Vinayagam A, Gibson T, Lee H, Yilmazel B, Roesel C, Hu Y, et al. Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets. Proc Natl Acad Sci U S A. 2016;113:4976-81 pubmed publisher
..Among the 56 genes, 46 of them have not been previously associated with cancer. This suggests that controllability analysis is very useful in identifying novel disease genes and potential drug targets. ..
Vinayagam A, Hu Y, Kulkarni M, Roesel C, Sopko R, Mohr S, et al. Protein complex-based analysis framework for high-throughput data sets. Sci Signal. 2013;6:rs5 pubmed publisher
..The analysis predicted that the Brahma complex participated in the insulin response. ..
Hu Y, Flockhart I, Vinayagam A, Bergwitz C, Berger B, Perrimon N, et al. An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC Bioinformatics. 2011;12:357 pubmed publisher
..org/diopt-dist). DIOPT and DIOPT-DIST are useful resources for researchers working with model organisms, especially those who are interested in exploiting model organisms such as Drosophila to study the functions of human disease genes. ..