Research Topics
Genomes and GenesSpecies | Claudio VinegoniSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomographyClaudio Vinegoni
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Opt Lett 35:1088-90. 2010....- High throughput transmission optical projection tomography using low cost graphics processing unitClaudio Vinegoni
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
Opt Express 17:22320-32. 2009..By implementing the GPU we have obtained a 300 fold performance enhancement in comparison to a CPU workstation implementation. This enables to obtain on-the-fly reconstructions enabling for high throughput imaging... - Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticlesClaudio Vinegoni
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Opt Lett 34:2566-8. 2009..The method holds great promise for artifact-free whole-body visualization of optical molecular probes... - Normalized Born ratio for fluorescence optical projection tomographyClaudio Vinegoni
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Opt Lett 34:319-21. 2009..We use the algorithm to three-dimensionally reconstruct and characterize a fluorescein isothiocyanate containing absorptive phantom and an infarcted mouse heart previously injected with a fluorescent molecular probe... 
In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomographyClaudio Vinegoni
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
Nat Methods 5:45-7. 2008..We demonstrate whole-body three-dimensional visualization of the morphogenesis of GFP-expressing salivary glands and wing imaginal discs in living Drosophila melanogaster pupae in vivo and over time...- Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomographyClaudio Vinegoni
Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, Boston, Massachusetts, United States of America
PLoS ONE 7:e34427. 2012..We observed extensive monocyte recruitment within and around the infarcted areas and discovered that monocytes were also extensively recruited into non-ischemic myocardium, beyond that of injured tissue, such as the septum... - Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaquesClaudio Vinegoni
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA
Sci Transl Med 3:84ra45. 2011..The atheroma-targeting capability of ICG has the potential to accelerate the clinical development of NIRF molecular imaging of high-risk plaques in humans... - Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaquesMarcella A Calfon
Massachusetts General Hospital, Cardiovascular Research Center and Cardiology Division, Boston, Massachusetts 02114, USA
J Biomed Opt 15:011107. 2010.... 
Real-time in vivo imaging of the beating mouse heart at microscopic resolutionSungon Lee
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, 185 Cambridge Street, Boston 02114, USA
Nat Commun 3:1054. 2012..The generic method could be adapted to other moving organs and thus broadly facilitate in vivo microscopic investigations...- Hybrid PET-optical imaging using targeted probesMatthias Nahrendorf
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 107:7910-5. 2010..The findings also suggest that FMT can serve as a surrogate modality for the screening and development of radionuclide-based imaging agents... - Improved intravital microscopy via synchronization of respiration and holder stabilizationSungon Lee
Massachusetts General Hospital and Harvard Medical School, Center for System Biology, Richard B Simches Research Center, 185 Cambridge Street, Boston, Massachusetts 02114, USA
J Biomed Opt 17:96018-1. 2012..The described methodology is easy to implement with any commercial imaging system, as are used by most biological imaging laboratories, and can be used for both confocal and multiphoton laser scanning microscopy... - Myocardial infarction accelerates atherosclerosisPartha Dutta
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 487:325-9. 2012..The progenitors then seeded the spleen, yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression... - Diffractionless beam in free space with adiabatic changing refractive index in a single mode tapered slab waveguideChang Ching Tsai
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Opt Express 17:21723-31. 2009..The proposed waveguide could find excellent applications for imaging purposes where an extended depth of field is required... - Noise suppressed, multifocus image fusion for enhanced intraoperative navigationPaolo Fumene Feruglio
Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, 185 Cambridge Street, Boston 02114, USA Department Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
J Biophotonics 6:363-70. 2013..The developed algorithm is made available as a plugin for Osirix. (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)... - Implantable microenvironments to attract hematopoietic stem/cancer cellsJungwoo Lee
Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 109:19638-43. 2012..This implantable construct can serve as a tool enabling the study of hematopoiesis... - Imaging therapeutic PARP inhibition in vivo through bioorthogonally developed companion imaging agentsThomas Reiner
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Neoplasia 14:169-77. 2012..This research represents a step toward developing a more generic approach for the rapid codevelopment of companion imaging agents based on small-molecule therapeutic inhibitors... - Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammationVirna Cortez-Retamozo
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Invest 118:4058-66. 2008..Both fluorescence-mediated tomography and fiberoptic bronchoscopy techniques have the potential to be translated into the clinic... - In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single-cell resolutionSarah Earley
Center for Systems Biology, Massachusetts General Hospital, Boston 02114, USA
Cancer Res 72:2949-56. 2012..Together, our findings show an imaging technique that can be used to directly visualize cell death within the tumor microenvironment in response to drug treatment... - Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosisFarouc A Jaffer
MGH CMIR, 149 13th St, Room 5406, Boston, MA 02129, USA
Circulation 118:1802-9. 2008..To enable intravascular detection of inflammation in atherosclerosis, we developed a near-infrared fluorescence (NIRF) catheter-based strategy to sense cysteine protease activity during vascular catheterization... - Bioorthogonal imaging of aurora kinase A in live cellsKatherine S Yang
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
Angew Chem Int Ed Engl 51:6598-603. 2012 - PET/MRI of inflammation in myocardial infarctionWon Woo Lee
Center for Systems Biology, Massachusetts General Hospital, Boston, USA
J Am Coll Cardiol 59:153-63. 2012..The aim of this study was to explore post-myocardial infarction (MI) myocardial inflammation... - Multispectral photoacoustic imaging of fluorochromes in small animalsDaniel Razansky
Center for Molecular Imaging Research, Massachusetts General Hospital, MA 02129, USA
Opt Lett 32:2891-3. 2007..The suggested method is well suited for enhancing visualization of functional and molecular information in vivo and longitudinally... - WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb budJerome Gros
Department of Genetics, Harvard Medical School, and Center for Systems Biology, Massachusetts General Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Curr Biol 20:1993-2002. 2010.... - Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analogThomas Reiner
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 108:12815-20. 2011..This near-infrared imaging probe, as well as future radioisotope-labeled versions of it, should prove to be important tools for monitoring diabetes, progression, and treatment in both experimental and clinical contexts... - Imaging cellular responses to mechanical stimuli within three-dimensional tissue constructsWei Tan
Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinoisat Urbana Champaign, Illinois 61801, USA
Microsc Res Tech 70:361-71. 2007..The microscopy technique presented here reveals unique complementary data on the structure and function of cells and their adhesions and interactions with the surrounding microenvironment... - High-spectral-resolution coherent anti-Stokes Raman scattering with interferometrically detected broadband chirped pulsesGareth W Jones
Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana--Champaign, 61801, USA
Opt Lett 31:1543-5. 2006..With the temporally resolved anti-Stokes signal, we can remove the chirp of the anti-Stokes pulse and restore high spectral resolution while also rejecting nonresonant scattering... - Spectroscopic spectral-domain optical coherence microscopyChengyang Xu
Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA
Opt Lett 31:1079-81. 2006..Simultaneous acquisition of multiphoton microscopy images is used to validate tissue structure and localization of nuclei within individual cells... - Molecularly sensitive optical coherence tomographyJeremy S Bredfeldt
Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA
Opt Lett 30:495-7. 2005..CARS can be generated and interferometrically measured over at least 600 microm of the depth of field of a low-numerical-aperture objective...