Sarah K Volkman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia
    Sungano Mharakurwa
    Harvard School of Public Health, Boston, MA, USA
    Malar J 13:89. 2014
  2. doi request reprint Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests
    Awa B Deme
    Broad Institute The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Malar J 13:34. 2014
  3. doi request reprint Harnessing genomics and genome biology to understand malaria biology
    Sarah K Volkman
    Department of Immunology and Infectious Disease, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Genet 13:315-28. 2012
  4. pmc Application of genomics to field investigations of malaria by the international centers of excellence for malaria research
    Sarah K Volkman
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Acta Trop 121:324-32. 2012
  5. pmc A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs
    Kate M Broadbent
    Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Genome Biol 12:R56. 2011
  6. pmc Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum
    Neekesh V Dharia
    Department of Cell Biology, ICND 202, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CA 92037, USA
    Genome Biol 10:R21. 2009
  7. pmc Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite
    Daniel J Park
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 109:13052-7. 2012
  8. pmc A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking
    Rachel Daniels
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Malar J 7:223. 2008
  9. pmc Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum
    Sarah K Volkman
    Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA, USA
    Gene 387:1-6. 2007
  10. pmc Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal
    Rachel Daniels
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 8:e60780. 2013

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia
    Sungano Mharakurwa
    Harvard School of Public Health, Boston, MA, USA
    Malar J 13:89. 2014
    ..This current study demonstrates application of pre-amplification methods for successful detection and genotyping of residual Plasmodium falciparum infections during a dramatic malarial decline...
  2. doi request reprint Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests
    Awa B Deme
    Broad Institute The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Malar J 13:34. 2014
    ..The goal of this study is to determine the extent of polymorphism in pfhrp2 among Senegal, Mali and Uganda parasite populations, and discuss the implications of these findings on the utility of RDTs that are based on HRP2 detection...
  3. doi request reprint Harnessing genomics and genome biology to understand malaria biology
    Sarah K Volkman
    Department of Immunology and Infectious Disease, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Genet 13:315-28. 2012
    ....
  4. pmc Application of genomics to field investigations of malaria by the international centers of excellence for malaria research
    Sarah K Volkman
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Acta Trop 121:324-32. 2012
    ....
  5. pmc A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs
    Kate M Broadbent
    Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Genome Biol 12:R56. 2011
    ..Long non-coding RNAs (lncRNAs) have recently emerged as a new paradigm in epigenetic remodeling. We therefore set out to investigate putative roles for lncRNAs in P. falciparum transcriptional regulation...
  6. pmc Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum
    Neekesh V Dharia
    Department of Cell Biology, ICND 202, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CA 92037, USA
    Genome Biol 10:R21. 2009
    ....
  7. pmc Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite
    Daniel J Park
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 109:13052-7. 2012
    ..falciparum...
  8. pmc A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking
    Rachel Daniels
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Malar J 7:223. 2008
    ....
  9. pmc Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum
    Sarah K Volkman
    Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA, USA
    Gene 387:1-6. 2007
    ....
  10. pmc Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal
    Rachel Daniels
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 8:e60780. 2013
    ..Our results imply that genetic surveillance can be used to evaluate the effectiveness of disease control strategies and assist a rational global malaria eradication campaign...
  11. ncbi request reprint A genome-wide map of diversity in Plasmodium falciparum
    Sarah K Volkman
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Genet 39:113-9. 2007
    ..We provide an initial map of genetic diversity in P. falciparum and demonstrate its potential utility in identifying genes subject to recent natural selection and in understanding the population genetics of this parasite...
  12. pmc Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum
    Daria Van Tyne
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1001383. 2011
    ..Our GWAS and follow-on functional validation demonstrate the potential of genome-wide studies to elucidate functionally important loci in the malaria parasite genome...
  13. pmc Rapid, field-deployable method for genotyping and discovery of single-nucleotide polymorphisms associated with drug resistance in Plasmodium falciparum
    Rachel Daniels
    Broad Institute, Cambridge, Massachusetts, USA
    Antimicrob Agents Chemother 56:2976-86. 2012
    ....
  14. pmc Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence
    Daniel E Neafsey
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Genome Biol 9:R171. 2008
    ..To that end, we have developed a high throughput single nucleotide polymorphism (SNP) genotyping platform for P. falciparum...
  15. ncbi request reprint Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum
    Lara L Bethke
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Mol Biochem Parasitol 150:10-24. 2006
    ..We also found that the gene encoding acyl-CoA binding protein has expanded and diversified in P. falciparum. We have described a new class of subtelomeric gene family with a unique capacity for diversity in P. falciparum...
  16. pmc Human cerebral malaria and Plasmodium falciparum genotypes in Malawi
    Danny A Milner
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Amory 3, Boston, MA 02115, USA
    Malar J 11:35. 2012
    ..A Taqman 24 Single Nucleotide Polymorphisms (SNP) molecular barcode assay was developed for use in laboratory parasites which estimates genotype number and identifies the predominant genotype...
  17. pmc Hybrid selection for sequencing pathogen genomes from clinical samples
    Alexandre Melnikov
    Genome Sequencing and Analysis Program, Broad Institute, Cambridge, MA 02142, USA
    Genome Biol 12:R73. 2011
    ..This approach will enable efficient genome sequencing of pathogens from clinical samples, as well as sequencing of endosymbiotic organisms such as Wolbachia that live inside diverse metazoan phyla...
  18. ncbi request reprint Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal
    Daria Van Tyne
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston 02115, USA
    Malar J 12:441. 2013
    ..Simple assays to monitor parasite drug response in direct patient samples (ex vivo) can detect drug resistance before it becomes clinically apparent, and can inform changes in treatment policy to prevent the spread of resistance...
  19. pmc Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome
    Martine M Zilversmit
    Department of Organismic and Evolutionary Biology, Harvard University, Boston, MA, USA
    Mol Biol Evol 27:2198-209. 2010
    ..We discuss how the discovery of these distinct species of PfLCRs helps to resolve previous contradictory studies on LCRs in malaria and contributes to our understanding of the evolution of the of the parasite's unusual genome...
  20. doi request reprint An adjustable gas-mixing device to increase feasibility of in vitro culture of plasmodium falciparum parasites in the field
    Amy K Bei
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America Laboratory of Bacteriology and Virology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal
    PLoS ONE 9:e90928. 2014
    ..This adjustable gas-mixing device will dramatically improve the feasibility of in vitro culture of Plasmodium falciparum parasites in malaria endemic countries given its numerous advantages. ..
  21. ncbi request reprint Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum
    Sarah K Volkman
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 298:216-8. 2002
    ..Genetic variation is also enriched in subtelomeric regions, which account for 22% of the chromosome but 76% of the polymorphisms...
  22. ncbi request reprint Plasmodium research in the postgenomic era
    Manoj Duraisingh
    Department of Immunology and Infectious Diseases, Harvard School of Public Health Building I, Room 715, 665 Huntington Avenue, Boston, MA 02115, USA
    Trends Parasitol 22:1-4. 2006
    ....
  23. ncbi request reprint The paradoxical population genetics of Plasmodium falciparum
    Daniel L Hartl
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA
    Trends Parasitol 18:266-72. 2002
    ..Resolution of this issue is important for the evaluation of the long-term efficacy of drug and immunological control strategies...
  24. ncbi request reprint Parasitology. A game of cat and mouth
    Sarah K Volkman
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 299:353-4. 2003