Claudio Vinegoni

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Opt Lett 34:2566-8. 2009
  2. pmc Normalized Born ratio for fluorescence optical projection tomography
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Opt Lett 34:319-21. 2009
  3. pmc High throughput transmission optical projection tomography using low cost graphics processing unit
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
    Opt Express 17:22320-32. 2009
  4. ncbi request reprint In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography
    Claudio Vinegoni
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Methods 5:45-7. 2008
  5. pmc Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Opt Lett 35:1088-90. 2010
  6. pmc Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomography
    Claudio Vinegoni
    Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e34427. 2012
  7. pmc Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques
    Claudio Vinegoni
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Sci Transl Med 3:84ra45. 2011
  8. pmc Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques
    Marcella A Calfon
    Massachusetts General Hospital, Cardiovascular Research Center and Cardiology Division, Boston, Massachusetts 02114, USA
    J Biomed Opt 15:011107. 2010
  9. pmc Noise suppressed, multifocus image fusion for enhanced intraoperative navigation
    Paolo Fumene Feruglio
    Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, 185 Cambridge Street, Boston 02114, USA
    J Biophotonics 6:363-70. 2013
  10. pmc Real-time in vivo imaging of the beating mouse heart at microscopic resolution
    Sungon Lee
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, 185 Cambridge Street, Boston 02114, USA
    Nat Commun 3:1054. 2012

Collaborators

Detail Information

Publications32

  1. pmc Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Opt Lett 34:2566-8. 2009
    ..The method holds great promise for artifact-free whole-body visualization of optical molecular probes...
  2. pmc Normalized Born ratio for fluorescence optical projection tomography
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Opt Lett 34:319-21. 2009
    ..We use the algorithm to three-dimensionally reconstruct and characterize a fluorescein isothiocyanate containing absorptive phantom and an infarcted mouse heart previously injected with a fluorescent molecular probe...
  3. pmc High throughput transmission optical projection tomography using low cost graphics processing unit
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
    Opt Express 17:22320-32. 2009
    ..By implementing the GPU we have obtained a 300 fold performance enhancement in comparison to a CPU workstation implementation. This enables to obtain on-the-fly reconstructions enabling for high throughput imaging...
  4. ncbi request reprint In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography
    Claudio Vinegoni
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Methods 5:45-7. 2008
    ..We demonstrate whole-body three-dimensional visualization of the morphogenesis of GFP-expressing salivary glands and wing imaginal discs in living Drosophila melanogaster pupae in vivo and over time...
  5. pmc Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Opt Lett 35:1088-90. 2010
    ....
  6. pmc Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomography
    Claudio Vinegoni
    Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e34427. 2012
    ..We observed extensive monocyte recruitment within and around the infarcted areas and discovered that monocytes were also extensively recruited into non-ischemic myocardium, beyond that of injured tissue, such as the septum...
  7. pmc Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques
    Claudio Vinegoni
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Sci Transl Med 3:84ra45. 2011
    ..The atheroma-targeting capability of ICG has the potential to accelerate the clinical development of NIRF molecular imaging of high-risk plaques in humans...
  8. pmc Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques
    Marcella A Calfon
    Massachusetts General Hospital, Cardiovascular Research Center and Cardiology Division, Boston, Massachusetts 02114, USA
    J Biomed Opt 15:011107. 2010
    ....
  9. pmc Noise suppressed, multifocus image fusion for enhanced intraoperative navigation
    Paolo Fumene Feruglio
    Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, 185 Cambridge Street, Boston 02114, USA
    J Biophotonics 6:363-70. 2013
    ..While the imaging system is integrated with a respiratory monitor triggering system, it can be easily adapted to any commercial imaging system. The developed algorithm is made available as a plugin for Osirix...
  10. pmc Real-time in vivo imaging of the beating mouse heart at microscopic resolution
    Sungon Lee
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, 185 Cambridge Street, Boston 02114, USA
    Nat Commun 3:1054. 2012
    ..The generic method could be adapted to other moving organs and thus broadly facilitate in vivo microscopic investigations...
  11. pmc Hybrid PET-optical imaging using targeted probes
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7910-5. 2010
    ..The findings also suggest that FMT can serve as a surrogate modality for the screening and development of radionuclide-based imaging agents...
  12. pmc Improved intravital microscopy via synchronization of respiration and holder stabilization
    Sungon Lee
    Massachusetts General Hospital and Harvard Medical School, Center for System Biology, Richard B Simches Research Center, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    J Biomed Opt 17:96018-1. 2012
    ..The described methodology is easy to implement with any commercial imaging system, as are used by most biological imaging laboratories, and can be used for both confocal and multiphoton laser scanning microscopy...
  13. pmc Myocardial infarction accelerates atherosclerosis
    Partha Dutta
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 487:325-9. 2012
    ..The progenitors then seeded the spleen, yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression...
  14. pmc Diffractionless beam in free space with adiabatic changing refractive index in a single mode tapered slab waveguide
    Chang Ching Tsai
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Opt Express 17:21723-31. 2009
    ..The proposed waveguide could find excellent applications for imaging purposes where an extended depth of field is required...
  15. pmc Implantable microenvironments to attract hematopoietic stem/cancer cells
    Jungwoo Lee
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:19638-43. 2012
    ..This implantable construct can serve as a tool enabling the study of hematopoiesis...
  16. pmc Imaging therapeutic PARP inhibition in vivo through bioorthogonally developed companion imaging agents
    Thomas Reiner
    Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neoplasia 14:169-77. 2012
    ..This research represents a step toward developing a more generic approach for the rapid codevelopment of companion imaging agents based on small-molecule therapeutic inhibitors...
  17. pmc Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation
    Virna Cortez-Retamozo
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 118:4058-66. 2008
    ..Both fluorescence-mediated tomography and fiberoptic bronchoscopy techniques have the potential to be translated into the clinic...
  18. pmc Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis
    Farouc A Jaffer
    MGH CMIR, 149 13th St, Room 5406, Boston, MA 02129, USA
    Circulation 118:1802-9. 2008
    ..To enable intravascular detection of inflammation in atherosclerosis, we developed a near-infrared fluorescence (NIRF) catheter-based strategy to sense cysteine protease activity during vascular catheterization...
  19. pmc In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single-cell resolution
    Sarah Earley
    Center for Systems Biology, Massachusetts General Hospital, Boston 02114, USA
    Cancer Res 72:2949-56. 2012
    ..Together, our findings show an imaging technique that can be used to directly visualize cell death within the tumor microenvironment in response to drug treatment...
  20. pmc Chronic variable stress activates hematopoietic stem cells
    Timo Heidt
    1 Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA 2
    Nat Med 20:754-8. 2014
    ..When atherosclerosis-prone Apoe(-/-) mice were subjected to chronic stress, accelerated hematopoiesis promoted plaque features associated with vulnerable lesions that cause myocardial infarction and stroke in humans. ..
  21. pmc Bioorthogonal imaging of aurora kinase A in live cells
    Katherine S Yang
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    Angew Chem Int Ed Engl 51:6598-603. 2012
  22. pmc PET/MRI of inflammation in myocardial infarction
    Won Woo Lee
    Center for Systems Biology, Massachusetts General Hospital, Boston, USA
    J Am Coll Cardiol 59:153-63. 2012
    ..The aim of this study was to explore post-myocardial infarction (MI) myocardial inflammation...
  23. pmc Automated motion artifact removal for intravital microscopy, without a priori information
    Sungon Lee
    1 Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, 185 Cambridge Street, Boston 02114, USA 2 Interaction and Robotics Research Center, Korea Institute of Science and Technology, Hwarangno 14 gil 5, Seongbuk gu, Seoul, Korea 3
    Sci Rep 4:4507. 2014
    ..The methodology, which is based on raw data acquisition followed by image processing, is here demonstrated for both cardiac and respiratory motion compensation in mice heart, kidney, liver, pancreas and dorsal window chamber. ..
  24. pmc Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog
    Thomas Reiner
    Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 108:12815-20. 2011
    ..This near-infrared imaging probe, as well as future radioisotope-labeled versions of it, should prove to be important tools for monitoring diabetes, progression, and treatment in both experimental and clinical contexts...
  25. ncbi request reprint Multispectral photoacoustic imaging of fluorochromes in small animals
    Daniel Razansky
    Center for Molecular Imaging Research, Massachusetts General Hospital, MA 02129, USA
    Opt Lett 32:2891-3. 2007
    ..The suggested method is well suited for enhancing visualization of functional and molecular information in vivo and longitudinally...
  26. pmc WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud
    Jerome Gros
    Department of Genetics, Harvard Medical School, and Center for Systems Biology, Massachusetts General Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Curr Biol 20:1993-2002. 2010
    ....
  27. ncbi request reprint Intravital imaging of cardiac function at the single-cell level
    Aaron D Aguirre
    Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114 Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115 and
    Proc Natl Acad Sci U S A 111:11257-62. 2014
    ..Quantification of cardiomyocyte contractile function in vivo opens many possibilities for investigating myocardial disease and therapeutic intervention at the cellular level. ..
  28. ncbi request reprint Imaging cellular responses to mechanical stimuli within three-dimensional tissue constructs
    Wei Tan
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinoisat Urbana Champaign, Illinois 61801, USA
    Microsc Res Tech 70:361-71. 2007
    ..The microscopy technique presented here reveals unique complementary data on the structure and function of cells and their adhesions and interactions with the surrounding microenvironment...
  29. ncbi request reprint High-spectral-resolution coherent anti-Stokes Raman scattering with interferometrically detected broadband chirped pulses
    Gareth W Jones
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, 61801, USA
    Opt Lett 31:1543-5. 2006
    ..With the temporally resolved anti-Stokes signal, we can remove the chirp of the anti-Stokes pulse and restore high spectral resolution while also rejecting nonresonant scattering...
  30. ncbi request reprint Spectroscopic spectral-domain optical coherence microscopy
    Chengyang Xu
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA
    Opt Lett 31:1079-81. 2006
    ..Simultaneous acquisition of multiphoton microscopy images is used to validate tissue structure and localization of nuclei within individual cells...
  31. ncbi request reprint Molecularly sensitive optical coherence tomography
    Jeremy S Bredfeldt
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA
    Opt Lett 30:495-7. 2005
    ..CARS can be generated and interferometrically measured over at least 600 microm of the depth of field of a low-numerical-aperture objective...