Lawrence Wald

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The future of acquisition speed, coverage, sensitivity, and resolution
    Lawrence L Wald
    AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Dept of Radiology, Charlestown, MA O2129, USA
    Neuroimage 62:1221-9. 2012
  2. ncbi request reprint Dynamic magnetic resonance inverse imaging of human brain function
    Fa Hsuan Lin
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 56:787-802. 2006
  3. ncbi request reprint Sensitivity-encoded (SENSE) proton echo-planar spectroscopic imaging (PEPSI) in the human brain
    Fa Hsuan Lin
    MGH HMS MIT Athinoula A Martinos Center for Biomedical Imaging, Charlestown 02129, and Department of Radiology, Massachusetts General Hospital, Boston, USA
    Magn Reson Med 57:249-57. 2007
  4. ncbi request reprint Degenerate mode band-pass birdcage coil for accelerated parallel excitation
    Vijayanand Alagappan
    AA Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Magn Reson Med 57:1148-58. 2007
  5. pmc Phase maps reveal cortical architecture
    Bruce Fischl
    Athinoula A Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 104:11513-4. 2007
  6. ncbi request reprint 3.0 T plaque imaging
    Denise P Hinton-Yates
    Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Top Magn Reson Imaging 18:389-400. 2007
  7. pmc Event-related single-shot volumetric functional magnetic resonance inverse imaging of visual processing
    Fa Hsuan Lin
    MGH HST Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 42:230-47. 2008
  8. pmc Stimulus-induced Rotary Saturation (SIRS): a potential method for the detection of neuronal currents with MRI
    Thomas Witzel
    Speech and Hearing Bioscience and Technology Program, Harvard MIT Division of Health Sciences and Technology, USA
    Neuroimage 42:1357-65. 2008
  9. pmc Predicting the location of entorhinal cortex from MRI
    Bruce Fischl
    Athinoula A Martinos Center, Department of Radiology, MGH, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 47:8-17. 2009
  10. pmc Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI
    Koen Van Leemput
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Hippocampus 19:549-57. 2009

Research Grants

  1. APPARATUS FOR CEREBRAL BLOOD FLOW MEASUREMENTS AT 3T
    Lawrence Wald; Fiscal Year: 2001
  2. Parallel Excitation Methods for High Field MRI
    Lawrence Wald; Fiscal Year: 2007
  3. Parallel Excitation Methods for High Field MRI
    Lawrence L Wald; Fiscal Year: 2010

Detail Information

Publications38

  1. pmc The future of acquisition speed, coverage, sensitivity, and resolution
    Lawrence L Wald
    AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Dept of Radiology, Charlestown, MA O2129, USA
    Neuroimage 62:1221-9. 2012
    ....
  2. ncbi request reprint Dynamic magnetic resonance inverse imaging of human brain function
    Fa Hsuan Lin
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 56:787-802. 2006
    ..InI is expected to improve the time resolution of MRI and provide increased flexibility in the trade-off between spatial and temporal resolution for studies of dynamic activation patterns in the human brain...
  3. ncbi request reprint Sensitivity-encoded (SENSE) proton echo-planar spectroscopic imaging (PEPSI) in the human brain
    Fa Hsuan Lin
    MGH HMS MIT Athinoula A Martinos Center for Biomedical Imaging, Charlestown 02129, and Department of Radiology, Massachusetts General Hospital, Boston, USA
    Magn Reson Med 57:249-57. 2007
    ..Thus, this technology is a promising means of reducing the scan times of 3D acquisitions and time-resolved 2D measurements...
  4. ncbi request reprint Degenerate mode band-pass birdcage coil for accelerated parallel excitation
    Vijayanand Alagappan
    AA Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Magn Reson Med 57:1148-58. 2007
    ..The orthogonal basis set provided by the Butler matrix was found to be advantageous when an orthogonal subset of these modes was used to mitigate B(1) transmit inhomogeneities using parallel excitation...
  5. pmc Phase maps reveal cortical architecture
    Bruce Fischl
    Athinoula A Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 104:11513-4. 2007
  6. ncbi request reprint 3.0 T plaque imaging
    Denise P Hinton-Yates
    Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Top Magn Reson Imaging 18:389-400. 2007
    ..The overall endeavor is to improve prospective assessment of atherosclerosis stage and stability for reduction of atherothrombotic event risk...
  7. pmc Event-related single-shot volumetric functional magnetic resonance inverse imaging of visual processing
    Fa Hsuan Lin
    MGH HST Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 42:230-47. 2008
    ..Robust results from both single subject and group analyses demonstrate the sensitivity and feasibility of using volumetric InI in high temporal resolution investigations of human brain function...
  8. pmc Stimulus-induced Rotary Saturation (SIRS): a potential method for the detection of neuronal currents with MRI
    Thomas Witzel
    Speech and Hearing Bioscience and Technology Program, Harvard MIT Division of Health Sciences and Technology, USA
    Neuroimage 42:1357-65. 2008
    ..Magn. Reson. Med. 50, 40-49], but is potentially less encumbered by temporal and spatial cancellation effects...
  9. pmc Predicting the location of entorhinal cortex from MRI
    Bruce Fischl
    Athinoula A Martinos Center, Department of Radiology, MGH, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 47:8-17. 2009
    ....
  10. pmc Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI
    Koen Van Leemput
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Hippocampus 19:549-57. 2009
    ..Unlike manual segmentations, our automated technique is fully reproducible, and fast enough to enable routine analysis of the hippocampal subfields in large imaging studies...
  11. pmc 96-Channel receive-only head coil for 3 Tesla: design optimization and evaluation
    Graham C Wiggins
    Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Magn Reson Med 62:754-62. 2009
    ..The performance of the array is demonstrated in highly accelerated brain images...
  12. pmc Laminar analysis of 7T BOLD using an imposed spatial activation pattern in human V1
    Jonathan R Polimeni
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 52:1334-46. 2010
    ....
  13. ncbi request reprint Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
    Neurobiol Aging 28:1556-67. 2007
    ..To our knowledge this is the first investigation reporting such alterations in the aging monkey...
  14. ncbi request reprint Comparison of cardiac MRI on 1.5 and 3.0 Tesla clinical whole body systems
    Denise P Hinton
    Department of Radiology, Massachusetts General Hospital NMR Center, Charlestown, MA 02129, USA
    Invest Radiol 38:436-42. 2003
    ..The goals were to compare the signal-to-noise (SNR) and contrast-to-noise (CNR) ratios on matched studies conducted at both field strengths and demonstrate the potential for functional and morphologic cardiac evaluation at 3.0 T...
  15. ncbi request reprint Bright and black blood imaging of the carotid bifurcation at 3.0T
    Denise P Hinton
    MGH MIT HMS, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Eur J Radiol 57:403-11. 2006
    ..0 T with imaging of the carotid bifurcation in healthy and atherosclerotic subjects. Application at 3.0 T is motivated by the signal-to-noise gain for improving spatial resolution and reducing signal averaging requirements...
  16. ncbi request reprint Stereopsis activates V3A and caudal intraparietal areas in macaques and humans
    Doris Y Tsao
    Massachusetts General Hospital, NMR Center, Athinoula A Martinos Center, Charlestown, Massachusetts 02129, USA
    Neuron 39:555-68. 2003
    ..Thus, in both primate species a small cluster of areas at the parieto-occipital junction appears to be specialized for stereopsis...
  17. ncbi request reprint Detection of entorhinal layer II using 7Tesla [corrected] magnetic resonance imaging
    Jean C Augustinack
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA
    Ann Neurol 57:489-94. 2005
    ..Our ex vivo results could break ground for high-resolution in vivo scanning that could ultimately benefit early diagnosis and treatment of neurodegenerative disease...
  18. pmc Functional MRI using regularized parallel imaging acquisition
    Fa Hsuan Lin
    Massachusetts General Hospital, Department of Radiology, MGH HMS MIT, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 54:343-53. 2005
    ..Human motor and visual fMRI data acquired at different field strengths and array coils also demonstrate that regularized SENSE improves the detection of functionally active brain regions...
  19. ncbi request reprint Accelerated volumetric MRI with a SENSE/GRAPPA combination
    Martin Blaimer
    Department of Experimental Physics 5, University of Wurzburg, Wurzburg, Germany
    J Magn Reson Imaging 24:444-50. 2006
    ..To combine the specific advantages of the generalized autocalibrating partially parallel acquisitions (GRAPPA) technique and sensitivity encoding (SENSE) with two-dimensional (2D) undersampling...
  20. pmc A 128-channel receive-only cardiac coil for highly accelerated cardiac MRI at 3 Tesla
    Melanie Schmitt
    Department of Radiology, A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 59:1431-9. 2008
    ..The ability of the 128-channel coil to facilitate highly accelerated cardiac imaging was demonstrated in four volunteers using acceleration factors up to seven-fold (R=7) in a single spatial dimension...
  21. pmc Fast slice-selective radio-frequency excitation pulses for mitigating B+1 inhomogeneity in the human brain at 7 Tesla
    Adam C Zelinski
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Magn Reson Med 59:1355-64. 2008
    ....
  22. ncbi request reprint In vivo tracing of major rat brain pathways using manganese-enhanced magnetic resonance imaging and three-dimensional digital atlasing
    Trygve B Leergaard
    Neural Systems and Graphics Computing Laboratory, Centre for Molecular Biology and Neuroscience and Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, N 0317 Oslo, Norway
    Neuroimage 20:1591-600. 2003
    ..The method allows a higher data throughput for 3-D studies of large-scale brain connectivity than conventional methods based on tissue sectioning...
  23. pmc Sparsity-enforced slice-selective MRI RF excitation pulse design
    Adam C Zelinski
    Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Med Imaging 27:1213-29. 2008
    ..28 times lower root mean square error than conventionally-designed 15-spoke pulses. To achieve this same level of uniformity, the conventional methods need to use 29-spoke pulses that are 7.8 ms long...
  24. ncbi request reprint A wavelet-based approximation of surface coil sensitivity profiles for correction of image intensity inhomogeneity and parallel imaging reconstruction
    Fa Hsuan Lin
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, Massachusetts, USA
    Hum Brain Mapp 19:96-111. 2003
    ..The results, using bi-orthogonal Daubechies 97 wavelets and other members in this family, are evaluated for T1-weighted and T2-weighted brain imaging...
  25. ncbi request reprint Modulation of brain and serum glutamatergic concentrations following a switch from conventional neuroleptics to olanzapine
    Donald C Goff
    Schizophrenia Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 51:493-7. 2002
    ..Recent evidence suggests that effects upon glutamatergic transmission may contribute to the therapeutic action of certain atypical antipsychotic agents...
  26. doi request reprint Accelerated proton echo planar spectroscopic imaging (PEPSI) using GRAPPA with a 32-channel phased-array coil
    Shang Yueh Tsai
    Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
    Magn Reson Med 59:989-98. 2008
    ..At 4-fold acceleration the mean CRLB for NAA, tCr, and Cho was less than 11%. In conclusion, the use of a 32-channel coil array and GRAPPA reconstruction can significantly reduce the measurement time for mapping brain metabolites...
  27. ncbi request reprint Brain proton magnetic resonance spectroscopy in Alzheimer disease: changes after treatment with xanomeline
    Blaise deB Frederick
    MacLean Hospital Brain Imaging Center, Belmont, MA 02478, USA
    Am J Geriatr Psychiatry 10:81-8. 2002
    ..Specifically, increased levels of cytosolic choline, a precursor pool for acetylcholine synthesis, were associated with greater progression in memory impairment during treatment...
  28. pmc Accurate prediction of V1 location from cortical folds in a surface coordinate system
    Oliver P Hinds
    Department of Cognitive and Neural Systems, Boston University, MA 02215, USA
    Neuroimage 39:1585-99. 2008
    ....
  29. ncbi request reprint Parallel imaging reconstruction using automatic regularization
    Fa Hsuan Lin
    Division of Health Sciences and Technology, Harvard Medical School MIT, Cambridge, Massachusetts, USA
    Magn Reson Med 51:559-67. 2004
    ..47 to 0.80 in twofold sensitivity encoding (SENSE) acceleration. In vivo anatomical images from an eight-channel system show an averaged g-factor reduction of 1.22 to 0.84 in 2.67-fold acceleration...
  30. ncbi request reprint Effect of spatial smoothing on physiological noise in high-resolution fMRI
    Christina Triantafyllou
    MGH MIT HMS A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Dept of Radiology, Mailcode 2301, Bldg 149, 13th Street, Charlestown, MA 02129, USA
    Neuroimage 32:551-7. 2006
    ....
  31. ncbi request reprint Direct parallel image reconstructions for spiral trajectories using GRAPPA
    Robin M Heidemann
    Universitat Wurzburg, Physikalisches Institut, EP5, Wurzburg, Germany
    Magn Reson Med 56:317-26. 2006
    ..The respective spiral images with two- to eightfold acceleration clearly benefit from the advantages of parallel imaging, such as enabling parallel MRI single-shot spiral imaging with the off-resonance behavior of multishot acquisitions...
  32. ncbi request reprint Parallel RF transmission with eight channels at 3 Tesla
    Kawin Setsompop
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Magn Reson Med 56:1163-71. 2006
    ..Parallel RF transmission may become critical for robust and routine human studies at very high field strengths where B(1) inhomogeneity is commonly severe...
  33. ncbi request reprint Hippocampal volume, PTSD, and alcoholism in combat veterans
    Steven H Woodward
    National Center for PTSD, Clinical Laboratory and Education Division, Mail Code 334 PTSD, VA Palo Alto HCS, 3801 Miranda Ave, Palo Alto, CA 94304, USA
    Am J Psychiatry 163:674-81. 2006
    ..Further examination of the role of alcoholism and other comorbid conditions in studies of brain structure and function in PTSD appears warranted...
  34. ncbi request reprint Aids to telemetry in the presurgical evaluation of epilepsy patients: MRI, MEG and other non-invasive imaging techniques
    Susanne Knake
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Suppl Clin Neurophysiol 57:494-502. 2004
  35. ncbi request reprint Degenerate mode birdcage volume coil for sensitivity-encoded imaging
    Fa Hsuan Lin
    Havard MIT Division of Health Sciences and Technology, Boston, Massachusetts 02129, USA
    Magn Reson Med 50:1107-11. 2003
    ..5 T. The maximal 2-fold acceleration in this dual-mode degenerate birdcage coil offers the potential to extend SENSE-type image reconstruction methods to applications demanding uniform whole brain coverage...
  36. pmc Visual word processing and experiential origins of functional selectivity in human extrastriate cortex
    Chris I Baker
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 4C104, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:9087-92. 2007
    ..These results indicate that extensive experience with a given visual category can produce strong selectivity for that category in discrete cortical regions...
  37. pmc Dissociation of neural regions associated with anticipatory versus consummatory phases of incentive processing
    Daniel G Dillon
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Psychophysiology 45:36-49. 2008
    ..Although the study features several methodological improvements and helps clarify the neural basis of incentive processing, replications in larger samples are needed...
  38. doi request reprint Physiological noise in MR images: an indicator of the tissue response to ischemia?
    Harris H Wang
    Medical Engineering Medical Physics Program, Division of Health Sciences and Technology, Harvard University Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Magn Reson Imaging 27:866-71. 2008
    ..To determine whether measuring signal intensity (SI) fluctuations in MRI time series data from acute stroke patients would identify ischemic tissue...

Research Grants7

  1. APPARATUS FOR CEREBRAL BLOOD FLOW MEASUREMENTS AT 3T
    Lawrence Wald; Fiscal Year: 2001
    ..This novel information could be valuable for guiding and following response to treatment of carotid artery stenosis. ..
  2. Parallel Excitation Methods for High Field MRI
    Lawrence Wald; Fiscal Year: 2007
    ....
  3. Parallel Excitation Methods for High Field MRI
    Lawrence L Wald; Fiscal Year: 2010
    ....