Matthew P Walker

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Practice with sleep makes perfect: sleep-dependent motor skill learning
    Matthew P Walker
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Neuron 35:205-11. 2002
  2. ncbi Sleep-dependent motor memory plasticity in the human brain
    M P Walker
    Sleep and Neuroimaging Laboratory, FD Feldberg 862, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuroscience 133:911-7. 2005
  3. ncbi It's practice, with sleep, that makes perfect: implications of sleep-dependent learning and plasticity for skill performance
    Matthew P Walker
    Sleep and Neuroimaging, Center for Sleep and Cognition, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Clin Sports Med 24:301-17, ix. 2005
  4. ncbi Sleep, memory, and plasticity
    Matthew P Walker
    Sleep and Neuroimaging, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Annu Rev Psychol 57:139-66. 2006
  5. ncbi Issues surrounding sleep-dependent memory consolidation and plasticity
    M P Walker
    Sleep and Neuroimaging Laboratory, Center for Sleep and Cognition, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 61:3009-15. 2004
  6. ncbi Sleep-dependent learning and memory consolidation
    Matthew P Walker
    Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center E FD 861, 330 Brookline Avenue, Boston, MA 02215, USA
    Neuron 44:121-33. 2004
  7. ncbi Dissociable stages of human memory consolidation and reconsolidation
    Matthew P Walker
    Laboratory of Neurophysiology, Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Nature 425:616-20. 2003
  8. pmc Sleep and the time course of motor skill learning
    Matthew P Walker
    Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
    Learn Mem 10:275-84. 2003
  9. ncbi Cognitive flexibility across the sleep-wake cycle: REM-sleep enhancement of anagram problem solving
    Matthew P Walker
    Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Brain Res Cogn Brain Res 14:317-24. 2002
  10. ncbi A refined model of sleep and the time course of memory formation
    Matthew P Walker
    Sleep and Neuroimaging Laboratory, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Behav Brain Sci 28:51-64; discussion 64-104. 2005

Detail Information

Publications35

  1. ncbi Practice with sleep makes perfect: sleep-dependent motor skill learning
    Matthew P Walker
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Neuron 35:205-11. 2002
    ..This finding of sleep-dependent motor skill improvement may have important implications for the efficient learning of all skilled actions in humans...
  2. ncbi Sleep-dependent motor memory plasticity in the human brain
    M P Walker
    Sleep and Neuroimaging Laboratory, FD Feldberg 862, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuroscience 133:911-7. 2005
    ..This evidence of an overnight, systems-level change in the representation of a motor memory holds important implications for acquiring real-life skills and in clinical rehabilitation following brain trauma, such as stroke...
  3. ncbi It's practice, with sleep, that makes perfect: implications of sleep-dependent learning and plasticity for skill performance
    Matthew P Walker
    Sleep and Neuroimaging, Center for Sleep and Cognition, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Clin Sports Med 24:301-17, ix. 2005
    ..In conclusion, a consideration of the fundamental importance of sleep in real-life skill learning is provided...
  4. ncbi Sleep, memory, and plasticity
    Matthew P Walker
    Sleep and Neuroimaging, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Annu Rev Psychol 57:139-66. 2006
    ....
  5. ncbi Issues surrounding sleep-dependent memory consolidation and plasticity
    M P Walker
    Sleep and Neuroimaging Laboratory, Center for Sleep and Cognition, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 61:3009-15. 2004
    ..Here we reflect on these findings, and explore how they maybe reconcilable in a unified approach to understanding the roles of wake, sleep and specific sleep stages in successful memory processing and brain plasticity...
  6. ncbi Sleep-dependent learning and memory consolidation
    Matthew P Walker
    Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center E FD 861, 330 Brookline Avenue, Boston, MA 02215, USA
    Neuron 44:121-33. 2004
    ..We close (4) with a consideration of unanswered questions as well as existing arguments against the role of sleep in learning and memory and (5) a concluding summary...
  7. ncbi Dissociable stages of human memory consolidation and reconsolidation
    Matthew P Walker
    Laboratory of Neurophysiology, Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Nature 425:616-20. 2003
    ....
  8. pmc Sleep and the time course of motor skill learning
    Matthew P Walker
    Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
    Learn Mem 10:275-84. 2003
    ..Finally, whereas the majority of sleep-dependent motor-skill learning develops during the first night of sleep following training, additional nights of sleep still offer continued improvements...
  9. ncbi Cognitive flexibility across the sleep-wake cycle: REM-sleep enhancement of anagram problem solving
    Matthew P Walker
    Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Brain Res Cogn Brain Res 14:317-24. 2002
    ....
  10. ncbi A refined model of sleep and the time course of memory formation
    Matthew P Walker
    Sleep and Neuroimaging Laboratory, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Behav Brain Sci 28:51-64; discussion 64-104. 2005
    ..These include the upregulation of select plasticity-associated genes, increased protein synthesis, changes in neurotransmitter concentration, and specific electrical events in neuronal networks that modulate synaptic potentiation...
  11. pmc The role of sleep in false memory formation
    Jessica D Payne
    Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurobiol Learn Mem 92:327-34. 2009
    ..While these effects produce memories that are less accurate after sleep, these memories may, in the end, be more useful...
  12. doi Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging
    Bryce A Mander
    Sleep and Neuroimaging Laboratory, University of California, Berkeley, California, USA
    Nat Neurosci 16:357-64. 2013
    ..Such findings suggest that sleep disruption in the elderly, mediated by structural brain changes, represents a contributing factor to age-related cognitive decline in later life...
  13. ncbi A deficit in the ability to form new human memories without sleep
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Neurosci 10:385-92. 2007
    ..It therefore appears that sleep before learning is critical in preparing the human brain for next-day memory formation-a worrying finding considering society's increasing erosion of sleep time...
  14. pmc REM sleep depotentiates amygdala activity to previous emotional experiences
    Els van der Helm
    Sleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, Berkeley, CA 94720 1650, USA
    Curr Biol 21:2029-32. 2011
    ....
  15. pmc Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences
    Ninad Gujar
    Sleep and Neuroimaging Laboratory, Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 1650, USA
    J Neurosci 31:4466-74. 2011
    ..Such findings may offer a neural foundation on which to consider interactions between sleep loss and emotional reactivity in a variety of clinical mood disorders...
  16. pmc Sleep-dependent memory consolidation and reconsolidation
    Robert Stickgold
    Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center E FD 861, 330 Brookline Ave, Boston, MA 02215, USA
    Sleep Med 8:331-43. 2007
    ..In this chapter, we review the role of sleep in supporting these disparate but related processes...
  17. ncbi Sleep and memory: the ongoing debate
    Robert Stickgold
    Department of Psychiatry, Harvard Medical School and Center for Sleep and Cognition, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Sleep 28:1225-7. 2005
    ..Despite this evidence, debate continues to rage over the very existence of sleep-dependent learning and memory processing. We briefly review here the evidence in support of sleep's role in memory consolidation...
  18. ncbi The functional anatomy of sleep-dependent visual skill learning
    Matthew P Walker
    Sleep and Neuroimaging Laboratory, Center for Sleep and Cognition, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Cereb Cortex 15:1666-75. 2005
    ..Together, these data provide evidence of overnight bi-directional changes in functional anatomy, differences that may form the neural basis of sleep-dependent learning expressed on this task...
  19. doi Sleep-dependent memory triage: evolving generalization through selective processing
    Robert Stickgold
    Center for Sleep and Cognition, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 16:139-45. 2013
    ....
  20. ncbi The influence of sleep on auditory learning: a behavioral study
    Nadine Gaab
    Department of Neurology, Music and Neuroimaging Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Neuroreport 15:731-4. 2004
    ..These data add to the growing literature describing sleep-dependent learning throughout sensory and motor domains...
  21. pmc Overnight therapy? The role of sleep in emotional brain processing
    Matthew P Walker
    Sleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, California 94720 1650, USA
    Psychol Bull 135:731-48. 2009
    ....
  22. pmc Sleep deprivation impairs the accurate recognition of human emotions
    Els van der Helm
    Sleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
    Sleep 33:335-42. 2010
    ..Investigate the impact of sleep deprivation on the ability to recognize the intensity of human facial emotions...
  23. doi The role of sleep in cognition and emotion
    Matthew P Walker
    Sleep and Neuroimaging Laboratory, Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 1650, USA
    Ann N Y Acad Sci 1156:168-97. 2009
    ..Finally, and building on this latter topic, a novel hypothesis and framework of sleep-dependent affective brain processing will be proposed, culminating in testable predictions and translational implications for mood disorders...
  24. ncbi Memory consolidation and reconsolidation: what is the role of sleep?
    Robert Stickgold
    Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center E FD 861, 330 Brookline Avenue, Boston MA 02215, USA
    Trends Neurosci 28:408-15. 2005
    ..As such, consolidation and reconsolidation might be better thought of as memory organization and reorganization. A rapidly growing body of evidence suggests that many of these processes are optimally engaged during sleep...
  25. ncbi Sleep facilitates consolidation of emotional declarative memory
    Peter Hu
    Sleep and Neuroimaging Laboratory, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Psychol Sci 17:891-8. 2006
    ..These findings hold important implications for understanding of human memory processing, suggesting that the facilitation of memory for emotionally salient information may preferentially develop during sleep...
  26. pmc Daytime naps, motor memory consolidation and regionally specific sleep spindles
    Masaki Nishida
    Sleep and Neuroimaging Laboratory, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e341. 2007
    ....
  27. pmc The role of sleep in directed forgetting and remembering of human memories
    Jared M Saletin
    Sleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
    Cereb Cortex 21:2534-41. 2011
    ..Instead, they suggest a model in which sleep may be more ecologically attuned to instructions present during learning while awake, supporting both remembering and targeted forgetting of human memories...
  28. pmc Sleep-dependent learning and motor-skill complexity
    Kenichi Kuriyama
    Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Learn Mem 11:705-13. 2004
    ..4% improvement. Together, these findings suggest that the sleep-dependent learning process selectively provides maximum benefit to motor-skill procedures that proved to be most difficult prior to sleep...
  29. doi Sleep, memory and emotion
    Matthew P Walker
    Sleep and Neuroimaging Laboratory, Department of Psychology, Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
    Prog Brain Res 185:49-68. 2010
    ..Finally, and building on this latter topic, a novel hypothesis and framework of sleep-dependent affective brain processing will be proposed, culminating in testable predictions and translational implications for mood disorders...
  30. pmc A role for REM sleep in recalibrating the sensitivity of the human brain to specific emotions
    Ninad Gujar
    Sleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
    Cereb Cortex 21:115-23. 2011
    ..These findings support the view that sleep, and specifically REM neurophysiology, may represent an important factor governing the optimal homeostasis of emotional brain regulation...
  31. pmc Human relational memory requires time and sleep
    Jeffrey M Ellenbogen
    Sleep and Neuroimaging Laboratory, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:7723-8. 2007
    ....
  32. doi Cognitive consequences of sleep and sleep loss
    Matthew P Walker
    Sleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
    Sleep Med 9:S29-34. 2008
    ..Taken together, these observations are of particular ecologic importance from a professional and education perspective when considering that sleep time continues to decrease across all age ranges throughout industrialized nations...
  33. pmc Linking brain and behavior in sleep-dependent learning and memory consolidation
    Robert Stickgold
    Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:16519-21. 2002
  34. pmc Nocturnal mnemonics: sleep and hippocampal memory processing
    Jared M Saletin
    Sleep and Neuroimaging Laboratory, Department of Psychology, University of California Berkeley, CA, USA
    Front Neurol 3:59. 2012
    ..Consequently, sleep promotes the targeted strengthening of some memories while actively forgetting others; a proposal with significant theoretical and clinical ramifications...
  35. ncbi The human emotional brain without sleep--a prefrontal amygdala disconnect
    Seung Schik Yoo
    Curr Biol 17:R877-8. 2007