 164:1858-64. 2004
    ..Low screening rates among black men may contribute to these disparities, but there are few data on racial differences in prostate cancer screening...
  56. ncbi Clozapine use and risk of diabetes mellitus
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Psychopharmacol 22:236-43. 2002
    ..Additional data from pharmacoepidemiologic studies and randomized controlled trials are needed to exclude the possibility of residual confounding and ensure the appropriate use of this agent...
  57. ncbi Association between SSRI use and hip fractures and the effect of residual confounding bias in claims database studies
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Psychopharmacol 24:632-8. 2004
    ..Using survey data, we determined the magnitude of such bias and corrected the association between SSRI use and hip fractures accordingly...
  58. ncbi Suboptimal antidepressant use in the elderly
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    J Clin Psychopharmacol 25:118-26. 2005
    ..Suboptimal antidepressant use remains common in the elderly, especially the use of inadequately intensive regimens. Interventions are needed to improve the quality and outcomes of antidepressant use in this vulnerable population...
  59. ncbi Trends in suicide ideation, plans, gestures, and attempts in the United States, 1990-1992 to 2001-2003
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Mass 02115, USA
    JAMA 293:2487-95. 2005
    ..Little is known about trends in suicidal ideation, plans, gestures, or attempts or about their treatment. Such data are needed to guide and evaluate policies to reduce suicide-related behaviors...
  60. ncbi Claims data studies of sedative-hypnotics and hip fractures in older people: exploring residual confounding using survey information
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Geriatr Soc 53:948-54. 2005
    ..To identify the magnitude of confounding bias caused by factors not measured in claims data studies of sedative-hypnotic use and fractures...
  61. ncbi Noncompliance with antihypertensive medications: the impact of depressive symptoms and psychosocial factors
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Boston, Mass 02115, USA
    J Gen Intern Med 17:504-11. 2002
    ..Addressing the epidemic of poor compliance with antihypertensive medications will require identifying factors associated with poor adherence, including modifiable psychosocial and behavioral characteristics of patients...
  62. ncbi How well do patients report noncompliance with antihypertensive medications?: a comparison of self-report versus filled prescriptions
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 13:11-9. 2004
    ..Although self-reports are often the only means available in routine practice, their accuracy and agreement with other data sources remain questionable...
  63. ncbi Distinguishing generalized anxiety disorder from major depression: prevalence and impairment from current pure and comorbid disorders in the US and Ontario
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston MA 02115, USA
    Int J Methods Psychiatr Res 11:99-111. 2002
    ..The paper closes with a discussion of the methodological complexities associated with generalizing to comorbidities that involve rare conditions or more than two disorders...
  64. ncbi Use of the case-crossover design to study prolonged drug exposures and insidious outcomes
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Epidemiol 14:296-303. 2004
    ..We investigated whether case-crossover methods can be used to study prolonged exposures and insidious outcomes...
  65. ncbi Recent patterns and predictors of antipsychotic medication regimens used to treat schizophrenia and other psychotic disorders
    P S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Schizophr Bull 26:451-7. 2000
    ..The APA PRN Study data are an important new resource for mental health services researchers...
  66. ncbi Benzodiazepine use and mortality of incident dialysis patients in the United States
    W C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Kidney Int 72:1388-93. 2007
    ..Further studies are needed to elucidate the safety of these drugs in the dialysis population, which may lead to cautious and restrictive utilization of omega-receptor agonists in dialysis patients...
  67. ncbi Medicaid's prior authorization program and access to atypical antipsychotic medications
    Jennifer M Polinski
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Health Aff (Millwood) 26:750-60. 2007
    ..More than a year later, no state had changed its PA policy in response. We discuss the roles of Medicaid and other insurers in responding to emerging drug safety issues and their challenges in weighing drug risks and benefits...
  68. ncbi Lipid levels and bone mineral density
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02120, USA
    Am J Med 118:1414. 2005
    ..The aim of this study was to examine the relationship between lipid levels and bone mineral density...
  69. ncbi Health advisories and patterns of patient monitoring among new users of antidepressant medications
    Joshua J Gagne
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Suite 3030, 1620 Tremont St, Boston, MA 02120, USA
    J Clin Psychopharmacol 29:590-4. 2009
    ..We sought to identify patterns of patient monitoring after antidepressant initiation in British Columbia before and after issuance of health advisories...
  70. ncbi Self-management education programs in chronic disease: a systematic review and methodological critique of the literature
    Asra Warsi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02120, USA
    Arch Intern Med 164:1641-9. 2004
    ..In light of evidence of publication bias, further trials that adhere to a standard methodology would help clarify whether self-management education is worthwhile...
  71. ncbi Antidepressant use and the risk of breast cancer: a non-association
    P S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Clin Epidemiol 54:728-34. 2001
    ..Animal studies have suggested that some antidepressant medications may act as breast tumor promoters and recent epidemiologic studies of antidepressant use and breast cancer outcomes in humans have also reported such associations...
  72. ncbi Zolpidem use and hip fractures in older people
    P S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Geriatr Soc 49:1685-90. 2001
    ..Rather than being a safer alternative, zolpidem may be associated with risks that are as great as those seen with conventional benzodiazepines in older patients...
  73. ncbi Adherence to therapy with oral antineoplastic agents
    Ann H Partridge
    Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 94:652-61. 2002
    ..Assessment of adherence among individuals with cancer and implementation of interventions in situations of poor adherence should improve clinical outcomes...
  74. ncbi Considering the costs of bipolar depression
    Ronald C Kessler
    Harvard Medical School, USA
    Behav Healthc 27:45-7. 2007
  75. ncbi Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer
    Ann H Partridge
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, D1210, Boston, MA 02215, USA
    J Clin Oncol 21:602-6. 2003
    ..We sought to estimate adherence and predictors of nonadherence in women starting tamoxifen as adjuvant breast cancer therapy...
  76. ncbi Parental anxiety associated with referral of a child to a pediatric cardiologist for evaluation of a Still's murmur
    Robert L Geggel
    Department of Cardiology, Children's Hospital, Boston, Massachusetts 02115, USA
    J Pediatr 140:747-52. 2002
    ..CONCLUSIONS: Parental anxiety is common among parents of children referred for specialty evaluation. Educational strategies to improve pediatrician communication skills with parents may improve quality of care...
  77. ncbi Urinary antispasmodic use and the risks of ventricular arrhythmia and sudden death in older patients
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Geriatr Soc 50:117-24. 2002
    ..Additional study will be required to confirm these results, exclude the possibility of unmeasured confounders contributing to any lack of an observed relationship, and extend these findings to newer agents such as tolterodine...
  78. ncbi Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys
    Philip S Wang
    Division of Services and Intervention Research, National Institute of Mental Health, Rockville, MD, USA
    Lancet 370:841-50. 2007
    ..We describe mental health care in 17 countries participating in the WHO world mental health (WMH) survey initiative and examine unmet needs for treatment...
  79. ncbi Treatment and adequacy of treatment of mental disorders among respondents to the Mexico National Comorbidity Survey
    Guilherme Borges
    Instituto Nacional de Psiquiatria and Universidad Autonoma Metropolitana Xochimilco, Calzada Mexico Xochimilco No 101, Col San Lorenzo Huipulco, Mexico D F C P 14370, Mexico
    Am J Psychiatry 163:1371-8. 2006
    ..This study described the rate and adequacy of mental health service use among participants in the Mexico National Comorbidity Survey and the correlates of any 12-month treatment and of adequate treatment...
  80. ncbi Suicide risk during antidepressant treatment
    Gregory E Simon
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Am J Psychiatry 163:41-7. 2006
    ..The authors used population-based data to evaluate the risk of suicide death and serious suicide attempt in relation to initiation of antidepressant treatment...
  81. ncbi Dropping out of mental health treatment: patterns and predictors among epidemiological survey respondents in the United States and Ontario
    Mark J Edlund
    UCLA Neuropsychiatric Institute, Los Angeles, CA, USA
    Am J Psychiatry 159:845-51. 2002
    ..Cost-effective interventions targeting these groups are needed to increase the proportion of patients who complete an adequate course of treatment...
  82. ncbi Clinical differences among patients treated for mental health problems in general medical and specialty mental health settings in the National Comorbidity Survey Replication
    Lisa A Uebelacker
    Department of Psychiatry and Human Behavior, Brown University and Butler Hospital, Providence, RI 02906, USA
    Gen Hosp Psychiatry 28:387-95. 2006
    ..We explored whether differences in the clinical characteristics of patients treated in each sector (GM-only or SMH-only) or in both sectors (GM+SMH) may help to explain this finding...
  83. ncbi Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys
    Koen Demyttenaere
    JAMA 291:2581-90. 2004
    ..Structural barriers exist to this reallocation. Careful consideration needs to be given to the value of treating some mild cases, especially those at risk for progressing to more serious disorders...
  84. ncbi Unmet need for services and interventions among adolescents with mental disorders
    Philip S Wang
    Am J Psychiatry 164:1-3. 2007
  85. ncbi The impact of cost sharing on antidepressant use among older adults in British Columbia
    Philip S Wang
    National Institute of Mental Health, Bethesda, MD 20892 9629, USA
    Psychiatr Serv 59:377-83. 2008
    ....
  86. ncbi Ventricular arrhythmias and cerebrovascular events in the elderly using conventional and atypical antipsychotic medications
    Philip S Wang
    J Clin Psychopharmacol 27:707-10. 2007
  87. ncbi Mental health service use among hurricane Katrina survivors in the eight months after the disaster
    Philip S Wang
    Interventional Research, National Institute of Mental Health, Bethesda, MD, USA
    Psychiatr Serv 58:1403-11. 2007
    ..This study examined use of mental health services among adult survivors of Hurricane Katrina in order to improve understanding of the impact of disasters on persons with mental disorders...
  88. ncbi Delay of first treatment of mental and substance use disorders in Mexico
    Guilherme Borges
    National Institute of Psychiatry and the Metropolitan Autonomous University, Mexico City, Mexico
    Am J Public Health 97:1638-43. 2007
    ..We studied failure and delay in making initial treatment contact after the first onset of a mental or substance use disorder in Mexico as a first step to understanding barriers to providing effective treatment in Mexico...
  89. ncbi Understanding mental health treatment in persons without mental diagnoses: results from the National Comorbidity Survey Replication
    Benjamin G Druss
    Department of Health Policy and Management, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 64:1196-203. 2007
    ..Concerns have been raised that this pattern might represent evidence of misallocation of treatment resources...
  90. ncbi Telephone screening, outreach, and care management for depressed workers and impact on clinical and work productivity outcomes: a randomized controlled trial
    Philip S Wang
    Division of Services and Intervention Research, National Institute of Mental Health, Rockville, Maryland, USA
    JAMA 298:1401-11. 2007
    ..Organized depression care programs significantly improve treatment quality, but employer purchasers have been slow to adopt these programs based on lack of evidence for cost-effectiveness from their perspective...

Research Grants6

  1. APPROPRIATENESS AND COMPLIANCE IN DEPRESSION TREATMENT
    Philip Wang; Fiscal Year: 2003
    ..Through his proposed training and mentored research, the candidate will acquire a set of synergistic skills which will prepare him to become an independent and productive mental health services researcher. ..
  2. Outreach and Treatment for Depression in the Labor Force
    Philip Wang; Fiscal Year: 2004
    ..This is an extremely important opportunity for rapid and widespread dissemination in an area of research where dissemination of positive results has traditionally been a serious problem. ..
  3. Remibursement Limits, Antidepressants, and Outcomes
    Philip Wang; Fiscal Year: 2005
    ..We will also use other national and international forums to inform ongoing debates over drug coverage for vulnerable elderly patients with depression. ..