Joseph J Volpe

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Neonatal encephalopathy: an inadequate term for hypoxic-ischemic encephalopathy
    Joseph J Volpe
    Department of Neurology, Harvard Medical School, Children s Hospital Boston, Boston, MA 02115, USA
    Ann Neurol 72:156-66. 2012
  2. pmc Cerebellum of the premature infant: rapidly developing, vulnerable, clinically important
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Child Neurol 24:1085-104. 2009
  3. pmc The encephalopathy of prematurity--brain injury and impaired brain development inextricably intertwined
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Semin Pediatr Neurol 16:167-78. 2009
  4. pmc The developing oligodendrocyte: key cellular target in brain injury in the premature infant
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 29:423-40. 2011
  5. ncbi request reprint Reprint of "The developing oligodendrocyte: key cellular target in brain injury in the premature infant"
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 29:565-82. 2011
  6. ncbi request reprint Encephalopathy of prematurity includes neuronal abnormalities
    Joseph J Volpe
    Department of Neurology, Fegan 1103, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 116:221-5. 2005
  7. pmc Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet Neurol 8:110-24. 2009
  8. ncbi request reprint Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter
    Rebecca D Folkerth
    From Departments of Pathology Neuropathology, Children s Hospital, Boston, USA
    J Neuropathol Exp Neurol 63:990-9. 2004
  9. ncbi request reprint Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate
    Pamela L Follett
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:4412-20. 2004
  10. ncbi request reprint Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Neurochem 98:213-22. 2006

Research Grants

Detail Information

Publications80

  1. doi request reprint Neonatal encephalopathy: an inadequate term for hypoxic-ischemic encephalopathy
    Joseph J Volpe
    Department of Neurology, Harvard Medical School, Children s Hospital Boston, Boston, MA 02115, USA
    Ann Neurol 72:156-66. 2012
    ..These imaging findings, coupled with clinical features consistent with perinatal hypoxic-ischemic insult(s), warrant the specific designation of neonatal HIE...
  2. pmc Cerebellum of the premature infant: rapidly developing, vulnerable, clinically important
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Child Neurol 24:1085-104. 2009
    ....
  3. pmc The encephalopathy of prematurity--brain injury and impaired brain development inextricably intertwined
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Semin Pediatr Neurol 16:167-78. 2009
    ..In the future, advances in neonatal neurology will likely reiterate the dependence of this field on neuropathologic studies, including new cellular and molecular approaches in developmental neurobiology...
  4. pmc The developing oligodendrocyte: key cellular target in brain injury in the premature infant
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 29:423-40. 2011
    ..The critical next step, i.e., clinical trials in the living infant, is now on the horizon...
  5. ncbi request reprint Reprint of "The developing oligodendrocyte: key cellular target in brain injury in the premature infant"
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 29:565-82. 2011
    ..The critical next step, i.e., clinical trials in the living infant, is now on the horizon...
  6. ncbi request reprint Encephalopathy of prematurity includes neuronal abnormalities
    Joseph J Volpe
    Department of Neurology, Fegan 1103, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 116:221-5. 2005
  7. pmc Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances
    Joseph J Volpe
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet Neurol 8:110-24. 2009
    ..This Review integrates the fascinating confluence of new insights into both brain injury and brain development during the human premature period...
  8. ncbi request reprint Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter
    Rebecca D Folkerth
    From Departments of Pathology Neuropathology, Children s Hospital, Boston, USA
    J Neuropathol Exp Neurol 63:990-9. 2004
    ..The previously unrecognized dissociation between the expression of the SODs and that of catalase and GPx in the fetal period has potential implications for future antioxidant therapy in PVL...
  9. ncbi request reprint Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate
    Pamela L Follett
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:4412-20. 2004
    ....
  10. ncbi request reprint Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Neurochem 98:213-22. 2006
    ..Therapeutic strategies targeting local glutamate concentration and mitochondrial injury during hypoxia-ischemia may be relevant to human disorders associated with pre-OL excitotoxicity...
  11. pmc Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia
    Saraid S Billiards
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Brain Pathol 18:153-63. 2008
    ..OL migration toward the "core" of injury may occur to replenish OL cell number. This study provides new insight into the cellular basis of the myelin deficits observed in survivors of PVL...
  12. ncbi request reprint Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury
    Olivier Baud
    Department of Neurology, Children s Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Eur J Neurosci 20:29-40. 2004
    ..These data suggest a primary involvement of superoxide in glutathione depletion toxicity in developing OLs, and suggest an important role for MnSOD in the resistance observed in mature OLs...
  13. pmc 17beta-estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brain
    Bettina Gerstner
    Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
    J Neurosci Res 87:2078-86. 2009
    ..These results suggest a potential role for estrogens in attenuation of hypoxic-ischemic and oxidative injury to developing OLs and in the prevention of periventricular leukomalacia...
  14. ncbi request reprint Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. I. Rodent cerebral white matter and cortex
    Delia M Talos
    Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 497:42-60. 2006
    ..Moreover, as demonstrated in part II, there are striking similarities between rat and human in the regional and temporal maturational regulation of neuronal and glial AMPAR expression...
  15. pmc Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalacia
    Tara M Desilva
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 508:238-48. 2008
    ..The previously unrecognized up-regulation of EAAT2 in reactive astrocytes and its presence in macrophages in PVL reported here may reflect a response to either hypoxic-ischemic injury or inflammation...
  16. pmc Regulation of glutamate transport in developing rat oligodendrocytes
    Tara M Desilva
    Department of Neurology and F M Kirby Neurobiology Center, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:7898-908. 2009
    ..The absence of GLT1 in mature OLs in the rat corpus callosum and its presence in mature rat cultured OLs may indicate that a signaling process in vivo is not activated in vitro...
  17. ncbi request reprint Periventricular hemorrhagic infarction: risk factors and neonatal outcome
    Haim Bassan
    Department of Neurology, Neonatal Neurology Research Group, Children s Hospital Boston and Harvard Medical School, Boston Massachusetts 02115, USA
    Pediatr Neurol 35:85-92. 2006
    ..A growing population of survivors is apparent among infants with birth weight<750 gm. Multiple hemodynamic factors associated with periventricular hemorrhagic infarction cluster in the intrapartum and early neonatal periods...
  18. pmc Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present
    Jianrong Li
    Department of Neurology and the F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5321-30. 2008
    ....
  19. pmc Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. II. Human cerebral white matter and cortex
    Delia M Talos
    Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 497:61-77. 2006
    ..Furthermore, these data help to validate specific rodent maturational stages as appropriate models for evaluation of H/I pathophysiology...
  20. pmc Thalamic damage in periventricular leukomalacia: novel pathologic observations relevant to cognitive deficits in survivors of prematurity
    Poonam Ligam
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 65:524-9. 2009
    ..01), with substantial involvement of the mediodorsal, and reticular nuclei in PVL. The prevention of thalamic damage may be required for the eradication of defects in survivors with PVL...
  21. pmc The cerebral cortex overlying periventricular leukomalacia: analysis of pyramidal neurons
    Sarah E Andiman
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Mass, USA
    Brain Pathol 20:803-14. 2010
    ..This study underscores the potential role of secondary cortical injury in the encephalopathy of prematurity...
  22. pmc Late development of the GABAergic system in the human cerebral cortex and white matter
    Gang Xu
    Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 70:841-58. 2011
    ..This period corresponds to the peak window of vulnerability to perinatal hypoxia-ischemia in which GABAergic neurons are potentially developmentally susceptible, including in the preterm infant...
  23. ncbi request reprint Impaired trophic interactions between the cerebellum and the cerebrum among preterm infants
    Catherine Limperopoulos
    Department of Neurology, Children s Hospital, Boston, MA 02115, USA
    Pediatrics 116:844-50. 2005
    ..Advanced neuroimaging techniques have brought increasing recognition of cerebellar injury among premature infants. The developmental relationship between early brain injury and effects on the cerebrum and cerebellum remains unclear...
  24. pmc NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia
    Simon M Manning
    Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 28:6670-8. 2008
    ..These protective doses of memantine do not affect normal myelination or cortical growth. Together, these data suggest that NMDAR blockade with memantine may provide an effective pharmacological prevention of PVL in the premature infant...
  25. pmc Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
    Seija Lehnardt
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:8514-9. 2003
    ..In contrast, animals bearing a loss-of-function mutation in the tlr4 gene are resistant to neuronal injury in the same model. The present study demonstrates a mechanistic link among innate immunity, TLRs, and neurodegeneration...
  26. ncbi request reprint Neurodevelopmental outcome in survivors of periventricular hemorrhagic infarction
    Haim Bassan
    Department of Neurology, Children s Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 120:785-92. 2007
    ..Our objective was to determine the neurodevelopmental and adaptive outcomes of periventricular hemorrhagic infarction survivors and identify early cranial ultrasound predictors of adverse outcome...
  27. ncbi request reprint Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes
    Yumin Zhang
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    J Biol Chem 281:9460-70. 2006
    ....
  28. ncbi request reprint A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia
    Seija Lehnardt
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 177:583-92. 2006
    ..We suggest that this process contributes substantially to the serious morbidity associated with neonatal GBS meningitis and may provide a potential therapeutic target...
  29. doi request reprint Hyperoxia causes maturation-dependent cell death in the developing white matter
    Bettina Gerstner
    Department of Neurology and the F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neurosci 28:1236-45. 2008
    ..These observations may be relevant to white matter injury observed in premature infants...
  30. pmc Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical development
    Tara M Desilva
    Department of Neurology and the FM Kirby Neurobiology Center, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 520:3912-32. 2012
    ..In addition, by studying the expression of EAAT1 and EAAT2 glutamate transporters, it was possible to document the development of protoplasmic astrocytes...
  31. pmc Diffuse axonal injury in periventricular leukomalacia as determined by apoptotic marker fractin
    Robin L Haynes
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 63:656-61. 2008
    ..We conclude that diffuse axonal injury, as determined by apoptotic marker fractin, occurs in PVL and that its cause likely includes primary ischemia and trophic degeneration secondary to corticothalamic neuronal damage...
  32. ncbi request reprint 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes
    Hong Wang
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 20:2049-58. 2004
    ..These results suggest that 12-LOX activation plays a key role in oxidative stress-induced OL death...
  33. ncbi request reprint Development of microglia in the cerebral white matter of the human fetus and infant
    Saraid S Billiards
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, MA 02115, USA
    J Comp Neurol 497:199-208. 2006
    ..j...
  34. ncbi request reprint Current definitions of hypotension do not predict abnormal cranial ultrasound findings in preterm infants
    Catherine Limperopoulos
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 120:966-77. 2007
    ..Our goal was to examine the relationship between current definitions of hypotension and early abnormal cranial ultrasound findings...
  35. ncbi request reprint The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter
    Tara M Desilva
    Neurobiology Program, Children s Hospital Boston, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 501:879-90. 2007
    ....
  36. ncbi request reprint Lipid peroxidation during human cerebral myelination
    Robin L Haynes
    Department of Pathology, Children s Hospital Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 65:894-904. 2006
    ....
  37. ncbi request reprint Ultrasonographic features and severity scoring of periventricular hemorrhagic infarction in relation to risk factors and outcome
    Haim Bassan
    Fetal Neonatal Neurology Research Group, Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 117:2111-8. 2006
    ....
  38. ncbi request reprint Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit composition and cAMP-response element-binding protein regulate oligodendrocyte excitotoxicity
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:36004-11. 2006
    ..Overall, these data suggest that targeting GluR2-lacking AMPARs or CREB may be a useful strategy for treating nervous system disorders associated with OL excitotoxicity...
  39. pmc Gray matter injury associated with periventricular leukomalacia in the premature infant
    Christopher R Pierson
    Department of Pathology, Children s Hospital Boston, Boston, MA, USA
    Acta Neuropathol 114:619-31. 2007
    ..Gray matter lesions occur in a third or more of PVL cases suggesting that white matter injury generally does not occur in isolation, and that the term "perinatal panencephalopathy" may better describe the scope of the neuropathology...
  40. ncbi request reprint Axonal development in the cerebral white matter of the human fetus and infant
    Robin L Haynes
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 484:156-67. 2005
    ..These data suggest that immature axons are susceptible to damage in PVL and that the timing of axonal maturation must be considered toward establishing its pathology relative to the oligodendrocyte/myelin/axonal unit...
  41. pmc Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia
    Robin L Haynes
    Departments of Pathology, Children s Hospital Boston, Boston, MA 02115, USA
    Acta Neuropathol 118:391-9. 2009
    ..This study supports an important role for iNOS-induced nitrosative stress in the reactive/inflammatory component of PVL...
  42. ncbi request reprint Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia
    Robin L Haynes
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 62:441-50. 2003
    ..Agents that prevent nitrosative and oxidative stress may play a key role in ameliorating PVL in premature infants in the intensive care nursery...
  43. ncbi request reprint Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants
    Janet S Soul
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Pediatr Res 61:467-73. 2007
    ..Future studies using consistent serial brain imaging are needed to define the relationship between PPI and cerebrovascular injury in the sick premature infant...
  44. pmc Neuron deficit in the white matter and subplate in periventricular leukomalacia
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 71:397-406. 2012
    ..We tested the hypothesis that the overall density of neurons in the white matter and subplate region is significantly lower in PVL cases compared to non-PVL controls...
  45. pmc The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain
    Simon M Manning
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Int J Dev Neurosci 29:767-73. 2011
    ..Evaluating clinically approved drugs in preclinical neonatal animal models of early brain development is an important prerequisite to considering them for clinical trial in preterm infants and early childhood...
  46. ncbi request reprint Late gestation cerebellar growth is rapid and impeded by premature birth
    Catherine Limperopoulos
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Ave, Fegan 11, Boston, Massachusetts 02115, USA
    Pediatrics 115:688-95. 2005
    ..The objective of this study was to examine the impact of prematurity itself, as well as prematurity-related brain injuries, on early postnatal cerebellar growth with quantitative MRI...
  47. ncbi request reprint Interferon-gamma expression in periventricular leukomalacia in the human brain
    Rebecca D Folkerth
    Department of Pathology Neuropathology, Children s Hospital and Harvard Medical School, Boston, MA, USA
    Brain Pathol 14:265-74. 2004
    ..In PVL, IFN-gamma produced by macrophages and reactive astrocytes may play a role in cytokine-induced toxicity to premyelinating oligodendrocytes as part of a cytokine response stimulated by ischemia and/or infection...
  48. ncbi request reprint Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons
    Jianrong Li
    Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
    J Neurosci 23:5816-26. 2003
    ....
  49. ncbi request reprint Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes
    Olivier Baud
    Department of Neurology, Division of Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:1531-40. 2004
    ..These data provide evidence for a key role for GPx-catalase cooperativity in the resistance of mature OLs to H2O2-induced cell death...
  50. pmc Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
    Jianrong Li
    Department of Neurology, Children s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:9936-41. 2005
    ..Our results reveal a role for NADPH oxidase in LPS-induced OL death and suggest that peroxynitrite produced by iNOS and NADPH oxidase in activated microglia may play an important role in the pathogenesis of white matter disorders...
  51. pmc Potential neuronal repair in cerebral white matter injury in the human neonate
    Robin L Haynes
    Departments of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 69:62-7. 2011
    ..e. 35-42 postconceptional weeks. These data provide the first evidence suggestive of an attempt at neuronal repair or regeneration in human neonatal white matter injury...
  52. pmc Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:6801-6. 2003
    ....
  53. ncbi request reprint Nitric oxide-induced cell death in developing oligodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocation
    Olivier Baud
    Department of Neurology, Division of Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 20:1713-26. 2004
    ..In conclusion, we suggest that the vulnerability of developing OLs to NO involves mitochondrial dysfunction and translocation of AIF from mitochondria to nuclei...
  54. pmc Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:7751-6. 2004
    ....
  55. ncbi request reprint Mature myelin basic protein-expressing oligodendrocytes are insensitive to kainate toxicity
    Paul A Rosenberg
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci Res 71:237-45. 2003
    ....
  56. ncbi request reprint Cerebellar hemorrhage in the preterm infant: ultrasonographic findings and risk factors
    Catherine Limperopoulos
    Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 116:717-24. 2005
    ..Information is limited, however, on the incidence, topography, and risk factors for CBH in the preterm infant...
  57. ncbi request reprint The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS
    Seija Lehnardt
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 22:2478-86. 2002
    ..Our data provide a general mechanistic link between (1) lipopolysaccharide and similar microbial molecular motifs and (2) injury to oligodendrocytes and myelin as occurs in periventricular leukomalacia and multiple sclerosis...
  58. ncbi request reprint Cerebral white matter injury of the premature infant-more common than you think
    Joseph J Volpe
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Pediatrics 112:176-80. 2003
  59. pmc Radial coherence of diffusion tractography in the cerebral white matter of the human fetus: neuroanatomic insights
    Gang Xu
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cereb Cortex 24:579-92. 2014
    ..This study provides baseline information for interpreting radial coherence in tractography studies of the preterm brain in the assessment of the encephalopathy of prematurity. ..
  60. ncbi request reprint Perinatal brain injury in the preterm and term newborn
    Adre J Du Plessis
    Children s Hospital, 300 Longwood Avenue, Neurology Fegan 11, Boston, Massachusetts, USA
    Curr Opin Neurol 15:151-7. 2002
    ..Recent insights into the mechanisms of oligodendrocyte injury and the role of inflammatory substances in perinatal brain injury are also discussed...
  61. pmc Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis
    Yinghua Ma
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Cell Biol 175:209-15. 2006
    ..These findings reveal novel functions for TLR8 in the mammalian nervous system that are distinct from the classical role of TLRs in immunity...
  62. pmc Positive screening for autism in ex-preterm infants: prevalence and risk factors
    Catherine Limperopoulos
    Department of Neurology and Neurosurgery, School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada
    Pediatrics 121:758-65. 2008
    ..The objective of this study was to perform screening tests for early autistic features in children with a history of very low birth weight and to identify risk factors associated with a positive screening result...
  63. ncbi request reprint In vivo visualization of white matter fiber tracts of preterm- and term-infant brains with diffusion tensor magnetic resonance imaging
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Invest Radiol 40:110-5. 2005
    ....
  64. ncbi request reprint Arrested oligodendrocyte lineage progression during human cerebral white matter development: dissociation between the timing of progenitor differentiation and myelinogenesis
    Stephen A Back
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neuropathol Exp Neurol 61:197-211. 2002
    ....
  65. pmc Modeling the encephalopathy of prematurity in animals: the important role of translational research
    Hannah C Kinney
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Neurol Res Int 2012:295389. 2012
    ....
  66. ncbi request reprint CSF removal in infantile posthemorrhagic hydrocephalus results in significant improvement in cerebral hemodynamics
    Janet S Soul
    Department of Neurology, Children s Hospital, Boston, MA 02115, USA
    Pediatr Res 55:872-6. 2004
    ..NIRS may be a useful technique to detect impending cerebral ischemia in such infants and thereby provide a means to guide the rational management of PHH...
  67. ncbi request reprint Prognostic value of neonatal discontinuous EEG
    Caroline C Menache
    Department of Neurology Children s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Neurol 27:93-101. 2002
    ..This easily quantitated EEG parameter could be valuable for the early estimation of neurologic prognosis...
  68. ncbi request reprint Mental Retardation Research Center at Boston Children's Hospital/Harvard Medical School. Introductory overview
    Joseph J Volpe
    Neurology Department, Children s Hospital, Boston, MA 02115, USA
    Int J Dev Neurosci 20:337-8. 2002
    ..The core research support facilities serve as the nidus for this large research effort, encompassing 65 externally funded clinical and basic scientists...
  69. ncbi request reprint Lowered electroencephalographic spectral edge frequency predicts the presence of cerebral white matter injury in premature infants
    Terrie E Inder
    Murdoch Children s Research Institute and Royal Women s and Royal Children s Hospital, Melbourne, Australia
    Pediatrics 111:27-33. 2003
    ..The critical measurement used, suggested largely by previous studies in animal models, was the spectral edge frequency (SEF), calculated here as the frequency below which 90% of the power in the EEG exists...
  70. ncbi request reprint Abnormal cerebral structure is present at term in premature infants
    Terrie E Inder
    Murdoch Children s Research Institute, Royal Women s Hospital, University of Melbourne, Melbourne, Australia
    Pediatrics 115:286-94. 2005
    ..However, there is a limited understanding of the nature of the cerebral abnormality underlying these adverse neurologic outcomes...
  71. pmc Postnatal sepsis, necrotizing entercolitis, and the critical role of systemic inflammation in white matter injury in premature infants
    Joseph J Volpe
    J Pediatr 153:160-3. 2008
  72. ncbi request reprint Estradiol attenuates hyperoxia-induced cell death in the developing white matter
    Bettina Gerstner
    Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
    Ann Neurol 61:562-73. 2007
    ..Furthermore, neuroprotective properties have been attributed to estrogens. We examined the effect of E2 on hyperoxia-induced cell death in the developing white matter in the rat brain...
  73. ncbi request reprint Markers of oxidative injury in the cerebrospinal fluid of a premature infant with meningitis and periventricular leukomalacia
    Terrie Inder
    Murdoch Children s Research Institute and Howard Florey Institute, Royal Women s Hospital, Melbourne, Australia
    J Pediatr 140:617-21. 2002
    ..This case report is the first to demonstrate a marked elevation in the levels of lipid and protein oxidative products in the cerebrospinal fluid during the evolution of periventricular leukomalacia in a premature infant with meningitis...
  74. ncbi request reprint White matter injury in the premature infant: a comparison between serial cranial sonographic and MR findings at term
    Terrie E Inder
    Murdoch Children s Research Institute, Melbourne, Australia
    AJNR Am J Neuroradiol 24:805-9. 2003
    ....
  75. ncbi request reprint Elevated free radical products in the cerebrospinal fluid of VLBW infants with cerebral white matter injury
    Terrie Inder
    The Murdoch Children s Research Institute and Howard Florey Institute and Royal Women s and Royal Children s Hospital, Melbourne, Australia
    Pediatr Res 52:213-8. 2002
    ..These preliminary data provide evidence of an association of elevated oxidative products during the evolution of white matter injury in the human premature infant...
  76. ncbi request reprint Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors?
    Catherine Limperopoulos
    Department of Neurology and Neurosurgery and School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada
    Pediatrics 120:584-93. 2007
    ..We sought to delineate the potential role of cerebellar hemorrhagic injury in the long-term disabilities of survivors of prematurity...
  77. pmc Neonatal encephalitis and white matter injury: more than just inflammation?
    Joseph J Volpe
    Ann Neurol 64:232-6. 2008
  78. ncbi request reprint Cerebral injury in association with profound iatrogenic hyperglycemia in a neonate
    Daryl Efron
    Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Melbourne, Australia
    Eur J Paediatr Neurol 7:167-71. 2003
    ....
  79. ncbi request reprint Combination of event-related fMRI and diffusion tensor imaging in an infant with perinatal stroke
    Mohamed L Seghier
    Department of Radiology, University Hospital of Geneva, 1211, Geneva, Switzerland
    Neuroimage 21:463-72. 2004
    ....
  80. ncbi request reprint The relationship of CSF and plasma cytokine levels to cerebral white matter injury in the premature newborn
    Vanessa J Ellison
    Neonatal Medicine, Royal Women s Hospital, Melbourne, Victoria, Australia
    Pediatr Res 57:282-6. 2005
    ..Plasma cytokine concentrations may not reflect CSF cytokine levels or inflammatory events within the brain. Elevated CSF levels of cytokines in infants with white matter injury suggest an altered inflammatory balance...

Research Grants2

  1. NEUROLOGICAL SCIENCES ACADEMIC DEVELOPMENT AWARD
    Joseph Volpe; Fiscal Year: 2003
    ..Fischbach, in research development of child neurology residents ensure the success of this NSADA program. ..