Jia huai Wang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Revisiting the putative TCR Cα dimerization model through structural analysis
    Jia huai Wang
    Laboratory of Immunobiology, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School Boston, MA, USA Department of Pediatrics, Harvard Medical School Boston, MA, USA Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School Boston, MA, USA
    Front Immunol 4:16. 2013
  2. pmc Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication
    Kemin Tan
    Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    J Cell Biol 159:373-82. 2002
  3. pmc A Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR Dimerization
    Bo Zhou
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Harvard Medical School Boston, MA, USA
    Front Immunol 2:5. 2011
  4. pmc The sequence signature of an Ig-fold
    Jia huai Wang
    Dana Farber Cancer Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA
    Protein Cell 4:569-72. 2013
  5. pmc Pull and push: talin activation for integrin signaling
    Jia huai Wang
    College of Life Sciences, Peking University, Beijing 100871, China 2 Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cell Res 22:1512-4. 2012
  6. ncbi request reprint Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors
    J H Wang
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 97:791-803. 1999
  7. ncbi request reprint Structural basis of cell-cell interactions in the immune system
    J Wang
    Dana Farber Cancer Institute and Department of Pediatrics and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Struct Biol 10:656-61. 2000
  8. ncbi request reprint Structural basis of T cell recognition of peptides bound to MHC molecules
    Jia huai Wang
    Laboratory of Immunobiology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Immunol 38:1039-49. 2002
  9. ncbi request reprint Protein recognition by cell surface receptors: physiological receptors versus virus interactions
    Jia huai Wang
    Dana Farber Cancer Institute, Dept Pediatrics, Harvard Medical School, Room SM 1036B, 44 Binney St, Boston, MA 02115, USA
    Trends Biochem Sci 27:122-6. 2002
  10. ncbi request reprint Structural basis for dimerization of ICAM-1 on the cell surface
    Yuting Yang
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 14:269-76. 2004

Research Grants

Collaborators

Detail Information

Publications54

  1. pmc Revisiting the putative TCR Cα dimerization model through structural analysis
    Jia huai Wang
    Laboratory of Immunobiology, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School Boston, MA, USA Department of Pediatrics, Harvard Medical School Boston, MA, USA Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School Boston, MA, USA
    Front Immunol 4:16. 2013
    ....
  2. pmc Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication
    Kemin Tan
    Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    J Cell Biol 159:373-82. 2002
    ..This is the first high-resolution crystal structure of a TSR domain that provides a prototypic architecture for structural and functional exploration of the diverse members of the TSR superfamily...
  3. pmc A Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR Dimerization
    Bo Zhou
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Harvard Medical School Boston, MA, USA
    Front Immunol 2:5. 2011
    ..Accordingly, we propose a dimeric pre-TCR model distinct from those suggested previously by others and discuss its functional and structural implications...
  4. pmc The sequence signature of an Ig-fold
    Jia huai Wang
    Dana Farber Cancer Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA
    Protein Cell 4:569-72. 2013
    ..These signature residues define the I-set Ig-like domain, which should aid structural and functional studies of cell surface receptors. ..
  5. pmc Pull and push: talin activation for integrin signaling
    Jia huai Wang
    College of Life Sciences, Peking University, Beijing 100871, China 2 Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cell Res 22:1512-4. 2012
    ....
  6. ncbi request reprint Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors
    J H Wang
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 97:791-803. 1999
    ..These features explain CD2-CD58 dynamic binding, offering insights into interactions of related immunoglobulin superfamily receptors...
  7. ncbi request reprint Structural basis of cell-cell interactions in the immune system
    J Wang
    Dana Farber Cancer Institute and Department of Pediatrics and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Struct Biol 10:656-61. 2000
    ....
  8. ncbi request reprint Structural basis of T cell recognition of peptides bound to MHC molecules
    Jia huai Wang
    Laboratory of Immunobiology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Immunol 38:1039-49. 2002
    ..The implications of these findings for thymic selection, helper versus cytolytic T cell recognition and alloreactivity are discussed...
  9. ncbi request reprint Protein recognition by cell surface receptors: physiological receptors versus virus interactions
    Jia huai Wang
    Dana Farber Cancer Institute, Dept Pediatrics, Harvard Medical School, Room SM 1036B, 44 Binney St, Boston, MA 02115, USA
    Trends Biochem Sci 27:122-6. 2002
    ..Viruses might take advantage of this low affinity to invade a host cell by evolving a stronger binding affinity to the surface receptors than that associated with physiological ligands. Structural data appear to support this notion...
  10. ncbi request reprint Structural basis for dimerization of ICAM-1 on the cell surface
    Yuting Yang
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 14:269-76. 2004
    ....
  11. ncbi request reprint Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
    Motomu Shimaoka
    The Center for Blood Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 112:99-111. 2003
    ..Pulling down on the C-terminal alpha 7 helix with introduced disulfide bonds ratchets the beta 6-alpha 7 loop into three different positions in the closed, intermediate, and open conformations, with a progressive increase in affinity...
  12. pmc The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin
    Kemin Tan
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Structure 14:33-42. 2006
    ..The TSPN-1 structure and identified adjacent linker region provide a structural framework for the analysis of the TSPN domain of various molecules, including TSPs, NELLs, many collagens, TSPEAR, and kielin...
  13. ncbi request reprint The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory
    Yiwei Liu
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 18:205-15. 2003
    ..At the same time, the TL/CD8alphaalpha interaction is strengthened through subtle structure changes in the TL alpha3 domain. Thus, TL functions to sequester and redirect CD8alphaalpha away from the TCR, modifying lck-dependent signaling...
  14. ncbi request reprint Assembling atomic resolution views of the immunological synapse
    Jia huai Wang
    Department of Pediatrics, Harvard Medical School, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Curr Opin Immunol 15:286-93. 2003
    ....
  15. pmc Involvement of the TCR Cbeta FG loop in thymic selection and T cell function
    Tetsuro Sasada
    Laboratory of Immunobiology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115
    J Exp Med 195:1419-31. 2002
    ..Compared with N15alphabeta, N15alphabeta.betaDeltaFG T cells respond poorly to cognate antigens and weak agonists. Thus, the Cbeta FG loop facilitates negative selection of thymocytes and activation of T cells...
  16. ncbi request reprint Disparate peptide-dependent thymic selection outcomes in beta2M-deficient mice versus TAP-1-deficient mice: implications for repertoire formation
    Tetsuro Sasada
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 33:368-80. 2003
    ..TCR-self-MHC interaction dominates Kb-based selection, subtly modulated by peptides as revealed by X-ray crystallography...
  17. ncbi request reprint Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration
    Zhi Song Qiao
    Laboratory of Immunobiology and Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:23138-46. 2005
    ..Moreover, this engineered mini-Env protein should facilitate three-dimensional structural studies of the prefusion e-gp41 and serve to guide future attempts at pharmacologic and immunologic intervention of HIV-1...
  18. ncbi request reprint Structural basis of Dscam isoform specificity
    Rob Meijers
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 449:487-91. 2007
    ..Phylogenetic analysis shows strong selection of matching peptide sequences only for epitope I. We propose that peptide complementarity of variable residues in epitope I of Dscam is essential for homophilic binding specificity...
  19. pmc Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain
    Kemin Tan
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 283:3932-41. 2008
    ..Dimer formation may also involve TSPN-1 domains from two separate TSP-1 molecules. This association would enable glycosaminoglycans to cluster TSP-1...
  20. pmc The crystal structure of the heparin-binding reelin-N domain of f-spondin
    Kemin Tan
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Mol Biol 381:1213-23. 2008
    ..The homophilic asymmetric dimer can potentially offer advantages in binding to ligands such as glycosaminoglycans, which may, in turn, bridge the two reelin-N domains and stabilize the dimer...
  21. pmc An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2
    Gang Song
    CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:3366-71. 2005
    ..Variation in composition of glycans on the periphery of the interfaces influences on-rate...
  22. ncbi request reprint Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance
    Rob Meijers
    Laboratory of Immunobiology, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Mol Biol 345:1099-110. 2005
    ....
  23. ncbi request reprint Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface
    Junichi Takagi
    The Center for Blood Research, Boston, Massachusetts 02115, USA
    Nature 424:969-74. 2003
    ....
  24. pmc Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family
    Kemin Tan
    Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 21:2076-86. 2002
    ..We discuss the structural basis of virus receptor activities of murine CEACAM1 proteins, binding of Neisseria to human CEACAM1, and other homophilic and heterophilic interactions of CEA family members...
  25. doi request reprint HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane
    Zhen Yu J Sun
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 28:52-63. 2008
    ....
  26. pmc Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization
    Mikyung Kim
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 18:1235-43. 2011
    ..Hence, target neutralization through this lipid-embedded viral segment places stringent requirements on the plasticity of the antibody combining site...
  27. pmc An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5
    Hongmin Zhang
    Department of Medical Oncology and Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell 31:432-7. 2008
    ..This remarkable feature allows the alpha7 helix to trigger integrin's large-scale conformational changes with little energy penalty. It serves as a mechanistic example of how a weakly bound adhesion molecule works in signaling...
  28. ncbi request reprint The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion
    Timothy A Springer
    CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Adv Protein Chem 68:29-63. 2004
    ....
  29. pmc Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1
    Hongmin Zhang
    Department of Pediatrics, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:18345-50. 2009
    ..The results explain AL-57's antagonistic mimicry of LFA-1's natural ligands, the ICAM molecules...
  30. ncbi request reprint Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer
    Hsiu Ching Chang
    Laboratory of Immunobiology, Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 23:661-71. 2005
    ..The implications of these findings and additional CD8alpha mutational studies for CD8alphabeta- versus CD8alphaalpha-MHCI binding are discussed...
  31. pmc Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop
    Yamei Yu
    Program in Cellular and Molecular Medicine, Children s Hospital Boston, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 288:6284-94. 2013
    ....
  32. pmc The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism
    Emilio Parisini
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Mol Biol 373:401-11. 2007
    ..It seems that evolution has selected slightly different adhesion mechanisms for type I and type II cadherins...
  33. pmc The RGD finger of Del-1 is a unique structural feature critical for integrin binding
    Thomas Schürpf
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    FASEB J 26:3412-20. 2012
    ..A database search for EGF domain sequences shows that this RGD finger is likely an evolutionary insertion and unique to the EGF domain of Del-1 and its homologue milk fat globule-EGF 8...
  34. pmc Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems
    Hongmin Zhang
    Dana Farber Cancer Institute, Boston, Massachusetts, USA
    FASEB J 23:2735-40. 2009
    ....
  35. ncbi request reprint Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins
    Hua Jing
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Structure 10:1453-64. 2002
    ..The third domain is predicted to adopt a beta helix fold. These domains have homologs in metazoan cell surface proteins, suggesting remarkable relationships between domains in archaeal SLPs and metazoan cell surface proteins...
  36. pmc The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function
    Jia huai Wang
    Laboratory of Immunobiology, Dana Farber Cancer Institute and Departments, Harvard Medical School, Boston, MA, USA
    Immunol Rev 250:102-19. 2012
    ..Potential insights from the structural biology relevant to immunity and immunosuppression are revealed...
  37. ncbi request reprint The role of alpha and beta chains in ligand recognition by beta 7 integrins
    J M Higgins
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 275:25652-64. 2000
    ..Thus, although specificity can be determined by the integrin alpha or beta chain, common structural features of both subunits are required for recognition of dissimilar ligands...
  38. ncbi request reprint Development of a competitive PCR method for physical titration of recombinant EBV vector in a helper-dependent packaging system
    J Wang
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Mol Ther 3:976-83. 2001
    ..In addition, it provides a sensitive and accurate way to evaluate future development of a helper-free packaging system by detecting any possible helper virus contamination...
  39. ncbi request reprint Hypothermia after cesarean delivery and its reversal with lorazepam
    P E Hess
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Int J Obstet Anesth 14:279-83. 2005
    ..Intrathecal morphine can produce hypothermia in animals. This side effect has been reported in humans, but has not been thoroughly studied in obstetrics...
  40. doi request reprint Immunodominant-peptide recognition: beta testing TCRalphabeta
    Jia huai Wang
    Laboratory of Immunobiology and Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Immunity 28:139-41. 2008
    ..2008) define human T cell-receptor recognition of an immunodominant influenza A matrix peptide bound to human leukocyte antigen HLA-A*0201 in atomic detail, raising provocative questions about beta chain function...
  41. pmc N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors
    Qiang Chen
    Department of Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 126:186-95. 2013
    ..The N-terminal horseshoe appears to be evolutionally selected as a platform for neural receptors...
  42. ncbi request reprint Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
    Tsan Xiao
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 432:59-67. 2004
    ..Allostery in the head thus disrupts interaction between the legs in a previously described low-affinity bent integrin conformation, and leg extension positions the high-affinity head far above the cell surface...
  43. pmc Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface
    Likai Song
    Cancer Vaccine Center, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:9057-62. 2009
    ..HIV-1 MPER features important for targeted vaccine design have been revealed, the implications of which extend to BNAb targets on other viral fusion proteins...
  44. ncbi request reprint Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
    J Wang
    Division of Cell and Molecular Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Biol Chem 270:12774-80. 1995
    ..The interaction does not displace the catalytic subunit of PI 3-kinase but is exclusive of Sos. Signaling through PI 3-kinase, therefore, may involve the ubiquitous adapter Grb2, which serves as a convergence point for multiple pathways...
  45. ncbi request reprint Molecular dissection of the CD2-CD58 counter-receptor interface identifies CD2 Tyr86 and CD58 Lys34 residues as the functional "hot spot"
    M Kim
    Laboratory of Immunobiology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    J Mol Biol 312:711-20. 2001
    ..The elucidation of this hot spot provides a new target for rational design of immunosuppressive compounds and suggests a general approach for other receptors...
  46. pmc The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1
    S Kharbanda
    Division of Cancer Pharmacology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 93:6898-901. 1996
    ..These findings indicate that SHPTP1 is involved in the response to genotoxic stress through a c-Abl-dependent mechanism...
  47. pmc A New Angle on TCR Activation
    Jia huai Wang
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Immunity 35:658-60. 2011
    ..Adams et al. (2011) in this issue of Immunity provide evidence that docking geometry may impact 2D binding and T cell activation...
  48. ncbi request reprint RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues
    R J Monroe
    Howard Hughes Medical Institute, The Children s Hospital, The Center for Blood Research and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 11:201-12. 1999
    ..The latter population decreases in size with age but reappears following immunization of older RAG2:GFP mice. We discuss the implications of these findings for current models of receptor assembly and diversification...
  49. ncbi request reprint Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1
    R W Johnstone
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:10880-7. 1998
    ..Thus, Ciao 1 appears to specifically modulate the transactivation activity of WT1 and may function to regulate the physiological functions of WT1 in cell growth and differentiation...
  50. pmc MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein
    P Ernst
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Mol Cell Biol 21:2249-58. 2001
    ..In contrast with paradigms in which factors compete for limiting quantities of CBP, these results reveal that two distinct transcription factor activation domains can cooperatively target the same motif on CBP...
  51. ncbi request reprint Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
    T Ikura
    Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 102:463-73. 2000
    ..These results indicate that the histone acetylase TIP60-containing complex plays a role in DNA repair and apoptosis...
  52. ncbi request reprint Differential expression in Arabidopsis of Lhca2, a PSI cab gene
    H Zhang
    Department of Genetics, Harvard Medical School, Boston, MA
    Plant Mol Biol 25:551-7. 1994
    ..This suggests that a different mechanism may be employed to regulate the expression of Lhca2...
  53. pmc A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1
    R W Johnstone
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 16:6945-56. 1996
    ..Significantly, par-4, but not a mutant unable to interact with WT1, rescued growth suppression caused by WT1. Thus, we identified a novel repressor that modulates transcription as well as growth suppression functions of WT1...

Research Grants5

  1. MHCL RESTRICTED TCR RECOGNITION--STRUCTURAL BASIS
    Jia huai Wang; Fiscal Year: 1999
    ..This should establish whether the docking mode is fixed or variable and whether there are restricted interactions between specific CDRs and MHC versus peptide residues. ..
  2. MHCL RESTRICTED TCR RECOGNITION--STRUCTURAL BASIS
    Jia huai Wang; Fiscal Year: 2000
    ..This should establish whether the docking mode is fixed or variable and whether there are restricted interactions between specific CDRs and MHC versus peptide residues. ..
  3. MHCL RESTRICTED TCR RECOGNITION--STRUCTURAL BASIS
    Jia huai Wang; Fiscal Year: 2001
    ..This should establish whether the docking mode is fixed or variable and whether there are restricted interactions between specific CDRs and MHC versus peptide residues. ..
  4. MHCL RESTRICTED TCR RECOGNITION--STRUCTURAL BASIS
    Jia huai Wang; Fiscal Year: 2002
    ..This should establish whether the docking mode is fixed or variable and whether there are restricted interactions between specific CDRs and MHC versus peptide residues. ..