Affiliation: Harvard University
- Wang G, Wang S. Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule. J Physiol. 2003;548:667-75 pubmed..We propose that VTD likewise blocks the wild-type open Na+ channel, albeit partially, to decrease the unitary conductance and to stabilize the open conformation for persistent opening. ..
- Wang G, Russell C, Wang S. Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels. J Physiol. 2004;554:621-33 pubmed..Our results together support the hypothesis that the in vivo efficacy of mexiletine is primarily due to the open-channel block of persistent late Na(+) currents, which may arise during various pathological conditions...
- Wang G, Calderon J, Wang S. State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine. Mol Pharmacol. 2008;73:940-8 pubmed....