Research Topics
| Brian P WalcottSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Infection following operations on the central nervous system: deconstructing the myth of the sterile fieldBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurg Focus 33:E8. 2012..The authors propose a paradigm shift in the nomenclature of the surgical field from "sterile" to "clean." Continued efforts aimed at optimizing immune capacity and host defenses to combat potential infection are warranted...- Chordoma: current concepts, management, and future directionsBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Lancet Oncol 13:e69-76. 2012..In this Review, we highlight current standards in diagnosis, clinical management, and molecular characterisation of chordomas, and discuss current research... 
Conflict of interest in spine research reportingBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
PLoS ONE 7:e44327. 2012..Medical studies are more likely to report favorable findings when a conflict of interest is declared. We aim to quantify and determine the effect of author disclosure of conflict of interest on scientific reporting...- Bilateral hemicraniectomy in non-penetrating traumatic brain injuryBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Neurotrauma 29:1879-85. 2012..The average ICU length of stay was 12 days. The GOS score was 3 in surviving patients. Bilateral hemicraniectomy is a heroic intervention for patients with severe TBI, but can be a life-saving procedure... - Pathological mechanism of lumbar disc herniation resulting in neurogenic muscle hypertrophyBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, White Building Room 502, Boston, MA 02114, USA
J Clin Neurosci 18:1682-4. 2011..To our knowledge this is the first report of both grouped atrophy and compensatory hypertrophy of both muscle fiber types seen in this phenomenon... - The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injuryBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
Eur Spine J 21:S492-4. 2012..Differentiating arterial from brisk venous bleeding would be ideal to assist in the intra-operative management. Definitive angiography is typically not feasible during most routine spine surgery... - Steroid responsive A3243G mutation MELAS: clinical and radiographic evidence for regional hyperperfusion leading to neuronal lossBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neurologist 18:159-70. 2012.... - Postlaminectomy synovial cyst formation: a possible consequence of ligamentum flavum excisionBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA 02114, USA
J Clin Neurosci 19:252-4. 2012..Secondary synovial cyst formation should be suspected in individuals who develop radiculopathy after laminectomy for stenosis... - Deep brain stimulation for medically refractory life-threatening status dystonicus in childrenBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
J Neurosurg Pediatr 9:99-102. 2012..Bilateral globus pallidus internus stimulation appears to be effective in the urgent treatment of medically refractory and life-threatening movement disorders... - Craniectomy for malignant cerebral infarction: prevalence and outcomes in US hospitalsBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e29193. 2011..Randomized trials have demonstrated the efficacy of craniectomy for the treatment of malignant cerebral edema following ischemic stroke. We sought to determine the prevalence and outcomes related to this by using a national database... - Microsurgical retrieval of an endovascular microcatheter trapped during Onyx embolization of a cerebral arteriovenous malformationBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Neurointerv Surg 3:77-9. 2011..We report on a patient for whom surgery was combined with endovascular embolization to obliterate an AVM and retrieve an entrapped endovascular microcatheter... - Determination of geographic variance in stroke prevalence using Internet search engine analyticsBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurg Focus 30:E19. 2011..The authors hypothesized that the use of search engine query data can determine the prevalence of stroke... - Surgical treatment and outcomes of metastatic breast cancer to the spineBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital, 55 Fruit St, White Building Room 502, Boston, MA 02114, USA
J Clin Neurosci 18:1336-9. 2011..We concluded that aggressive therapy, including surgery, is warranted for patients with symptomatic metastatic epidural spinal cord compression from breast cancer, including in the setting of advanced and progressive systemic disease... - Early experience with flow diverting endoluminal stents for the treatment of intracranial aneurysmsBrian P Walcott
Department of Neurological Surgery, Massachusetts General Hospital and Harvard Medical School, White Building, Room 502, 55 Fruit Street, Boston, MA 02114, USA
J Clin Neurosci 18:891-4. 2011..Long-term efficacy, optimal antithrombotic agent regimen, and perforator stroke risk are yet to be determined... - Diagnostic pitfalls in spine surgery: masqueraders of surgical spine diseaseBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurg Focus 31:E1. 2011..Awareness of these diagnoses can help reduce diagnostic error, thereby avoiding the morbidity and expense associated with an unnecessary operation... - Interfacility helicopter ambulance transport of neurosurgical patients: observations, utilization, and outcomes from a quaternary level care hospitalBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e26216. 2011..We sought to determine actual practice patterns, utilization, and outcomes of patients undergoing interfacility transport for neurosurgical conditions... - Determinants of initial bone graft volume loss in posterolateral lumbar fusionManish K Aghi
Department of Neurosurgery, University of California, San Francisco, CA, USA
J Clin Neurosci 18:1193-6. 2011..We concluded that bone graft exhibited resorption 3 months postoperatively on both sides of all patients in this series, and that smoking was significantly associated with increased bone graft resorption... - Incidence of cerebrospinal fluid leak following petrosectomy and analysis of avoidance techniquesBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Neurosci 19:92-4. 2012..CSF diversion and vascularized temporalis muscle flaps are effective in preventing the development of postoperative CSF leaks following petrosectomy... - Cerebral revascularization for the treatment of complex intracranial aneurysms of the posterior circulation: microsurgical anatomy, techniques and outcomesJared M Pisapia
Department of Neurological Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Neurointerv Surg 3:249-54. 2011..This review discusses the microsurgical anatomy of the posterior fossa intracranial circulation, as well as the techniques and outcomes related to cerebrovascular bypass... - En bloc excision of a dermal sinus tractJean Valery Coumans
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, WACC 745, 15 Parkman Street, Boston, MA 02114, USA
J Clin Neurosci 18:554-8. 2011..We conclude that en bloc excision of a dermal sinus tract down to the intradural space is feasible with modifications to standard operative technique... - Glioblastoma multiforme and cerebral cavernous malformations: intersection of pathophysiologic pathwaysMatthew K Mian
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Neurosci 19:884-6. 2012..We review the literature on the genetics of cavernous malformations and propose a mechanism for the tumorigenic potential of these vascular malformations... - Trapped fourth ventricle phenomenon following aneurysm rupture of the posterior circulation: case reportsManuel Ferreira
Department of Neurosurgery, University of Washington Medical School, Seattle, Washington, USA
Neurosurgery 70:E253-8; discussion E258. 2012..We describe the first adult case series of individuals who developed delayed isolated fourth ventricles after rupture of intracranial posterior circulation aneurysms and define treatment modality... - Intraspinal migration of a clavicular Steinmann pin: case report and management strategyMatthew K Mian
Department of Neurosurgery, Massachusetts General Hospital, 55 Fruit Street, White Building 502, Boston, Massachusetts 02114, USA
J Clin Neurosci 19:310-3. 2012..We conclude that a principle of safe surgical removal includes adequate exposure to allow for direct visualization of the pin and neural structures. We review the evaluation and management strategies of this unusual condition... - Cerebrovascular bypass and aneurysm trapping for the treatment of an A2-segment anterior cerebral artery pseudoaneurysm and herniation through a skull base defect following traumaBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA 0211H, USA
J Clin Neurosci 19:149-51. 2012..We present a unique case of a traumatic proximal anterior cerebral artery pseudoaneurysm, herniating through a skull base defect. Treatment consisted of aneurysm trapping and bypass with skull base reconstruction... - Trends in inpatient setting laminectomy for excision of herniated intervertebral disc: Population-based estimates from the US nationwide inpatient sampleBrian P Walcott
Department of Neurological Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Surg Neurol Int 2:7. 2011..Treatment for this condition is categorized as surgical or non-surgical. We sought to identify trends in inpatient surgical management of herniated intervertebral discs using a national database... - Dual ipsilateral craniotomies through a single incision for the surgical management of multiple intracranial aneurysmsGavin P Dunn
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
World Neurosurg 77:502-6. 2012..To examine whether multiple aneurysms located in the anterior cerebral artery (ACA), middle cerebral artery (MCA), or internal carotid artery (ICA) could be treated through single-stage, ipsilateral dual craniotomies... - Familial Chiari malformation: case seriesBenjamin D Schanker
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA
Neurosurg Focus 31:E1. 2011..Recent advances in the understanding of the genetic influences and pathogenesis of familial Chiari malformation are expected to improve management of affected patients and monitoring of at-risk family members... - Time-resolved contrast-enhanced magnetic resonance angiography in the investigation of suspected intracranial dural arteriovenous fistulaBenjamin D Schanker
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts 02114, USA
J Clin Neurosci 18:837-9. 2011..There was no evidence of arteriovenous shunting. Retrograde venous flow explained the signal abnormality seen on time-of-flight MRA. We concluded that time-resolved MRA is useful in the investigation of suspected intracranial dAVF... - Lateral sacral artery aneurysm of the lumbar spine: hemorrhage resulting in cauda equina syndromeRaul G Nogueira
Division of Interventional Neuroradiology and Endovascular Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA
J Neurointerv Surg 2:399-401. 2010..To describe the effective treatment of a ruptured lateral sacral artery aneurysm presenting as a spinal epidural hematoma... - Dural scalp and intracranial hemangiomas causing hydrocephalus and venous sinus thrombosis in an infantBrian V Nahed
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Child Neurol 26:777-81. 2011..Innocuous scalp hemangioma in an infant may herald more concerning intracranial pathology, which can be treated effectively if diagnosed with appropriate imaging studies... - Socioeconomic status correlates with the prevalence of advanced coronary artery disease in the United StatesBronislava Bashinskaya
Massachusetts General Hospital and Department of Medicine Cardiology Division, Harvard Medical School, Boston, Massachusetts, USA
PLoS ONE 7:e46314. 2012..We seek to identify whether socioeconomic factors contribute to advanced coronary artery disease prevalence in the United States... - Predictors of cranioplasty complications in stroke and trauma patientsBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
J Neurosurg 118:757-62. 2013..Cranioplasty infection rates are predicted by reoperation following craniectomy and therapeutic indication (stroke). These variables may be associated with patient-centered risk factors that increase cranioplasty infection risk... - Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activityChristopher J Stapleton
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Neurosci 18:857-60. 2011..We review issues relevant to the pathology and treatment of these lesions... - Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitisBrian V Nahed
Department of Neurosurgery, Massachusetts General Hospital, 15 Parkman Street, Boston, Massachusetts 02114 3117, USA
J Clin Neurosci 17:1085-8. 2010..This example highlights one of the potential complications of rigid cervical collar immobilization in patients with spinal instability... - Vertebral artery pexy for microvascular decompression of the facial nerve in the treatment of hemifacial spasmManuel Ferreira
Department of Neurosurgery, University of Washington, Seattle, Washington 98104 2499, USA
J Neurosurg 114:1800-4. 2011..The authors report the use of a new technique of VA pexy to the petrous or clival dura mater in patients with HFS attributed to a severely ectatic and tortuous VA, and detail the results in a series of patients... - Novel treatment targets for cerebral edemaBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Neurotherapeutics 9:65-72. 2012..A specific antagonist of the vasopressin V1A- and V2-receptor, conivaptan, promotes water excretion while sparing electrolytes through a process known as aquaresis... - Hyponatremia associated with Ipilimumab-induced hypophysitisZachary R Barnard
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA 02114, USA
Med Oncol 29:374-7. 2012..Effective treatment consisted of fluid restriction, hyperosmolar therapy, and steroids... - Volumetric analysis of syringomyelia following hindbrain decompression for Chiari malformation Type I: syringomyelia resolution follows exponential kineticsJean Valery Coumans
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurg Focus 31:E4. 2011..Resolution of syringomyelia is common following hindbrain decompression for Chiari malformation, yet little is known about the kinetics governing this process. The authors sought to establish the volumetric rate of syringomyelia resolution... - The quality of randomized controlled trial reporting in spine literatureMatthew R Naunheim
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02214, USA
Spine (Phila Pa 1976) 36:1326-30. 2011..Retrospective literature review... - Diffuse central neurocytoma with craniospinal disseminationChristopher J Stapleton
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA, USA
J Clin Neurosci 19:163-6. 2012..At 18 months followup, the patient has completed 6 of 8 total cycles of vincristine and carboplatin and serial imaging shows stable disease within the craniospinal axis... - Arterial tortuosity syndrome with multiple intracranial aneurysms: a case reportMatthew R Naunheim
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
Arch Neurol 68:369-71. 2011..To report a new manifestation of the rare connective tissue disorder arterial tortuosity syndrome in the absence of skin and soft-tissue abnormalities and with bilateral, giant fusiform intracranial aneurysms... - Pial arteriovenous fistulae in pediatric patients: associated syndromes and treatment outcomeBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
J Neurointerv Surg 5:10-4. 2013..The presentation, treatment and syndromes associated with pAVF in children are reported here... - Delayed post-traumatic bilateral abducens nerve palsy with complete recoveryVijay Yanamadala
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02115, United States
J Clin Neurosci 19:585-6. 2012..Full recovery is the natural history in the majority of traumatic abducens nerve palsies, and this is an important consideration when counseling patients with such injuries... - Incidental vertebral lesionsJean Valery C E Coumans
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurg Focus 31:E17. 2011..In this article we review incidental findings within the vertebral column and review management of these lesions, based on available Class III data... - Cerebrospinal fluid fistula prevention and treatment following frontal sinus fractures: a review of initial management and outcomesBrandyn Castro
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurg Focus 32:E1. 2012.... - Operative management of brainstem cavernous malformationsWael F Asaad
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Neurosurg Focus 29:E10. 2010..The resection of brainstem CMs in properly selected patients has been demonstrated to reduce the risk of rehemorrhage and can be achieved relatively safely in experienced hands... - Trends in Peptic Ulcer Disease and the Identification of Helicobacter Pylori as a Causative Organism: Population-based Estimates from the US Nationwide Inpatient SampleBronislava Bashinskaya
Department of Biology, Boston University, Boston, USA
J Glob Infect Dis 3:366-70. 2011..We sought to determine trends related to this discovery by using a national database... - Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infectionKristopher T Kahle
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, White Building, Room 502, 55 Fruit Street, Boston, Massachusetts 02114, USA
J Clin Neurosci 18:1245-8. 2011.... - Fourth ventricular neurocystercercosis presenting with acute hydrocephalusBrian W Hanak
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Neurosci 18:867-9. 2011..Resection may also avoid the need for permanent CSF diversion. We also reviewed the evidence-based management strategies described in the literature... - Factors affecting successful localization of the central sulcus using the somatosensory evoked potential phase reversal techniqueSameer A Sheth
Departments of Neurosurgery and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
Neurosurgery 72:828-34. 2013..Awareness of factors that lengthen the time required for MSSEP PRT has important implications for surgical planning... - Neurological surgery: the influence of physical and mental demands on humans performing complex operationsSarah K Bourne
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA 02114, USA
J Clin Neurosci 20:342-8. 2013..In this review, we explore the delicate balance of training and performance, as well as some routinely used adjuncts to improve human performance... - Retrograde third ventriculocisternostomy from the posterior fossaVijay Yanamadala
Neurosurgical Service, Massachusetts General Hospital, Department of Surgery Neurosurgery, Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurgery 72:9-13; discussion 13-4. 2013..Prophylactic ventriculocisternostomy has been described with success in this patient population to prevent postoperative hydrocephalus... - Continuous hyperosmolar therapy for traumatic brain injury-associated cerebral edema: as good as it gets, or an iatrogenic secondary insult?Kristopher T Kahle
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Neurosci 20:30-1. 2013..This practice is highly controversial, is in widespread use, and lacks robust evidence for efficacy. Herein, we review details of the controversy regarding this practice... - Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransportKristopher T Kahle
Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
J Child Neurol 26:205-8. 2011.... - Rapidly progressive lumbar subdural empyema following acromial bursal injectionJean Valery C E Coumans
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Neurosci 18:1562-3. 2011..Two lumbar MRI conducted 62 hours apart revealed a newly developed subdural empyema that was successfully treated with surgical evacuation and post-operative antibiotics... - Managing malignant cerebral infarctionJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite S12D, Baltimore, MD, 21201 1595, USA
Curr Treat Options Neurol 13:217-29. 2011..Under appropriate circumstances, decompressive craniectomy may be warranted to improve outcome or to prevent death... - Diagnosis of acute lymphoblastic leukemia from intracerebral hemorrhage and blast crisis. A case report and review of the literatureMatthew R Naunheim
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Clin Neurol Neurosurg 112:575-7. 2010..This case demonstrates that the presence of hyperleukocytosis in a patient with intracerebral hemorrhage should raise clinical suspicion for acute leukemia as the cause of the ICH... - Dural arteriovenous fistulae in pediatric patients: associated conditions and treatment outcomesBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
J Neurointerv Surg 5:6-9. 2013..Dural arteriovenous fistulae (dAVF) are rare vascular lesions of the CNS with potentially significant morbidity and mortality. Our experience in the treatment of children with dAVF is reported...