James Wang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Unlocking and opening a DNA gate
    James C Wang
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:4773-4. 2007
  2. doi request reprint A journey in the world of DNA rings and beyond
    James C Wang
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Annu Rev Biochem 78:31-54. 2009
  3. ncbi request reprint Cellular roles of DNA topoisomerases: a molecular perspective
    James C Wang
    Department of Molecular and Cellular Biology, Harvard University, Fairchild Building, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Rev Mol Cell Biol 3:430-40. 2002
  4. pmc DNA axial rotation and the merge of oppositely supercoiled DNA domains in Escherichia coli: effects of DNA bends
    Vera A Stupina
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 101:8608-13. 2004
  5. pmc Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta
    Yi Lisa Lyu
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:7123-8. 2003
  6. pmc Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta
    Kelvin Y Kwan
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:2526-31. 2003
  7. pmc Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus
    Yong Wang
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 99:12114-9. 2002
  8. pmc Development of autoimmunity in mice lacking DNA topoisomerase 3beta
    Kelvin Y Kwan
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:9242-7. 2007
  9. ncbi request reprint On the molecular basis of the thermal sensitivity of an Escherichia coli topA mutant
    Yong Wang
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 277:1203-9. 2002
  10. pmc Role of topoisomerase IIbeta in the expression of developmentally regulated genes
    Yi Lisa Lyu
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Mol Cell Biol 26:7929-41. 2006

Research Grants

Collaborators

  • Yi Lisa Lyu
  • Yong Wang
  • P B Moens
  • Kelvin Y Kwan
  • Anna M Azarova
  • Vera A Stupina
  • Yuan Chin Tsai
  • Arlene H Sharpe
  • Johnson Yiu Nam Lau
  • Albert C Shaw
  • Subhasis Mohanty
  • Chao Po Lin
  • Rebecca J Greenwald
  • Leroy F Liu

Detail Information

Publications11

  1. pmc Unlocking and opening a DNA gate
    James C Wang
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:4773-4. 2007
  2. doi request reprint A journey in the world of DNA rings and beyond
    James C Wang
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Annu Rev Biochem 78:31-54. 2009
    ..The fascinating ability of the topoisomerases in passing DNA strands or double helices through one another and their importance in cellular processes have kept me and many others excited in their studies...
  3. ncbi request reprint Cellular roles of DNA topoisomerases: a molecular perspective
    James C Wang
    Department of Molecular and Cellular Biology, Harvard University, Fairchild Building, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Rev Mol Cell Biol 3:430-40. 2002
    ..In this review, the cellular roles of these enzymes are examined from a molecular point of view...
  4. pmc DNA axial rotation and the merge of oppositely supercoiled DNA domains in Escherichia coli: effects of DNA bends
    Vera A Stupina
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 101:8608-13. 2004
    ..coli, as suggested by previous in vitro studies...
  5. pmc Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta
    Yi Lisa Lyu
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:7123-8. 2003
    ..The enzyme may be required in implementing particular genetic programs in postmitotic cells, such as reelin expression in Cajal-Retzius cells, perhaps through its action on nucleoprotein structure of particular chromosomal regions...
  6. pmc Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta
    Kelvin Y Kwan
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:2526-31. 2003
    ..This interpretation is most likely applicable to mitotic cells as well and can explain the universal presence of at least one type IA DNA topoisomerase in all organisms...
  7. pmc Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus
    Yong Wang
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 99:12114-9. 2002
    ..Given the presence of at least one type IA DNA topoisomerase in all forms of life examined to date, the finding of a type IA enzyme in mitochondria further supports the notion of a key role of such enzymes in DNA transactions...
  8. pmc Development of autoimmunity in mice lacking DNA topoisomerase 3beta
    Kelvin Y Kwan
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:9242-7. 2007
    ....
  9. ncbi request reprint On the molecular basis of the thermal sensitivity of an Escherichia coli topA mutant
    Yong Wang
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 277:1203-9. 2002
    ..Our results thus implicate an indispensable role of DNA topoisomerase I in E. coli cells grown in media of any osmolarity...
  10. pmc Role of topoisomerase IIbeta in the expression of developmentally regulated genes
    Yi Lisa Lyu
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Mol Cell Biol 26:7929-41. 2006
    ..Together, these results support a role of TopIIbeta in activation/repression of developmentally regulated genes at late stages of neuronal differentiation...
  11. pmc Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies
    Anna M Azarova
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:11014-9. 2007
    ..These results point to the importance of developing Top2alpha-specific anticancer drugs for effective chemotherapy without the development of treatment-related secondary malignancies...

Research Grants17

  1. PHYSICOCHEMICAL STUDIES OF NUCLEIC ACIDS
    James Wang; Fiscal Year: 1980
    ..The preparation and characterization of double-stranded knotted DNA rings will be carried out, and the use of such substrates for studying the mechanisms of DNA topoisomerization will be explored...
  2. DNA TOPOISOMERASES--BIOLOGICAL FUNCTIONS & MECHANISMS
    James Wang; Fiscal Year: 2003
    ....