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Genomes and Genes | Joseph J VolpeSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Neonatal encephalopathy: an inadequate term for hypoxic-ischemic encephalopathyJoseph J Volpe
Department of Neurology, Harvard Medical School, Children s Hospital Boston, Boston, MA 02115, USA
Ann Neurol 72:156-66. 2012..These imaging findings, coupled with clinical features consistent with perinatal hypoxic-ischemic insult(s), warrant the specific designation of neonatal HIE...
The developing oligodendrocyte: key cellular target in brain injury in the premature infantJoseph J Volpe
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Dev Neurosci 29:423-40. 2011..The critical next step, i.e., clinical trials in the living infant, is now on the horizon...- Cerebellum of the premature infant: rapidly developing, vulnerable, clinically importantJoseph J Volpe
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Child Neurol 24:1085-104. 2009.... - The encephalopathy of prematurity--brain injury and impaired brain development inextricably intertwinedJoseph J Volpe
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Semin Pediatr Neurol 16:167-78. 2009..In the future, advances in neonatal neurology will likely reiterate the dependence of this field on neuropathologic studies, including new cellular and molecular approaches in developmental neurobiology... 
Encephalopathy of prematurity includes neuronal abnormalitiesJoseph J Volpe
Department of Neurology, Fegan 1103, Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA
Pediatrics 116:221-5. 2005- Brain injury in premature infants: a complex amalgam of destructive and developmental disturbancesJoseph J Volpe
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Lancet Neurol 8:110-24. 2009..This Review integrates the fascinating confluence of new insights into both brain injury and brain development during the human premature period... - Reprint of "The developing oligodendrocyte: key cellular target in brain injury in the premature infant"Joseph J Volpe
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Dev Neurosci 29:565-82. 2011..The critical next step, i.e., clinical trials in the living infant, is now on the horizon... - Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matterRebecca D Folkerth
From Departments of Pathology Neuropathology, Children s Hospital, Boston, USA
J Neuropathol Exp Neurol 63:990-9. 2004..The previously unrecognized dissociation between the expression of the SODs and that of catalase and GPx in the fetal period has potential implications for future antioxidant therapy in PVL... - Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramatePamela L Follett
Department of Neurology and Program in Neuroscience, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 24:4412-20. 2004.... - Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial functionWenbin Deng
Department of Neurology and Program in Neuroscience, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA
J Neurochem 98:213-22. 2006..Therapeutic strategies targeting local glutamate concentration and mitochondrial injury during hypoxia-ischemia may be relevant to human disorders associated with pre-OL excitotoxicity... - Myelin abnormalities without oligodendrocyte loss in periventricular leukomalaciaSaraid S Billiards
Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Brain Pathol 18:153-63. 2008..OL migration toward the "core" of injury may occur to replenish OL cell number. This study provides new insight into the cellular basis of the myelin deficits observed in survivors of PVL... - Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injuryOlivier Baud
Department of Neurology, Children's Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
Eur J Neurosci 20:29-40. 2004..These data suggest a primary involvement of superoxide in glutathione depletion toxicity in developing OLs, and suggest an important role for MnSOD in the resistance observed in mature OLs... - Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalaciaTara M Desilva
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Comp Neurol 508:238-48. 2008..The previously unrecognized up-regulation of EAAT2 in reactive astrocytes and its presence in macrophages in PVL reported here may reflect a response to either hypoxic-ischemic injury or inflammation... - Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. I. Rodent cerebral white matter and cortexDelia M Talos
Department of Neurology, Children's Hospital, Boston, Massachusetts 02115, USA
J Comp Neurol 497:42-60. 2006..Moreover, as demonstrated in part II, there are striking similarities between rat and human in the regional and temporal maturational regulation of neuronal and glial AMPAR expression... - 17beta-estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brainBettina Gerstner
Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
J Neurosci Res 87:2078-86. 2009..These results suggest a potential role for estrogens in attenuation of hypoxic-ischemic and oxidative injury to developing OLs and in the prevention of periventricular leukomalacia... - Regulation of glutamate transport in developing rat oligodendrocytesTara M Desilva
Department of Neurology and F M Kirby Neurobiology Center, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 29:7898-908. 2009..The absence of GLT1 in mature OLs in the rat corpus callosum and its presence in mature rat cultured OLs may indicate that a signaling process in vivo is not activated in vitro... - Thalamic damage in periventricular leukomalacia: novel pathologic observations relevant to cognitive deficits in survivors of prematurityPoonam Ligam
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatr Res 65:524-9. 2009..01), with substantial involvement of the mediodorsal, and reticular nuclei in PVL. The prevention of thalamic damage may be required for the eradication of defects in survivors with PVL... - Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are presentJianrong Li
Department of Neurology and the F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 28:5321-30. 2008.... - Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. II. Human cerebral white matter and cortexDelia M Talos
Department of Neurology, Children's Hospital, Boston, Massachusetts 02115, USA
J Comp Neurol 497:61-77. 2006..Furthermore, these data help to validate specific rodent maturational stages as appropriate models for evaluation of H/I pathophysiology... - Periventricular hemorrhagic infarction: risk factors and neonatal outcomeHaim Bassan
Department of Neurology, Neonatal Neurology Research Group, Children's Hospital Boston and Harvard Medical School, Boston Massachusetts 02115, USA
Pediatr Neurol 35:85-92. 2006..A growing population of survivors is apparent among infants with birth weight<750 gm. Multiple hemodynamic factors associated with periventricular hemorrhagic infarction cluster in the intrapartum and early neonatal periods... - Late development of the GABAergic system in the human cerebral cortex and white matterGang Xu
Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Neuropathol Exp Neurol 70:841-58. 2011..This period corresponds to the peak window of vulnerability to perinatal hypoxia-ischemia in which GABAergic neurons are potentially developmentally susceptible, including in the preterm infant... - The cerebral cortex overlying periventricular leukomalacia: analysis of pyramidal neuronsSarah E Andiman
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Mass, USA
Brain Pathol 20:803-14. 2010..This study underscores the potential role of secondary cortical injury in the encephalopathy of prematurity... - Impaired trophic interactions between the cerebellum and the cerebrum among preterm infantsCatherine Limperopoulos
Department of Neurology, Children's Hospital, Boston, MA 02115, USA
Pediatrics 116:844-50. 2005..Early-life cerebellar injury may contribute importantly to the high rates of cognitive, behavioral, and motor deficits reported for premature infants... - Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathwaySeija Lehnardt
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:8514-9. 2003..In contrast, animals bearing a loss-of-function mutation in the tlr4 gene are resistant to neuronal injury in the same model. The present study demonstrates a mechanistic link among innate immunity, TLRs, and neurodegeneration... - NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalaciaSimon M Manning
Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
J Neurosci 28:6670-8. 2008..These protective doses of memantine do not affect normal myelination or cortical growth. Together, these data suggest that NMDAR blockade with memantine may provide an effective pharmacological prevention of PVL in the premature infant... - Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytesYumin Zhang
Department of Neurology and Program in Neuroscience, Children's Hospital and Harvard Medical School, Boston, Mass 02115, USA
J Biol Chem 281:9460-70. 2006.... - Hyperoxia causes maturation-dependent cell death in the developing white matterBettina Gerstner
Department of Neurology and the F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Neurosci 28:1236-45. 2008..These observations may be relevant to white matter injury observed in premature infants... - Neurodevelopmental outcome in survivors of periventricular hemorrhagic infarctionHaim Bassan
Department of Neurology, Children s Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
Pediatrics 120:785-92. 2007..Our objective was to determine the neurodevelopmental and adaptive outcomes of periventricular hemorrhagic infarction survivors and identify early cranial ultrasound predictors of adverse outcome... - A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microgliaSeija Lehnardt
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Immunol 177:583-92. 2006..We suggest that this process contributes substantially to the serious morbidity associated with neonatal GBS meningitis and may provide a potential therapeutic target... - Ultrasonographic features and severity scoring of periventricular hemorrhagic infarction in relation to risk factors and outcomeHaim Bassan
Fetal/Neonatal Neurology Research Group, Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Pediatrics 117:2111-8. 2006..Higher severity scores predict worse outcome. Such severity scoring could improve the clinician's ability to counsel parents regarding management decisions and early intervention strategies... - Lipid peroxidation during human cerebral myelinationRobin L Haynes
Department of Pathology, Children s Hospital Boston, Massachusetts 02115, USA
J Neuropathol Exp Neurol 65:894-904. 2006.... - The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matterTara M Desilva
Neurobiology Program, Children s Hospital Boston, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Comp Neurol 501:879-90. 2007.... - Development of microglia in the cerebral white matter of the human fetus and infantSaraid S Billiards
Department of Pathology, Children s Hospital Boston and Harvard Medical School, MA 02115, USA
J Comp Neurol 497:199-208. 2006..j... - Diffuse axonal injury in periventricular leukomalacia as determined by apoptotic marker fractinRobin L Haynes
Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatr Res 63:656-61. 2008..We conclude that diffuse axonal injury, as determined by apoptotic marker fractin, occurs in PVL and that its cause likely includes primary ischemia and trophic degeneration secondary to corticothalamic neuronal damage... - Current definitions of hypotension do not predict abnormal cranial ultrasound findings in preterm infantsCatherine Limperopoulos
Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatrics 120:966-77. 2007..Our goal was to examine the relationship between current definitions of hypotension and early abnormal cranial ultrasound findings... - 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytesHong Wang
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Eur J Neurosci 20:2049-58. 2004..These results suggest that 12-LOX activation plays a key role in oxidative stress-induced OL death... - Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical developmentTara M Desilva
Department of Neurology and the FM Kirby Neurobiology Center, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
J Comp Neurol 520:3912-32. 2012..In addition, by studying the expression of EAAT1 and EAAT2 glutamate transporters, it was possible to document the development of protoplasmic astrocytes... - Gray matter injury associated with periventricular leukomalacia in the premature infantChristopher R Pierson
Department of Pathology, Children s Hospital Boston, Boston, MA, USA
Acta Neuropathol 114:619-31. 2007.... - Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalaciaRobin L Haynes
Departments of Pathology, Children s Hospital Boston, Boston, MA 02115, USA
Acta Neuropathol 118:391-9. 2009..This study supports an important role for iNOS-induced nitrosative stress in the reactive/inflammatory component of PVL... - Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalaciaRobin L Haynes
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Neuropathol Exp Neurol 62:441-50. 2003..Agents that prevent nitrosative and oxidative stress may play a key role in ameliorating PVL in premature infants in the intensive care nursery... - Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit composition and cAMP-response element-binding protein regulate oligodendrocyte excitotoxicityWenbin Deng
Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 281:36004-11. 2006..Overall, these data suggest that targeting GluR2-lacking AMPARs or CREB may be a useful strategy for treating nervous system disorders associated with OL excitotoxicity... - Axonal development in the cerebral white matter of the human fetus and infantRobin L Haynes
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
J Comp Neurol 484:156-67. 2005..These data suggest that immature axons are susceptible to damage in PVL and that the timing of axonal maturation must be considered toward establishing its pathology relative to the oligodendrocyte/myelin/axonal unit... - Neuron deficit in the white matter and subplate in periventricular leukomalaciaHannah C Kinney
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Ann Neurol 71:397-406. 2012..We tested the hypothesis that the overall density of neurons in the white matter and subplate region is significantly lower in PVL cases compared to non-PVL controls... - The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brainSimon M Manning
Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Int J Dev Neurosci 29:767-73. 2011..Evaluating clinically approved drugs in preclinical neonatal animal models of early brain development is an important prerequisite to considering them for clinical trial in preterm infants and early childhood... - Potential neuronal repair in cerebral white matter injury in the human neonateRobin L Haynes
Departments of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatr Res 69:62-7. 2011..e. 35-42 postconceptional weeks. These data provide the first evidence suggestive of an attempt at neuronal repair or regeneration in human neonatal white matter injury... - Interferon-gamma expression in periventricular leukomalacia in the human brainRebecca D Folkerth
Department of Pathology Neuropathology, Children s Hospital and Harvard Medical School, Boston, MA, USA
Brain Pathol 14:265-74. 2004..In PVL, IFN-gamma produced by macrophages and reactive astrocytes may play a role in cytokine-induced toxicity to premyelinating oligodendrocytes as part of a cytokine response stimulated by ischemia and/or infection... - Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infantsJanet S Soul
Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Pediatr Res 61:467-73. 2007..Future studies using consistent serial brain imaging are needed to define the relationship between PPI and cerebrovascular injury in the sick premature infant... - Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neuronsJianrong Li
Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
J Neurosci 23:5816-26. 2003.... - Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytesOlivier Baud
Department of Neurology, Division of Neuroscience, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 24:1531-40. 2004..These data provide evidence for a key role for GPx-catalase cooperativity in the resistance of mature OLs to H2O2-induced cell death... - Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytesJianrong Li
Department of Neurology, Children s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:9936-41. 2005..Our results reveal a role for NADPH oxidase in LPS-induced OL death and suggest that peroxynitrite produced by iNOS and NADPH oxidase in activated microglia may play an important role in the pathogenesis of white matter disorders... - Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stressWenbin Deng
Department of Neurology and Program in Neuroscience, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:7751-6. 2004.... - Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursorsWenbin Deng
Department of Neurology and Program in Neuroscience, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:6801-6. 2003.... - Mature myelin basic protein-expressing oligodendrocytes are insensitive to kainate toxicityPaul A Rosenberg
Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci Res 71:237-45. 2003.... - Late gestation cerebellar growth is rapid and impeded by premature birthCatherine Limperopoulos
Department of Neurology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Ave, Fegan 11, Boston, Massachusetts 02115, USA
Pediatrics 115:688-95. 2005..The objective of this study was to examine the impact of prematurity itself, as well as prematurity-related brain injuries, on early postnatal cerebellar growth with quantitative MRI... - Nitric oxide-induced cell death in developing oligodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocationOlivier Baud
Department of Neurology, Division of Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Eur J Neurosci 20:1713-26. 2004..In conclusion, we suggest that the vulnerability of developing OLs to NO involves mitochondrial dysfunction and translocation of AIF from mitochondria to nuclei... - Cerebral white matter injury of the premature infant-more common than you thinkJoseph J Volpe
Department of Neurology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
Pediatrics 112:176-80. 2003 - Cerebellar hemorrhage in the preterm infant: ultrasonographic findings and risk factorsCatherine Limperopoulos
Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Pediatrics 116:717-24. 2005..Predictors of CBH seem to be multifactorial and include combined maternal, intrapartum, and early postnatal factors... - The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNSSeija Lehnardt
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
J Neurosci 22:2478-86. 2002..Our data provide a general mechanistic link between (1) lipopolysaccharide and similar microbial molecular motifs and (2) injury to oligodendrocytes and myelin as occurs in periventricular leukomalacia and multiple sclerosis... - Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosisYinghua Ma
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
J Cell Biol 175:209-15. 2006..These findings reveal novel functions for TLR8 in the mammalian nervous system that are distinct from the classical role of TLRs in immunity... - Perinatal brain injury in the preterm and term newbornAdre J Du Plessis
Children s Hospital, 300 Longwood Avenue, Neurology Fegan 11, Boston, Massachusetts, USA
Curr Opin Neurol 15:151-7. 2002..Recent insights into the mechanisms of oligodendrocyte injury and the role of inflammatory substances in perinatal brain injury are also discussed... - Positive screening for autism in ex-preterm infants: prevalence and risk factorsCatherine Limperopoulos
Department of Neurology and Neurosurgery, School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada
Pediatrics 121:758-65. 2008..The objective of this study was to perform screening tests for early autistic features in children with a history of very low birth weight and to identify risk factors associated with a positive screening result... - Arrested oligodendrocyte lineage progression during human cerebral white matter development: dissociation between the timing of progenitor differentiation and myelinogenesisStephen A Back
Department of Neurology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Neuropathol Exp Neurol 61:197-211. 2002.... - In vivo visualization of white matter fiber tracts of preterm- and term-infant brains with diffusion tensor magnetic resonance imagingSeung Schik Yoo
Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Invest Radiol 40:110-5. 2005.... - Modeling the encephalopathy of prematurity in animals: the important role of translational researchHannah C Kinney
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Neurol Res Int 2012:295389. 2012.... - Mental Retardation Research Center at Boston Children's Hospital/Harvard Medical School. Introductory overviewJoseph J Volpe
Neurology Department, Children s Hospital, Boston, MA 02115, USA
Int J Dev Neurosci 20:337-8. 2002..The core research support facilities serve as the nidus for this large research effort, encompassing 65 externally funded clinical and basic scientists... - Prognostic value of neonatal discontinuous EEGCaroline C Menache
Department of Neurology; Children's Hospital; Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatr Neurol 27:93-101. 2002..This easily quantitated EEG parameter could be valuable for the early estimation of neurologic prognosis... - CSF removal in infantile posthemorrhagic hydrocephalus results in significant improvement in cerebral hemodynamicsJanet S Soul
Department of Neurology, Children's Hospital, Boston, MA 02115, USA
Pediatr Res 55:872-6. 2004..NIRS may be a useful technique to detect impending cerebral ischemia in such infants and thereby provide a means to guide the rational management of PHH... - White matter injury in the premature infant: a comparison between serial cranial sonographic and MR findings at termTerrie E Inder
Murdoch Children's Research Institute, Melbourne, Australia
AJNR Am J Neuroradiol 24:805-9. 2003..This deficiency of neonatal cranial US is important, because noncystic WM injury is considerably more common than cystic WM injury... - Estradiol attenuates hyperoxia-induced cell death in the developing white matterBettina Gerstner
Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
Ann Neurol 61:562-73. 2007..Furthermore, neuroprotective properties have been attributed to estrogens. We examined the effect of E2 on hyperoxia-induced cell death in the developing white matter in the rat brain... - Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors?Catherine Limperopoulos
Department of Neurology and Neurosurgery and School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada
Pediatrics 120:584-93. 2007..We sought to delineate the potential role of cerebellar hemorrhagic injury in the long-term disabilities of survivors of prematurity... - Abnormal cerebral structure is present at term in premature infantsTerrie E Inder
Murdoch Children s Research Institute, Royal Women s Hospital, University of Melbourne, Melbourne, Australia
Pediatrics 115:286-94. 2005..However, there is a limited understanding of the nature of the cerebral abnormality underlying these adverse neurologic outcomes... - Markers of oxidative injury in the cerebrospinal fluid of a premature infant with meningitis and periventricular leukomalaciaTerrie Inder
Murdoch Children's Research Institute and Howard Florey Institute, Royal Women's Hospital, Melbourne, Australia
J Pediatr 140:617-21. 2002..This case report is the first to demonstrate a marked elevation in the levels of lipid and protein oxidative products in the cerebrospinal fluid during the evolution of periventricular leukomalacia in a premature infant with meningitis... - Elevated free radical products in the cerebrospinal fluid of VLBW infants with cerebral white matter injuryTerrie Inder
The Murdoch Children s Research Institute and Howard Florey Institute and Royal Women s and Royal Children s Hospital, Melbourne, Australia
Pediatr Res 52:213-8. 2002..These preliminary data provide evidence of an association of elevated oxidative products during the evolution of white matter injury in the human premature infant... - Lowered electroencephalographic spectral edge frequency predicts the presence of cerebral white matter injury in premature infantsTerrie E Inder
Murdoch Children s Research Institute and Royal Women s and Royal Children s Hospital, Melbourne, Australia
Pediatrics 111:27-33. 2003..The critical measurement used, suggested largely by previous studies in animal models, was the spectral edge frequency (SEF), calculated here as the frequency below which 90% of the power in the EEG exists... - Postnatal sepsis, necrotizing entercolitis, and the critical role of systemic inflammation in white matter injury in premature infantsJoseph J Volpe
J Pediatr 153:160-3. 2008 - Combination of event-related fMRI and diffusion tensor imaging in an infant with perinatal strokeMohamed L Seghier
Department of Radiology, University Hospital of Geneva, 1211, Geneva, Switzerland
Neuroimage 21:463-72. 2004.... - The relationship of CSF and plasma cytokine levels to cerebral white matter injury in the premature newbornVanessa J Ellison
Neonatal Medicine, Royal Women's Hospital, Melbourne, Victoria, Australia
Pediatr Res 57:282-6. 2005..Plasma cytokine concentrations may not reflect CSF cytokine levels or inflammatory events within the brain. Elevated CSF levels of cytokines in infants with white matter injury suggest an altered inflammatory balance... - Neonatal encephalitis and white matter injury: more than just inflammation?Joseph J Volpe
Ann Neurol 64:232-6. 2008 - Cerebral injury in association with profound iatrogenic hyperglycemia in a neonateDaryl Efron
Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Melbourne, Australia
Eur J Paediatr Neurol 7:167-71. 2003....
Research Grants
- NEUROLOGICAL SCIENCES ACADEMIC DEVELOPMENT AWARDJoseph Volpe; Fiscal Year: 2003..Fischbach, in research development of child neurology residents ensure the success of this NSADA program. ..