Amy J Wagers

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Shifting foci of hematopoiesis during reconstitution from single stem cells
    Yu An Cao
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:221-6. 2004
  2. ncbi request reprint Stem cell grand SLAM
    Amy J Wagers
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Cell 121:967-70. 2005
  3. pmc Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors
    Yu An Cao
    Departments of Pediatrics, Stanford University School of Medicine, CA, USA
    Blood 112:4494-502. 2008
  4. pmc Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles
    Massimiliano Cerletti
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA
    Cell 134:37-47. 2008
  5. pmc Hematopoietic cells maintain hematopoietic fates upon entering the brain
    Mei Massengale
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 201:1579-89. 2005
  6. pmc Efficient generation of iPS cells from skeletal muscle stem cells
    Kah Yong Tan
    Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts, United Stated of America
    PLoS ONE 6:e26406. 2011
  7. doi request reprint The stem cell niche in regenerative medicine
    Amy J Wagers
    Howard Hughes Medical Institute, Cambridge, MA, USA
    Cell Stem Cell 10:362-9. 2012
  8. doi request reprint Wnt not, waste not
    Amy J Wagers
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center and the Harvard Stem Cell Institute, Boston, MA 02215, USA
    Cell Stem Cell 2:6-7. 2008
  9. ncbi request reprint Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis
    Amy J Wagers
    Joslin Diabetes Center and Department of Pathology Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 122:659-67. 2005
  10. ncbi request reprint Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, California, USA
    Stem Cells 24:1087-94. 2006

Detail Information

Publications63

  1. pmc Shifting foci of hematopoiesis during reconstitution from single stem cells
    Yu An Cao
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:221-6. 2004
    ....
  2. ncbi request reprint Stem cell grand SLAM
    Amy J Wagers
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Cell 121:967-70. 2005
    ....
  3. pmc Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors
    Yu An Cao
    Departments of Pediatrics, Stanford University School of Medicine, CA, USA
    Blood 112:4494-502. 2008
    ..Control of stem cell stress response by HO-1 presents opportunities for metabolic manipulation of stem cell-based therapies...
  4. pmc Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles
    Massimiliano Cerletti
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA
    Cell 134:37-47. 2008
    ..Together, these studies indicate the presence in adult skeletal muscle of prospectively isolatable muscle-forming stem cells and directly demonstrate the efficacy of myogenic stem cell transplant for treating muscle degenerative disease...
  5. pmc Hematopoietic cells maintain hematopoietic fates upon entering the brain
    Mei Massengale
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 201:1579-89. 2005
    ..These data strongly suggest that HSCs and their progeny maintain lineage fidelity in the brain and do not adopt neural cell fates with any measurable frequency...
  6. pmc Efficient generation of iPS cells from skeletal muscle stem cells
    Kah Yong Tan
    Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts, United Stated of America
    PLoS ONE 6:e26406. 2011
    ....
  7. doi request reprint The stem cell niche in regenerative medicine
    Amy J Wagers
    Howard Hughes Medical Institute, Cambridge, MA, USA
    Cell Stem Cell 10:362-9. 2012
    ..This Perspective will discuss how the niche influences stem cells in homeostasis, in the progression of degenerative and malignant diseases, and in therapeutic strategies for tissue repair...
  8. doi request reprint Wnt not, waste not
    Amy J Wagers
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center and the Harvard Stem Cell Institute, Boston, MA 02215, USA
    Cell Stem Cell 2:6-7. 2008
    ..In this issue of Cell Stem Cell, Brack et al. (2008) report that direct molecular crosstalk between stem cell self-renewal and differentiation pathways determines the timing and efficiency of muscle repair...
  9. ncbi request reprint Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis
    Amy J Wagers
    Joslin Diabetes Center and Department of Pathology Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 122:659-67. 2005
    ....
  10. ncbi request reprint Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, California, USA
    Stem Cells 24:1087-94. 2006
    ....
  11. ncbi request reprint Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells
    Richard I Sherwood
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    Stem Cells 22:1292-304. 2004
    ..It is not yet clear whether such events represent a normal myogenic pathway or a pathological response to muscle damage...
  12. ncbi request reprint Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle
    Richard I Sherwood
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 119:543-54. 2004
    ..Together, these studies describe the clonal isolation of functional adult myogenic progenitors and demonstrate that these cells do not arise from hematopoietic or other bone marrow or circulating precursors...
  13. doi request reprint The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells
    Irene M Min
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Boston, MA 02115, USA
    Cell Stem Cell 2:380-91. 2008
    ..The ability of this single factor to regulate both proliferation and mobilization of HSCs suggests that EGR1 commands a genetic program that coordinates stem cell division and migration to maintain appropriate HSC number and function...
  14. pmc Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    Emmanuelle Passegue
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 202:1599-611. 2005
    ....
  15. pmc Use of the parabiotic model in studies of cutaneous wound healing to define the participation of circulating cells
    Guodong Song
    Division of Plastic Surgery, Brigham and Women s Hospital, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Wound Repair Regen 18:426-32. 2010
    ..Application of this approach enables further investigation into the contribution of peripheral blood in normal and abnormal healing responses...
  16. ncbi request reprint Little evidence for developmental plasticity of adult hematopoietic stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 297:2256-9. 2002
    ..These data indicate that "transdifferentiation" of circulating HSCs and/or their progeny is an extremely rare event, if it occurs at all...
  17. pmc Cell intrinsic alterations underlie hematopoietic stem cell aging
    Derrick J Rossi
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:9194-9. 2005
    ....
  18. ncbi request reprint Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 433:760-4. 2005
    ..These results suggest that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age...
  19. pmc Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
    Lior Zangi
    1 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA 2 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA 4 Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, Massachusetts, USA 5 Boston and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA 6
    Nat Biotechnol 31:898-907. 2013
    ..Our results suggest that modRNA is a versatile approach for expressing paracrine factors as cell fate switches to control progenitor cell fate and thereby enhance long-term organ repair. ..
  20. ncbi request reprint Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
    Manisha Sinha
    Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA
    Science 344:649-52. 2014
    ..These data indicate that GDF11 systemically regulates muscle aging and may be therapeutically useful for reversing age-related skeletal muscle and stem cell dysfunction. ..
  21. ncbi request reprint Systemic signals regulate ageing and rejuvenation of blood stem cell niches
    Shane R Mayack
    Department of Stem Cell and Regenerative Biology, Harvard University, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02115, USA
    Nature 463:495-500. 2010
    ....
  22. ncbi request reprint Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
    ..1(lo) Lin- Sca-1+ long-term reconstituting haematopoietic stem cells adopt only traditional haematopoietic fates...
  23. pmc Circulation and chemotaxis of fetal hematopoietic stem cells
    Julie L Christensen
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 2:E75. 2004
    ..This finding indicates the importance of the combined effects of SLF and SDF-1alpha in the migration of fetal HSCs, and is, to our knowledge, the first demonstration of a synergistic effect of two chemoattractive agents on HSCs...
  24. pmc Induction of histiocytic sarcoma in mouse skeletal muscle
    Jianing Liu
    Howard Hughes Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, and Joslin Diabetes Center, Cambridge, Massachusetts, USA
    PLoS ONE 7:e44044. 2012
    ..This study establishes a novel, transplantable model of murine histiocytic/myeloid sarcoma that recapitulates the natural progression of these malignancies to systemic disease and indicates a cell autonomous leukemogenic mechanism...
  25. pmc Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
    Jose M Polo
    Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, Massachusetts, USA
    Nat Biotechnol 28:848-55. 2010
    ..These observations may influence ongoing attempts to use iPSCs for disease modeling and could also be exploited in potential therapeutic applications to enhance differentiation into desired cell lineages...
  26. ncbi request reprint Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Exp Hematol 30:176-85. 2002
    ....
  27. pmc Osteolineage niche cells initiate hematopoietic stem cell mobilization
    Shane R Mayack
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Department of Stem Cell and Regenerative Biology, Harvard University, and Harvard Stem Cell Institute, Boston, MA 02215, USA
    Blood 112:519-31. 2008
    ..This work also establishes that direct interaction with osteolineage niche cells, in the absence of additional environmental inputs, is sufficient to modulate stem cell activity...
  28. ncbi request reprint Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors
    Lida Katsimpardi
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Science 344:630-4. 2014
    ..The identification of factors that slow the age-dependent deterioration of the neurogenic niche in mice may constitute the basis for new methods of treating age-related neurodegenerative and neurovascular diseases. ..
  29. pmc A special population of regulatory T cells potentiates muscle repair
    Dalia Burzyn
    Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell 155:1282-95. 2013
    ..Thus, Treg cells and their products may provide new therapeutic opportunities for wound repair and muscular dystrophies...
  30. pmc Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia
    Florence C Guibal
    Center for Life Sciences, Harvard Medical School, Boston, MA, USA
    Blood 114:5415-25. 2009
    ..Our findings provide further understanding of the biology of APL by demonstrating that a committed transformed progenitor can initiate and propagate the disease...
  31. pmc Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells
    David T Breault
    Divisions of Endocrinology and Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:10420-5. 2008
    ....
  32. pmc Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells
    Simone Hettmer
    The Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:20002-7. 2011
    ....
  33. ncbi request reprint Harnessing the potential of myogenic satellite cells
    Richard I Sherwood
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Trends Mol Med 12:189-92. 2006
    ..A recent study from Montarras and colleagues has provided new insights into the requirements for efficient muscle engraftment from purified muscle satellite cells, suggesting possible strategies to enhance their therapeutic potential...
  34. pmc Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
    Tim J Schulz
    the Joslin Diabetes Center, Harvard Medical School, and Harvard Stem Cell Institute, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:143-8. 2011
    ..These data establish the molecular characteristics of tissue-resident adipose progenitors and demonstrate a dynamic interplay between these progenitors and inductive signals that act in concert to specify brown adipocyte development...
  35. pmc Early life nutrition modulates muscle stem cell number: implications for muscle mass and repair
    MELISSA WOO
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Stem Cells Dev 20:1763-9. 2011
    ....
  36. ncbi request reprint Plasticity of adult stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 116:639-48. 2004
    ....
  37. pmc Hematopoietic stem cells are uniquely selective in their migratory response to chemokines
    Douglas E Wright
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 195:1145-54. 2002
    ..The sharply restricted chemotactic responsiveness of HSC is unique among leukocytes and may be necessary for the specific homing of circulating HSC to bone marrow, as well as for the maintenance of HSC in hematopoietic microenvironments...
  38. pmc Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis
    Joo Hyeon Lee
    Stem Cell Program, Boston Children s Hospital, Boston, MA 02115, USA Harvard Stem Cell Institute, Cambridge, MA 02138, USA Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 156:440-55. 2014
    ..These findings elucidate a pathway that may be a critical target in lung diseases and provide tools to understand the mechanisms of respiratory diseases at the single-cell level. ..
  39. ncbi request reprint Ovulated oocytes in adult mice derive from non-circulating germ cells
    Kevin Eggan
    The Stowers Medical Institute, Harvard Stem Cell Institute and The Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 441:1109-14. 2006
    ..Instead, cells that travelled to the ovary through the bloodstream exhibited properties characteristic of committed blood leukocytes...
  40. pmc Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues
    Steffen Massberg
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:994-1008. 2007
    ..Thus, HSPCs can survey peripheral organs and can foster the local production of tissue-resident innate immune cells under both steady-state conditions and in response to inflammatory signals...
  41. pmc Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells
    Deepak Kumar
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 20:3170-7. 2009
    ....
  42. pmc Mutations in Hedgehog pathway genes in fetal rhabdomyomas
    Simone Hettmer
    Howard Hughes Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, MA, USA
    J Pathol 231:44-52. 2013
    ..These data suggest that activated Hedgehog signalling contributes to the biology of human FRM...
  43. pmc A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development
    Xiuning Le
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 140:2354-64. 2013
    ..Our work demonstrates that the activated pathways in RAS induction during embryogenesis are also important in oncogenesis and that inhibition of these pathways suppresses tumor growth...
  44. pmc Short-term calorie restriction enhances skeletal muscle stem cell function
    Massimiliano Cerletti
    Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Cell Stem Cell 10:515-9. 2012
    ..These studies indicate that metabolic factors play a critical role in regulating stem cell function and that this regulation can influence the efficacy of recovery from injury and the engraftment of transplanted cells...
  45. pmc Pax3 induces differentiation of juvenile skeletal muscle stem cells without transcriptional upregulation of canonical myogenic regulatory factors
    Arthur P Young
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA
    J Cell Sci 123:2632-9. 2010
    ..Taken together, our results suggest that there are distinct myogenic regulatory pathways that control the embryonic development, juvenile myogenesis and adult regeneration of skeletal myofibers...
  46. ncbi request reprint Improved cutaneous healing in diabetic mice exposed to healthy peripheral circulation
    Giorgio Pietramaggiori
    Department of Stem Cell and Regenerative Biology, Joslin Diabetes Center, Harvard University, Boston, Massachusetts 02215, USA
    J Invest Dermatol 129:2265-74. 2009
    ..This study establishes a new model for studying db wound healing, and shows a key role for circulating factors in normalizing wound repair in diabetes...
  47. ncbi request reprint Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers
    Simone Hettmer
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Division of Pediatric Hematology Oncology, Boston Children s Hospital, Boston, Massachusetts Department of Pediatrics, Harvard Medical School, Boston, Massachusetts Howard Hughes Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, Massachusetts Joslin Diabetes Center, Boston, Massachusetts
    Cancer 120:1068-75. 2014
    ..This study examines the question if RMS predisposition due to germline TP53 mutations correlates with certain RMS histologies...
  48. pmc A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species
    Cong Xu
    Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA Howard Hughes Medical Institute, Harvard Stem Cell Institute, Boston, MA 02115, USA Harvard Medical School, Boston, MA 02115, USA
    Cell 155:909-21. 2013
    ..In summary, these studies reveal functionally conserved pathways regulating myogenesis across species and identify chemical compounds that expand mouse satellite cells and differentiate human iPSCs into engraftable muscle...
  49. pmc Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states
    Abdelfattah El Ouaamari
    Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 3:401-10. 2013
    ..These data implicate the liver as a critical source of β cell growth factor(s) in insulin-resistant states...
  50. pmc Stem cells for skeletal muscle repair
    Jennifer L Shadrach
    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard University and Joslin Diabetes Center, Bauer Center, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Philos Trans R Soc Lond B Biol Sci 366:2297-306. 2011
    ....
  51. pmc Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
    Francesco S Loffredo
    Harvard Stem Cell Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cell 153:828-39. 2013
    ..Treatment of old mice to restore GDF11 to youthful levels recapitulated the effects of parabiosis and reversed age-related hypertrophy, revealing a therapeutic opportunity for cardiac aging...
  52. doi request reprint Myocardial infarction triggers chronic cardiac autoimmunity in type 1 diabetes
    Raju V S R K Gottumukkala
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Sci Transl Med 4:138ra80. 2012
    ..Our findings suggest that PIA may contribute to worsened post-MI outcomes in T1D and highlight a role for antigen-specific immunointervention to selectively block this pathway...
  53. ncbi request reprint The Immunological Genome Project: networks of gene expression in immune cells
    Tracy S P Heng
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Nat Immunol 9:1091-4. 2008
    ..The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immune cells...
  54. pmc Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity
    Xiaodong Jiang
    Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 483:227-31. 2012
    ..These findings have important implications for our understanding of protective immune memory at epithelial interfaces with the environment, and suggest novel strategies for vaccines that protect against tissue tropic organisms...
  55. pmc Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model
    Paul A Monach
    Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 56:2968-74. 2007
    ..The aim of this study was to test, in a mouse model of rheumatoid arthritis, whether C3 synthesized within the synovium is important in promoting inflammation...
  56. pmc Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice
    Christian Rask-Madsen
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Cell Metab 11:379-89. 2010
    ..Therefore, improving insulin sensitivity in the endothelium of patients with insulin resistance or type 2 diabetes may prevent cardiovascular complications...
  57. doi request reprint Patients beware: commercialized stem cell treatments on the web
    Patrick L Taylor
    Children s Hospital Boston, Boston, MA 02115, USA
    Cell Stem Cell 7:43-9. 2010
    ..A report by the International Society for Stem Cell Research (ISSCR)'s Task Force on Unproven Stem Cell Treatments outlines development of resources for patients, their families, and physicians seeking information on stem cell treatments...
  58. ncbi request reprint Simple and efficient isolation of hematopoietic stem cells from H2K-zFP transgenic mice
    Didier Surdez
    Department of Life Science, Swiss Federal Institute of Technology, Lausanne, Switzerland
    Stem Cells 23:1617-25. 2005
    ..This approach will greatly facilitate gene transfer, including short interfering RNA for gene knockdown, into HSCs and, consequently, into all other hematopoietic lineages...
  59. ncbi request reprint No place like home: anatomy and function of the stem cell niche
    D Leanne Jones
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Nat Rev Mol Cell Biol 9:11-21. 2008
    ....
  60. ncbi request reprint Biology of hematopoietic stem cells and progenitors: implications for clinical application
    Motonari Kondo
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Immunol 21:759-806. 2003
    ....
  61. ncbi request reprint Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:3019-27. 2008
    ..Overall, these data demonstrate that the two circulating subsets of monocytes give rise to distinct tissue DC populations...
  62. ncbi request reprint Regulating quiescence: new insights into hematopoietic stem cell biology
    Emmanuelle Passegue
    Developmental and Stem Cell Biology Program, University of California, San Francisco, 94143, USA
    Dev Cell 10:415-7. 2006
    ....
  63. doi request reprint Stem cell trafficking in tissue development, growth, and disease
    Diana J Laird
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10058, USA
    Cell 132:612-30. 2008
    ....